Kainate-mediated excitotoxicity induces neuronal death in the rat spinal cord in vitro via a PARP-1 dependent cell death pathway (Parthanatos).

PubWeight™: 0.84‹?›

🔗 View Article (PMID 20502958)

Published in Cell Mol Neurobiol on May 26, 2010

Authors

Anujaianthi Kuzhandaivel1, Andrea Nistri, Miranda Mladinic

Author Affiliations

1: Neurobiology Sector, International School for Advanced Studies (SISSA), Via Bonomea 265, Trieste, Italy.

Articles citing this

Pathophysiologic cascades in ischemic stroke. Int J Stroke (2012) 1.03

Molecular Mechanisms Underlying Cell Death in Spinal Networks in Relation to Locomotor Activity After Acute Injury in vitro. Front Cell Neurosci (2011) 0.84

Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment. Brain (2015) 0.82

Annonaceous acetogenin mimic AA005 induces cancer cell death via apoptosis inducing factor through a caspase-3-independent mechanism. BMC Cancer (2015) 0.78

YM155, a survivin suppressant, triggers PARP-dependent cell death (parthanatos) and inhibits esophageal squamous-cell carcinoma xenografts in mice. Oncotarget (2015) 0.78

Effects of 6(5H)-phenanthridinone, an inhibitor of poly(ADP-ribose)polymerase-1 activity (PARP-1), on locomotor networks of the rat isolated spinal cord. Cell Mol Neurobiol (2011) 0.77

Effect of the PARP-1 inhibitor PJ 34 on excitotoxic damage evoked by kainate on rat spinal cord organotypic slices. Cell Mol Neurobiol (2010) 0.77

Mechanisms underlying cell death in ischemia-like damage to the rat spinal cord in vitro. Cell Death Dis (2013) 0.76

3-aminobenzamide, one of poly(ADP-ribose)polymerase-1 inhibitors, rescuesapoptosisin rat models of spinal cord injury. Int J Clin Exp Pathol (2015) 0.75

Microelectrode arrays in combination with in vitro models of spinal cord injury as tools to investigate pathological changes in network activity: facts and promises. Front Neuroeng (2013) 0.75

Articles cited by this

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ (2008) 10.45

Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science (2002) 8.41

Time is brain--quantified. Stroke (2005) 6.96

Excitotoxic cell death. J Neurobiol (1992) 4.76

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nat Med (1997) 4.12

Poly(ADP-ribose) in the cellular response to DNA damage. Radiat Res (1985) 3.52

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44

Poly(ADP-ribose) (PAR) polymer is a death signal. Proc Natl Acad Sci U S A (2006) 3.41

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature (2009) 3.36

Cell death modalities: classification and pathophysiological implications. Cell Death Differ (2007) 3.19

Neuronal and glial apoptosis after traumatic spinal cord injury. J Neurosci (1997) 2.88

Diversity in the mechanisms of neuronal cell death. Neuron (2003) 2.79

Kainate, a double agent that generates seizures: two decades of progress. Trends Neurosci (2000) 2.78

Tissue subcellular fractionation and protein extraction for use in mass-spectrometry-based proteomics. Nat Protoc (2006) 2.52

The role of excitotoxicity in secondary mechanisms of spinal cord injury: a review with an emphasis on the implications for white matter degeneration. J Neurotrauma (2004) 2.48

Distribution of networks generating and coordinating locomotor activity in the neonatal rat spinal cord in vitro: a lesion study. J Neurosci (1996) 2.42

CPP32/apopain is a key interleukin 1 beta converting enzyme-like protease involved in Fas-mediated apoptosis. J Biol Chem (1996) 2.40

Induction of a common pathway of apoptosis by staurosporine. Exp Cell Res (1994) 2.34

Identification of neuronal nuclei (NeuN) as Fox-3, a new member of the Fox-1 gene family of splicing factors. J Biol Chem (2009) 2.16

Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity. Nat Med (1998) 2.06

Neuroprotection and acute spinal cord injury: a reappraisal. NeuroRx (2004) 1.98

Parthanatos, a messenger of death. Front Biosci (Landmark Ed) (2009) 1.84

Cell death in models of spinal cord injury. Prog Brain Res (2002) 1.80

Comparing deficits following excitotoxic and contusion injuries in the thoracic and lumbar spinal cord of the adult rat. Exp Neurol (1999) 1.78

Pharmacological approaches to repair the injured spinal cord. J Neurotrauma (2006) 1.77

Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury. Nat Med (1999) 1.75

Poly(ADP-ribose) polymerase-1 and apoptosis inducing factor in neurotoxicity. Neurobiol Dis (2003) 1.69

Poly ADP-ribose polymerase-1: an international molecule of mystery. DNA Repair (Amst) (2008) 1.64

Mitochondrial and nuclear cross talk in cell death: parthanatos. Ann N Y Acad Sci (2008) 1.62

NMDA but not non-NMDA excitotoxicity is mediated by Poly(ADP-ribose) polymerase. J Neurosci (2000) 1.61

Monoclonal antibodies to poly(adenosine diphosphate ribose) recognize different structures. Biochemistry (1984) 1.60

Cellular and molecular pathways of ischemic neuronal death. J Biochem Mol Biol (2002) 1.57

Apoptosis of microglia and oligodendrocytes after spinal cord contusion in rats. J Neurosci Res (1997) 1.55

The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray. J Neurosci (1993) 1.46

Non-nuclear Wld(S) determines its neuroprotective efficacy for axons and synapses in vivo. J Neurosci (2009) 1.46

Characterization of the neuronal marker NeuN as a multiply phosphorylated antigen with discrete subcellular localization. J Neurosci Res (2005) 1.45

Stroke treatment: time is brain. Lancet (1998) 1.44

Radiation-induced H2AX phosphorylation and neural precursor apoptosis in the developing brain of mice. Radiat Res (2006) 1.43

Pathology of experimental spinal cord trauma. I. The necrotic lesion as a function of vascular injury. Lab Invest (1978) 1.41

DNA damage induced by DNA topoisomerase I- and topoisomerase II-inhibitors detected by histone H2AX phosphorylation in relation to the cell cycle phase and apoptosis. Cell Cycle (2003) 1.38

High-concentration rapid transients of glutamate mediate neural-glial communication via ectopic release. J Neurosci (2005) 1.36

Role of metabotropic glutamate receptors in oligodendrocyte excitotoxicity and oxidative stress. Proc Natl Acad Sci U S A (2004) 1.33

Staurosporine and conventional anticancer drugs induce overlapping, yet distinct pathways of apoptosis and caspase activation. Oncogene (2001) 1.29

Update on the treatment of spinal cord injury. Prog Brain Res (2007) 1.29

Fas-mediated suicide of tumor-reactive T cells following activation by specific tumor: selective rescue by caspase inhibition. J Immunol (1999) 1.26

Excitotoxic damage to white matter. J Anat (2007) 1.19

Poly(ADP-ribose) synthetase activation mediates mitochondrial injury during oxidant-induced cell death. J Immunol (1998) 1.18

Caspase-independent programmed cell death following ischemic stroke. J Invest Surg (2008) 1.14

Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease. Brain (1999) 1.14

Selective neuronal death after transient forebrain ischemia in the Mongolian gerbil: a silver impregnation study. Neuroscience (1988) 1.11

Measurement of cell death. Methods Cell Biol (1998) 1.10

DNA damage response and apoptosis. Methods Enzymol (2008) 1.09

Epidemiology of pediatric spinal cord injury in the United States: years 1997 and 2000. J Pediatr Orthop (2006) 1.08

Cleavage of Poly(ADP-ribose) polymerase measured in situ in individual cells: relationship to DNA fragmentation and cell cycle position during apoptosis. Exp Cell Res (2000) 1.03

Neurotoxicity of glutamate at the concentration released upon spinal cord injury. Neuroscience (1999) 1.02

Astrocytosis, microglia activation, oligodendrocyte degeneration, and pyknosis following acute spinal cord injury. Exp Neurol (2004) 1.00

Roles of the major apoptotic nuclease-DNA fragmentation factor-in biology and disease. Cell Mol Life Sci (2009) 0.97

Characteristics of acute and chronic kainate excitotoxic damage to the optic nerve. Proc Natl Acad Sci U S A (1998) 0.96

Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors mediate excitotoxicity in the oligodendroglial lineage. J Neurochem (1995) 0.96

Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats. Br J Pharmacol (2002) 0.94

Peroxynitrite production and activation of poly (adenosine diphosphate-ribose) synthetase in spinal cord injury. Ann Neurol (1999) 0.93

AMPA receptor-mediated toxicity in oligodendrocyte progenitors involves free radical generation and activation of JNK, calpain and caspase 3. J Neurochem (2002) 0.92

Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma. J Pharmacol Exp Ther (2004) 0.91

The role of autophagy in spinal cord injury. Autophagy (2009) 0.86

Lapbelt injuries and the seatbelt syndrome in pediatric spinal cord injury. J Spinal Cord Med (2007) 0.85

Poly(ADP-ribose) synthetase activation: an early indicator of neurotoxic DNA damage. J Neurochem (1995) 0.85

Release of intact, monomeric cytochrome c from apoptotic and necrotic cells. Cell Death Differ (2002) 0.84

Involvement of mitochondrial signaling pathways in the mechanism of Fas-mediated apoptosis after spinal cord injury. Eur J Neurosci (2009) 0.84

Immunosuppressive activities of 6(5H)-phenanthridinone, a new poly(ADP-ribose)polymerase inhibitor. Int J Immunopharmacol (1995) 0.84

Kainate-induced delayed onset of excitotoxicity with functional loss unrelated to the extent of neuronal damage in the in vitro spinal cord. Neuroscience (2010) 0.83

Poly(ADP-ribose) polymerase as a key player in excitotoxicity and post-ischemic brain damage. Toxicol Lett (2003) 0.83

The mechanisms of pyknosis: hypercondensation and death. Exp Cell Res (1999) 0.83

Intrinsic mechanisms of poly(ADP-ribose) neurotoxicity: three hypotheses. Neurotoxicology (2005) 0.83

Kainic acid-induced neuronal cell death in cerebellar granule cells is not prevented by caspase inhibitors. Br J Pharmacol (2002) 0.83

Dynamics of early locomotor network dysfunction following a focal lesion in an in vitro model of spinal injury. Eur J Neurosci (2009) 0.82

Nitric oxide and superoxide anion differentially activate poly(ADP-ribose) polymerase-1 and Bax to induce nuclear translocation of apoptosis-inducing factor and mitochondrial release of cytochrome c after spinal cord injury. J Neurotrauma (2009) 0.80

Kainate and metabolic perturbation mimicking spinal injury differentially contribute to early damage of locomotor networks in the in vitro neonatal rat spinal cord. Neuroscience (2008) 0.80

Endogenous humoral autoreactive immune responses to apoptotic cells: Effects on phagocytic uptake, chemotactic migration and antigenic spread. Eur J Immunol (2008) 0.78

Extracellular magnesium enhances the damage to locomotor networks produced by metabolic perturbation mimicking spinal injury in the neonatal rat spinal cord in vitro. Neuroscience (2009) 0.77

Extensive glial apoptosis develops early after hypoxic-dysmetabolic insult to the neonatal rat spinal cord in vitro. Neuroscience (2010) 0.77

Neuroprotection of locomotor networks after experimental injury to the neonatal rat spinal cord in vitro. Neuroscience (2009) 0.76

Oscillatory circuits underlying locomotor networks in the rat spinal cord. Crit Rev Neurobiol (2006) 0.76

Articles by these authors

Desensitization of nicotinic ACh receptors: shaping cholinergic signaling. Trends Neurosci (2005) 2.20

Exocytotic release of ATP from cultured astrocytes. J Biol Chem (2007) 1.75

Calcium/calmodulin-dependent serine protein kinase (CASK) is a new intracellular modulator of P2X3 receptors. J Neurochem (2013) 1.49

Molecular biology and electrophysiology of neuronal nicotinic receptors of rat chromaffin cells. Eur J Neurosci (2003) 1.33

Molecular mechanisms of sensitization of pain-transducing P2X3 receptors by the migraine mediators CGRP and NGF. Mol Neurobiol (2008) 1.21

Delayed upregulation of ATP P2X3 receptors of trigeminal sensory neurons by calcitonin gene-related peptide. J Neurosci (2006) 1.16

Comparison of P2X and TRPV1 receptors in ganglia or primary culture of trigeminal neurons and their modulation by NGF or serotonin. Mol Pain (2006) 1.13

Riluzole blocks persistent Na+ and Ca2+ currents and modulates release of glutamate via presynaptic NMDA receptors on neonatal rat hypoglossal motoneurons in vitro. Eur J Neurosci (2008) 1.08

Calcitonin gene-related peptide-mediated enhancement of purinergic neuron/glia communication by the algogenic factor bradykinin in mouse trigeminal ganglia from wild-type and R192Q Cav2.1 Knock-in mice: implications for basic mechanisms of migraine pain. J Neurosci (2011) 1.06

Expression and dendritic mRNA localization of GABAC receptor rho1 and rho2 subunits in developing rat brain and spinal cord. Eur J Neurosci (2002) 1.04

A structural model of agonist binding to the alpha3beta4 neuronal nicotinic receptor. Br J Pharmacol (2003) 1.02

Identification of negative residues in the P2X3 ATP receptor ectodomain as structural determinants for desensitization and the Ca2+-sensing modulatory sites. J Biol Chem (2004) 1.01

The C-terminal Src inhibitory kinase (Csk)-mediated tyrosine phosphorylation is a novel molecular mechanism to limit P2X3 receptor function in mouse sensory neurons. J Biol Chem (2009) 1.00

Neutralization of nerve growth factor induces plasticity of ATP-sensitive P2X3 receptors of nociceptive trigeminal ganglion neurons. J Neurosci (2007) 0.99

Experimental and modeling studies of desensitization of P2X3 receptors. Mol Pharmacol (2006) 0.98

Familial hemiplegic migraine Ca(v)2.1 channel mutation R192Q enhances ATP-gated P2X3 receptor activity of mouse sensory ganglion neurons mediating trigeminal pain. Mol Pain (2010) 0.98

Agonist-dependence of recovery from desensitization of P2X(3) receptors provides a novel and sensitive approach for their rapid up or downregulation. Br J Pharmacol (2004) 0.95

Quantal release of ATP from clusters of PC12 cells. J Physiol (2004) 0.95

Activation and desensitization of neuronal nicotinic receptors modulate glutamatergic transmission on neonatal rat hypoglossal motoneurons. Eur J Neurosci (2005) 0.94

Inhibition of spinal or hypoglossal motoneurons of the newborn rat by glycine or GABA. Eur J Neurosci (2002) 0.93

TNFα levels and macrophages expression reflect an inflammatory potential of trigeminal ganglia in a mouse model of familial hemiplegic migraine. PLoS One (2013) 0.93

ERG conductance expression modulates the excitability of ventral horn GABAergic interneurons that control rhythmic oscillations in the developing mouse spinal cord. J Neurosci (2007) 0.92

Lipid rafts control P2X3 receptor distribution and function in trigeminal sensory neurons of a transgenic migraine mouse model. Mol Pain (2011) 0.92

The Cdk5 kinase downregulates ATP-gated ionotropic P2X3 receptor function via serine phosphorylation. Cell Mol Neurobiol (2009) 0.89

Metabotropic glutamate receptor activity induces a novel oscillatory pattern in neonatal rat hypoglossal motoneurones. J Physiol (2004) 0.89

Modulation of neuronal nicotinic receptor function by the neuropeptides CGRP and substance P on autonomic nerve cells. Br J Pharmacol (2003) 0.89

Functional crosstalk in culture between macrophages and trigeminal sensory neurons of a mouse genetic model of migraine. BMC Neurosci (2012) 0.89

Activation of group I metabotropic glutamate receptors enhances efficacy of glutamatergic inputs to neonatal rat hypoglossal motoneurons in vitro. Eur J Neurosci (2004) 0.88

Modulation of rhythmic patterns and cumulative depolarization by group I metabotropic glutamate receptors in the neonatal rat spinal cord in vitro. Eur J Neurosci (2004) 0.87

Effects of LPS on P2X3 receptors of trigeminal sensory neurons and macrophages from mice expressing the R192Q Cacna1a gene mutation of familial hemiplegic migraine-1. Purinergic Signal (2012) 0.85

Respiratory motoneurons and pathological conditions: lessons from hypoglossal motoneurons challenged by excitotoxic or oxidative stress. Respir Physiol Neurobiol (2011) 0.85

Glutamate uptake block triggers deadly rhythmic bursting of neonatal rat hypoglossal motoneurons. J Physiol (2006) 0.85

Experimental and modeling studies of novel bursts induced by blocking na(+) pump and synaptic inhibition in the rat spinal cord. J Neurophysiol (2002) 0.85

Postnatal developmental profile of neurons and glia in motor nuclei of the brainstem and spinal cord, and its comparison with organotypic slice cultures. Dev Neurobiol (2012) 0.85

B-type natriuretic peptide-induced delayed modulation of TRPV1 and P2X3 receptors of mouse trigeminal sensory neurons. PLoS One (2013) 0.85

Riluzole: what it does to spinal and brainstem neurons and how it does it. Neuroscientist (2012) 0.85

Regulation of P2X3 receptor structure and function. CNS Neurol Disord Drug Targets (2012) 0.84

Molecular Mechanisms Underlying Cell Death in Spinal Networks in Relation to Locomotor Activity After Acute Injury in vitro. Front Cell Neurosci (2011) 0.84

A repertoire of rhythmic bursting produced by hypoglossal motoneurons in physiological and pathological conditions. Philos Trans R Soc Lond B Biol Sci (2009) 0.84

Bimodal action of protons on ATP currents of rat PC12 cells. J Gen Physiol (2003) 0.82

Dynamics of early locomotor network dysfunction following a focal lesion in an in vitro model of spinal injury. Eur J Neurosci (2009) 0.82

Long-term exposure to the new nicotinic antagonist 1,2-bisN-cytisinylethane upregulates nicotinic receptor subtypes of SH-SY5Y human neuroblastoma cells. Br J Pharmacol (2005) 0.82

The mechanism of functional up-regulation of P2X3 receptors of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine type 1 (FHM-1). PLoS One (2013) 0.82

Role of group II and III metabotropic glutamate receptors in rhythmic patterns of the neonatal rat spinal cord in vitro. Exp Brain Res (2004) 0.82

Desensitization of neuronal nicotinic receptors of human neuroblastoma SH-SY5Y cells during short or long exposure to nicotine. Br J Pharmacol (2005) 0.81

Modulation of P2X3 receptors by Mg2+ on rat DRG neurons in culture. Neuropharmacology (2003) 0.80

Transient oxidative stress evokes early changes in the functional properties of neonatal rat hypoglossal motoneurons in vitro. Eur J Neurosci (2010) 0.80

Unusual increase in lumbar network excitability of the rat spinal cord evoked by the PARP-1 inhibitor PJ-34 through inhibition of glutamate uptake. Neuropharmacology (2012) 0.79

A novel class of peptides with facilitating action on neuronal nicotinic receptors of rat chromaffin cells in vitro: functional and molecular dynamics studies. Mol Pharmacol (2002) 0.79

Effect of metabotropic glutamate receptor activity on rhythmic discharges of the neonatal rat spinal cord in vitro. Exp Brain Res (2003) 0.79

Activation of group I metabotropic glutamate receptors depresses recurrent inhibition of motoneurons in the neonatal rat spinal cord in vitro. Exp Brain Res (2005) 0.79

Riluzole is a potent drug to protect neonatal rat hypoglossal motoneurons in vitro from excitotoxicity due to glutamate uptake block. Eur J Neurosci (2011) 0.78

Electrochemical detection of endogenous glutamate release from rat spinal cord organotypic slices as a real-time method to monitor excitotoxicity. J Neurosci Methods (2011) 0.78

Functional differences between ATP-gated human and rat P2X3 receptors are caused by critical residues of the intracellular C-terminal domain. J Neurochem (2012) 0.78

Activity-independent intracellular Ca2+ oscillations are spontaneously generated by ventral spinal neurons during development in vitro. Cell Calcium (2006) 0.78

Studies of locomotor network neuroprotection by the selective poly(ADP-ribose) polymerase-1 inhibitor PJ-34 against excitotoxic injury to the rat spinal cord in vitro. Eur J Neurosci (2011) 0.78

Distinct subtypes of group I metabotropic glutamate receptors on rat spinal neurons mediate complex facilitatory and inhibitory effects. Eur J Neurosci (2003) 0.78

Adenine-based acyclic nucleotides as novel P2X3 receptor ligands. J Med Chem (2009) 0.78

The patterns of spontaneous Ca2+ signals generated by ventral spinal neurons in vitro show time-dependent refinement. Eur J Neurosci (2009) 0.78

Persistent rhythmic oscillations induced by nicotine on neonatal rat hypoglossal motoneurons in vitro. Eur J Neurosci (2006) 0.78

Effects of caffeine on the excitability and intracellular Ca(2+) transients of neonatal rat hypoglossal motoneurons in vitro. Neurosci Lett (2003) 0.77

Chronic NGF treatment of rat nociceptive DRG neurons in culture facilitates desensitization and deactivation of GABAA receptor-mediated currents. Br J Pharmacol (2004) 0.77

Effect of the PARP-1 inhibitor PJ 34 on excitotoxic damage evoked by kainate on rat spinal cord organotypic slices. Cell Mol Neurobiol (2010) 0.77

Effects of 6(5H)-phenanthridinone, an inhibitor of poly(ADP-ribose)polymerase-1 activity (PARP-1), on locomotor networks of the rat isolated spinal cord. Cell Mol Neurobiol (2011) 0.77

S100β as an early biomarker of excitotoxic damage in spinal cord organotypic cultures. J Neurochem (2014) 0.77

Evaluation of adenine as scaffold for the development of novel P2X3 receptor antagonists. Eur J Med Chem (2013) 0.76

Oscillatory circuits underlying locomotor networks in the rat spinal cord. Crit Rev Neurobiol (2006) 0.76

Cystic fibrosis transmembrane conductance regulator modulates synaptic chloride homeostasis in motoneurons of the rat spinal cord during neonatal development. Dev Neurobiol (2011) 0.76

The ATP-mediated fast current of rat dorsal root ganglion neurons is a novel effector for GABA(B) receptor activation. Neurosci Lett (2003) 0.76

Microelectrode arrays in combination with in vitro models of spinal cord injury as tools to investigate pathological changes in network activity: facts and promises. Front Neuroeng (2013) 0.75

Mutated CaV2.1 channels dysregulate CASK/P2X3 signaling in mouse trigeminal sensory neurons of R192Q Cacna1a knock-in mice. Mol Pain (2013) 0.75

Deconstructing locomotor networks with experimental injury to define their membership. Ann N Y Acad Sci (2010) 0.75

An electron microscopy study of changes in dense core vesicles of PC12 cells following pulse depolarization. Neuroreport (2005) 0.75

Pre and postsynaptic effects of metabotropic glutamate receptor activation on neonatal rat hypoglossal motoneurons. Neurosci Lett (2003) 0.75

Whole-cell recording of intracellular pH with silanized and oiled patch-type single or double-barreled microelectrodes. Pflugers Arch (2003) 0.75

Chromaffin cells at the beginning of the 21st century. Acta Physiol (Oxf) (2008) 0.75