Published in EMBO Rep on May 21, 2010
The giant protein titin: a regulatory node that integrates myocyte signaling pathways. J Biol Chem (2011) 1.11
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A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes. JCI Insight (2016) 0.80
Binding of Myomesin to Obscurin-Like-1 to the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection. Structure (2016) 0.78
Biophysical characterization of naturally occurring titin M10 mutations. Protein Sci (2015) 0.77
Titin and obscurin: giants holding hands and discovery of a new Ig domain subset. J Mol Biol (2014) 0.76
Solution NMR structures of immunoglobulin-like domains 7 and 12 from obscurin-like protein 1 contribute to the structural coverage of the Human Cancer Protein Interaction Network. J Struct Funct Genomics (2014) 0.75
Increasing Role of Titin Mutations in Neuromuscular Disorders. J Neuromuscul Dis (2016) 0.75
Many of the immunoglobulin superfamily domains in cell adhesion molecules and surface receptors belong to a new structural set which is close to that containing variable domains. J Mol Biol (1994) 3.57
Tibial muscular dystrophy is a titinopathy caused by mutations in TTN, the gene encoding the giant skeletal-muscle protein titin. Am J Hum Genet (2002) 2.14
Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly. J Cell Biol (2001) 1.97
Muscle giants: molecular scaffolds in sarcomerogenesis. Physiol Rev (2009) 1.92
Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band: implications for hereditary myopathies. J Cell Sci (2008) 1.84
Structural basis for vertebrate filamin dimerization. Structure (2005) 1.67
From A to Z and back? Multicompartment proteins in the sarcomere. Trends Cell Biol (2005) 1.43
Obscurin determines the architecture of the longitudinal sarcoplasmic reticulum. J Cell Sci (2009) 1.40
The primordial growth disorder 3-M syndrome connects ubiquitination to the cytoskeletal adaptor OBSL1. Am J Hum Genet (2009) 1.35
Atomic structures of two novel immunoglobulin-like domain pairs in the actin cross-linking protein filamin. J Biol Chem (2009) 1.31
Obscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly. Mol Biol Cell (2009) 1.23
Different obscurin isoforms localize to distinct sites at sarcomeres. FEBS Lett (2007) 1.20
Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin. Genomics (2007) 1.19
Tibial muscular dystrophy in a Belgian family. Ann Neurol (2003) 1.01
The first Italian family with tibial muscular dystrophy caused by a novel titin mutation. J Neurol (2009) 0.98
Terminal assembly of sarcomeric filaments by intermolecular beta-sheet formation. Trends Biochem Sci (2008) 0.85
Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers. Genes Dev (2003) 2.99
Combinatorial control of gene expression. Nat Struct Mol Biol (2004) 2.66
Steered molecular dynamics studies of titin I1 domain unfolding. Biophys J (2002) 2.13
Single-molecule investigation of the interference between kinesin, tau and MAP2c. EMBO J (2002) 1.91
Mechanical strength of the titin Z1Z2-telethonin complex. Structure (2006) 1.79
On the routine use of soft X-rays in macromolecular crystallography. Part IV. Efficient determination of anomalous substructures in biomacromolecules using longer X-ray wavelengths. Acta Crystallogr D Biol Crystallogr (2007) 1.78
Unusual binding properties of the SH3 domain of the yeast actin-binding protein Abp1: structural and functional analysis. J Biol Chem (2001) 1.69
Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk. Nature (2006) 1.57
Downregulation of lipopolysaccharide response in Drosophila by negative crosstalk between the AP1 and NF-kappaB signaling modules. Nat Immunol (2005) 1.48
Proteome-wide identification of mycobacterial pupylation targets. Mol Syst Biol (2010) 1.44
Structural evidence for ammonia tunneling across the (beta alpha)(8) barrel of the imidazole glycerol phosphate synthase bienzyme complex. Structure (2002) 1.44
The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk. Proc Natl Acad Sci U S A (2009) 1.40
Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences. Proc Natl Acad Sci U S A (2005) 1.38
Recognition of a functional peroxisome type 1 target by the dynamic import receptor pex5p. Mol Cell (2006) 1.37
The impact of protein characterization in structural proteomics. Acta Crystallogr D Biol Crystallogr (2006) 1.32
Nucleotide-induced conformations in the neck region of dimeric kinesin. EMBO J (2003) 1.32
Molecular basis of the death-associated protein kinase-calcium/calmodulin regulator complex. Sci Signal (2010) 1.31
Mechanical network in titin immunoglobulin from force distribution analysis. PLoS Comput Biol (2009) 1.25
Topography for independent binding of alpha-helical and PPII-helical ligands to a peroxisomal SH3 domain. Mol Cell (2002) 1.17
Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase. J Biol Chem (2004) 1.16
Regulation of the transcription factor Ets-1 by DNA-mediated homo-dimerization. EMBO J (2008) 1.14
Structural conservation between the actin monomer-binding sites of twinfilin and actin-depolymerizing factor (ADF)/cofilin. J Biol Chem (2002) 1.13
Crystal structure of the resuscitation-promoting factor (DeltaDUF)RpfB from M. tuberculosis. J Mol Biol (2008) 1.13
The Mycobacterium tuberculosis LipB enzyme functions as a cysteine/lysine dyad acyltransferase. Proc Natl Acad Sci U S A (2006) 1.11
Cellular target genes of Epstein-Barr virus nuclear antigen 2. J Virol (2006) 1.10
Solution scattering suggests cross-linking function of telethonin in the complex with titin. J Biol Chem (2002) 1.10
MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators. Proc Natl Acad Sci U S A (2004) 1.09
A unique Oct4 interface is crucial for reprogramming to pluripotency. Nat Cell Biol (2013) 1.08
Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circ Res (2011) 1.07
The Effects of Lactobacillus rhamnosus on the Prevention of Asthma in a Murine Model. Allergy Asthma Immunol Res (2010) 1.07
Differential activity by DNA-induced quarternary structures of POU transcription factors. Biochem Pharmacol (2002) 1.07
Dynamic architecture of the peroxisomal import receptor Pex5p. Biochim Biophys Acta (2006) 1.07
Improved mycobacterial protein production using a Mycobacterium smegmatis groEL1ΔC expression strain. BMC Biotechnol (2011) 1.06
Bisubstrate specificity in histidine/tryptophan biosynthesis isomerase from Mycobacterium tuberculosis by active site metamorphosis. Proc Natl Acad Sci U S A (2011) 1.06
Rapid development of genetically encoded FRET reporters. ACS Chem Biol (2011) 1.05
Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19. EMBO J (2009) 1.01
High-resolution structural analysis of mammalian profilin 2a complex formation with two physiological ligands: the formin homology 1 domain of mDia1 and the proline-rich domain of VASP. J Mol Biol (2007) 1.00
Stoichiometric protein complex formation and over-expression using the prokaryotic native operon structure. FEBS Lett (2010) 0.99
Evolutionary markers in the (beta/alpha)8-barrel fold. Curr Opin Chem Biol (2003) 0.99
Molecular basis of the C-terminal tail-to-tail assembly of the sarcomeric filament protein myomesin. EMBO J (2007) 0.98
Two-fold repeated (betaalpha)4 half-barrels may provide a molecular tool for dual substrate specificity. EMBO Rep (2005) 0.98
Accurate solution structures of proteins from X-ray data and a minimal set of NMR data: calmodulin-peptide complexes as examples. J Am Chem Soc (2009) 0.97
A previously unobserved conformation for the human Pex5p receptor suggests roles for intrinsic flexibility and rigid domain motions in ligand binding. BMC Struct Biol (2007) 0.97
Superhelical architecture of the myosin filament-linking protein myomesin with unusual elastic properties. PLoS Biol (2012) 0.96
Insights into ubiquitin-conjugating enzyme/ co-activator interactions from the structure of the Pex4p:Pex22p complex. EMBO J (2011) 0.96
Molecular requirements for peroxisomal targeting of alanine-glyoxylate aminotransferase as an essential determinant in primary hyperoxaluria type 1. PLoS Biol (2012) 0.95
Polymorphisms in GSDMA and GSDMB are associated with asthma susceptibility, atopy and BHR. Pediatr Pulmonol (2011) 0.95
Age-dependent changes of gene expression in the Drosophila head. Neurobiol Aging (2005) 0.95
Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and -2 Are essential for lectin pathway activation and reveal structural plasticity of MASP-2. J Biol Chem (2012) 0.94
Differential regulation of a hyperthermophilic alpha-amylase with a novel (Ca,Zn) two-metal center by zinc. J Biol Chem (2002) 0.94
Evidence for a dimeric assembly of two titin/telethonin complexes induced by the telethonin C-terminus. J Struct Biol (2006) 0.93
Elucidating human phosphatase-substrate networks. Sci Signal (2013) 0.93
Regulation of the hetero-octameric ATP phosphoribosyl transferase complex from Thermotoga maritima by a tRNA synthetase-like subunit. Mol Microbiol (2005) 0.92
The Ig doublet Z1Z2: a model system for the hybrid analysis of conformational dynamics in Ig tandems from titin. Structure (2006) 0.92
Solution structure of human Pex5.Pex14.PTS1 protein complexes obtained by small angle X-ray scattering. J Biol Chem (2009) 0.91
OBF1 enhances transcriptional potential of Oct1. EMBO J (2003) 0.91
Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITF. Genes Dev (2012) 0.91
Rigid conformation of an immunoglobulin domain tandem repeat in the A-band of the elastic muscle protein titin. J Mol Biol (2007) 0.91
Structure of the Mycobacterium tuberculosis type VII secretion system chaperone EspG5 in complex with PE25-PPE41 dimer. Mol Microbiol (2014) 0.90
Fast-folding alpha-helices as reversible strain absorbers in the muscle protein myomesin. Proc Natl Acad Sci U S A (2011) 0.89
The peroxisomal receptor Pex19p forms a helical mPTS recognition domain. EMBO J (2010) 0.89
Crystal structure of the S187F variant of human liver alanine: glyoxylate [corrected] aminotransferase associated with primary hyperoxaluria type I and its functional implications. Proteins (2013) 0.88
The structure of the 2[4Fe-4S] ferredoxin from Pseudomonas aeruginosa at 1.32-A resolution: comparison with other high-resolution structures of ferredoxins and contributing structural features to reduction potential values. J Biol Inorg Chem (2006) 0.88
Protein translocation into peroxisomes by ring-shaped import receptors. FEBS Lett (2007) 0.88
Structure-based prediction of the Saccharomyces cerevisiae SH3-ligand interactions. J Mol Biol (2009) 0.88
Paxillin and ponsin interact in nascent costameres of muscle cells. J Mol Biol (2007) 0.87
Expression of protein complexes using multiple Escherichia coli protein co-expression systems: a benchmarking study. J Struct Biol (2011) 0.87
Structural and functional diversity in the activity and regulation of DAPK-related protein kinases. FEBS J (2013) 0.86
Structural diversity in the six-fold redundant set of acyl-CoA carboxyltransferases in Mycobacterium tuberculosis. FEBS Lett (2006) 0.86
Bronchiectasis in children: 10-year experience at a single institution. Allergy Asthma Immunol Res (2010) 0.85
Terminal assembly of sarcomeric filaments by intermolecular beta-sheet formation. Trends Biochem Sci (2008) 0.85
Structural synthetic biotechnology: from molecular structure to predictable design for industrial strain development. Trends Biotechnol (2010) 0.85
Mycobacterium tuberculosis prokaryotic ubiquitin-like protein-deconjugating enzyme is an unusual aspartate amidase. J Biol Chem (2012) 0.85
Difference in TB10.4 T-cell epitope recognition following immunization with recombinant TB10.4, BCG or infection with Mycobacterium tuberculosis. Eur J Immunol (2010) 0.85
Ligand-induced compaction of the PEX5 receptor-binding cavity impacts protein import efficiency into peroxisomes. Traffic (2014) 0.84
Catalysis uncoupling in a glutamine amidotransferase bienzyme by unblocking the glutaminase active site. Chem Biol (2012) 0.84
Understanding a mechanism of organic cosolvent inactivation in heme monooxygenase P450 BM-3. J Am Chem Soc (2007) 0.84
Investigation of the ligand spectrum of human sterol carrier protein 2 using a direct mass spectrometry assay. Arch Biochem Biophys (2007) 0.84
Identification of Xin-repeat proteins as novel ligands of the SH3 domains of nebulin and nebulette and analysis of their interaction during myofibril formation and remodeling. Mol Biol Cell (2013) 0.84
Stabilization of a (betaalpha)8-barrel protein by an engineered disulfide bridge. Eur J Biochem (2002) 0.84
Structural and biochemical characterisation of a NAD⁺-dependent alcohol dehydrogenase from Oenococcus oeni as a new model molecule for industrial biotechnology applications. Appl Microbiol Biotechnol (2013) 0.83
The progress made in determining the Mycobacterium tuberculosis structural proteome. Proteomics (2011) 0.83
Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a resuscitation-promoting factor from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.83
Second SH3 domain of ponsin solved from powder diffraction. J Am Chem Soc (2007) 0.82
Structural analysis of two enzymes catalysing reverse metabolic reactions implies common ancestry. EMBO J (2002) 0.82
The crystal structure of the allosteric non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeum Thermoproteus tenax. J Biol Chem (2002) 0.82
The lasso segment is required for functional dimerization of the Plasmodium formin 1 FH2 domain. PLoS One (2012) 0.81
Structural studies of the catalytic reaction pathway of a hyperthermophilic histidinol-phosphate aminotransferase. J Biol Chem (2004) 0.81
Structural characterization of a D-isomer specific 2-hydroxyacid dehydrogenase from Lactobacillus delbrueckii ssp. bulgaricus. J Struct Biol (2012) 0.81
Development of accessible peptidic tool compounds to study the phosphatase PTP1B in intact cells. ACS Chem Biol (2014) 0.81
Probing lipid- and drug-binding domains with fluorescent dyes. Bioorg Med Chem (2007) 0.81