Published in Diabetes on April 01, 2003
Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol Rev (2007) 6.53
PPAR gamma and human metabolic disease. J Clin Invest (2006) 3.83
PPARγ signaling and metabolism: the good, the bad and the future. Nat Med (2013) 3.71
Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension. Cell Metab (2008) 2.17
Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPARγ and RhoA/Rho-kinase. Cell Metab (2012) 1.99
Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma. J Clin Invest (2004) 1.91
Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice. Proc Natl Acad Sci U S A (2003) 1.89
Hypotension, lipodystrophy, and insulin resistance in generalized PPARgamma-deficient mice rescued from embryonic lethality. J Clin Invest (2007) 1.85
Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes. Hepatology (2014) 1.81
It's not how fat you are, it's what you do with it that counts. PLoS Biol (2008) 1.69
PPARgamma in human and mouse physiology. Biochim Biophys Acta (2007) 1.58
Non-DNA binding, dominant-negative, human PPARgamma mutations cause lipodystrophic insulin resistance. Cell Metab (2006) 1.57
Neuroendocrine and metabolic components of dopamine agonist amelioration of metabolic syndrome in SHR rats. Diabetol Metab Syndr (2014) 1.43
Balancing the fat: lipid droplets and human disease. EMBO Mol Med (2013) 1.40
A supersized list of obesity genes. Nat Genet (2009) 1.38
Peroxisome proliferator-activated receptor-gamma: too much of a good thing causes harm. EMBO Rep (2004) 1.33
Relationship of fat distribution with adipokines in human immunodeficiency virus infection. J Clin Endocrinol Metab (2007) 1.24
Metabolic syndrome, inflammation and atherosclerosis. Vasc Health Risk Manag (2006) 1.23
Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease. World J Gastroenterol (2008) 1.22
Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes. Proc Natl Acad Sci U S A (2014) 1.21
Evidence for pleiotropic factors in genetics of the musculoskeletal system. Bone (2010) 1.06
Endothelial and vascular muscle PPARgamma in arterial pressure regulation: lessons from genetic interference and deficiency. Hypertension (2009) 1.06
Trans-10, cis-12 conjugated linoleic acid antagonizes ligand-dependent PPARgamma activity in primary cultures of human adipocytes. J Nutr (2008) 1.05
PPAR-γ as a therapeutic target in cardiovascular disease: evidence and uncertainty. J Lipid Res (2012) 1.04
PPARs in Liver Diseases and Cancer: Epigenetic Regulation by MicroRNAs. PPAR Res (2012) 1.03
PPAR-gamma in the Cardiovascular System. PPAR Res (2008) 1.01
PPARγ Pro12Ala and ACE ID polymorphisms are associated with BMI and fat distribution, but not metabolic syndrome. Cardiovasc Diabetol (2011) 1.00
Is there a human model for the 'metabolic syndrome' with a defined aetiology? Diabetologia (2010) 0.97
PPAR Action in Human Placental Development and Pregnancy and Its Complications. PPAR Res (2008) 0.96
Decreased PPAR gamma expression compromises perigonadal-specific fat deposition and insulin sensitivity. Mol Endocrinol (2009) 0.95
Peroxisome proliferator-activated receptor γ: innate protection from excessive fibrogenesis and potential therapeutic target in systemic sclerosis. Curr Opin Rheumatol (2010) 0.95
Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor. Mol Cell Proteomics (2009) 0.95
'Striking the Right Balance' in Targeting PPARgamma in the Metabolic Syndrome: Novel Insights from Human Genetic Studies. PPAR Res (2007) 0.94
Human lipodystrophies: genetic and acquired diseases of adipose tissue. Endocr Dev (2010) 0.94
PPAR-gamma expression modulates insulin sensitivity in C2C12 skeletal muscle cells. Br J Pharmacol (2004) 0.94
Defective peroxisomal proliferators activated receptor gamma activity due to dominant-negative mutation synergizes with hypertension to accelerate cardiac fibrosis in mice. Eur J Heart Fail (2009) 0.94
Applications of metabolomics for understanding the action of peroxisome proliferator-activated receptors (PPARs) in diabetes, obesity and cancer. Genome Med (2012) 0.93
Peroxisomal proliferator activated receptor-gamma deficiency in a Canadian kindred with familial partial lipodystrophy type 3 (FPLD3). BMC Med Genet (2006) 0.91
Obesity and lipodystrophy--where do the circles intersect? Endocrinology (2008) 0.91
Adiponectin: a key playmaker adipocytokine in non-alcoholic fatty liver disease. Clin Exp Med (2013) 0.88
Peroxisome proliferator-activated receptor γ-dependent regulation of lipolytic nodes and metabolic flexibility. Mol Cell Biol (2012) 0.87
Suppression of the C/EBP family of transcription factors in adipose tissue causes lipodystrophy. J Mol Endocrinol (2011) 0.86
PPAR Gamma: Coordinating Metabolic and Immune Contributions to Female Fertility. PPAR Res (2008) 0.86
Adipocytes in skin health and disease. Cold Spring Harb Perspect Med (2014) 0.85
Unbuckling lipodystrophy from insulin resistance and hypertension. J Clin Invest (2004) 0.85
Revisiting PPARγ as a target for the treatment of metabolic disorders. BMB Rep (2014) 0.85
The genetic pleiotropy of musculoskeletal aging. Front Physiol (2012) 0.85
Leptin therapy for partial lipodystrophy linked to a PPAR-gamma mutation. Clin Endocrinol (Oxf) (2007) 0.85
Molecular determinants of the cardiometabolic phenotype. Endocr Metab Immune Disord Drug Targets (2010) 0.84
Nuclear receptors and metabolism: from feast to famine. Diabetologia (2014) 0.84
Adipokines, hormones related to body composition, and insulin resistance in HIV fat redistribution syndrome. BMC Infect Dis (2014) 0.84
Steatosis and steatohepatitis: complex disorders. Int J Mol Sci (2014) 0.83
PPARγ2 polymorphism and human health. PPAR Res (2009) 0.82
Monogenic syndromes of abnormal glucose homeostasis: clinical review and relevance to the understanding of the pathology of insulin resistance and beta cell failure. J Med Genet (2005) 0.81
PPAR-γ -- a possible drug target for complicated pregnancies. Br J Pharmacol (2013) 0.80
Effect of selective expression of dominant-negative PPARγ in pro-opiomelanocortin neurons on the control of energy balance. Physiol Genomics (2016) 0.80
Peroxisome proliferator-activated receptors and hepatitis C virus. Therap Adv Gastroenterol (2011) 0.79
Carbon-nanoparticle-triggered acute lung inflammation and its resolution are not altered in PPARγ-defective (P465L) mice. Part Fibre Toxicol (2011) 0.78
A case of acquired generalized lipodystrophy with cerebellar degeneration and type 2 diabetes mellitus. Rev Diabet Stud (2005) 0.78
HIV-1 infection and the PPARγ-dependent control of adipose tissue physiology. PPAR Res (2008) 0.78
A clinical link between peroxisome proliferator-activated receptor γ and the renin-angiotensin system. Arterioscler Thromb Vasc Biol (2013) 0.78
Nervous System Expression of PPARγ and Mutant PPARγ Has Profound Effects on Metabolic Regulation and Brain Development. Endocrinology (2016) 0.78
Pioglitazone treatment increases food intake and decreases energy expenditure partially via hypothalamic adiponectin/adipoR1/AMPK pathway. Int J Obes (Lond) (2015) 0.77
Cell biology of fat storage. Mol Biol Cell (2016) 0.77
Structural dataset for the PPARγ V290M mutant. Data Brief (2016) 0.76
Downregulation of de Novo Fatty Acid Synthesis in Subcutaneous Adipose Tissue of Moderately Obese Women. Int J Mol Sci (2015) 0.75
A Dominant-Negative PPARgamma Mutant Promotes Cell Cycle Progression and Cell Growth in Vascular Smooth Muscle Cells. PPAR Res (2010) 0.75
Photoperiod induced obesity in the Brandt's vole (Lasiopodomys brandtii): a model of 'healthy obesity'? Dis Model Mech (2016) 0.75
Transgenic Adipose-specific Expression of the Nuclear Receptor RORα Drives a Striking Shift in Fat Distribution and Impairs Glycemic Control. EBioMedicine (2016) 0.75
Familial partial lipodystrophy, Dunnigan variety - challenges for patient care during pregnancy: a case report. BMC Res Notes (2015) 0.75
Single-Nucleotide Polymorphism of PPARγ, a Protein at the Crossroads of Physiological and Pathological Processes. Int J Mol Sci (2017) 0.75
Postprandial Hypertriglyceridemia Predicts Development of Insulin Resistance Glucose Intolerance and Type 2 Diabetes. PLoS One (2016) 0.75
Genetics of Lipodystrophy. Endocrinol Metab Clin North Am (2017) 0.75
Is the Mouse a Good Model of Human PPARγ-Related Metabolic Diseases? Int J Mol Sci (2016) 0.75
A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes (2017) 0.75
Interactions between PPAR Gamma and the Canonical Wnt/Beta-Catenin Pathway in Type 2 Diabetes and Colon Cancer. PPAR Res (2017) 0.75
Critical appraisal and pooled analysis of telmisartan alone or in combination with hydrochlorothiazide for achieving blood pressure goals. Integr Blood Press Control (2010) 0.75
Retinol-binding protein 7 is an endothelium-specific PPARγ cofactor mediating an antioxidant response through adiponectin. JCI Insight (2017) 0.75
Lack of AKT in adipocytes causes severe lipodystrophy. Mol Metab (2016) 0.75
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature (2012) 14.67
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science (2007) 9.86
The GPR54 gene as a regulator of puberty. N Engl J Med (2003) 9.54
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell (2004) 8.58
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet (2012) 6.97
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest (2010) 6.96
Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med (2003) 6.87
Manual closed-loop insulin delivery in children and adolescents with type 1 diabetes: a phase 2 randomised crossover trial. Lancet (2010) 6.50
Diets with high or low protein content and glycemic index for weight-loss maintenance. N Engl J Med (2010) 5.86
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest (2002) 5.83
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes (2005) 5.68
Genetics of obesity in humans. Endocr Rev (2006) 5.42
Large, rare chromosomal deletions associated with severe early-onset obesity. Nature (2009) 5.20
The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J (2009) 4.78
Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metab (2005) 4.65
betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science (2002) 4.47
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1. Nat Med (2011) 3.96
Pathways to the analysis of microarray data. Trends Biotechnol (2005) 3.88
PPAR gamma and human metabolic disease. J Clin Invest (2006) 3.83
Obesity associated genetic variation in FTO is associated with diminished satiety. J Clin Endocrinol Metab (2008) 3.80
Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes (2008) 3.76
Nuclear receptor corepressor RIP140 regulates fat accumulation. Proc Natl Acad Sci U S A (2004) 3.67
The hormonal control of food intake. Cell (2007) 3.61
A family with severe insulin resistance and diabetes due to a mutation in AKT2. Science (2004) 3.54
Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate. Diabetes (2006) 3.51
International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol Rev (2006) 3.48
Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation. Proc Natl Acad Sci U S A (2004) 3.45
Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice. Proc Natl Acad Sci U S A (2007) 3.40
PTEN mutations as a cause of constitutive insulin sensitivity and obesity. N Engl J Med (2012) 3.39
Leptin regulates striatal regions and human eating behavior. Science (2007) 3.31
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome--an allostatic perspective. Biochim Biophys Acta (2010) 3.19
Modernising medical careers, medical training application service, and the postgraduate medical education and training board: time for the emperors to don their clothes. Lancet (2007) 3.12
Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57. Nat Genet (2008) 3.06
The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells. Cell Metab (2012) 2.97
The central melanocortin system directly controls peripheral lipid metabolism. J Clin Invest (2007) 2.97
Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with higher-risk plaques in humans. Circulation (2013) 2.94
PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. PLoS Genet (2007) 2.91
Distribution and development of brown adipocytes in the murine and human adipose organ. Cell Metab (2010) 2.90
Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab (2008) 2.89
Pregnancy, Primary Aldosteronism, and Adrenal CTNNB1 Mutations. N Engl J Med (2015) 2.87
Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. PLoS Biol (2006) 2.86
Modulation of blood pressure by central melanocortinergic pathways. N Engl J Med (2008) 2.86
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med (2010) 2.76
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet (2011) 2.73
Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization. Endocrinology (2002) 2.72
A mutation in the thyroid hormone receptor alpha gene. N Engl J Med (2011) 2.62
A genome-wide association meta-analysis identifies new childhood obesity loci. Nat Genet (2012) 2.60
Partitioning glucose distribution/transport, disposal, and endogenous production during IVGTT. Am J Physiol Endocrinol Metab (2002) 2.59
KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation. Cell (2013) 2.56
Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. N Engl J Med (2007) 2.56
Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry. Nat Methods (2011) 2.56
White adipose tissue lacks significant vagal innervation and immunohistochemical evidence of parasympathetic innervation. Am J Physiol Regul Integr Comp Physiol (2006) 2.55
Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis. J Clin Invest (2009) 2.53
Overnight closed-loop insulin delivery in young people with type 1 diabetes: a free-living, randomized clinical trial. Diabetes Care (2014) 2.53
Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy. J Clin Endocrinol Metab (2008) 2.53
Monogenic obesity in humans. Annu Rev Med (2005) 2.53
Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. Cell Metab (2012) 2.41
The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest (2005) 2.40
Estimating under-reporting of energy intake in dietary surveys using an individualised method. Br J Nutr (2007) 2.39
A de novo mutation affecting human TrkB associated with severe obesity and developmental delay. Nat Neurosci (2004) 2.39
Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance. Cell Metab (2006) 2.37
Adipogenesis and WNT signalling. Trends Endocrinol Metab (2008) 2.37
Second-to-fourth digit ratio predicts success among high-frequency financial traders. Proc Natl Acad Sci U S A (2009) 2.35
Where is the honor in honorary authorship? Radiology (2011) 2.35
Influence of leptin on arterial distensibility: a novel link between obesity and cardiovascular disease? Circulation (2002) 2.30
Critical role for peptide YY in protein-mediated satiation and body-weight regulation. Cell Metab (2006) 2.23
BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell (2012) 2.20
Patterns and trends of beverage consumption among children and adults in Great Britain, 1986-2009. Br J Nutr (2011) 2.20
TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population. Diabetes (2007) 2.20
AMPK: a metabolic gauge regulating whole-body energy homeostasis. Trends Mol Med (2008) 2.16
The obese healthy paradox: is inflammation the answer? Biochem J (2010) 2.14
Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action. PLoS Biol (2003) 2.13
The imprinted signaling protein XL alpha s is required for postnatal adaptation to feeding. Nat Genet (2004) 2.13
Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations. Am J Hum Genet (2009) 2.09
A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet (2009) 2.09
Insulin resistance in morbid obesity: reversal with intramyocellular fat depletion. Diabetes (2002) 2.06
Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis. J Clin Invest (2007) 2.03
Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity. Diabetes (2007) 2.01
Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding. Gut (2013) 2.01
Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis. BMC Syst Biol (2007) 2.01