Published in Proc Natl Acad Sci U S A on June 01, 1991
The transition from meiotic to mitotic spindle assembly is gradual during early mammalian development. J Cell Biol (2012) 2.18
Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants. Nature (2012) 1.95
Dynamic blastomere behaviour reflects human embryo ploidy by the four-cell stage. Nat Commun (2012) 1.62
Fertility preservation for children treated for cancer (1): scientific advances and research dilemmas. Arch Dis Child (2001) 1.46
An essential role for the Plasmodium Nek-2 Nima-related protein kinase in the sexual development of malaria parasites. J Biol Chem (2009) 1.26
Preimplantation genetic screening: does it help or hinder IVF treatment and what is the role of the embryo? J Assist Reprod Genet (2011) 1.21
Restarting life: fertilization and the transition from meiosis to mitosis. Nat Rev Mol Cell Biol (2013) 1.18
The presence, role and clinical use of spermatozoal RNAs. Hum Reprod Update (2013) 1.11
Mitochondrial DNA disease: new options for prevention. Hum Mol Genet (2011) 1.06
The role of centrosomes in mammalian fertilization and its significance for ICSI. Mol Hum Reprod (2009) 1.01
Successful twin birth following blastocyst culture of embryos derived from the immotile ejaculated spermatozoa from a patient with primary ciliary dyskinesia: a case report. J Assist Reprod Genet (2008) 0.89
Congenital hyperinsulinism and mosaic abnormalities of the ploidy. J Med Genet (2005) 0.87
Maternal inheritance of centrosomes in mammals? Studies on parthenogenesis and polyspermy in mice. Proc Natl Acad Sci U S A (1991) 0.85
Diploid, but not haploid, human embryonic stem cells can be derived from microsurgically repaired tripronuclear human zygotes. Cell Cycle (2012) 0.84
Prediction model for aneuploidy in early human embryo development revealed by single-cell analysis. Nat Commun (2015) 0.83
Altered cleavage patterns in human tripronuclear embryos and their association to fertilization method: a time-lapse study. J Assist Reprod Genet (2014) 0.83
Pronuclear and morphological features as a cumulative score to select embryos in ICSI (intracytoplasmic sperm injection) cycles according to sperm origin. J Assist Reprod Genet (2003) 0.82
Chromosomal instability in mammalian pre-implantation embryos: potential causes, detection methods, and clinical consequences. Cell Tissue Res (2015) 0.79
Dephosphorylation of sperm midpiece antigens initiates aster formation in rabbit oocytes. Proc Natl Acad Sci U S A (1994) 0.79
Paternal centrosomal dynamics in early human development and infertility. J Assist Reprod Genet (1998) 0.78
Diagnosis of abnormal human fertilization status based on pronuclear origin and/or centrosome number. J Assist Reprod Genet (2015) 0.77
Male and female meiotic behaviour of an intrachromosomal insertion determined by preimplantation genetic diagnosis. Mol Cytogenet (2010) 0.75
Direct Unequal Cleavages: Embryo Developmental Competence, Genetic Constitution and Clinical Outcome. PLoS One (2016) 0.75
The parental origin correlates with the karyotype of human embryos developing from tripronuclear zygotes. Clin Exp Reprod Med (2015) 0.75
Absence of centrioles in the first and second meiotic spindles of mouse oocytes. J Cell Sci (1972) 3.24
Centrosome development in early mouse embryos as defined by an autoantibody against pericentriolar material. Cell (1983) 3.12
The chromosome cycle and the centrosome cycle in the mitotic cycle. Int Rev Cytol (1987) 2.35
Behavior of centrosomes during fertilization and cell division in mouse oocytes and in sea urchin eggs. Proc Natl Acad Sci U S A (1986) 1.66
Tripronuclear human oocytes: altered cleavage patterns and subsequent karyotypic analysis of embryos. Biol Reprod (1987) 1.22
The influence of cooling on the organization of the meiotic spindle of the mouse oocyte. Hum Reprod (1987) 1.17
Cytoskeletal organization in fresh, aged and spontaneously activated human oocytes. Hum Reprod (1988) 1.08
The effects of cooling human oocytes. Hum Reprod (1988) 1.06
A cytological study of the relation of the cortical reaction to subsequent events of fertilization in urethane-treated eggs of the sea urchin, Arbacia punctulata. J Cell Biol (1970) 0.98
Ultrastructural observations on human oocytes fertilized in vitro. Fertil Steril (1974) 0.94
Ultrastructural aspects of fertilization in the domestic pig: sperm penetration and pronucleus formation. J Anat (1973) 0.93
Microtubule and centrosome distribution during sheep fertilization. Eur J Cell Biol (1989) 0.90
Ultrastructure of the human preovulatory oocyte. J In Vitro Fert Embryo Transf (1986) 0.87
Fertilization of the human egg and growth of the human zygote in vitro: the Singapore experience. Asia Oceania J Obstet Gynaecol (1985) 0.82
Fine structural studies of the bipolarization of the mitotic apparatus in the fertilized sea urchin egg. II. Bipolarization before the first mitosis. Eur J Cell Biol (1987) 0.82
Human micro-insemination by injection of single or multiple sperm: ultrastructure. Hum Reprod (1989) 0.81
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature (1998) 60.62
Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat Biotechnol (2000) 12.41
Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science (1997) 6.10
Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin. Proc Natl Acad Sci U S A (1992) 3.72
Pregnancy established in an infertile patient after transfer of a donated embryo fertilised in vitro. Br Med J (Clin Res Ed) (1983) 3.56
Human pregnancy following cryopreservation, thawing and transfer of an eight-cell embryo. Nature (1983) 3.39
Synthesis of N-substituted glycine peptoid libraries. Methods Enzymol (1996) 2.97
BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics. Hum Mol Genet (2001) 2.76
A hitchhiker's guide to the human Hsp70 family. Cell Stress Chaperones (1996) 2.70
A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses. Proc Natl Acad Sci U S A (1995) 2.57
Susceptibility to melanoma: influence of skin type and polymorphism in the melanocyte stimulating hormone receptor gene. J Invest Dermatol (1998) 2.37
Methotrexate for prophylaxis of choriocarcinoma. Am J Obstet Gynecol (1971) 2.22
Translocation of Lippes loop (the missing loop). Br Med J (1968) 2.22
Who are the residents of a nursing home in Singapore? Singapore Med J (2003) 2.19
NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP. Nature (1999) 2.18
Storage and disposal of embryos and gametes. BMJ (1996) 2.03
Cathepsin K knockout mice develop osteopetrosis due to a deficit in matrix degradation but not demineralization. J Bone Miner Res (1999) 2.02
Human embryonic stem cells. J Cell Sci (2000) 1.87
Women physicians in dual-physician relationships compared with those in other dual-career relationships. Acad Med (1992) 1.75
Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide. J Biol Chem (1998) 1.73
Use of benzodiazepines in the management of eclampsia. J Obstet Gynaecol Br Commonw (1968) 1.71
Phenotypic characterization of an alpha 4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse. J Neurosci (2000) 1.70
Crystal structure and mutagenic analysis of the inhibitor-of-apoptosis protein survivin. Mol Cell (2000) 1.70
A clinical assessment of nine pregnancies obtained by in vitro fertilization and embryo transfer. Fertil Steril (1981) 1.67
NMR structure and mutagenesis of the FADD (Mort1) death-effector domain. Nature (1998) 1.65
Oncological implications in the replacement of ovarian tissue. Hum Reprod (1997) 1.65
Birth following vitrification of a small number of human oocytes: case report. Hum Reprod (1999) 1.63
The establishment and maintenance of pregnancy using in vitro fertilization and embryo donation in a patient with primary ovarian failure. Nature (1984) 1.58
Cloning of complementary DNA for GAP-43, a neuronal growth-related protein. Science (1987) 1.57
Pediatric rheumatology in the United Kingdom: data from the British Pediatric Rheumatology Group National Diagnostic Register. J Rheumatol (1996) 1.54
Skin score. A semiquantitative measure of cutaneous involvement that improves prediction of prognosis in systemic sclerosis. Arthritis Rheum (1990) 1.53
Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs. Genome Res (2001) 1.53
Dopamine treatment for severe ovarian hyperstimulation syndrome. Hum Reprod (1992) 1.50
Missed appointments and Medicaid managed care. Arch Fam Med (1996) 1.50
Safe childbirth needs more than medical services. World Health Forum (1992) 1.49
Cocultures: a new lead in embryo quality improvement for assisted reproduction. Fertil Steril (1991) 1.49
A comparison between visual estimation and laboratory determination of blood loss during the third stage of labour. Aust N Z J Obstet Gynaecol (1996) 1.47
Fertilizing ability of DNA-damaged spermatozoa. J Exp Zool (1999) 1.46
Primary evaluation of patients suspected of having interstitial cystitis (IC). Eur Urol (2004) 1.46
Decreased natural killer cell activity in endometriosis patients: relationship to disease pathogenesis. Fertil Steril (1994) 1.45
Down-regulation of survivin by antisense oligonucleotides increases apoptosis, inhibits cytokinesis and anchorage-independent growth. Neoplasia (2000) 1.42
Microinjection of human oocytes: a technique for severe oligoasthenoteratozoospermia. Fertil Steril (1991) 1.42
Review article: the optimal medical management of acute severe ulcerative colitis. Aliment Pharmacol Ther (2010) 1.42
Fetal acoustic stimulation in early labor in patients screened with the admission test. Am J Obstet Gynecol (1988) 1.40
Genotypic and phenotypic characterization of "Streptococcus milleri" group isolates from a Veterans Administration hospital population. J Clin Microbiol (1999) 1.39
Unwarranted demand for body parts of endangered animal species for treatment of male infertility. Asian J Androl (2000) 1.39
One-two rural residency tracks in family practice: are they getting the job done? Fam Med (1998) 1.39
Somatic cell nuclear transfer (cloning): implications for the medical practitioner. Singapore Med J (2002) 1.38
Age at diagnosis of chronic myeloid leukaemia. Malays J Pathol (1990) 1.38
Uterine activity during spontaneous labour after previous lower-segment caesarean section. Br J Obstet Gynaecol (1989) 1.38
Medical treatment of placenta accreta with methotrexate. Acta Obstet Gynecol Scand (1986) 1.38
Simian virus 40 maturation in cells harboring mutants deleted in the agnogene. J Biol Chem (1985) 1.37
Isolation and culture of inner cell mass cells from human blastocysts. Hum Reprod (1994) 1.36
An integrative computational model for intestinal tissue renewal. Cell Prolif (2009) 1.36
Admission test: a screening test for fetal distress in labor. Obstet Gynecol (1986) 1.36
A multicentre evaluation of the diagnostic efficiency of serological investigations for C1 inhibitor deficiency. J Clin Pathol (2002) 1.36
CDKL5 mutations cause infantile spasms, early onset seizures, and severe mental retardation in female patients. J Med Genet (2006) 1.35
Elevation in the ratio of Cu/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is mediated by hydrogen peroxide. Hum Mol Genet (1996) 1.34
Genetic ablation and restoration of the olfactory topographic map. Cell (2000) 1.34
A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer. Oncogene (1997) 1.33
The "gene dosage effect" hypothesis versus the "amplified developmental instability" hypothesis in Down syndrome. J Neural Transm Suppl (1999) 1.28
ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway. Hum Mol Genet (2003) 1.28
FLI1 and EWS-FLI1 function as ternary complex factors and ELK1 and SAP1a function as ternary and quaternary complex factors on the Egr1 promoter serum response elements. Oncogene (1997) 1.27
A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13-15, a region subject to LOH and rearrangement in human carcinoma cell lines. Oncogene (1998) 1.27
Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice. Nature (1996) 1.25
Lymphangioleiomyomatosis and tuberous sclerosis. Respir Med (2002) 1.25
Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury. J Neurochem (2001) 1.23
Comparative growth behaviour and characterization of stem cells from human Wharton's jelly. Reprod Biomed Online (2007) 1.23
Tripronuclear human oocytes: altered cleavage patterns and subsequent karyotypic analysis of embryos. Biol Reprod (1987) 1.22
Adult and microfilarial stages of the filarial parasite Brugia malayi stimulate contrasting cytokine and Ig isotype responses in BALB/c mice. J Immunol (1994) 1.20
Complementary DNA and derived amino acid sequence of the alpha subunit of human complement protein C8: evidence for the existence of a separate alpha subunit messenger RNA. Biochemistry (1987) 1.20
Nippostrongylus brasiliensis: cytokine responses and nematode expulsion in normal and IL-4-deficient mice. Exp Parasitol (1996) 1.20
ETS1, NFkappaB and AP1 synergistically transactivate the human GM-CSF promoter. Oncogene (1997) 1.18
Simian virus 40 chromatin interaction with the capsid proteins. J Biomol Struct Dyn (1983) 1.18
Factors influencing pregnancy rates following in vitro fertilization and embryo transfer. Fertil Steril (1985) 1.18
Ongoing normal pregnancy after transfer of zona-free blastocysts: implications for embryo transfer in the human. Hum Reprod (1997) 1.17
Response of a primary human fibroblast cell line to H2O2: senescence-like growth arrest or apoptosis? Cell Growth Differ (1997) 1.17
Expression of the potent vasoconstrictor endothelin in the human central nervous system. J Clin Invest (1990) 1.16
Production of embryos from in vitro-matured primary human oocytes. Fertil Steril (1996) 1.16
Survivin does not inhibit caspase-3 activity. Blood (2000) 1.15
Effects of social disincentive policies on fertility behavior in Singapore. Am J Public Health (1978) 1.14
Fc gammaRIIA polymorphism as a risk factor for invasive pneumococcal infections in systemic lupus erythematosus. Arthritis Rheum (1997) 1.14
SV40 morphogenesis. Cold Spring Harb Symp Quant Biol (1983) 1.14
Developmental capacity of damaged spermatozoa. Hum Reprod (1999) 1.13
Research in human in-vitro fertilisation and embryo transfer. Br Med J (Clin Res Ed) (1982) 1.13
Modulation of paclitaxel resistance by annexin IV in human cancer cell lines. Br J Cancer (2000) 1.12
The technique for human embryo transfer. Fertil Steril (1982) 1.12
CD8+ and CD45RA+ human peripheral blood lymphocytes are potent sources of macrophage inflammatory protein 1 alpha, interleukin-8 and RANTES. Eur J Immunol (1995) 1.12
Role of interferons in the regulation of cell proliferation, differentiation, and development. Mol Reprod Dev (1994) 1.12
Observations on choriocarcinoma in Singapore. Obstet Gynecol (1972) 1.12
Bacteremia caused by a novel isolate resembling leptotrichia species in a neutropenic patient. J Clin Microbiol (1999) 1.12
Validity and reliability of the EQ-5D self-report questionnaire in English-speaking Asian patients with rheumatic diseases in Singapore. Qual Life Res (2003) 1.10
Methylation-dependent silencing of the testis-specific Pdha-2 basal promoter occurs through selective targeting of an activating transcription factor/cAMP-responsive element-binding site. J Biol Chem (2000) 1.10
Microinjection: choice of embryo transfer technique. Reprod Fertil Dev (1994) 1.09
Lymphangioleiomyomatosis: a review of the literature. Respir Med (2002) 1.09
Early malignant disease of the chorion. Acta Obstet Gynecol Scand (1971) 1.08