Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants.

PubWeight™: 7.57‹?› | Rank: Top 0.1%

🔗 View Article (PMC 153051)

Published in Proc Natl Acad Sci U S A on March 17, 2003

Authors

Jessica C Greene1, Alexander J Whitworth, Isabella Kuo, Laurie A Andrews, Mel B Feany, Leo J Pallanck

Author Affiliations

1: Department of Genome Sciences, University of Washington, P.O. Box 357730, Seattle, WA 98195, USA.

Articles citing this

(truncated to the top 100)

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol (2008) 17.81

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol (2010) 11.85

Mechanisms of mitophagy. Nat Rev Mol Cell Biol (2011) 10.66

Mitochondrial fission, fusion, and stress. Science (2012) 7.45

The PINK1/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci U S A (2008) 7.41

Mitochondria: in sickness and in health. Cell (2012) 6.05

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin. J Cell Biol (2010) 5.94

Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc Natl Acad Sci U S A (2006) 5.78

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc Natl Acad Sci U S A (2008) 5.43

Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin. Proc Natl Acad Sci U S A (2010) 5.17

Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases. Hum Mol Genet (2009) 5.15

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy. Hum Mol Genet (2011) 4.41

Genetic animal models of Parkinson's disease. Neuron (2010) 3.86

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL. J Cell Biol (2010) 3.68

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy (2010) 3.68

PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science (2013) 3.60

PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease. Sci Transl Med (2010) 3.48

Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease. Proc Natl Acad Sci U S A (2005) 3.40

Mitochondria in neuroplasticity and neurological disorders. Neuron (2008) 3.35

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. Nature (2014) 3.26

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J Clin Invest (2009) 3.17

The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway. PLoS One (2010) 3.16

Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control. EMBO J (2014) 2.93

The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease. Neuron (2015) 2.82

Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. J Biol Chem (2009) 2.64

Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP. Proc Natl Acad Sci U S A (2008) 2.64

Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling. Proc Natl Acad Sci U S A (2005) 2.58

Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. Dev Cell (2012) 2.52

The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ (2012) 2.45

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss. Nat Neurosci (2009) 2.35

Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts. Ann Neurol (2008) 2.34

Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin. Dis Model Mech (2008) 2.29

Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update. Hum Mutat (2010) 2.29

Recent advances in the genetics of Parkinson's disease. Annu Rev Genomics Hum Genet (2011) 2.29

Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery. Pharmacol Rev (2011) 2.25

Muscle mitohormesis promotes longevity via systemic repression of insulin signaling. Cell (2013) 2.21

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue. Mol Brain (2012) 2.18

Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein. J Neurosci (2009) 2.11

Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling. Hum Mol Genet (2009) 2.10

The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo. Proc Natl Acad Sci U S A (2013) 2.10

Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells. Proc Natl Acad Sci U S A (2010) 2.10

Mitochondrial quality control mediated by PINK1 and Parkin: links to parkinsonism. Cold Spring Harb Perspect Biol (2012) 2.10

Toward a comprehensive genetic analysis of male fertility in Drosophila melanogaster. Genetics (2004) 2.08

Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. J Biol Chem (2005) 2.07

New insights into the role of mitochondria in aging: mitochondrial dynamics and more. J Cell Sci (2010) 2.03

Parkin protein deficiency exacerbates cardiac injury and reduces survival following myocardial infarction. J Biol Chem (2012) 1.98

The role of parkin in familial and sporadic Parkinson's disease. Mov Disord (2010) 1.90

Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Mol Med (2009) 1.89

PINK1- and Parkin-mediated mitophagy at a glance. J Cell Sci (2012) 1.89

The role of oxidative stress in Parkinson's disease. J Parkinsons Dis (2013) 1.86

Maintaining the brain: insight into human neurodegeneration from Drosophila melanogaster mutants. Nat Rev Genet (2009) 1.84

Mitochondrial quality control: a matter of life and death for neurons. EMBO J (2012) 1.83

Targeting mitochondrial dysfunction: role for PINK1 and Parkin in mitochondrial quality control. Antioxid Redox Signal (2011) 1.82

Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans. PLoS Biol (2012) 1.80

Whole exome sequencing of rare variants in EIF4G1 and VPS35 in Parkinson disease. Neurology (2013) 1.78

100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future. Nat Rev Neurosci (2010) 1.76

Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson disease. J Biol Chem (2011) 1.75

The PINK1/Parkin pathway: a mitochondrial quality control system? J Bioenerg Biomembr (2009) 1.72

VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. Neuron (2013) 1.70

The genetics of Parkinson disease. J Geriatr Psychiatry Neurol (2010) 1.69

Mitochondrial trafficking in neurons. Cold Spring Harb Perspect Biol (2013) 1.69

Drosophila models of neurodegenerative diseases. Annu Rev Pathol (2009) 1.67

Stressin' Sestrins take an aging fight. EMBO Mol Med (2010) 1.65

Mitochondria-targeted peptide antioxidants: novel neuroprotective agents. AAPS J (2006) 1.65

Spatial parkin translocation and degradation of damaged mitochondria via mitophagy in live cortical neurons. Curr Biol (2012) 1.64

LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans. J Neurosci (2009) 1.64

PINK1 is degraded through the N-end rule pathway. Autophagy (2013) 1.63

Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts. PLoS One (2011) 1.62

Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. PLoS One (2010) 1.62

Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature (2015) 1.62

Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster. Cell Death Differ (2012) 1.60

Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism. Cell Res (2013) 1.59

How does parkin ligate ubiquitin to Parkinson's disease? EMBO Rep (2004) 1.54

Parkinson's disease: insights from pathways. Hum Mol Genet (2010) 1.52

DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function. Proc Natl Acad Sci U S A (2010) 1.49

Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila. Proc Natl Acad Sci U S A (2005) 1.48

Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps. Apoptosis (2009) 1.43

The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila. PLoS Genet (2010) 1.41

Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism. Neurobiol Dis (2012) 1.39

Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease. Br J Pharmacol (2011) 1.39

Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin. Cell Death Differ (2009) 1.36

Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the PINK1/PARKIN pathway in vivo. J Neurosci (2008) 1.36

Calcium homeostasis, selective vulnerability and Parkinson's disease. Trends Neurosci (2009) 1.34

Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice. J Neurochem (2009) 1.34

Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan. Proc Natl Acad Sci U S A (2013) 1.34

Calcium, cellular aging, and selective neuronal vulnerability in Parkinson's disease. Cell Calcium (2010) 1.34

Drosophila melanogaster in the study of human neurodegeneration. CNS Neurol Disord Drug Targets (2010) 1.33

PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease. PLoS One (2009) 1.30

Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification. Exp Cell Res (2008) 1.29

Neuronal autophagy and neurodegenerative diseases. Exp Mol Med (2012) 1.28

Recent advances in our understanding of neurodegeneration. J Neural Transm (Vienna) (2009) 1.27

Mitochondrial dynamics in Parkinson's disease. Exp Neurol (2009) 1.24

RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism. PLoS Genet (2006) 1.23

Inhibition of proteasomal activity causes inclusion formation in neuronal and non-neuronal cells overexpressing Parkin. Mol Biol Cell (2003) 1.23

Mitochondrial turnover in the heart. Biochim Biophys Acta (2010) 1.23

Parkin selectively alters the intrinsic threshold for mitochondrial cytochrome c release. Hum Mol Genet (2009) 1.22

Probing mechanisms that underlie human neurodegenerative diseases in Drosophila. Annu Rev Genet (2012) 1.21

Clueless, a conserved Drosophila gene required for mitochondrial subcellular localization, interacts genetically with parkin. Dis Model Mech (2009) 1.20

Mitochondrial dysfunction and oxidative stress in Parkinson's disease. Prog Neurobiol (2013) 1.20

Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice. Int J Biol Sci (2007) 1.20

Articles cited by this

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development (1993) 58.26

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature (1998) 21.49

Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat Neurosci (2000) 10.62

BEHAVIORAL MUTANTS OF Drosophila ISOLATED BY COUNTERCURRENT DISTRIBUTION. Proc Natl Acad Sci U S A (1967) 10.07

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet (2000) 7.83

A Drosophila model of Parkinson's disease. Nature (2000) 7.82

High-frequency P element loss in Drosophila is homolog dependent. Cell (1990) 6.64

Mitochondrial complex I deficiency in Parkinson's disease. Lancet (1989) 5.72

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1. Proc Natl Acad Sci U S A (2000) 4.83

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. Cell (2001) 4.41

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nat Med (2001) 4.22

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease. Science (2001) 4.18

Mitochondrial complex I deficiency in Parkinson's disease. J Neurochem (1990) 4.03

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity. J Biol Chem (2000) 3.86

A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade. Nature (1997) 3.54

Genetic dissection of behavior. Sci Am (1973) 2.93

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. Life Sci (1985) 2.70

The role of DNA fragmentation in apoptosis. Trends Cell Biol (1995) 2.49

The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living. Neurology (1998) 2.32

Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease. Biochem Biophys Res Commun (1989) 2.23

Wingless signaling induces nautilus expression in the ventral mesoderm of the Drosophila embryo. Dev Biol (1996) 2.13

Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss. Brain Res (1999) 2.02

Mechanistic approaches to Parkinson's disease pathogenesis. Brain Pathol (2002) 1.39

Genetics of parkinsonism. Mov Disord (2002) 1.38

Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in Parkinson's disease. Ann Neurol (1991) 1.32

Mitochondrial involvement in Parkinson's disease. Neurochem Int (2002) 1.31

Inhibition of mitochondrial NADH-ubiquinone oxidoreductase activity by 1-methyl-4-phenylpyridinium ion. Biochem Biophys Res Commun (1987) 1.23

Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonism. Biochem Biophys Res Commun (1986) 1.12

Unaltered aconitase activity, but decreased complex I activity in substantia nigra pars compacta of patients with Parkinson's disease. Neurosci Lett (1994) 1.10

Genetics of Parkinsonism: a review. Ann Hum Genet (2001) 1.08

Does neuronal loss in Parkinson's disease involve programmed cell death? Bioessays (2001) 1.07

Articles by these authors

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

The PINK1/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci U S A (2008) 7.41

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science (2007) 5.49

Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin. Proc Natl Acad Sci U S A (2010) 5.17

Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease. Proc Natl Acad Sci U S A (2005) 3.40

Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo. Nat Cell Biol (2006) 2.93

Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease. Nat Neurosci (2005) 2.91

Parkinson's disease: genetics and pathogenesis. Annu Rev Pathol (2011) 2.39

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss. Nat Neurosci (2009) 2.35

Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease. Curr Biol (2005) 2.35

PINK1 cleavage at position A103 by the mitochondrial protease PARL. Hum Mol Genet (2010) 2.30

The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo. Proc Natl Acad Sci U S A (2013) 2.10

Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity. Hum Mol Genet (2006) 2.03

TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model. Curr Biol (2006) 1.88

Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS. Proc Natl Acad Sci U S A (2009) 1.78

In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons. J Neurosci (2008) 1.77

Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo. J Neurosci (2007) 1.75

The PINK1/Parkin pathway: a mitochondrial quality control system? J Bioenerg Biomembr (2009) 1.72

Genetic modifiers of tauopathy in Drosophila. Genetics (2003) 1.70

Accelerated accumulation of misfolded prion protein and spongiform degeneration in a Drosophila model of Gerstmann-Sträussler-Scheinker syndrome. J Neurosci (2006) 1.69

Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo. Mol Brain (2009) 1.62

Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis. Hum Mol Genet (2005) 1.61

Tau promotes neurodegeneration via DRP1 mislocalization in vivo. Neuron (2012) 1.58

Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation. Am J Pathol (2007) 1.54

Ataxin-2 and its Drosophila homolog, ATX2, physically assemble with polyribosomes. Hum Mol Genet (2006) 1.43

Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations. Open Biol (2011) 1.42

Oxidative stress mediates tau-induced neurodegeneration in Drosophila. J Clin Invest (2006) 1.40

Tau phosphorylation sites work in concert to promote neurotoxicity in vivo. Mol Biol Cell (2007) 1.37

Comparison of pathways controlling toxicity in the eye and brain in Drosophila models of human neurodegenerative diseases. Hum Mol Genet (2004) 1.36

Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation. J Clin Invest (2009) 1.35

Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms. Hum Mol Genet (2013) 1.32

Alexander disease. J Neurosci (2012) 1.30

Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease. J Neurosci (2008) 1.28

Modelling neurodegenerative diseases in Drosophila: a fruitful approach? Nat Rev Neurosci (2002) 1.23

From fruit fly to bedside: translating lessons from Drosophila models of neurodegenerative disease. Curr Opin Neurol (2003) 1.21

Drosophila NPC1b promotes an early step in sterol absorption from the midgut epithelium. Cell Metab (2007) 1.21

Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease. Hum Mol Genet (2003) 1.20

The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy. Nat Neurosci (2013) 1.19

A Drosophila homolog of the polyglutamine disease gene SCA2 is a dosage-sensitive regulator of actin filament formation. Genetics (2002) 1.19

S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila. J Neurosci Res (2007) 1.16

Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease. J Neuropathol Exp Neurol (2009) 1.15

Cathepsin D-deficient Drosophila recapitulate the key features of neuronal ceroid lipofuscinoses. Neurobiol Dis (2005) 1.15

Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo. PLoS Genet (2010) 1.12

How could Parkin-mediated ubiquitination of mitofusin promote mitophagy? Autophagy (2010) 1.11

Mutations of a Drosophila NPC1 gene confer sterol and ecdysone metabolic defects. Genetics (2005) 1.09

Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model. Dis Model Mech (2009) 1.09

Functional screening of Alzheimer pathology genome-wide association signals in Drosophila. Am J Hum Genet (2011) 1.08

Parkin: a multipurpose neuroprotective agent? Neuron (2003) 1.07

Yeast genetics targets lipids in Parkinson's disease. Trends Genet (2004) 1.05

Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1. Exp Cell Res (2010) 1.03

Drosophila models pioneer a new approach to drug discovery for Parkinson's disease. Drug Discov Today (2006) 1.01

Mitochondrial dysfunction in NnaD mutant flies and Purkinje cell degeneration mice reveals a role for Nna proteins in neuronal bioenergetics. Neuron (2010) 1.00

Proliferative potential of human astrocytes. J Neuropathol Exp Neurol (2005) 0.95

TRAP1 rescues PINK1 loss-of-function phenotypes. Hum Mol Genet (2013) 0.93

The unfolded protein response protects from tau neurotoxicity in vivo. PLoS One (2010) 0.93

Protein misfolding and oxidative stress promote glial-mediated neurodegeneration in an Alexander disease model. J Neurosci (2011) 0.92

Glial fibrillary tangles and JAK/STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy. J Neurosci (2010) 0.90

Parkinson's disease: insights from non-traditional model organisms. Prog Neurobiol (2010) 0.89

A neuroprotective role for the DNA damage checkpoint in tauopathy. Aging Cell (2012) 0.89

Connecting cell-cycle activation to neurodegeneration in Drosophila. Biochim Biophys Acta (2006) 0.87

Molecular mechanisms of PINK1-related neurodegeneration. Curr Neurol Neurosci Rep (2011) 0.87

Modeling pathogenic mutations of human twinkle in Drosophila suggests an apoptosis role in response to mitochondrial defects. PLoS One (2012) 0.86

Mediators of a long-term movement abnormality in a Drosophila melanogaster model of classic galactosemia. Dis Model Mech (2012) 0.86

A genetic screen for synaptic transmission mutants mapping to the right arm of chromosome 3 in Drosophila. Genetics (2003) 0.86

A SCA7 CAG/CTG repeat expansion is stable in Drosophila melanogaster despite modulation of genomic context and gene dosage. Gene (2005) 0.83

Post-transcriptional suppression of pathogenic prion protein expression in Drosophila neurons. J Neurochem (2003) 0.82

The many faces of mitophagy. EMBO Rep (2014) 0.79

Translating translation: regulated protein translation as a biomedical intervention. Fly (Austin) (2009) 0.77

Genetic models of Parkinson's disease: mechanisms and therapies. SEB Exp Biol Ser (2008) 0.76

Senseless makes sense for spinocerebellar ataxia-1. Nat Neurosci (2005) 0.75