Published in J Biol Chem on June 17, 2004
Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPases. Acc Chem Res (2009) 1.62
dUTPase activity is critical to maintain genetic stability in Saccharomyces cerevisiae. Nucleic Acids Res (2006) 1.14
Quantitative determination of uracil residues in Escherichia coli DNA: Contribution of ung, dug, and dut genes to uracil avoidance. DNA Repair (Amst) (2006) 1.07
Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins. Nucleic Acids Res (2006) 1.02
Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase. Nucleic Acids Res (2010) 0.95
Herpes simplex virus 1 protein kinase Us3 phosphorylates viral dUTPase and regulates its catalytic activity in infected cells. J Virol (2013) 0.90
Kaposi's sarcoma-associated herpesvirus ORF54/dUTPase downregulates a ligand for the NK activating receptor NKp44. J Virol (2012) 0.87
The dUTPase enzyme is essential in Mycobacterium smegmatis. PLoS One (2012) 0.86
Nucleotide pyrophosphatase employs a P-loop-like motif to enhance catalytic power and NDP/NTP discrimination. Proc Natl Acad Sci U S A (2011) 0.85
Study of solvent-protein coupling effects by neutron scattering. J Biol Phys (2009) 0.80
Direct contacts between conserved motifs of different subunits provide major contribution to active site organization in human and mycobacterial dUTPases. FEBS Lett (2010) 0.80
Catalytic mechanism of α-phosphate attack in dUTPase is revealed by X-ray crystallographic snapshots of distinct intermediates, 31P-NMR spectroscopy and reaction path modelling. Nucleic Acids Res (2013) 0.80
The crystal structure of the Leishmania major deoxyuridine triphosphate nucleotidohydrolase in complex with nucleotide analogues, dUMP, and deoxyuridine. J Biol Chem (2011) 0.80
dUTPase: the frequently overlooked enzyme encoded by many retroviruses. Retrovirology (2015) 0.78
The flexible motif V of Epstein-Barr virus deoxyuridine 5'-triphosphate pyrophosphatase is essential for catalysis. J Biol Chem (2009) 0.78
Crystallization and preliminary crystallographic analysis of dUTPase from the φ11 helper phage of Staphylococcus aureus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.78
Evidence-Based Structural Model of the Staphylococcal Repressor Protein: Separation of Functions into Different Domains. PLoS One (2015) 0.77
Quantum mechanical modeling: a tool for the understanding of enzyme reactions. Biomolecules (2013) 0.77
The dUTPase-related gene of bovine immunodeficiency virus is critical for viral replication, despite the lack of dUTPase activity of the encoded protein. Retrovirology (2014) 0.76
Trading in cooperativity for specificity to maintain uracil-free DNA. Sci Rep (2016) 0.75
Crystallization and preliminary X-ray analysis of three dUTPases from Gram-positive bacteria. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.75
A hidden active site in the potential drug target Mycobacterium tuberculosis dUTPase is accessible through small-amplitude protein conformational changes. J Biol Chem (2016) 0.75
Structural insights into the mechanism defining substrate affinity in Arabidopsis thaliana dUTPase: the role of tryptophan 93 in ligand orientation. BMC Res Notes (2015) 0.75
Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers. Genes Dev (2003) 2.99
Combinatorial control of gene expression. Nat Struct Mol Biol (2004) 2.66
Steered molecular dynamics studies of titin I1 domain unfolding. Biophys J (2002) 2.13
Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights. Acta Crystallogr D Biol Crystallogr (2013) 2.03
Mechanical strength of the titin Z1Z2-telethonin complex. Structure (2006) 1.79
On the routine use of soft X-rays in macromolecular crystallography. Part IV. Efficient determination of anomalous substructures in biomacromolecules using longer X-ray wavelengths. Acta Crystallogr D Biol Crystallogr (2007) 1.78
Unusual binding properties of the SH3 domain of the yeast actin-binding protein Abp1: structural and functional analysis. J Biol Chem (2001) 1.69
Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk. Nature (2006) 1.57
Proteome-wide identification of mycobacterial pupylation targets. Mol Syst Biol (2010) 1.44
Structural evidence for ammonia tunneling across the (beta alpha)(8) barrel of the imidazole glycerol phosphate synthase bienzyme complex. Structure (2002) 1.44
The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk. Proc Natl Acad Sci U S A (2009) 1.40
Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences. Proc Natl Acad Sci U S A (2005) 1.38
Recognition of a functional peroxisome type 1 target by the dynamic import receptor pex5p. Mol Cell (2006) 1.37
The impact of protein characterization in structural proteomics. Acta Crystallogr D Biol Crystallogr (2006) 1.32
Molecular basis of the death-associated protein kinase-calcium/calmodulin regulator complex. Sci Signal (2010) 1.31
Mechanical network in titin immunoglobulin from force distribution analysis. PLoS Comput Biol (2009) 1.25
Topography for independent binding of alpha-helical and PPII-helical ligands to a peroxisomal SH3 domain. Mol Cell (2002) 1.17
Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme. J Biol Chem (2007) 1.14
Active site of mycobacterial dUTPase: structural characteristics and a built-in sensor. Biochem Biophys Res Commun (2008) 1.14
Regulation of the transcription factor Ets-1 by DNA-mediated homo-dimerization. EMBO J (2008) 1.14
Structural conservation between the actin monomer-binding sites of twinfilin and actin-depolymerizing factor (ADF)/cofilin. J Biol Chem (2002) 1.13
Crystal structure of the resuscitation-promoting factor (DeltaDUF)RpfB from M. tuberculosis. J Mol Biol (2008) 1.13
The Mycobacterium tuberculosis LipB enzyme functions as a cysteine/lysine dyad acyltransferase. Proc Natl Acad Sci U S A (2006) 1.11
Cellular target genes of Epstein-Barr virus nuclear antigen 2. J Virol (2006) 1.10
Solution scattering suggests cross-linking function of telethonin in the complex with titin. J Biol Chem (2002) 1.10
A unique Oct4 interface is crucial for reprogramming to pluripotency. Nat Cell Biol (2013) 1.08
Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circ Res (2011) 1.07
Differential activity by DNA-induced quarternary structures of POU transcription factors. Biochem Pharmacol (2002) 1.07
Dynamic architecture of the peroxisomal import receptor Pex5p. Biochim Biophys Acta (2006) 1.07
Improved mycobacterial protein production using a Mycobacterium smegmatis groEL1ΔC expression strain. BMC Biotechnol (2011) 1.06
Bisubstrate specificity in histidine/tryptophan biosynthesis isomerase from Mycobacterium tuberculosis by active site metamorphosis. Proc Natl Acad Sci U S A (2011) 1.06
Rapid development of genetically encoded FRET reporters. ACS Chem Biol (2011) 1.05
Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase. FEBS Lett (2007) 1.05
Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins. Nucleic Acids Res (2006) 1.02
Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19. EMBO J (2009) 1.01
High-resolution structural analysis of mammalian profilin 2a complex formation with two physiological ligands: the formin homology 1 domain of mDia1 and the proline-rich domain of VASP. J Mol Biol (2007) 1.00
Evolutionary markers in the (beta/alpha)8-barrel fold. Curr Opin Chem Biol (2003) 0.99
Stoichiometric protein complex formation and over-expression using the prokaryotic native operon structure. FEBS Lett (2010) 0.99
Molecular basis of the C-terminal tail-to-tail assembly of the sarcomeric filament protein myomesin. EMBO J (2007) 0.98
Two-fold repeated (betaalpha)4 half-barrels may provide a molecular tool for dual substrate specificity. EMBO Rep (2005) 0.98
Accurate solution structures of proteins from X-ray data and a minimal set of NMR data: calmodulin-peptide complexes as examples. J Am Chem Soc (2009) 0.97
A previously unobserved conformation for the human Pex5p receptor suggests roles for intrinsic flexibility and rigid domain motions in ligand binding. BMC Struct Biol (2007) 0.97
Superhelical architecture of the myosin filament-linking protein myomesin with unusual elastic properties. PLoS Biol (2012) 0.96
Insights into ubiquitin-conjugating enzyme/ co-activator interactions from the structure of the Pex4p:Pex22p complex. EMBO J (2011) 0.96
Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans. J Cell Sci (2011) 0.96
Molecular requirements for peroxisomal targeting of alanine-glyoxylate aminotransferase as an essential determinant in primary hyperoxaluria type 1. PLoS Biol (2012) 0.95
Altered active site flexibility and a structural metal-binding site in eukaryotic dUTPase: kinetic characterization, folding, and crystallographic studies of the homotrimeric Drosophila enzyme. J Biol Chem (2004) 0.95
A tradeoff between protein stability and conformational mobility in homotrimeric dUTPases. FEBS Lett (2004) 0.94
Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and -2 Are essential for lectin pathway activation and reveal structural plasticity of MASP-2. J Biol Chem (2012) 0.94
Differential regulation of a hyperthermophilic alpha-amylase with a novel (Ca,Zn) two-metal center by zinc. J Biol Chem (2002) 0.94
Elucidating human phosphatase-substrate networks. Sci Signal (2013) 0.93
Evidence for a dimeric assembly of two titin/telethonin complexes induced by the telethonin C-terminus. J Struct Biol (2006) 0.93
Regulation of the hetero-octameric ATP phosphoribosyl transferase complex from Thermotoga maritima by a tRNA synthetase-like subunit. Mol Microbiol (2005) 0.92
The Ig doublet Z1Z2: a model system for the hybrid analysis of conformational dynamics in Ig tandems from titin. Structure (2006) 0.92
Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITF. Genes Dev (2012) 0.91
Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site. Proteins (2008) 0.91
Rigid conformation of an immunoglobulin domain tandem repeat in the A-band of the elastic muscle protein titin. J Mol Biol (2007) 0.91
OBF1 enhances transcriptional potential of Oct1. EMBO J (2003) 0.91
Solution structure of human Pex5.Pex14.PTS1 protein complexes obtained by small angle X-ray scattering. J Biol Chem (2009) 0.91
dUTPase and nucleocapsid polypeptides of the Mason-Pfizer monkey virus form a fusion protein in the virion with homotrimeric organization and low catalytic efficiency. J Biol Chem (2003) 0.90
Structure of the Mycobacterium tuberculosis type VII secretion system chaperone EspG5 in complex with PE25-PPE41 dimer. Mol Microbiol (2014) 0.90
Molecular shape and prominent role of beta-strand swapping in organization of dUTPase oligomers. FEBS Lett (2009) 0.89
Dynamics of re-constitution of the human nuclear proteome after cell division is regulated by NLS-adjacent phosphorylation. Cell Cycle (2014) 0.89
Uracil-containing DNA in Drosophila: stability, stage-specific accumulation, and developmental involvement. PLoS Genet (2012) 0.89
The peroxisomal receptor Pex19p forms a helical mPTS recognition domain. EMBO J (2010) 0.89
Fast-folding alpha-helices as reversible strain absorbers in the muscle protein myomesin. Proc Natl Acad Sci U S A (2011) 0.89
Structure-based prediction of the Saccharomyces cerevisiae SH3-ligand interactions. J Mol Biol (2009) 0.88
Protein translocation into peroxisomes by ring-shaped import receptors. FEBS Lett (2007) 0.88
Crystal structure of the S187F variant of human liver alanine: glyoxylate [corrected] aminotransferase associated with primary hyperoxaluria type I and its functional implications. Proteins (2013) 0.88
The structure of the 2[4Fe-4S] ferredoxin from Pseudomonas aeruginosa at 1.32-A resolution: comparison with other high-resolution structures of ferredoxins and contributing structural features to reduction potential values. J Biol Inorg Chem (2006) 0.88
Paxillin and ponsin interact in nascent costameres of muscle cells. J Mol Biol (2007) 0.87
Expression of protein complexes using multiple Escherichia coli protein co-expression systems: a benchmarking study. J Struct Biol (2011) 0.87
Developmental regulation of dUTPase in Drosophila melanogaster. J Biol Chem (2004) 0.87
Structural diversity in the six-fold redundant set of acyl-CoA carboxyltransferases in Mycobacterium tuberculosis. FEBS Lett (2006) 0.86
Structural and functional diversity in the activity and regulation of DAPK-related protein kinases. FEBS J (2013) 0.86
A one-step method for quantitative determination of uracil in DNA by real-time PCR. Nucleic Acids Res (2010) 0.86
Nucleotide pyrophosphatase employs a P-loop-like motif to enhance catalytic power and NDP/NTP discrimination. Proc Natl Acad Sci U S A (2011) 0.85
Mycobacterium tuberculosis prokaryotic ubiquitin-like protein-deconjugating enzyme is an unusual aspartate amidase. J Biol Chem (2012) 0.85
Terminal assembly of sarcomeric filaments by intermolecular beta-sheet formation. Trends Biochem Sci (2008) 0.85
Structural synthetic biotechnology: from molecular structure to predictable design for industrial strain development. Trends Biotechnol (2010) 0.85
A novel fruitfly protein under developmental control degrades uracil-DNA. Biochem Biophys Res Commun (2007) 0.85
Catalysis uncoupling in a glutamine amidotransferase bienzyme by unblocking the glutaminase active site. Chem Biol (2012) 0.84
Stabilization of a (betaalpha)8-barrel protein by an engineered disulfide bridge. Eur J Biochem (2002) 0.84
Understanding a mechanism of organic cosolvent inactivation in heme monooxygenase P450 BM-3. J Am Chem Soc (2007) 0.84
Investigation of the ligand spectrum of human sterol carrier protein 2 using a direct mass spectrometry assay. Arch Biochem Biophys (2007) 0.84
Ligand-induced compaction of the PEX5 receptor-binding cavity impacts protein import efficiency into peroxisomes. Traffic (2014) 0.84
Identification of Xin-repeat proteins as novel ligands of the SH3 domains of nebulin and nebulette and analysis of their interaction during myofibril formation and remodeling. Mol Biol Cell (2013) 0.84
Structural and biochemical characterisation of a NAD⁺-dependent alcohol dehydrogenase from Oenococcus oeni as a new model molecule for industrial biotechnology applications. Appl Microbiol Biotechnol (2013) 0.83
Cellular response to efficient dUTPase RNAi silencing in stable HeLa cell lines perturbs expression levels of genes involved in thymidylate metabolism. Nucleosides Nucleotides Nucleic Acids (2011) 0.83
Molecular basis of the head-to-tail assembly of giant muscle proteins obscurin-like 1 and titin. EMBO Rep (2010) 0.83
The progress made in determining the Mycobacterium tuberculosis structural proteome. Proteomics (2011) 0.83
Preventive DNA repair by sanitizing the cellular (deoxy)nucleoside triphosphate pool. FEBS J (2014) 0.83
Crystallization and preliminary X-ray studies of dUTPase from Mason-Pfizer monkey retrovirus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.83
Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a resuscitation-promoting factor from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.83