Published in PLoS Genet on October 28, 2010
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol (2012) 3.93
The Rotterdam Study: 2012 objectives and design update. Eur J Epidemiol (2011) 3.26
Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nat Genet (2011) 1.97
Microvascular abnormality in schizophrenia as shown by retinal imaging. Am J Psychiatry (2013) 1.53
Overlap between common genetic polymorphisms underpinning kidney traits and cardiovascular disease phenotypes: the CKDGen consortium. Am J Kidney Dis (2013) 1.52
A genome-wide association study identifies a potential novel gene locus for keratoconus, one of the commonest causes for corneal transplantation in developed countries. Hum Mol Genet (2011) 1.11
The Rotterdam Scan Study: design and update up to 2012. Eur J Epidemiol (2011) 1.07
Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets. PLoS Genet (2013) 1.04
Gene expression endophenotypes: a novel approach for gene discovery in Alzheimer's disease. Mol Neurodegener (2011) 1.04
Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma. Nat Genet (2016) 1.02
12q24 locus association with type 1 diabetes: SH2B3 or ATXN2? World J Diabetes (2014) 0.95
Strategies to design and analyze targeted sequencing data: cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. Circ Cardiovasc Genet (2014) 0.93
Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin. Hum Genet (2013) 0.84
Single nucleotide polymorphisms associated with abnormal coronary microvascular function. Coron Artery Dis (2014) 0.84
Rap1 signaling in endothelial barrier control. Cell Adh Migr (2014) 0.84
Association between phosphatase related gene variants and coronary artery disease: case-control study and meta-analysis. Int J Mol Sci (2014) 0.84
The Rotterdam Scan Study: design update 2016 and main findings. Eur J Epidemiol (2015) 0.83
High-density genotyping of immune loci in Kawasaki disease and IVIG treatment response in European-American case-parent trio study. Genes Immun (2014) 0.82
FLT1 genetic variation predisposes to neovascular AMD in ethnically diverse populations and alters systemic FLT1 expression. Invest Ophthalmol Vis Sci (2014) 0.82
Overweight condition and waist circumference and a candidate gene within the 12q24 locus. Cardiovasc Diabetol (2013) 0.82
Genome-wide analyses identify common variants associated with macular telangiectasia type 2. Nat Genet (2017) 0.81
Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore? PLoS One (2013) 0.81
Effect of genetic variants associated with plasma homocysteine levels on stroke risk. Stroke (2014) 0.81
Genetic loci for retinal arteriolar microcirculation. PLoS One (2013) 0.80
Exploiting Single-Cell Quantitative Data to Map Genetic Variants Having Probabilistic Effects. PLoS Genet (2016) 0.78
Novel Genetic Loci Associated With Retinal Microvascular Diameter. Circ Cardiovasc Genet (2015) 0.78
Proteasome modulator 9 SNPs are linked to hypertension in type 2 diabetes families. Cardiovasc Diabetol (2011) 0.78
Genetic susceptibility to hypertensive renal disease. Cell Mol Life Sci (2012) 0.78
Thrombotic antiphospholipid syndrome shows strong haplotypic association with SH2B3-ATXN2 locus. PLoS One (2013) 0.78
Novel Genes Affecting Blood Pressure Detected Via Gene-Based Association Analysis. G3 (Bethesda) (2015) 0.78
On the analysis of a repeated measure design in genome-wide association analysis. Int J Environ Res Public Health (2014) 0.77
Genetic variation in retinal vascular patterning predicts variation in pial collateral extent and stroke severity. Angiogenesis (2014) 0.77
Retinal microvascular calibre and risk of diabetes mellitus: a systematic review and participant-level meta-analysis. Diabetologia (2015) 0.76
Associations between depression and anxiety symptoms and retinal vessel caliber in adolescents and young adults. Psychosom Med (2014) 0.76
Retinal microvessels reflect familial vulnerability to psychotic symptoms: A comparison of twins discordant for psychotic symptoms and controls. Schizophr Res (2015) 0.76
Heritability of the retinal microcirculation in Flemish families. Am J Hypertens (2013) 0.76
No association of 9p21 with arterial elasticity and retinal microvascular findings. Atherosclerosis (2013) 0.76
Six Novel Loci Associated with Circulating VEGF Levels Identified by a Meta-analysis of Genome-Wide Association Studies. PLoS Genet (2016) 0.76
Association Study of rs3184504 C>T Polymorphism in Patients With Coronary Artery Disease. Int J Mol Cell Med (2014) 0.75
Microvascular dysfunction: genetic polymorphisms suggest sex-specific differences in disease phenotype. Coron Artery Dis (2014) 0.75
Mendelian and trans-generational inheritance in hypertensive renal disease. Ann Med (2012) 0.75
T2D and Depression Risk Gene Proteasome Modulator 9 is Linked to Insomnia. Sci Rep (2015) 0.75
Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function. J Clin Invest (2017) 0.75
Why Are Omics Technologies Important to Understanding the Role of Nutrition in Inflammatory Bowel Diseases? Int J Mol Sci (2016) 0.75
The role of LNK/SH2B3 genetic alterations in Myeloproliferative Neoplasms and other hematological disorders. Leukemia (2017) 0.75
Determinants of retinal microvascular features and their relationships in two European populations. J Hypertens (2017) 0.75
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
Finding the missing heritability of complex diseases. Nature (2009) 67.95
The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. The ARIC investigators. Am J Epidemiol (1989) 37.83
The Cardiovascular Health Study: design and rationale. Ann Epidemiol (1991) 27.24
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Genome-wide association study of blood pressure and hypertension. Nat Genet (2009) 11.54
Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of prospective meta-analyses of genome-wide association studies from 5 cohorts. Circ Cardiovasc Genet (2009) 8.42
Shared and distinct genetic variants in type 1 diabetes and celiac disease. N Engl J Med (2008) 7.66
The risk of myocardial infarction associated with antihypertensive drug therapies. JAMA (1995) 7.31
Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics. Am J Epidemiol (2007) 7.06
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet (2009) 6.31
Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the Atherosclerosis Risk in Communities Study. Ophthalmology (1999) 6.07
Coronary microvascular dysfunction. N Engl J Med (2007) 5.22
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nat Genet (2009) 4.28
Revised formulas for summarizing retinal vessel diameters. Curr Eye Res (2003) 3.47
The Rotterdam Study: 2010 objectives and design update. Eur J Epidemiol (2009) 3.44
Genome-wide significance for dense SNP and resequencing data. Genet Epidemiol (2008) 3.26
Retinal vascular caliber, cardiovascular risk factors, and inflammation: the multi-ethnic study of atherosclerosis (MESA). Invest Ophthalmol Vis Sci (2006) 2.79
Hypertensive retinopathy. N Engl J Med (2004) 2.65
Are retinal arteriolar or venular diameters associated with markers for cardiovascular disorders? The Rotterdam Study. Invest Ophthalmol Vis Sci (2004) 2.53
Genetic susceptibility to coronary artery disease: from promise to progress. Nat Rev Genet (2006) 2.32
Antihypertensive drug therapies and the risk of ischemic stroke. Arch Intern Med (2001) 2.24
Retinal arteriolar diameter and risk for hypertension. Ann Intern Med (2004) 2.18
Genetic and environmental factors in age-related nuclear cataracts in monozygotic and dizygotic twins. N Engl J Med (2000) 2.08
Retinal vessel caliber and microvascular and macrovascular disease in type 2 diabetes: XXI: the Wisconsin Epidemiologic Study of Diabetic Retinopathy. Ophthalmology (2007) 2.07
Retinal arteriolar narrowing and risk of diabetes mellitus in middle-aged persons. JAMA (2002) 1.80
Genome-wide linkage study of retinal vessel diameters in the Beaver Dam Eye Study. Hypertension (2006) 1.80
Structural basis of Vta1 function in the multivesicular body sorting pathway. Dev Cell (2008) 1.71
Relationship of retinal vascular caliber with diabetes and retinopathy: the Multi-Ethnic Study of Atherosclerosis (MESA). Diabetes Care (2007) 1.66
Retinal and cerebral microvascular signs and diabetes: the age, gene/environment susceptibility-Reykjavik study. Diabetes (2008) 1.62
Prediction of incident stroke events based on retinal vessel caliber: a systematic review and individual-participant meta-analysis. Am J Epidemiol (2009) 1.60
Retinal vessel diameters and cerebral small vessel disease: the Rotterdam Scan Study. Brain (2005) 1.57
Associations between findings on cranial magnetic resonance imaging and retinal photography in the elderly: the Cardiovascular Health Study. Am J Epidemiol (2006) 1.56
Meta-analysis: retinal vessel caliber and risk for coronary heart disease. Ann Intern Med (2009) 1.54
Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation. Mol Cell Biol (2005) 1.37
Twins eye study in Tasmania (TEST): rationale and methodology to recruit and examine twins. Twin Res Hum Genet (2009) 1.11
Rasip1 is required for endothelial cell motility, angiogenesis and vessel formation. Dev Biol (2009) 1.10
Risk of endometrial cancer in relation to use of combined oral contraceptives. A practitioner's guide to meta-analysis. Hum Reprod (1997) 1.03
Retinal vascular caliber and age-related macular degeneration: the Singapore Malay Eye Study. Am J Ophthalmol (2008) 0.89
Genetic determinants of retinal vascular caliber: additional insights into hypertension pathogenesis. Hypertension (2006) 0.86
Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon. Am J Physiol Gastrointest Liver Physiol (2004) 0.86
Induction of nitric oxide synthase in human vascular smooth muscle: interactions between proinflammatory cytokines. Cardiovasc Res (1998) 0.82
Complement factor h polymorphism, inflammatory mediators, and retinal vessel diameters: the rotterdam study. Invest Ophthalmol Vis Sci (2007) 0.81
Lipid hydroperoxide stimulates leukocyte-endothelium interaction in the retinal microcirculation. Exp Eye Res (2002) 0.80
Apolipoprotein E gene polymorphisms and retinal vascular signs: the atherosclerosis risk in communities (ARIC) study. Arch Ophthalmol (2007) 0.80
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Common SNPs explain a large proportion of the heritability for human height. Nat Genet (2010) 35.02
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science (2006) 27.49
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med (2006) 23.83
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet (2008) 20.73
A common allele on chromosome 9 associated with coronary heart disease. Science (2007) 20.37
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet (2007) 19.08
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet (2006) 19.03
Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol (2004) 18.86
GenABEL: an R library for genome-wide association analysis. Bioinformatics (2007) 18.10
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science (2012) 17.12
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. N Engl J Med (2006) 16.17
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
Replicating genotype-phenotype associations. Nature (2007) 16.11
C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med (2004) 15.30
Cystatin C and the risk of death and cardiovascular events among elderly persons. N Engl J Med (2005) 15.30
Long-term exposure to air pollution and incidence of cardiovascular events in women. N Engl J Med (2007) 14.90
Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL. Nat Genet (2007) 13.78
Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol (2004) 13.78
Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature (2012) 13.71
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet (2007) 13.28
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25