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1
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Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
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Nat Genet
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2008
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20.73
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2
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Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
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Nature
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2011
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13.25
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3
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SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations.
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Nat Genet
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2008
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8.63
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4
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The rise of chronic non-communicable diseases in southeast Asia: time for action.
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Lancet
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2011
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5.77
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5
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Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
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Nat Genet
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2011
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4.50
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6
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Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations.
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Diabetes
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2008
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4.20
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7
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Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
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Nat Genet
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2014
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4.13
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8
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Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
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Nat Genet
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2011
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4.04
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9
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Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.
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PLoS Med
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2011
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3.94
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10
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Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci.
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Nat Genet
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2011
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3.46
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11
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A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.
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Nat Genet
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2010
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2.81
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12
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Meta-analysis identifies common variants associated with body mass index in east Asians.
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Nat Genet
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2012
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2.70
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13
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A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.
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Nat Genet
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2010
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2.62
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14
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Identification of new genetic risk variants for type 2 diabetes.
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PLoS Genet
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2010
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2.62
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15
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Prevalence and risk factors for diabetic retinopathy: the Singapore Malay Eye Study.
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Ophthalmology
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2008
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2.11
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16
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A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis.
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Nat Genet
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2011
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2.05
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17
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Rationale and methodology for a population-based study of eye diseases in Malay people: The Singapore Malay eye study (SiMES).
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Ophthalmic Epidemiol
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2007
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1.68
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18
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Methodology of the Singapore Indian Chinese Cohort (SICC) eye study: quantifying ethnic variations in the epidemiology of eye diseases in Asians.
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Ophthalmic Epidemiol
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2009
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1.64
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19
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Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo.
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PLoS Genet
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2010
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1.57
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20
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Collagen-related genes influence the glaucoma risk factor, central corneal thickness.
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Hum Mol Genet
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2010
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1.52
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21
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Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
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Nat Genet
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2013
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1.49
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22
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Polymorphisms identified through genome-wide association studies and their associations with type 2 diabetes in Chinese, Malays, and Asian-Indians in Singapore.
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J Clin Endocrinol Metab
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2009
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1.46
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23
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Peripheral artery disease and glaucoma: the singapore malay eye study.
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Arch Ophthalmol
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2009
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1.42
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24
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Retinal vascular fractal and blood pressure in a multiethnic population.
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J Hypertens
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2013
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1.39
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25
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Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
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Diabetes
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2013
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1.36
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26
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Retinal arteriolar narrowing increases the likelihood of chronic kidney disease in hypertension.
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J Hypertens
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2009
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1.30
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27
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Genetic variation in KCNQ1 associates with fasting glucose and beta-cell function: a study of 3,734 subjects comprising three ethnicities living in Singapore.
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Diabetes
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2009
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1.24
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28
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The case for strategic international alliances to harness nutritional genomics for public and personal health.
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Br J Nutr
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2005
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1.24
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29
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Ethnic disparities in prevalence and impact of risk factors of chronic kidney disease.
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Nephrol Dial Transplant
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2010
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1.23
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30
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Is there a clear threshold for fasting plasma glucose that differentiates between those with and without neuropathy and chronic kidney disease?: the Singapore Prospective Study Program.
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Am J Epidemiol
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2009
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1.23
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31
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Candidate gene association study for diabetic retinopathy in persons with type 2 diabetes: the Candidate gene Association Resource (CARe).
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Invest Ophthalmol Vis Sci
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2011
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1.22
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32
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Perilipin gene variation determines higher susceptibility to insulin resistance in Asian women when consuming a high-saturated fat, low-carbohydrate diet.
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Diabetes Care
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2006
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1.17
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33
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Modification of the NCEP ATP III definitions of the metabolic syndrome for use in Asians identifies individuals at risk of ischemic heart disease.
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Atherosclerosis
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2005
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1.16
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34
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Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.
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PLoS One
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2013
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1.16
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35
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C-reactive protein, body mass index, and diabetic retinopathy.
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Invest Ophthalmol Vis Sci
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2010
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1.14
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36
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Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype association with increased obesity risk in a multiethnic Asian population.
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J Mol Med (Berl)
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2005
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1.13
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37
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Prevalence and causes of low vision and blindness in an urban malay population: the Singapore Malay Eye Study.
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Arch Ophthalmol
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2008
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1.13
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38
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Nutrigenetics and nutrigenomics: viewpoints on the current status and applications in nutrition research and practice.
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J Nutrigenet Nutrigenomics
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2011
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1.12
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39
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Retinal microvascular caliber and chronic kidney disease in an Asian population.
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Am J Epidemiol
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2008
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1.10
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40
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Risk factors associated with hypertension awareness, treatment, and control in a multi-ethnic Asian population.
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J Hypertens
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2009
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1.09
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41
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Association between body mass index and chronic kidney disease in men and women: population-based study of Malay adults in Singapore.
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Nephrol Dial Transplant
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2007
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1.09
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42
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Prevalence of and risk factors for age-related macular degeneration in a multiethnic Asian cohort.
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Arch Ophthalmol
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2011
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1.07
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43
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Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci.
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Hypertension
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2013
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1.03
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44
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Why study gene-environment interactions?
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Curr Opin Lipidol
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2008
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1.03
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45
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Myopia-related fundus changes in Singapore adults with high myopia.
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Am J Ophthalmol
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2013
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1.02
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46
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The Singapore impaired glucose tolerance follow-up study: does the ticking clock go backward as well as forward?
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Diabetes Care
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2003
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1.01
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47
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Validity of the International Physical Activity Questionnaire and the Singapore Prospective Study Program physical activity questionnaire in a multiethnic urban Asian population.
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BMC Med Res Methodol
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2011
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0.99
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48
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Macro-thyrotropin: a case report and review of literature.
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J Clin Endocrinol Metab
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2012
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0.99
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49
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Patterns of physical activity in different domains and implications for intervention in a multi-ethnic Asian population: a cross-sectional study.
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BMC Public Health
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2010
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0.99
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50
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Clinical features and treatment of maturity onset diabetes of the young (MODY).
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Diabetes Metab Syndr Obes
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2012
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0.98
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51
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The metabolic syndrome in Chinese, Malays and Asian Indians. Factor analysis of data from the 1998 Singapore National Health Survey.
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Diabetes Res Clin Pract
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2005
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52
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Television screen time, but not computer use and reading time, is associated with cardio-metabolic biomarkers in a multiethnic Asian population: a cross-sectional study.
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Int J Behav Nutr Phys Act
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2013
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0.96
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53
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Retinal vascular caliber, blood pressure, and cardiovascular risk factors in an Asian population: the Singapore Malay Eye Study.
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Invest Ophthalmol Vis Sci
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2008
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0.96
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54
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Structural changes in the retinal microvasculature and renal function.
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Invest Ophthalmol Vis Sci
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2013
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0.96
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55
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The association between socioeconomic status and overweight/obesity in a Malay population in Singapore.
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Asia Pac J Public Health
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2009
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0.95
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56
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Impact of diabetic retinopathy on vision-specific function.
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Ophthalmology
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2010
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0.95
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57
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Relationships between cholesterol efflux and high-density lipoprotein particles in patients with type 2 diabetes mellitus.
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J Clin Lipidol
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2011
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0.95
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58
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Racial differences in the prevalence of diabetes but not diabetic retinopathy in a multi-ethnic Asian population.
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Invest Ophthalmol Vis Sci
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2011
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0.95
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59
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Early retinal arteriolar changes and peripheral neuropathy in diabetes.
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Diabetes Care
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2012
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60
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Adverse Associations between Visceral Adiposity, Brain Structure, and Cognitive Performance in Healthy Elderly.
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Front Aging Neurosci
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2011
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Genetic variation in CDH13 is associated with lower plasma adiponectin levels but greater adiponectin sensitivity in East Asian populations.
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Diabetes
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2013
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0.93
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62
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C-reactive protein and microalbuminuria in a multi-ethnic Asian population.
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Nephrol Dial Transplant
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2009
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63
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The V227A polymorphism at the PPARA locus is associated with serum lipid concentrations and modulates the association between dietary polyunsaturated fatty acid intake and serum high density lipoprotein concentrations in Chinese women.
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Atherosclerosis
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2005
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64
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A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
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Hum Mol Genet
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2013
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0.91
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65
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Fractal analysis of the retinal vasculature and chronic kidney disease.
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Nephrol Dial Transplant
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2010
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0.91
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66
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Metabolic syndrome components and age-related cataract: the Singapore Malay eye study.
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Invest Ophthalmol Vis Sci
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2011
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0.91
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67
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Retinal vascular caliber and diabetes in a multiethnic Asian population.
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Microcirculation
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2009
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68
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Associations of diabetes mellitus and ethnicity with mortality in a multiethnic Asian population: data from the 1992 Singapore National Health Survey.
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Am J Epidemiol
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2003
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0.89
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69
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C-reactive protein and retinal microvascular caliber in a multiethnic asian population.
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Am J Epidemiol
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2009
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70
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Socioeconomic status and microalbuminuria in an Asian population.
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2008
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71
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The relevance of the metabolic syndrome.
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Ann Acad Med Singapore
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2009
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0.89
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Genome-wide association study identifies ZFHX1B as a susceptibility locus for severe myopia.
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Hum Mol Genet
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2013
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Lack of awareness amongst community patients with diabetes and diabetic retinopathy: the Singapore Malay eye study.
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Ann Acad Med Singapore
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2009
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The CKD-EPI equation and MDRD study equation find similar prevalence of chronic kidney disease in Asian populations.
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Ann Intern Med
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2009
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Diagnosis of diabetes mellitus using HbA1c in Asians: relationship between HbA1c and retinopathy in a multiethnic Asian population.
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J Clin Endocrinol Metab
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2014
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A family history of type 2 diabetes is associated with glucose intolerance and obesity-related traits with evidence of excess maternal transmission for obesity-related traits in a South East Asian population.
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Diabetes Res Clin Pract
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2008
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Automated segmentation of visceral and subcutaneous (deep and superficial) adipose tissues in normal and overweight men.
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J Magn Reson Imaging
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Ophthalmology
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Body fat partitioning does not explain the interethnic variation in insulin sensitivity among Asian ethnicity: the Singapore adults metabolism study.
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Metabolic syndrome and risk of age-related macular degeneration.
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The impact of central obesity as a prerequisite for the diagnosis of metabolic syndrome.
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Obesity (Silver Spring)
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J Atheroscler Thromb
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Minimal difference between aerobic and progressive resistance exercise on metabolic profile and fitness in older adults with diabetes mellitus: a randomised trial.
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Diabetes Res Clin Pract
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Uncoupling protein 2 promoter polymorphism -866G/A, central adiposity, and metabolic syndrome in Asians.
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Trends in the incidence and mortality of coronary heart disease in asian pacific region: the Singapore experience.
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PLoS One
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A natural polymorphism in peroxisome proliferator-activated receptor-alpha hinge region attenuates transcription due to defective release of nuclear receptor corepressor from chromatin.
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Distribution of ankle--brachial index and the risk factors of peripheral artery disease in a multi-ethnic Asian population.
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PLoS One
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Recalibration of the Global Registry of Acute Coronary Events risk score in a multiethnic Asian population.
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Am Heart J
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Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium.
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Health status of older adults with Type 2 diabetes mellitus after aerobic or resistance training: a randomised trial.
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