How could Parkin-mediated ubiquitination of mitofusin promote mitophagy?

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy. Hum Mol Genet (2011) 4.41

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy. Hum Mol Genet (2010) 3.77

A mitochondrial etiology of Alzheimer and Parkinson disease. Biochim Biophys Acta (2011) 1.52

Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan. Proc Natl Acad Sci U S A (2013) 1.34

Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons. J Biol Chem (2012) 1.26

Bioenergetic origins of complexity and disease. Cold Spring Harb Symp Quant Biol (2011) 1.19

Mutant Parkin impairs mitochondrial function and morphology in human fibroblasts. PLoS One (2010) 1.14

Mitochondrial dynamics in the adult cardiomyocytes: which roles for a highly specialized cell? Front Physiol (2013) 1.08

Mechanisms of mitochondria and autophagy crosstalk. Cell Cycle (2011) 1.01

How mitochondrial dynamism orchestrates mitophagy. Circ Res (2015) 0.98

Transglutaminase 2 ablation leads to mitophagy impairment associated with a metabolic shift towards aerobic glycolysis. Cell Death Differ (2014) 0.94

Mitochondria in heart failure: the emerging role of mitochondrial dynamics. Heart Fail Rev (2013) 0.90

Mitochondrial fission and autophagy in the normal and diseased heart. Curr Hypertens Rep (2010) 0.88

ULK1, mammalian target of rapamycin, and mitochondria: linking nutrient availability and autophagy. Antioxid Redox Signal (2011) 0.88

Modeling pathogenic mutations of human twinkle in Drosophila suggests an apoptosis role in response to mitochondrial defects. PLoS One (2012) 0.86

Mitochondrial dynamics and cell death in heart failure. Heart Fail Rev (2016) 0.83

Antiaging properties of a grape-derived antioxidant are regulated by mitochondrial balance of fusion and fission leading to mitophagy triggered by a signaling network of Sirt1-Sirt3-Foxo3-PINK1-PARKIN. Oxid Med Cell Longev (2014) 0.83

LK6/Mnk2a is a new kinase of alpha synuclein phosphorylation mediating neurodegeneration. Sci Rep (2015) 0.79

Mitochondrial homeostasis molecules: regulation by a trio of recessive Parkinson's disease genes. Exp Neurobiol (2014) 0.77

Deregulated Expression of Mitochondrial Proteins Mfn2 and Bcnl3L in Placentae from Sheep Somatic Cell Nuclear Transfer (SCNT) Conceptuses. PLoS One (2017) 0.75

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants. Proc Natl Acad Sci U S A (2003) 7.57

The PINK1/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci U S A (2008) 7.41

Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin. Proc Natl Acad Sci U S A (2010) 5.17

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss. Nat Neurosci (2009) 2.35

Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease. Curr Biol (2005) 2.35

PINK1 cleavage at position A103 by the mitochondrial protease PARL. Hum Mol Genet (2010) 2.30

Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis. Hum Mol Genet (2005) 1.61

Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations. Open Biol (2011) 1.42

The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy. Nat Neurosci (2013) 1.19

Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1. Exp Cell Res (2010) 1.03

TRAP1 rescues PINK1 loss-of-function phenotypes. Hum Mol Genet (2013) 0.93

Molecular mechanisms of PINK1-related neurodegeneration. Curr Neurol Neurosci Rep (2011) 0.87

Modeling pathogenic mutations of human twinkle in Drosophila suggests an apoptosis role in response to mitochondrial defects. PLoS One (2012) 0.86

The many faces of mitophagy. EMBO Rep (2014) 0.79

Translating translation: regulated protein translation as a biomedical intervention. Fly (Austin) (2009) 0.77