Published in Biochem J on August 15, 2010
AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest (2013) 2.44
Multimorbidity patterns in primary care: interactions among chronic diseases using factor analysis. PLoS One (2012) 1.71
Increased gut permeability and microbiota change associate with mesenteric fat inflammation and metabolic dysfunction in diet-induced obese mice. PLoS One (2012) 1.59
Low-grade inflammation, diet composition and health: current research evidence and its translation. Br J Nutr (2015) 1.50
Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans. Biochem Biophys Res Commun (2010) 1.31
Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes. PLoS One (2012) 1.28
Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. J Lipid Res (2012) 1.26
Adipose tissue gene expression of factors related to lipid processing in obesity. PLoS One (2011) 1.10
Stearoyl-CoA desaturase-1 is associated with insulin resistance in morbidly obese subjects. Mol Med (2010) 1.05
Contributions of adipose tissue architectural and tensile properties toward defining healthy and unhealthy obesity. Am J Physiol Endocrinol Metab (2013) 1.02
Endotoxin increase after fat overload is related to postprandial hypertriglyceridemia in morbidly obese patients. J Lipid Res (2012) 0.95
Resistance to type 2 diabetes mellitus: a matter of hormesis? Nat Rev Endocrinol (2011) 0.94
The Interactions of Obesity, Inflammation and Insulin Resistance in Breast Cancer. Cancers (Basel) (2015) 0.93
Adipose tissue inflammation and insulin resistance: all obese humans are not created equal. Biochem J (2010) 0.90
Zinc-alpha 2-glycoprotein gene expression in adipose tissue is related with insulin resistance and lipolytic genes in morbidly obese patients. PLoS One (2012) 0.90
Is vitamin D status a determining factor for metabolic syndrome? A case-control study. Diabetes Metab Syndr Obes (2011) 0.90
Oxidative stress and protein carbonylation in adipose tissue - implications for insulin resistance and diabetes mellitus. J Proteomics (2013) 0.88
Adipose-tissue and intestinal inflammation - visceral obesity and creeping fat. Front Immunol (2014) 0.88
High fat feeding promotes obesity and renal inflammation and protects against post cardiopulmonary bypass acute kidney injury in swine. Crit Care (2013) 0.88
Peroxisome proliferator-activated receptor γ-dependent regulation of lipolytic nodes and metabolic flexibility. Mol Cell Biol (2012) 0.87
Indoleamine 2,3-diooxygenase in periaortic fat: mechanisms of inhibition of contraction. Am J Physiol Heart Circ Physiol (2011) 0.87
Does Metabolically Healthy Obesity Exist? Nutrients (2016) 0.86
Impaired adipose tissue expandability and lipogenic capacities as ones of the main causes of metabolic disorders. J Diabetes Res (2015) 0.86
Progression from high insulin resistance to type 2 diabetes does not entail additional visceral adipose tissue inflammation. PLoS One (2012) 0.86
An eicosanoid-centric view of atherothrombotic risk factors. Cell Mol Life Sci (2012) 0.84
Could metabolic syndrome, lipodystrophy, and aging be mesenchymal stem cell exhaustion syndromes? Stem Cells Int (2011) 0.83
Carnosic acid inhibits TLR4-MyD88 signaling pathway in LPS-stimulated 3T3-L1 adipocytes. Nutr Res Pract (2014) 0.82
Obesity improves myocardial ischaemic tolerance and RISK signalling in insulin-insensitive rats. Dis Model Mech (2012) 0.82
Severity of non-alcoholic fatty liver disease is associated with high systemic levels of tumor necrosis factor alpha and low serum interleukin 10 in morbidly obese patients. Clin Exp Med (2015) 0.80
Expression of ceramide-metabolising enzymes in subcutaneous and intra-abdominal human adipose tissue. Lipids Health Dis (2012) 0.80
Relationship of the Chemokine, CXCL12, to Effects of Dietary Fat on Feeding-Related Behaviors and Hypothalamic Neuropeptide Systems. Front Behav Neurosci (2016) 0.78
Proinflammatory and prothrombotic state in subjects with different glucose tolerance status before cardiovascular disease. J Diabetes Res (2014) 0.78
Proteasome Dysfunction Associated to Oxidative Stress and Proteotoxicity in Adipocytes Compromises Insulin Sensitivity in Human Obesity. Antioxid Redox Signal (2015) 0.78
Obesity and cancer: the role of adipose tissue and adipo-cytokines-induced chronic inflammation. J Cancer (2016) 0.77
Inflammation, obesity, and the promise of immunotherapy for metabolic disease. Surg Obes Relat Dis (2012) 0.77
Skeletal Muscle Insulin Resistance and Absence of Inflammation Characterize Insulin-Resistant Grade I Obese Women. PLoS One (2016) 0.77
Differences in the Osteogenic Differentiation Capacity of Omental Adipose-Derived Stem Cells in Obese Patients With and Without Metabolic Syndrome. Endocrinology (2015) 0.76
Peroxisome proliferator activated receptor gamma 2 modulates late pregnancy homeostatic metabolic adaptations. Mol Med (2016) 0.75
Transcriptomic analysis of visceral adipose from healthy and diabetic obese subjects. Indian J Endocrinol Metab (2013) 0.75
Prenatal fat-rich diet exposure alters responses of embryonic neurons to the chemokine, CCL2, in the hypothalamus. Neuroscience (2016) 0.75
An anti-inflammatory sterol decreases obesity-related inflammation-induced insulin resistance and metabolic dysregulation. Mediators Inflamm (2013) 0.75
Diabetic and dyslipidaemic morbidly obese exhibit more liver alterations compared with healthy morbidly obese. BBA Clin (2016) 0.75
Growth hormone-releasing hormone is produced by adipocytes and regulates lipolysis through growth hormone receptor. Int J Obes (Lond) (2017) 0.75
Pathways to the analysis of microarray data. Trends Biotechnol (2005) 3.88
Nuclear receptor corepressor RIP140 regulates fat accumulation. Proc Natl Acad Sci U S A (2004) 3.67
Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome--an allostatic perspective. Biochim Biophys Acta (2010) 3.19
Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with higher-risk plaques in humans. Circulation (2013) 2.94
PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. PLoS Genet (2007) 2.91
Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab (2008) 2.89
Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. PLoS Biol (2006) 2.86
Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med (2010) 2.76
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet (2011) 2.73
Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus. Nature (2011) 2.59
Effect of iodine prophylaxis during pregnancy on neurocognitive development of children during the first two years of life. J Clin Endocrinol Metab (2009) 2.42
Adipogenesis and WNT signalling. Trends Endocrinol Metab (2008) 2.37
Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma. Diabetes (2003) 2.28
BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell (2012) 2.20
AMPK: a metabolic gauge regulating whole-body energy homeostasis. Trends Mol Med (2008) 2.16
Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis. J Clin Invest (2007) 2.03
Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis. BMC Syst Biol (2007) 2.01
Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Diabetes (2011) 1.91
Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans. PLoS Biol (2011) 1.89
The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform. Diabetes (2005) 1.76
Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation. Nat Med (2009) 1.72
Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study. BMC Med (2013) 1.71
It's not how fat you are, it's what you do with it that counts. PLoS Biol (2008) 1.69
CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance. Cell Metab (2009) 1.68
IGF-binding protein-2 protects against the development of obesity and insulin resistance. Diabetes (2007) 1.56
Response to a urate-lowering diet according to polymorphisms in the apolipoprotein AI-CIII-AIV cluster. J Rheumatol (2005) 1.53
Lipidomics: a new window to biomedical frontiers. Trends Biotechnol (2008) 1.52
ETO/MTG8 is an inhibitor of C/EBPbeta activity and a regulator of early adipogenesis. Mol Cell Biol (2004) 1.52
Using brown adipose tissue to treat obesity - the central issue. Trends Mol Med (2011) 1.51
Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta. PLoS One (2008) 1.50
Influence of red wine polyphenols and ethanol on the gut microbiota ecology and biochemical biomarkers. Am J Clin Nutr (2012) 1.49
Deletion of the metabolic transcriptional coactivator PGC1β induces cardiac arrhythmia. Cardiovasc Res (2011) 1.46
Adipose tissue expandability: the metabolic problems of obesity may arise from the inability to become more obese. Biochem Soc Trans (2008) 1.45
Wnt signalling and the control of cellular metabolism. Biochem J (2010) 1.42
Metabolomic approaches to phenotype characterization and applications to complex diseases. Expert Rev Mol Diagn (2006) 1.41
Metabolically healthy but obese, a matter of time? Findings from the prospective Pizarra study. J Clin Endocrinol Metab (2013) 1.41
Leptin deficiency unmasks the deleterious effects of impaired peroxisome proliferator-activated receptor gamma function (P465L PPARgamma) in mice. Diabetes (2006) 1.39
Visfatin: the missing link between intra-abdominal obesity and diabetes? Trends Mol Med (2005) 1.37
Informatics and computational strategies for the study of lipids. Mol Biosyst (2007) 1.37
DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome. Circ Res (2010) 1.36
Digenic inheritance of severe insulin resistance in a human pedigree. Nat Genet (2002) 1.36
Beyond the sympathetic tone: the new brown fat activators. Cell Metab (2013) 1.32
PGC-1β deficiency accelerates the transition to heart failure in pressure overload hypertrophy. Circ Res (2011) 1.31
Decreased brown adipocyte recruitment and thermogenic capacity in mice with impaired peroxisome proliferator-activated receptor (P465L PPARgamma) function. Endocrinology (2006) 1.29
Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase. Diabetes (2012) 1.28
Regional differences in the response of human pre-adipocytes to PPARgamma and RXRalpha agonists. Diabetes (2002) 1.27
Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice. Free Radic Biol Med (2009) 1.26
Characterisation of the phosphorylation of beta-catenin at the GSK-3 priming site Ser45. Biochem Biophys Res Commun (2002) 1.26
A MUFA-rich diet improves posprandial glucose, lipid and GLP-1 responses in insulin-resistant subjects. J Am Coll Nutr (2007) 1.26
Role of the POZ zinc finger transcription factor FBI-1 in human and murine adipogenesis. J Biol Chem (2003) 1.25
Energization-dependent endogenous activation of proton conductance in skeletal muscle mitochondria. Biochem J (2008) 1.23
Stimulators of AMP-activated protein kinase inhibit the respiratory burst in human neutrophils. FEBS Lett (2004) 1.20
Executive functions profile in extreme eating/weight conditions: from anorexia nervosa to obesity. PLoS One (2012) 1.18
UCPs--unlikely calcium porters. Nat Cell Biol (2008) 1.17
Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender. FASEB J (2010) 1.16
Hemoglobin A1c versus oral glucose tolerance test in postpartum diabetes screening. Diabetes Care (2012) 1.15
Obesity as a clinical and public health problem: is there a need for a new definition based on lipotoxicity effects? Biochim Biophys Acta (2010) 1.15
Benefits of polyphenols on gut microbiota and implications in human health. J Nutr Biochem (2013) 1.13
The gene expression of the main lipogenic enzymes is downregulated in visceral adipose tissue of obese subjects. Obesity (Silver Spring) (2009) 1.12
Hypertension is related to the degradation of dietary frying oils. Am J Clin Nutr (2003) 1.12
Gut microbiota composition in male rat models under different nutritional status and physical activity and its association with serum leptin and ghrelin levels. PLoS One (2013) 1.12
The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/-/ApoE-/- mice. Free Radic Biol Med (2011) 1.10
Metabolic phenotyping of a model of adipocyte differentiation. Physiol Genomics (2009) 1.10
Oxidative stress in severely obese persons is greater in those with insulin resistance. Obesity (Silver Spring) (2008) 1.10
Below thermoneutrality, changes in activity do not drive changes in total daily energy expenditure between groups of mice. Cell Metab (2012) 1.10
Adipose tissue gene expression of factors related to lipid processing in obesity. PLoS One (2011) 1.10
Adipogenesis and lipotoxicity: role of peroxisome proliferator-activated receptor gamma (PPARgamma) and PPARgammacoactivator-1 (PGC1). Public Health Nutr (2007) 1.09
Stimulation of mitochondrial proton conductance by hydroxynonenal requires a high membrane potential. Biosci Rep (2008) 1.09
Bsx, a novel hypothalamic factor linking feeding with locomotor activity, is regulated by energy availability. Endocrinology (2008) 1.08
Regulation of adiponectin expression in human adipocytes: effects of adiposity, glucocorticoids, and tumor necrosis factor alpha. Obes Res (2005) 1.08
Transcript and metabolite analysis of the effects of tamoxifen in rat liver reveals inhibition of fatty acid synthesis in the presence of hepatic steatosis. FASEB J (2005) 1.06
Stearoyl-CoA desaturase-1 is associated with insulin resistance in morbidly obese subjects. Mol Med (2010) 1.05
Pharmacological strategies for targeting BAT thermogenesis. Trends Pharmacol Sci (2013) 1.04
Hypothalamic fatty acid metabolism: a housekeeping pathway that regulates food intake. Bioessays (2007) 1.04
Extracellular fatty acid synthase: a possible surrogate biomarker of insulin resistance. Diabetes (2010) 1.02
Obesity-associated insulin resistance is correlated to adipose tissue vascular endothelial growth factors and metalloproteinase levels. BMC Physiol (2012) 1.02
An allostatic control of membrane lipid composition by SREBP1. FEBS Lett (2010) 1.02
Assessment of brown adipose tissue function. Front Physiol (2013) 1.01
Increasing circulating IGFBP1 levels improves insulin sensitivity, promotes nitric oxide production, lowers blood pressure, and protects against atherosclerosis. Diabetes (2012) 1.01
A role for adipocyte-derived lipopolysaccharide-binding protein in inflammation- and obesity-associated adipose tissue dysfunction. Diabetologia (2013) 1.00
The -1131T>C SNP of the APOA5 gene modulates response to fenofibrate treatment in patients with the metabolic syndrome: a postprandial study. Atherosclerosis (2009) 1.00
15-deoxy-delta 12,14-prostaglandin J2 induces heme oxygenase-1 gene expression in a reactive oxygen species-dependent manner in human lymphocytes. J Biol Chem (2004) 1.00
Study of the potential association of adipose tissue GLP-1 receptor with obesity and insulin resistance. Endocrinology (2011) 1.00
Obesity short-circuits stemness gene network in human adipose multipotent stem cells. FASEB J (2011) 1.00
Lifetime obesity in patients with eating disorders: increasing prevalence, clinical and personality correlates. Eur Eat Disord Rev (2012) 1.00
Apelin levels are increased in morbidly obese subjects with type 2 diabetes mellitus. Obes Surg (2009) 0.99
Visceral fat accumulation during lipid overfeeding is related to subcutaneous adipose tissue characteristics in healthy men. J Clin Endocrinol Metab (2013) 0.99
PPARs and adipocyte function. Mol Cell Endocrinol (2009) 0.98
Intelligence quotient and iodine intake: a cross-sectional study in children. J Clin Endocrinol Metab (2004) 0.98
Central resistin regulates hypothalamic and peripheral lipid metabolism in a nutritional-dependent fashion. Endocrinology (2008) 0.98
PPARgamma expression after a high-fat meal is associated with plasma superoxide dismutase activity in morbidly obese persons. Obesity (Silver Spring) (2009) 0.97
Origins of metabolic complications in obesity: ectopic fat accumulation. The importance of the qualitative aspect of lipotoxicity. Curr Opin Clin Nutr Metab Care (2011) 0.97
Signalling activity of beta-catenin targeted to different subcellular compartments. Biochem J (2004) 0.96
Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome. Dis Model Mech (2009) 0.95
Leptin-mediated changes in hepatic mitochondrial metabolism, structure, and protein levels. Proc Natl Acad Sci U S A (2009) 0.95