Published in EMBO J on November 15, 2011
RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination. Biochim Biophys Acta (2013) 1.64
Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly. Mol Cell (2014) 1.38
The peroxisome: an update on mysteries. Histochem Cell Biol (2012) 1.15
Allosteric regulation of E2:E3 interactions promote a processive ubiquitination machine. EMBO J (2013) 1.05
Recent advances in peroxisomal matrix protein import. Curr Opin Cell Biol (2012) 1.02
A structurally unique E2-binding domain activates ubiquitination by the ERAD E2, Ubc7p, through multiple mechanisms. Mol Cell (2013) 0.95
Import of proteins into the peroxisomal matrix. Front Physiol (2013) 0.90
Unique requirements for mono- and polyubiquitination of the peroxisomal targeting signal co-receptor, Pex20. J Biol Chem (2013) 0.87
The unique degradation pathway of the PTS2 receptor, Pex7, is dependent on the PTS receptor/coreceptor, Pex5 and Pex20. Mol Biol Cell (2014) 0.78
Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B. J Biol Chem (2015) 0.78
Peripheral nervous system defects in a mouse model for peroxisomal biogenesis disorders. Dev Biol (2014) 0.77
The cytosolic domain of Pex22p stimulates the Pex4p-dependent ubiquitination of the PTS1-receptor. PLoS One (2014) 0.76
Cysteine-specific ubiquitination protects the peroxisomal import receptor Pex5p against proteasomal degradation. Biosci Rep (2015) 0.76
The ubiquitin-associated domain of cellular inhibitor of apoptosis proteins facilitates ubiquitylation. J Biol Chem (2014) 0.76
Colletotrichum orbiculare FAM1 Encodes a Novel Woronin Body-Associated Pex22 Peroxin Required for Appressorium-Mediated Plant Infection. MBio (2015) 0.76
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr (1997) 137.43
MolProbity: all-atom structure validation for macromolecular crystallography. Acta Crystallogr D Biol Crystallogr (2009) 53.36
Inference of macromolecular assemblies from crystalline state. J Mol Biol (2007) 44.95
Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. Acta Crystallogr D Biol Crystallogr (2004) 31.52
Use of TLS parameters to model anisotropic displacements in macromolecular refinement. Acta Crystallogr D Biol Crystallogr (2001) 21.01
Maximum-likelihood density modification. Acta Crystallogr D Biol Crystallogr (2000) 20.67
Automated structure solution with autoSHARP. Methods Mol Biol (2007) 14.67
Version 1.2 of the Crystallography and NMR system. Nat Protoc (2007) 13.01
Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol (2007) 8.16
Building ubiquitin chains: E2 enzymes at work. Nat Rev Mol Cell Biol (2009) 5.41
Comparison of super-secondary structures in proteins. J Mol Biol (1973) 4.85
Auto-rickshaw: an automated crystal structure determination platform as an efficient tool for the validation of an X-ray diffraction experiment. Acta Crystallogr D Biol Crystallogr (2005) 4.74
Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex. Nature (2005) 4.63
A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination. Mol Cell (2006) 3.30
Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer. Cell (2001) 3.09
Structural mechanisms underlying posttranslational modification by ubiquitin-like proteins. Annu Rev Biophys Biomol Struct (2007) 2.98
Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates. Cell (2009) 2.40
An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. Cell (2011) 2.35
RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia. Cell (2007) 2.34
Saccharomyces cerevisiae pex3p and pex19p are required for proper localization and stability of peroxisomal membrane proteins. EMBO J (2000) 2.25
The KSHV immediate-early transcription factor RTA encodes ubiquitin E3 ligase activity that targets IRF7 for proteosome-mediated degradation. Immunity (2005) 2.14
The Pas2 protein essential for peroxisome biogenesis is related to ubiquitin-conjugating enzymes. Nature (1992) 1.98
Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation. EMBO J (2007) 1.97
The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins. FASEB J (2009) 1.91
Allosteric activation of E2-RING finger-mediated ubiquitylation by a structurally defined specific E2-binding region of gp78. Mol Cell (2009) 1.83
Taking it step by step: mechanistic insights from structural studies of ubiquitin/ubiquitin-like protein modification pathways. Curr Opin Struct Biol (2007) 1.76
E2s: structurally economical and functionally replete. Biochem J (2011) 1.64
The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type. Nat Struct Mol Biol (2004) 1.64
Ubiquitination of the peroxisomal import receptor Pex5p is required for its recycling. J Cell Biol (2007) 1.47
A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. Mol Syst Biol (2009) 1.43
A conserved cysteine is essential for Pex4p-dependent ubiquitination of the peroxisomal import receptor Pex5p. J Biol Chem (2007) 1.41
Identification and functional characterization of Arabidopsis PEROXIN4 and the interacting protein PEROXIN22. Plant Cell (2005) 1.41
Pex2 and pex12 function as protein-ubiquitin ligases in peroxisomal protein import. Mol Cell Biol (2009) 1.39
The peroxisome biogenesis factors pex4p, pex22p, pex1p, and pex6p act in the terminal steps of peroxisomal matrix protein import. Mol Cell Biol (2000) 1.39
The Pichia pastoris PAS4 gene encodes a ubiquitin-conjugating enzyme required for peroxisome assembly. J Biol Chem (1994) 1.34
Ubiquitination of the peroxisomal import receptor Pex5p. Biochem J (2004) 1.31
Pex22p of Pichia pastoris, essential for peroxisomal matrix protein import, anchors the ubiquitin-conjugating enzyme, Pex4p, on the peroxisomal membrane. J Cell Biol (1999) 1.30
Cue1p is an activator of Ubc7p E2 activity in vitro and in vivo. J Biol Chem (2008) 1.29
The Saccharomyces cerevisiae peroxisomal import receptor Pex5p is monoubiquitinated in wild type cells. J Biol Chem (2005) 1.24
Crystal structure of a class I ubiquitin conjugating enzyme (Ubc7) from Saccharomyces cerevisiae at 2.9 angstroms resolution. Biochemistry (1997) 1.20
Solution structure of the flexible class II ubiquitin-conjugating enzyme Ubc1 provides insights for polyubiquitin chain assembly. J Biol Chem (2004) 1.15
Pex10p functions as an E3 ligase for the Ubc4p-dependent ubiquitination of Pex5p. Biochem Biophys Res Commun (2008) 1.13
Crystal structure of the Saccharomyces cerevisiae ubiquitin-conjugating enzyme Rad6 at 2.6 A resolution. J Biol Chem (1998) 1.06
Pex10p links the ubiquitin conjugating enzyme Pex4p to the protein import machinery of the peroxisome. J Cell Sci (2003) 1.03
Properties of the ubiquitin-pex5p thiol ester conjugate. J Biol Chem (2009) 1.02
A Ubc7p-binding domain in Cue1p activates ER-associated protein degradation. J Cell Sci (2009) 1.01
Obstruction of polyubiquitination affects PTS1 peroxisomal matrix protein import. Biochim Biophys Acta (2005) 0.91
The AAA peroxins Pex1p and Pex6p function as dislocases for the ubiquitinated peroxisomal import receptor Pex5p. Biochem Soc Trans (2008) 0.88
Structure of Importin13-Ubc9 complex: nuclear import and release of a key regulator of sumoylation. EMBO J (2010) 0.85
Saccharomyces cerevisiae Pex14p contains two independent Pex5p binding sites, which are both essential for PTS1 protein import. FEBS Lett (2005) 0.84
Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers. Genes Dev (2003) 2.99
Combinatorial control of gene expression. Nat Struct Mol Biol (2004) 2.66
Steered molecular dynamics studies of titin I1 domain unfolding. Biophys J (2002) 2.13
Mechanical strength of the titin Z1Z2-telethonin complex. Structure (2006) 1.79
On the routine use of soft X-rays in macromolecular crystallography. Part IV. Efficient determination of anomalous substructures in biomacromolecules using longer X-ray wavelengths. Acta Crystallogr D Biol Crystallogr (2007) 1.78
Unusual binding properties of the SH3 domain of the yeast actin-binding protein Abp1: structural and functional analysis. J Biol Chem (2001) 1.69
Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk. Nature (2006) 1.57
Strictosidine synthase: mechanism of a Pictet-Spengler catalyzing enzyme. J Am Chem Soc (2008) 1.50
Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation. Proc Natl Acad Sci U S A (2012) 1.46
Structure-based engineering of strictosidine synthase: auxiliary for alkaloid libraries. Chem Biol (2007) 1.46
Proteome-wide identification of mycobacterial pupylation targets. Mol Syst Biol (2010) 1.44
Structural evidence for ammonia tunneling across the (beta alpha)(8) barrel of the imidazole glycerol phosphate synthase bienzyme complex. Structure (2002) 1.44
Automated technologies and novel techniques to accelerate protein crystallography for structural genomics. Proteomics (2008) 1.43
A conserved cysteine is essential for Pex4p-dependent ubiquitination of the peroxisomal import receptor Pex5p. J Biol Chem (2007) 1.41
Involvement of the endoplasmic reticulum in peroxisome formation. Mol Biol Cell (2003) 1.41
The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk. Proc Natl Acad Sci U S A (2009) 1.40
Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences. Proc Natl Acad Sci U S A (2005) 1.38
Recognition of a functional peroxisome type 1 target by the dynamic import receptor pex5p. Mol Cell (2006) 1.37
The structural basis of signal transduction for the response regulator PrrA from Mycobacterium tuberculosis. J Biol Chem (2006) 1.34
Peroxisomal fatty acid beta-oxidation is not essential for virulence of Candida albicans. Eukaryot Cell (2006) 1.32
The structure of Rauvolfia serpentina strictosidine synthase is a novel six-bladed beta-propeller fold in plant proteins. Plant Cell (2006) 1.32
The impact of protein characterization in structural proteomics. Acta Crystallogr D Biol Crystallogr (2006) 1.32
Molecular basis of the death-associated protein kinase-calcium/calmodulin regulator complex. Sci Signal (2010) 1.31
Role of the alpha-glucanase Agn1p in fission-yeast cell separation. Mol Biol Cell (2004) 1.31
On the routine use of soft X-rays in macromolecular crystallography. Part III. The optimal data-collection wavelength. Acta Crystallogr D Biol Crystallogr (2005) 1.30
Saccharomyces cerevisiae acyl-CoA oxidase follows a novel, non-PTS1, import pathway into peroxisomes that is dependent on Pex5p. J Biol Chem (2002) 1.30
C4-dicarboxylates sensing mechanism revealed by the crystal structures of DctB sensor domain. J Mol Biol (2008) 1.28
Endoplasmic reticulum-directed Pex3p routes to peroxisomes and restores peroxisome formation in a Saccharomyces cerevisiae pex3Delta strain. J Biol Chem (2005) 1.27
Crystal structure of vinorine synthase, the first representative of the BAHD superfamily. J Biol Chem (2005) 1.26
Mechanical network in titin immunoglobulin from force distribution analysis. PLoS Comput Biol (2009) 1.25
The Saccharomyces cerevisiae peroxisomal import receptor Pex5p is monoubiquitinated in wild type cells. J Biol Chem (2005) 1.24
Intracellular acetyl unit transport in fungal carbon metabolism. Eukaryot Cell (2010) 1.18
Topography for independent binding of alpha-helical and PPII-helical ligands to a peroxisomal SH3 domain. Mol Cell (2002) 1.17
Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase. J Biol Chem (2004) 1.16
Enzymology of the carnitine biosynthesis pathway. IUBMB Life (2010) 1.16
Regulation of the transcription factor Ets-1 by DNA-mediated homo-dimerization. EMBO J (2008) 1.14
Structural conservation between the actin monomer-binding sites of twinfilin and actin-depolymerizing factor (ADF)/cofilin. J Biol Chem (2002) 1.13
Crystal structure of the resuscitation-promoting factor (DeltaDUF)RpfB from M. tuberculosis. J Mol Biol (2008) 1.13
Pex10p functions as an E3 ligase for the Ubc4p-dependent ubiquitination of Pex5p. Biochem Biophys Res Commun (2008) 1.13
The Mycobacterium tuberculosis LipB enzyme functions as a cysteine/lysine dyad acyltransferase. Proc Natl Acad Sci U S A (2006) 1.11
Cellular target genes of Epstein-Barr virus nuclear antigen 2. J Virol (2006) 1.10
Solution scattering suggests cross-linking function of telethonin in the complex with titin. J Biol Chem (2002) 1.10
A unique Oct4 interface is crucial for reprogramming to pluripotency. Nat Cell Biol (2013) 1.08
Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circ Res (2011) 1.07
Differential activity by DNA-induced quarternary structures of POU transcription factors. Biochem Pharmacol (2002) 1.07
On the influence of the incident photon energy on the radiation damage in crystalline biological samples. J Synchrotron Radiat (2005) 1.07
Dynamic architecture of the peroxisomal import receptor Pex5p. Biochim Biophys Acta (2006) 1.07
Cyanuric acid hydrolase: evolutionary innovation by structural concatenation. Mol Microbiol (2013) 1.06
Improved mycobacterial protein production using a Mycobacterium smegmatis groEL1ΔC expression strain. BMC Biotechnol (2011) 1.06
Structural insights into the mechanism of protein O-fucosylation. PLoS One (2011) 1.06
Structure of the motor subunit of type I restriction-modification complex EcoR124I. Nat Struct Mol Biol (2008) 1.06
Bisubstrate specificity in histidine/tryptophan biosynthesis isomerase from Mycobacterium tuberculosis by active site metamorphosis. Proc Natl Acad Sci U S A (2011) 1.06
Molecular architecture of strictosidine glucosidase: the gateway to the biosynthesis of the monoterpenoid indole alkaloid family. Plant Cell (2007) 1.05
Pex15p of Saccharomyces cerevisiae provides a molecular basis for recruitment of the AAA peroxin Pex6p to peroxisomal membranes. Mol Biol Cell (2003) 1.05
Rapid development of genetically encoded FRET reporters. ACS Chem Biol (2011) 1.05
Structural basis for parasite-specific functions of the divergent profilin of Plasmodium falciparum. Structure (2008) 1.05
3D-Structure and function of strictosidine synthase--the key enzyme of monoterpenoid indole alkaloid biosynthesis. Plant Physiol Biochem (2008) 1.02
Structural and functional aspects of the sensor histidine kinase PrrB from Mycobacterium tuberculosis. Structure (2006) 1.02
Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19. EMBO J (2009) 1.01
The BC component of ABC toxins is an RHS-repeat-containing protein encapsulation device. Nature (2013) 1.00
High-resolution structural analysis of mammalian profilin 2a complex formation with two physiological ligands: the formin homology 1 domain of mDia1 and the proline-rich domain of VASP. J Mol Biol (2007) 1.00
The crystal structure of the herpes simplex virus 1 ssDNA-binding protein suggests the structural basis for flexible, cooperative single-stranded DNA binding. J Biol Chem (2004) 1.00
Stoichiometric protein complex formation and over-expression using the prokaryotic native operon structure. FEBS Lett (2010) 0.99
Evolutionary markers in the (beta/alpha)8-barrel fold. Curr Opin Chem Biol (2003) 0.99
Nonprocessive [2 + 2]e- off-loading reductase domains from mycobacterial nonribosomal peptide synthetases. Proc Natl Acad Sci U S A (2012) 0.98
Molecular basis of the C-terminal tail-to-tail assembly of the sarcomeric filament protein myomesin. EMBO J (2007) 0.98
Two-fold repeated (betaalpha)4 half-barrels may provide a molecular tool for dual substrate specificity. EMBO Rep (2005) 0.98
Accurate solution structures of proteins from X-ray data and a minimal set of NMR data: calmodulin-peptide complexes as examples. J Am Chem Soc (2009) 0.97
A previously unobserved conformation for the human Pex5p receptor suggests roles for intrinsic flexibility and rigid domain motions in ligand binding. BMC Struct Biol (2007) 0.97
Superhelical architecture of the myosin filament-linking protein myomesin with unusual elastic properties. PLoS Biol (2012) 0.96
The three-dimensional structure of the extracellular adhesion domain of the sialic acid-binding adhesin SabA from Helicobacter pylori. J Biol Chem (2013) 0.96
Carnitine-dependent transport of acetyl coenzyme A in Candida albicans is essential for growth on nonfermentable carbon sources and contributes to biofilm formation. Eukaryot Cell (2008) 0.96
Crystal structures of a poplar thioredoxin peroxidase that exhibits the structure of glutathione peroxidases: insights into redox-driven conformational changes. J Mol Biol (2007) 0.96
Molecular requirements for peroxisomal targeting of alanine-glyoxylate aminotransferase as an essential determinant in primary hyperoxaluria type 1. PLoS Biol (2012) 0.95
Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and -2 Are essential for lectin pathway activation and reveal structural plasticity of MASP-2. J Biol Chem (2012) 0.94
Ube3a reinstatement identifies distinct developmental windows in a murine Angelman syndrome model. J Clin Invest (2015) 0.94
Differential regulation of a hyperthermophilic alpha-amylase with a novel (Ca,Zn) two-metal center by zinc. J Biol Chem (2002) 0.94
Elucidating human phosphatase-substrate networks. Sci Signal (2013) 0.93
Evidence for a dimeric assembly of two titin/telethonin complexes induced by the telethonin C-terminus. J Struct Biol (2006) 0.93
Identification and characterization of a complete carnitine biosynthesis pathway in Candida albicans. FASEB J (2009) 0.93
The activity of the glyoxylate cycle in peroxisomes of Candida albicans depends on a functional beta-oxidation pathway: evidence for reduced metabolite transport across the peroxisomal membrane. Microbiology (2008) 0.93
The Ig doublet Z1Z2: a model system for the hybrid analysis of conformational dynamics in Ig tandems from titin. Structure (2006) 0.92
Regulation of the hetero-octameric ATP phosphoribosyl transferase complex from Thermotoga maritima by a tRNA synthetase-like subunit. Mol Microbiol (2005) 0.92
Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITF. Genes Dev (2012) 0.91
OBF1 enhances transcriptional potential of Oct1. EMBO J (2003) 0.91
Rigid conformation of an immunoglobulin domain tandem repeat in the A-band of the elastic muscle protein titin. J Mol Biol (2007) 0.91
Structural basis for the oxidation of protein-bound sulfur by the sulfur cycle molybdohemo-enzyme sulfane dehydrogenase SoxCD. J Biol Chem (2010) 0.91
Solution structure of human Pex5.Pex14.PTS1 protein complexes obtained by small angle X-ray scattering. J Biol Chem (2009) 0.91
Structure of the Mycobacterium tuberculosis type VII secretion system chaperone EspG5 in complex with PE25-PPE41 dimer. Mol Microbiol (2014) 0.90
The crystal structure of the CRISPR-associated protein Csn2 from Streptococcus agalactiae. J Struct Biol (2012) 0.90