Published in Cell Metab on April 01, 2009
Adipokines in inflammation and metabolic disease. Nat Rev Immunol (2011) 8.92
Chemokines and chemokine receptors: new insights into cancer-related inflammation. Trends Mol Med (2010) 3.10
PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization. Proc Natl Acad Sci U S A (2009) 2.38
Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell Metab (2013) 2.17
Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int J Mol Sci (2014) 2.03
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. PLoS Genet (2012) 1.97
Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance. Biochim Biophys Acta (2013) 1.60
Adipose tissue recruitment of leukocytes. Curr Opin Lipidol (2010) 1.60
CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status. Diabetes (2012) 1.56
Keratinocyte-derived chemokine in obesity: expression, regulation, and role in adipose macrophage infiltration and glucose homeostasis. J Biol Chem (2009) 1.34
The role of chemokines in recruitment of immune cells to the artery wall and adipose tissue. Vascul Pharmacol (2009) 1.27
Glucocorticoids and thiazolidinediones interfere with adipocyte-mediated macrophage chemotaxis and recruitment. J Biol Chem (2009) 1.19
Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training. Compr Physiol (2013) 1.17
Chemokine systems link obesity to insulin resistance. Diabetes Metab J (2013) 1.09
Adipose tissue-derived stem cells secrete CXCL5 cytokine with chemoattractant and angiogenic properties. Biochem Biophys Res Commun (2010) 1.00
Insulin signalling mechanisms for triacylglycerol storage. Diabetologia (2013) 1.00
Adipose tissue macrophages in the development of obesity-induced inflammation, insulin resistance and type 2 diabetes. Arch Pharm Res (2013) 0.99
Absence of macrophage inflammatory protein-1{alpha} does not impact macrophage accumulation in adipose tissue of diet-induced obese mice. Am J Physiol Endocrinol Metab (2010) 0.99
CXCL5 limits macrophage foam cell formation in atherosclerosis. J Clin Invest (2013) 0.97
Increased serum CXCL1 and CXCL5 are linked to obesity, hyperglycemia, and impaired islet function. J Endocrinol (2014) 0.93
Chemokine Expression in Inflamed Adipose Tissue Is Mainly Mediated by NF-κB. PLoS One (2013) 0.92
Macrophage recruitment in obese adipose tissue. Obes Rev (2015) 0.92
Loss of CCR5 results in glucose intolerance in diet-induced obese mice. Am J Physiol Endocrinol Metab (2013) 0.92
Lipocalin-2, glucose metabolism and chronic low-grade systemic inflammation in Chinese people. Cardiovasc Diabetol (2012) 0.92
Chemokine network during adipogenesis in 3T3-L1 cells: Differential response between growth and proinflammatory factor in preadipocytes vs. adipocytes. Adipocyte (2014) 0.90
Roles of Chemokines and Chemokine Receptors in Obesity-Associated Insulin Resistance and Nonalcoholic Fatty Liver Disease. Biomolecules (2015) 0.89
Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance. Proc Natl Acad Sci U S A (2011) 0.88
Marrow adipocyte-derived CXCL1 and CXCL2 contribute to osteolysis in metastatic prostate cancer. Clin Exp Metastasis (2015) 0.88
CXCL5 drives obesity to diabetes, and further. Aging (Albany NY) (2009) 0.85
CXCL5 plasma levels decrease in patients with chronic liver disease. J Gastroenterol Hepatol (2011) 0.85
Roles of the chemokine system in development of obesity, insulin resistance, and cardiovascular disease. J Immunol Res (2014) 0.85
The macrophage at the intersection of immunity and metabolism in obesity. Diabetol Metab Syndr (2011) 0.84
Insulin resistance is associated with MCP1-mediated macrophage accumulation in skeletal muscle in mice and humans. PLoS One (2014) 0.84
A lower degree of PBMC L1 methylation is associated with excess body weight and higher HOMA-IR in the presence of lower concentrations of plasma folate. PLoS One (2013) 0.83
Solution structure of CXCL5--a novel chemokine and adipokine implicated in inflammation and obesity. PLoS One (2014) 0.82
Elevated Tumor Expression of PAI-1 and SNAI2 in Obese Esophageal Adenocarcinoma Patients and Impact on Prognosis. Clin Transl Gastroenterol (2012) 0.82
Molecular Basis of Chemokine CXCL5-Glycosaminoglycan Interactions. J Biol Chem (2016) 0.81
Stress in obesity and associated metabolic and cardiovascular disorders. Scientifica (Cairo) (2012) 0.81
Egg yolks inhibit activation of NF-κB and expression of its target genes in adipocytes after partial delipidation. J Agric Food Chem (2015) 0.79
Overexpression of acetyl-coenzyme A carboxylase beta increases proinflammatory cytokines in cultured human renal proximal tubular epithelial cells. Clin Exp Nephrol (2010) 0.79
Deficiency in adipocyte chemokine receptor CXCR4 exacerbates obesity and compromises thermoregulatory responses of brown adipose tissue in a mouse model of diet-induced obesity. FASEB J (2014) 0.79
Transgenic Overexpression of Aryl Hydrocarbon Receptor Repressor (AhRR) and AhR-Mediated Induction of CYP1A1, Cytokines, and Acute Toxicity. Environ Health Perspect (2016) 0.78
CXCL5 polymorphisms are associated with variable blood pressure in cardiovascular disease-free adults. Hum Genomics (2012) 0.77
Differential Chemokine Signature between Human Preadipocytes and Adipocytes. Immune Netw (2016) 0.76
Leptin in whales: validation and measurement of mRNA expression by absolute quantitative real-time PCR. PLoS One (2013) 0.75
The effect of aerobic training on CXL5, tumor necrosis factor α and insulin resistance index (HOMA-IR) in sedentary obese women. Cent Eur J Immunol (2014) 0.75
Neutrophils as protagonists and targets in chronic inflammation. Nat Rev Immunol (2017) 0.75
CCR5: A novel player in the adipose tissue inflammation and insulin resistance? Adipocyte (2013) 0.75
Mechanisms of inflammatory responses and development of insulin resistance: how are they interlinked? J Biomed Sci (2016) 0.75
CC-chemokine receptor 7 (CCR7) deficiency alters adipose tissue leukocyte populations in mice. Physiol Rep (2016) 0.75
Genome diversification mechanism of rodent and Lagomorpha chemokine genes. Biomed Res Int (2013) 0.75
Prednisolone induces the Wnt signalling pathway in 3T3-L1 adipocytes. Arch Physiol Biochem (2013) 0.75
Differences in Sulfotyrosine Binding amongst CXCR1 and CXCR2 Chemokine Ligands. Int J Mol Sci (2017) 0.75
Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22
Inflammation and metabolic disorders. Nature (2006) 33.33
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 32.01
Inflammation, stress, and diabetes. J Clin Invest (2005) 17.11
The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature (1998) 13.58
CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest (2005) 10.44
Adipocytes as regulators of energy balance and glucose homeostasis. Nature (2006) 9.52
A family of cytokine-inducible inhibitors of signalling. Nature (1997) 9.22
Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc Natl Acad Sci U S A (2003) 6.06
Adipose tissue as an endocrine organ. Trends Endocrinol Metab (2000) 4.07
Adipose tissue-derived factors: impact on health and disease. Endocr Rev (2006) 3.16
Acquirement of brown fat cell features by human white adipocytes. J Biol Chem (2003) 3.05
Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects. FASEB J (2004) 2.82
Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue. Diabetes (2007) 2.54
Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8. J Exp Med (1991) 2.46
Epithelial-neutrophil activating peptide (ENA-78) is an important angiogenic factor in non-small cell lung cancer. J Clin Invest (1998) 2.42
The chemokine and chemokine receptor superfamilies and their molecular evolution. Genome Biol (2006) 2.42
Adiposity elevates plasma MCP-1 levels leading to the increased CD11b-positive monocytes in mice. J Biol Chem (2003) 2.36
Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J Biol Chem (1998) 2.32
Macrophages in human visceral adipose tissue: increased accumulation in obesity and a source of resistin and visfatin. Diabetologia (2006) 2.27
Endocrine functions of adipose tissue. Annu Rev Pathol (2007) 2.13
The adipocyte as an active participant in energy balance and metabolism. Gastroenterology (2007) 2.02
Cyclin D3 promotes adipogenesis through activation of peroxisome proliferator-activated receptor gamma. Mol Cell Biol (2005) 1.63
Peroxisome proliferator-activated receptor gamma regulates E-cadherin expression and inhibits growth and invasion of prostate cancer. Mol Cell Biol (2006) 1.37
Cdk4 promotes adipogenesis through PPARgamma activation. Cell Metab (2005) 1.31
Regulation and function of the CXC chemokine ENA-78 in monocytes and its role in disease. J Leukoc Biol (1997) 1.31
The nuclear receptor liver receptor homolog-1 is an estrogen receptor target gene. Oncogene (2005) 1.21
The role of an epithelial neutrophil-activating peptide-78-like protein in rat adjuvant-induced arthritis. J Immunol (1999) 1.18
Plasma levels and adipose tissue messenger ribonucleic acid expression of retinol-binding protein 4 are reduced during calorie restriction in obese subjects but are not related to diet-induced changes in insulin sensitivity. J Clin Endocrinol Metab (2007) 1.00
Upregulation of bronchioloalveolar carcinoma-derived C-X-C chemokines by tumor infiltrating inflammatory cells. Inflamm Res (2004) 0.94
Neutrophil-activating peptide ENA-78. Adv Exp Med Biol (1993) 0.89
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature (2006) 9.36
TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab (2009) 6.91
Transcriptional control of brown fat determination by PRDM16. Cell Metab (2007) 6.79
Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes (2005) 5.68
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab (2008) 5.44
Pathways to the analysis of microarray data. Trends Biotechnol (2005) 3.88
Nuclear receptor corepressor RIP140 regulates fat accumulation. Proc Natl Acad Sci U S A (2004) 3.67
Mitochondrial dynamics in mammalian health and disease. Physiol Rev (2009) 3.59
Multinational study of subcutaneous model-predictive closed-loop control in type 1 diabetes mellitus: summary of the results. J Diabetes Sci Technol (2010) 3.48
Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab (2010) 3.46
Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity. J Biol Chem (2003) 3.45
Functional cooperation between interleukin-17 and tumor necrosis factor-alpha is mediated by CCAAT/enhancer-binding protein family members. J Biol Chem (2003) 3.41
Fully integrated artificial pancreas in type 1 diabetes: modular closed-loop glucose control maintains near normoglycemia. Diabetes (2012) 3.40
Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome--an allostatic perspective. Biochim Biophys Acta (2010) 3.19
The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab (2012) 3.18
Acquirement of brown fat cell features by human white adipocytes. J Biol Chem (2003) 3.05
Artificial pancreas: past, present, future. Diabetes (2011) 3.03
Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with higher-risk plaques in humans. Circulation (2013) 2.94
PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. PLoS Genet (2007) 2.91
Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab (2008) 2.89
Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. PLoS Biol (2006) 2.86
Incremental value of continuous glucose monitoring when starting pump therapy in patients with poorly controlled type 1 diabetes: the RealTrend study. Diabetes Care (2009) 2.84
Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects. FASEB J (2004) 2.82
Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med (2010) 2.76
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet (2011) 2.73
The Charcot-Marie-Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system. Hum Mol Genet (2005) 2.72
The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell. Proc Natl Acad Sci U S A (2002) 2.57
Persistent organic pollutant exposure leads to insulin resistance syndrome. Environ Health Perspect (2009) 2.57
Lipolysis and lipid mobilization in human adipose tissue. Prog Lipid Res (2009) 2.57
Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance. Cell (2013) 2.43
Adipogenesis and WNT signalling. Trends Endocrinol Metab (2008) 2.37
Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation. Mol Cell (2004) 2.31
Closed-loop artificial pancreas using subcutaneous glucose sensing and insulin delivery and a model predictive control algorithm: preliminary studies in Padova and Montpellier. J Diabetes Sci Technol (2009) 2.31
CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer. J Exp Med (2006) 2.30
Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma. Diabetes (2003) 2.28
Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity. Cell (2011) 2.26
Feasibility of outpatient fully integrated closed-loop control: first studies of wearable artificial pancreas. Diabetes Care (2013) 2.26
Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity. Genome Biol (2008) 2.22
BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell (2012) 2.20
A wave of nascent transcription on activated human genes. Proc Natl Acad Sci U S A (2009) 2.18
AMPK: a metabolic gauge regulating whole-body energy homeostasis. Trends Mol Med (2008) 2.16
The obese healthy paradox: is inflammation the answer? Biochem J (2010) 2.14
Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis. J Clin Invest (2007) 2.03
Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis. BMC Syst Biol (2007) 2.01
Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple sclerosis. Proc Natl Acad Sci U S A (2010) 2.00
Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis. Proc Natl Acad Sci U S A (2012) 2.00
Oestrogen receptor negative breast cancers exhibit high cytokine content. Breast Cancer Res (2007) 1.95
RelB, a new partner of aryl hydrocarbon receptor-mediated transcription. Mol Endocrinol (2007) 1.95
Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise. J Physiol (2005) 1.94
Contribution of adipose triglyceride lipase and hormone-sensitive lipase to lipolysis in hMADS adipocytes. J Biol Chem (2009) 1.93
Worsening of obesity and metabolic status yields similar molecular adaptations in human subcutaneous and visceral adipose tissue: decreased metabolism and increased immune response. J Clin Endocrinol Metab (2010) 1.92
Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Diabetes (2011) 1.91
Evidence for a mitochondrial regulatory pathway defined by peroxisome proliferator-activated receptor-gamma coactivator-1 alpha, estrogen-related receptor-alpha, and mitofusin 2. Diabetes (2006) 1.91
Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans. PLoS Biol (2011) 1.89
Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1. Mol Cell Biol (2007) 1.89
Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass. PLoS Biol (2013) 1.87
miR-143 interferes with ERK5 signaling, and abrogates prostate cancer progression in mice. PLoS One (2009) 1.84
Peroxisome proliferator-activated receptor alpha agonists increase nitric oxide synthase expression in vascular endothelial cells. Arterioscler Thromb Vasc Biol (2004) 1.83
Consensus report of the coalition for clinical research-self-monitoring of blood glucose. J Diabetes Sci Technol (2008) 1.81
Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Med (2011) 1.78
The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform. Diabetes (2005) 1.76
Comparison between SLC3A1 and SLC7A9 cystinuria patients and carriers: a need for a new classification. J Am Soc Nephrol (2002) 1.73
Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation. Nat Med (2009) 1.72
IL-8 expression and its possible relationship with estrogen-receptor-negative status of breast cancer cells. Oncogene (2003) 1.72
2008 Japanese Society for Dialysis Therapy: guidelines for renal anemia in chronic kidney disease. Ther Apher Dial (2010) 1.71
Accuracy and reliability of continuous glucose monitoring systems: a head-to-head comparison. Diabetes Technol Ther (2013) 1.71
Myeloid suppressor cell depletion augments antitumor activity in lung cancer. PLoS One (2012) 1.70
It's not how fat you are, it's what you do with it that counts. PLoS Biol (2008) 1.69
The human lipodystrophy gene BSCL2/seipin may be essential for normal adipocyte differentiation. Diabetes (2008) 1.67
In vitro and in vivo anti-melanoma effects of ciglitazone. J Invest Dermatol (2009) 1.67
Mfn2 modulates the UPR and mitochondrial function via repression of PERK. EMBO J (2013) 1.65
Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress. J Cell Sci (2011) 1.65
Long-acting insulin analogs versus insulin pump therapy for the treatment of type 1 and type 2 diabetes. Diabetes Care (2008) 1.64
Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis. Cardiovasc Res (2007) 1.63
Cyclin D3 promotes adipogenesis through activation of peroxisome proliferator-activated receptor gamma. Mol Cell Biol (2005) 1.63
Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure. J Biol Chem (2011) 1.62
CXC chemokines located in the 4q21 region are up-regulated in breast cancer. Endocr Relat Cancer (2007) 1.62
Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2. J Biol Chem (2003) 1.62
dDOR is an EcR coactivator that forms a feed-forward loop connecting insulin and ecdysone signaling. Curr Biol (2010) 1.62
Macrophages and adipocytes in human obesity: adipose tissue gene expression and insulin sensitivity during calorie restriction and weight stabilization. Diabetes (2009) 1.59
LRH-1-dependent glucose sensing determines intermediary metabolism in liver. J Clin Invest (2012) 1.58
Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice. EMBO J (2012) 1.58
Pilot studies of wearable outpatient artificial pancreas in type 1 diabetes. Diabetes Care (2012) 1.57
UTILLdb, a Pisum sativum in silico forward and reverse genetics tool. Genome Biol (2008) 1.56
IGF-binding protein-2 protects against the development of obesity and insulin resistance. Diabetes (2007) 1.56
Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice. J Clin Invest (2004) 1.55
beta3-Adrenergic stimulation produces a decrease of cardiac contractility ex vivo in mice overexpressing the human beta3-adrenergic receptor. Cardiovasc Res (2003) 1.55
Adipose triglyceride lipase and hormone-sensitive lipase protein expression is decreased in the obese insulin-resistant state. J Clin Endocrinol Metab (2007) 1.54
Cell-penetrating and cell-targeting peptides in drug delivery. Biochim Biophys Acta (2008) 1.54
Lipidomics: a new window to biomedical frontiers. Trends Biotechnol (2008) 1.52