Published in J Neurosci on November 01, 2000
Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Proc Natl Acad Sci U S A (2006) 3.47
Poly(ADP-ribose) (PAR) polymer is a death signal. Proc Natl Acad Sci U S A (2006) 3.41
NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation. Nat Neurosci (2009) 2.71
Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos. Exp Neurol (2009) 2.24
Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations. Proc Natl Acad Sci U S A (2006) 2.07
Parthanatos, a messenger of death. Front Biosci (Landmark Ed) (2009) 1.84
Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos). Sci Signal (2011) 1.73
Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2. Proc Natl Acad Sci U S A (2006) 1.68
Therapeutic applications of PARP inhibitors: anticancer therapy and beyond. Mol Aspects Med (2013) 1.62
Mitochondrial and nuclear cross talk in cell death: parthanatos. Ann N Y Acad Sci (2008) 1.62
Ca2+-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicity. J Physiol (2007) 1.45
Metformin induces both caspase-dependent and poly(ADP-ribose) polymerase-dependent cell death in breast cancer cells. Mol Cancer Res (2011) 1.43
Hypoxic-ischemic encephalopathy in the term infant. Clin Perinatol (2009) 1.35
Nicotinic acetylcholine receptor-mediated calcium signaling in the nervous system. Acta Pharmacol Sin (2009) 1.30
AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis. J Cell Biol (2010) 1.17
Calpain activation is not required for AIF translocation in PARP-1-dependent cell death (parthanatos). J Neurochem (2009) 1.16
Mitochondria, calcium-dependent neuronal death and neurodegenerative disease. Pflugers Arch (2012) 1.16
Critical appraisal of neuroprotection trials in head injury: what have we learned? NeuroRx (2004) 1.15
Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling. Genome Biol (2009) 1.14
Preconditioning provides neuroprotection in models of CNS disease: paradigms and clinical significance. Prog Neurobiol (2014) 1.13
Outer mitochondrial membrane localization of apoptosis-inducing factor: mechanistic implications for release. ASN Neuro (2009) 1.09
Time course and mechanism of hippocampal neuronal death in an in vitro model of status epilepticus: role of NMDA receptor activation and NMDA dependent calcium entry. Eur J Pharmacol (2008) 1.04
Inhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte death. Brain (2010) 1.01
Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1. J Biol Chem (2010) 1.01
Ischemia-reperfusion-related repair deficit after oxidative stress: implications of faulty transcripts in neuronal sensitivity after brain injury. J Biomed Sci (2003) 0.96
Postnatal age influences hypoglycemia-induced poly(ADP-ribose) polymerase-1 activation in the brain regions of rats. Pediatr Res (2009) 0.94
NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by β-lapachone. Cell Death Dis (2015) 0.93
Nicotinamide rescues human embryonic stem cell-derived neuroectoderm from parthanatic cell death. Stem Cells (2009) 0.92
Blockade of PARP activity attenuates poly(ADP-ribosyl)ation but offers only partial neuroprotection against NMDA-induced cell death in the rat retina. J Neurochem (2006) 0.92
Ethanol-mediated DNA damage and PARP-1 apoptotic responses in cultured fetal cortical neurons. Alcohol Clin Exp Res (2008) 0.92
Aag DNA glycosylase promotes alkylation-induced tissue damage mediated by Parp1. PLoS Genet (2013) 0.91
NMDA receptor-mediated activation of NADPH oxidase and glomerulosclerosis in hyperhomocysteinemic rats. Antioxid Redox Signal (2010) 0.89
Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration. J Exp Med (2013) 0.89
Minocycline protects cardiac myocytes against simulated ischemia–reperfusion injury by inhibiting poly(ADP-ribose) polymerase-1. J Cardiovasc Pharmacol (2010) 0.87
Spatial and functional relationship between poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in the brain. Neuroscience (2007) 0.86
Drug targets for traumatic brain injury from poly(ADP-ribose)polymerase pathway modulation. Br J Pharmacol (2009) 0.85
Molecular Mechanisms Underlying Cell Death in Spinal Networks in Relation to Locomotor Activity After Acute Injury in vitro. Front Cell Neurosci (2011) 0.84
Kainate-mediated excitotoxicity induces neuronal death in the rat spinal cord in vitro via a PARP-1 dependent cell death pathway (Parthanatos). Cell Mol Neurobiol (2010) 0.84
Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia. J Neurochem (2010) 0.84
Mitochondrial dysfunction induced by nuclear poly(ADP-ribose) polymerase-1: a treatable cause of cell death in stroke. Transl Stroke Res (2013) 0.82
PARP1 enhances inflammatory cytokine expression by alteration of promoter chromatin structure in microglia. Brain Behav (2014) 0.82
NADPH oxidase-2: linking glucose, acidosis, and excitotoxicity in stroke. Antioxid Redox Signal (2015) 0.80
Role of Bax in death of uninfected retinal cells during murine cytomegalovirus retinitis. Invest Ophthalmol Vis Sci (2014) 0.77
Transcripts of damaged genes in the brain during cerebral oxidative stress. J Neurosci Res (2002) 0.76
Pathophysiological Role of Peroxynitrite Induced DNA Damage in Human Diseases: A Special Focus on Poly(ADP-ribose) Polymerase (PARP). Indian J Clin Biochem (2015) 0.76
Mitochondrial Dysfunction Mediated by Poly(ADP-Ribose) Polymerase-1 Activation Contributes to Hippocampal Neuronal Damage Following Status Epilepticus. Int J Mol Sci (2017) 0.75
Minocycline targets multiple secondary injury mechanisms in traumatic spinal cord injury. Neural Regen Res (2017) 0.75
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature (1994) 10.22
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ (2011) 9.44
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell (1995) 9.22
Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem J (1999) 9.00
Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res (1993) 6.31
c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science (1994) 5.97
Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci U S A (1991) 5.70
Targeted disruption of the neuronal nitric oxide synthase gene. Cell (1993) 5.02
Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat Med (1999) 4.88
Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1. Proc Natl Acad Sci U S A (2000) 4.83
Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med (1997) 4.57
Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nat Med (2001) 4.22
Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Science (2001) 4.13
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nat Med (1997) 4.12
Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases. J Biol Chem (1996) 3.97
Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell (1994) 3.91
Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. Science (1994) 3.86
Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature (1996) 3.83
Insulin degludec: four times lower pharmacodynamic variability than insulin glargine under steady-state conditions in type 1 diabetes. Diabetes Obes Metab (2012) 3.68
Immunolocalization of CENP-A suggests a distinct nucleosome structure at the inner kinetochore plate of active centromeres. Curr Biol (1997) 3.62
Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury. Proc Natl Acad Sci U S A (1996) 3.29
Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase. Nature (1995) 3.15
Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. J Biol Chem (1992) 2.97
Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution. Proc Natl Acad Sci U S A (1995) 2.89
Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks. Trends Biochem Sci (1995) 2.85
Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion. Trends Pharmacol Sci (1998) 2.78
A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats. Science (1999) 2.68
Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase. Neuron (1991) 2.60
A convenient method for the ATPase assay. Anal Biochem (1978) 2.56
Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation. Br J Pharmacol (1996) 2.55
Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions. Nat Genet (1999) 2.53
A novel neuronal messenger molecule in brain: the free radical, nitric oxide. Ann Neurol (1992) 2.47
Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture. Hum Mol Genet (1998) 2.39
Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structure. Proc Natl Acad Sci U S A (1982) 2.37
Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase. J Cereb Blood Flow Metab (1997) 2.31
Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis. Proc Natl Acad Sci U S A (1996) 2.31
Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells. Curr Biol (2001) 2.21
Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures. J Neurosci (1993) 2.16
Nitric oxide synthase in cardiac sarcoplasmic reticulum. Proc Natl Acad Sci U S A (1999) 2.13
ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J Biol Chem (1996) 2.12
Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity. Proc Natl Acad Sci U S A (1996) 2.10
Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7. J Biol Chem (1999) 2.09
The absence of c-fos prevents light-induced apoptotic cell death of photoreceptors in retinal degeneration in vivo. Nat Med (1997) 2.07
Neuroprotective agents for clinical trials in Parkinson's disease: a systematic assessment. Neurology (2003) 2.04
Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin. Nat Med (1999) 1.98
Oxidative stress and genetics in the pathogenesis of Parkinson's disease. Neurobiol Dis (2000) 1.97
Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. J Invest Dermatol (2000) 1.97
Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains. Ann Neurol (1994) 1.95
Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (PARP-1): implication of lysosomal proteases. Cell Death Differ (2001) 1.91
Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B. Proc Natl Acad Sci U S A (1996) 1.90
Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism. Proc Natl Acad Sci U S A (1999) 1.88
Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis. J Biol Chem (1997) 1.88
Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death. Mutat Res (2001) 1.85
Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism. Exp Cell Res (2001) 1.85
Cancer incidence and risk estimation among medical x-ray workers in China, 1950-1995. Health Phys (2002) 1.85
Nitric oxide synthase in models of focal ischemia. Stroke (1997) 1.85
Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers. J Biol Chem (1998) 1.79
Expression of the subtype 2 angiotensin (AT2) receptor protein in rat kidney. Hypertension (1997) 1.77
Immunologic NO synthase: elevation in severe AIDS dementia and induction by HIV-1 gp41. Science (1996) 1.76
Differential immunohistochemical localization of inositol 1,4,5-trisphosphate- and ryanodine-sensitive Ca2+ release channels in rat brain. J Neurosci (1993) 1.76
New approaches to understanding p53 gene tumor mutation spectra. Mutat Res (1999) 1.75
Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures. Proc Natl Acad Sci U S A (1993) 1.75
Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis. Hum Mol Genet (2001) 1.74
Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice. J Neurosci (1996) 1.73
Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes. Proc Natl Acad Sci U S A (1999) 1.71
Osteoblasts are target cells for transformation in c-fos transgenic mice. J Cell Biol (1993) 1.70
Nitric oxide in neurodegeneration. Prog Brain Res (1998) 1.69
Bcl-2 and adenovirus E1B 19 kDA protein prevent E1A-induced processing of CPP32 and cleavage of poly(ADP-ribose) polymerase. Oncogene (1996) 1.64
Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression. Nat Genet (2001) 1.60
Requirement for nitric oxide activation of p21(ras)/extracellular regulated kinase in neuronal ischemic preconditioning. Proc Natl Acad Sci U S A (2000) 1.60
The prevalence and spectrum of alpha and beta thalassaemia in Guangdong Province: implications for the future health burden and population screening. J Clin Pathol (2004) 1.59
Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: implications for synaptic plasticity. Proc Natl Acad Sci U S A (1994) 1.59
Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool. Oncogene (2001) 1.57
JunB is essential for mammalian placentation. EMBO J (1999) 1.57
Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability. Nat Genet (1999) 1.56
Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS. Science (1994) 1.56
Coronary artery calcification in older adults to age 99: prevalence and risk factors. Circulation (2001) 1.56
Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells. J Biol Chem (1995) 1.56