Published in Mediators Inflamm on May 23, 2010
Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int J Mol Sci (2014) 2.03
The inflammation highway: metabolism accelerates inflammatory traffic in obesity. Immunol Rev (2012) 2.01
Inflammatory pathway genes belong to major targets of persistent organic pollutants in adipose cells. Environ Health Perspect (2012) 1.78
Increased gut permeability and microbiota change associate with mesenteric fat inflammation and metabolic dysfunction in diet-induced obese mice. PLoS One (2012) 1.59
Adipose tissue microRNAs as regulators of CCL2 production in human obesity. Diabetes (2012) 1.44
Normal breast tissue of obese women is enriched for macrophage markers and macrophage-associated gene expression. Breast Cancer Res Treat (2011) 1.24
1,25-Dihydroxyvitamin D3 inhibits the cytokine-induced secretion of MCP-1 and reduces monocyte recruitment by human preadipocytes. Int J Obes (Lond) (2012) 1.13
Comprehensive analysis of circulating adipokines and hsCRP association with cardiovascular disease risk factors and metabolic syndrome in Arabs. Cardiovasc Diabetol (2014) 1.09
Effects of endurance exercise training, metformin, and their combination on adipose tissue leptin and IL-10 secretion in OLETF rats. J Appl Physiol (1985) (2012) 1.08
Inflammatory Signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice. J Inflamm (Lond) (2011) 1.05
Amyloid precursor protein and proinflammatory changes are regulated in brain and adipose tissue in a murine model of high fat diet-induced obesity. PLoS One (2012) 1.03
Cortisol and inflammatory processes in ovarian cancer patients following primary treatment: relationships with depression, fatigue, and disability. Brain Behav Immun (2012) 1.03
Diet-induced obesity significantly increases the severity of posttraumatic arthritis in mice. Arthritis Rheum (2012) 1.02
Centrally located body fat is associated with lower bone mineral density in older Puerto Rican adults. Am J Clin Nutr (2011) 0.96
Exercise-induced Signals for Vascular Endothelial Adaptations: Implications for Cardiovascular Disease. Curr Cardiovasc Risk Rep (2012) 0.95
Body mass index and musculoskeletal pain: is there a connection? Chiropr Man Therap (2013) 0.93
Critical appraisal of four IL-6 immunoassays. PLoS One (2012) 0.92
Effects of bariatric surgery on adipokine-induced inflammation and insulin resistance. Front Endocrinol (Lausanne) (2013) 0.90
Inflammatory markers and bariatric surgery: a meta-analysis. Inflamm Res (2012) 0.90
Interleukin-1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes. Am J Physiol Endocrinol Metab (2014) 0.89
Does inflammation determine whether obesity is metabolically healthy or unhealthy? The aging perspective. Mediators Inflamm (2012) 0.89
Perivascular adipose tissue of the descending thoracic aorta is associated with systemic lupus erythematosus and vascular calcification in women. Atherosclerosis (2013) 0.88
Adipose-tissue and intestinal inflammation - visceral obesity and creeping fat. Front Immunol (2014) 0.88
Differential effects of dietary protein sources on postprandial low-grade inflammation after a single high fat meal in obese non-diabetic subjects. Nutr J (2011) 0.88
Marrow adipocyte-derived CXCL1 and CXCL2 contribute to osteolysis in metastatic prostate cancer. Clin Exp Metastasis (2015) 0.88
Apoptosis, mastocytosis, and diminished adipocytokine gene expression accompany reduced epididymal fat mass in long-standing diet-induced obese mice. Lipids Health Dis (2011) 0.86
Obesity indices and inflammatory markers in obese non-diabetic normo- and hypertensive patients: a comparative pilot study. Lipids Health Dis (2014) 0.85
Early Markers of Atherosclerotic Disease in Individuals with Excess Weight and Dyslipidemia. Arq Bras Cardiol (2016) 0.85
Deficiency of lymphotoxin-α does not exacerbate high-fat diet-induced obesity but does enhance inflammation in mice. Am J Physiol Endocrinol Metab (2012) 0.83
Inflammation as a Mediator of the Association Between Race and Atrial Fibrillation: Results from the Health, Aging, and Body Composition Study. JACC Clin Electrophysiol (2015) 0.82
Fatty acids, lipid mediators, and T-cell function. Front Immunol (2014) 0.81
Over-expression of TLR4-CD14, pro-inflammatory cytokines, metabolic markers and NEFAs in obese non-diabetic Mexicans. J Inflamm (Lond) (2014) 0.81
Negative influence of a long-term high-fat diet on murine bone architecture. Int J Endocrinol (2014) 0.80
Osteoarthritis: toward a comprehensive understanding of pathological mechanism. Bone Res (2017) 0.80
New obesity classification criteria as a tool for bariatric surgery indication. World J Gastroenterol (2016) 0.80
Insight into the impact of diabetes mellitus on the increased risk of hepatocellular carcinoma: mini-review. J Diabetes Metab Disord (2014) 0.79
The expression of LEP, LEPR, IGF1 and IL10 in obesity and the relationship with microRNAs. PLoS One (2014) 0.79
Expression of innate immune response genes in liver and three types of adipose tissue in cloned pigs. Cell Reprogram (2012) 0.79
Role of adiponectin and proinflammatory gene expression in adipose tissue chronic inflammation in women with metabolic syndrome. Diabetol Metab Syndr (2014) 0.78
n-3 polyunsaturated fatty acids and mechanisms to mitigate inflammatory paracrine signaling in obesity-associated breast cancer. Nutrients (2014) 0.78
Human adipose-derived mesenchymal stromal cell pigment epithelium-derived factor cytotherapy modifies genetic and epigenetic profiles of prostate cancer cells. Cytotherapy (2014) 0.78
Adipose tissue metabolic and inflammatory responses to a mixed meal in lean, overweight and obese men. Eur J Nutr (2015) 0.78
Acute reduction of lipolysis reduces adiponectin and IL-18: evidence from an intervention study with acipimox and insulin. Diabetologia (2013) 0.77
Gut microbiota and sirtuins in obesity-related inflammation and bowel dysfunction. J Transl Med (2011) 0.77
Skeletal integration of energy homeostasis: Translational implications. Bone (2015) 0.76
Identification of active miRNA and transcription factor regulatory pathways in human obesity-related inflammation. BMC Bioinformatics (2015) 0.76
Maternal adipokines and insulin as biomarkers of pregnancies complicated by overweight and obesity. Diabetol Metab Syndr (2016) 0.76
Effects of long-term exercise training on adipose tissue expression of fractalkine and MCP-1 in patients with type 2 diabetes and stable coronary artery disease: a substudy of a randomized controlled trial. Diabetes Metab Syndr Obes (2016) 0.75
Correlative studies on the effects of obesity, diabetes and hypertension on gene expression in omental adipose tissue of obese women. Nutr Diabetes (2011) 0.75
Diagnosis and body mass index effects on hippocampal volumes and neurochemistry in bipolar disorder. Transl Psychiatry (2017) 0.75
CXCL-16, IL-17, and bone morphogenetic protein 2 (BMP-2) are associated with overweight and obesity conditions in middle-aged and elderly women. Immun Ageing (2017) 0.75
Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation. Mol Metab (2016) 0.75
Immunological characterization of the teleost adipose tissue and its modulation in response to viral infection and fat-content in the diet. PLoS One (2014) 0.75
Android shape independent of aerobic fitness: a risk factor for low bone mineral content in overweight and obese latina women. Clin Med Insights Womens Health (2013) 0.75
Amyloid precursor protein modulates macrophage phenotype and diet-dependent weight gain. Sci Rep (2017) 0.75
3T3-L1 preadipocytes exhibit heightened monocyte-chemoattractant protein-1 response to acute fatty acid exposure. PLoS One (2014) 0.75
Cloning changes the response to obesity of innate immune factors in blood, liver, and adipose tissues in domestic pigs. Cell Reprogram (2013) 0.75
Endocan and the respiratory system: a review. Int J Chron Obstruct Pulmon Dis (2016) 0.75
Triiodothyronine modulates the expression of leptin and adiponectin in 3T3-L1 adipocytes. Einstein (Sao Paulo) (2015) 0.75
Crosstalk between immune cells and adipocytes requires both paracrine factors and cell contact to modify cytokine secretion. PLoS One (2013) 0.75
Experimental type 2 diabetes induction reduces serum vaspin, but not serum omentin, in Wistar rats. Int J Exp Pathol (2017) 0.75
Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 32.01
Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J Mol Endocrinol (2000) 29.28
METABOLISM OF ISOLATED FAT CELLS. I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM AND LIPOLYSIS. J Biol Chem (1964) 21.04
Inflammation, stress, and diabetes. J Clin Invest (2005) 17.11
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res (2005) 11.88
Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev (2000) 8.15
C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol (1999) 7.15
Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab (1998) 7.05
Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr (2004) 6.31
Retracted Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes (2007) 5.67
Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J Biol Chem (2001) 5.61
Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk. Arterioscler Thromb Vasc Biol (2008) 5.19
Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study. Circulation (2007) 5.10
Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab (2007) 4.94
Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology (2004) 4.67
Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler Thromb Vasc Biol (2006) 4.07
Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. Mol Cell Biol (2009) 3.96
Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year. Circulation (2002) 3.84
Human epicardial adipose tissue: a review. Am Heart J (2007) 3.74
Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration. Int J Obes (Lond) (2007) 3.72
The relation of body fat mass and distribution to markers of chronic inflammation. Int J Obes Relat Metab Disord (2001) 3.39
Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-alpha expression. Diabetes (2003) 3.29
Body fat distribution and risk of coronary heart disease in men and women in the European Prospective Investigation Into Cancer and Nutrition in Norfolk cohort: a population-based prospective study. Circulation (2007) 3.20
Emerging role of adipose tissue hypoxia in obesity and insulin resistance. Int J Obes (Lond) (2008) 3.17
Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity. Diabetes (2006) 3.06
Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice. J Lipid Res (2008) 3.03
The perils of portliness: causes and consequences of visceral adiposity. Diabetes (2000) 2.96
Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity? Br J Nutr (2008) 2.73
Obesity-induced inflammation: a metabolic dialogue in the language of inflammation. J Intern Med (2007) 2.72
Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome. Clin Chem (2006) 2.63
Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat. Obesity (Silver Spring) (2008) 2.32
Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects. J Clin Endocrinol Metab (2003) 2.25
Obesity is associated with increased levels of circulating hepatocyte growth factor. J Am Coll Cardiol (2003) 2.14
Tumor necrosis factor-alpha in sera of obese patients: fall with weight loss. J Clin Endocrinol Metab (1998) 2.12
Waist circumference correlates with metabolic syndrome indicators better than percentage fat. Obesity (Silver Spring) (2006) 2.00
Leptin secretion from subcutaneous and visceral adipose tissue in women. Diabetes (1998) 1.99
Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro. J Clin Endocrinol Metab (2002) 1.98
Omentin plasma levels and gene expression are decreased in obesity. Diabetes (2007) 1.98
A role for protein kinase Bbeta/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes. Mol Cell Biol (1999) 1.95
Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-kappaB pathway in adipocytes links nutritional signalling with innate immunity. Immunology (2008) 1.91
Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion. Obes Res (2001) 1.89
Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses. J Clin Invest (2003) 1.87
The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes. J Biol Chem (2000) 1.87
Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue. Am J Physiol Endocrinol Metab (2008) 1.85
Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications. PLoS Med (2006) 1.81
MicroRNA expression in human omental and subcutaneous adipose tissue. PLoS One (2009) 1.81
Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters. Int J Obes (Lond) (2006) 1.76
Differences in mRNA expression of the proteins secreted by the adipocytes in human subcutaneous and visceral adipose tissues. Biochim Biophys Acta (2000) 1.76
IL-1 receptor antagonist serum levels are increased in human obesity: a possible link to the resistance to leptin? J Clin Endocrinol Metab (2002) 1.74
The dual role of IL-10. Trends Immunol (2003) 1.72
Resistin release by human adipose tissue explants in primary culture. Biochem Biophys Res Commun (2003) 1.65
Inducible Toll-like receptor and NF-kappaB regulatory pathway expression in human adipose tissue. Obesity (Silver Spring) (2008) 1.63
Depot-specific differences in adipose tissue gene expression in lean and obese subjects. Diabetes (1998) 1.63
Bacterial endotoxin stimulates adipose lipolysis via toll-like receptor 4 and extracellular signal-regulated kinase pathway. J Biol Chem (2009) 1.61
Regional differences of insulin action in adipose tissue: insights from in vivo and in vitro studies. Acta Physiol Scand (2005) 1.60
The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones. Trends Endocrinol Metab (2003) 1.58
Expression of macrophage-selective markers in human and rodent adipocytes. FEBS Lett (2005) 1.52
Dysregulation of adipose glutathione peroxidase 3 in obesity contributes to local and systemic oxidative stress. Mol Endocrinol (2008) 1.51
Association of low interleukin-10 levels with the metabolic syndrome in obese women. J Clin Endocrinol Metab (2003) 1.50
Elevated serum vascular endothelial growth factor is associated with visceral fat accumulation in human obese subjects. Diabetologia (2003) 1.44
Uncoupling protein-1 and related messenger ribonucleic acids in human epicardial and other adipose tissues: epicardial fat functioning as brown fat. J Clin Endocrinol Metab (2009) 1.43
Higher production of IL-8 in visceral vs. subcutaneous adipose tissue. Implication of nonadipose cells in adipose tissue. Am J Physiol Endocrinol Metab (2003) 1.43
Plasma interleukin-8 concentrations are increased in obese subjects and related to fat mass and tumor necrosis factor-alpha system. J Clin Endocrinol Metab (2002) 1.43
Obesity and impaired fibrinolysis: role of adipose production of plasminogen activator inhibitor-1. Int J Obes Relat Metab Disord (2004) 1.43
LOCALIZATION OF LIPOPROTEIN LIPASE IN FAT CELLS OF RAT ADIPOSE TISSUE. J Biol Chem (1964) 1.42
Weight loss reduces interleukin-18 levels in obese women. J Clin Endocrinol Metab (2002) 1.40
Visceral obesity and plasma glucose-insulin homeostasis: contributions of interleukin-6 and tumor necrosis factor-alpha in men. J Clin Endocrinol Metab (2008) 1.39
Circulating levels of oxidative stress markers and endothelial adhesion molecules in men with abdominal obesity. J Clin Endocrinol Metab (2005) 1.37
Increased plasma concentration of macrophage migration inhibitory factor (MIF) and MIF mRNA in mononuclear cells in the obese and the suppressive action of metformin. J Clin Endocrinol Metab (2004) 1.34
Leptin expression in adipose tissue from obese humans: depot-specific regulation by insulin and dexamethasone. Am J Physiol (1998) 1.33
Circulating nerve growth factor levels in relation to obesity and the metabolic syndrome in women. Eur J Endocrinol (2007) 1.31
Vaspin gene expression in human adipose tissue: association with obesity and type 2 diabetes. Biochem Biophys Res Commun (2005) 1.30
Interleukin-6 and insulin resistance. Vitam Horm (2009) 1.27
TNFalpha release by the nonfat cells of human adipose tissue. Int J Obes Relat Metab Disord (2004) 1.26
Presence of functional TLR2 and TLR4 on human adipocytes. Histochem Cell Biol (2006) 1.25
Allometric relationship between changes of visceral fat and total fat mass. Int J Obes (Lond) (2007) 1.24
Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed and secreted by human (SGBS) adipocytes. FEBS Lett (2005) 1.24
Plasma levels of the soluble fraction of tumor necrosis factor receptor 2 and insulin resistance. Diabetes (1998) 1.23
Increased leptin concentrations correlate with increased concentrations of inflammatory markers in morbidly obese individuals. Int J Obes Relat Metab Disord (2001) 1.22
Identification of omentin mRNA in human epicardial adipose tissue: comparison to omentin in subcutaneous, internal mammary artery periadventitial and visceral abdominal depots. Int J Obes (Lond) (2008) 1.20
Simple anthropometric measures correlate with metabolic risk indicators as strongly as magnetic resonance imaging-measured adipose tissue depots in both HIV-infected and control subjects. Am J Clin Nutr (2008) 1.18
Serum levels of interleukin-6 and C-reactive protein correlate with body mass index across the broad range of obesity. JPEN J Parenter Enteral Nutr (2004) 1.18
Leptin receptor expression on T lymphocytes modulates chronic intestinal inflammation in mice. Gut (2004) 1.17
Plasminogen activator inhibitor-1, adipose tissue and insulin resistance. Curr Opin Lipidol (2007) 1.14
Molecular characteristics of serum visfatin and differential detection by immunoassays. J Clin Endocrinol Metab (2007) 1.11
Regulation of inflammation-related genes in human adipose tissue. J Intern Med (2007) 1.10
Uncoupling protein-1 mRNA expression in obese human subjects: the role of sequence variations at the uncoupling protein-1 gene locus. J Lipid Res (1998) 1.10
Transforming growth factor beta1 release by human adipose tissue is enhanced in obesity. Metabolism (2005) 1.08
Is PBEF/visfatin/Nampt an authentic adipokine relevant to the metabolic syndrome? Curr Hypertens Rep (2007) 1.08
The differential effect of food intake and beta-adrenergic stimulation on adipose-derived hormones and cytokines in man. J Clin Endocrinol Metab (1999) 1.08
The adipokine zinc-alpha2-glycoprotein (ZAG) is downregulated with fat mass expansion in obesity. Clin Endocrinol (Oxf) (2009) 1.08
Regional differences in oxidative capacity of rat white adipose tissue are linked to the mitochondrial content of mature adipocytes. Mol Cell Biochem (2004) 1.06
Determinants of human plasma glutathione peroxidase (GPx-3) expression. J Biol Chem (2004) 1.06
Comparison of messenger RNA distribution for 60 proteins in fat cells vs the nonfat cells of human omental adipose tissue. Metabolism (2008) 1.04
Human epicardial adipokine messenger RNAs: comparisons of their expression in substernal, subcutaneous, and omental fat. Metabolism (2010) 1.03
Comparison of hormone-sensitive lipase activity in visceral and subcutaneous human adipose tissue. J Clin Endocrinol Metab (1997) 1.02
Correlation of circulating full-length visfatin (PBEF/NAMPT) with metabolic parameters in subjects with and without diabetes: a cross-sectional study. Clin Endocrinol (Oxf) (2008) 1.02
Osteoprotegerin in relation to body weight, lipid parameters insulin sensitivity, adipocytokines, and C-reactive protein in obese and non-obese young individuals: results from both cross-sectional and interventional study. Eur J Endocrinol (2008) 0.99
Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol (2009) 0.78