Published in Nature on October 21, 1999
The protein structures that shape caspase activity, specificity, activation and inhibition. Biochem J (2004) 4.85
Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. EMBO Rep (2006) 4.15
IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer. Nat Rev Cancer (2010) 4.08
Targeting IAP proteins for therapeutic intervention in cancer. Nat Rev Drug Discov (2012) 3.88
IAPs: what's in a name? Mol Cell (2008) 3.66
Characterization of XIAP-deficient mice. Mol Cell Biol (2001) 3.32
Mechanisms of apoptosis. Am J Pathol (2000) 3.23
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death. Proc Natl Acad Sci U S A (2001) 3.19
XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs. EMBO J (2005) 2.27
Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes. EMBO J (2001) 2.06
XIAP mediates NOD signaling via interaction with RIP2. Proc Natl Acad Sci U S A (2009) 1.95
SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP. Cancer Res (2008) 1.87
The Survivin saga goes in vivo. J Clin Invest (2001) 1.66
Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53. J Clin Invest (2001) 1.64
Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis. Genes Dev (2003) 1.63
Regulation of apoptosis by XIAP ubiquitin-ligase activity. Genes Dev (2008) 1.63
Fas death receptor signalling: roles of Bid and XIAP. Cell Death Differ (2011) 1.63
XIAP as a ubiquitin ligase in cellular signaling. Cell Death Differ (2010) 1.57
Caspase activation, inhibition, and reactivation: a mechanistic view. Protein Sci (2004) 1.48
Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP. EMBO J (2001) 1.43
The mitochondrial ARTS protein promotes apoptosis through targeting XIAP. EMBO J (2004) 1.42
The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites. J Cell Biol (2002) 1.41
IAP-antagonists exhibit non-redundant modes of action through differential DIAP1 binding. EMBO J (2003) 1.38
XIAP regulates cytosol-specific innate immunity to Listeria infection. PLoS Pathog (2008) 1.36
Caspase-3 activation as a bifurcation point between plasticity and cell death. Neurosci Bull (2012) 1.32
Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP. Biochem J (2005) 1.31
The maize ID1 flowering time regulator is a zinc finger protein with novel DNA binding properties. Nucleic Acids Res (2004) 1.28
Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152). J Med Chem (2012) 1.27
Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonucleotide combined with idarubicin and cytarabine in patients with relapsed or primary refractory acute myeloid leukemia. J Clin Oncol (2009) 1.23
Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family. Mol Cell Biol (2001) 1.23
MicroRNA-24 regulates XIAP to reduce the apoptosis threshold in cancer cells. Oncogene (2012) 1.17
Inhibitor of apoptosis protein family as diagnostic markers and therapeutic targets of colorectal cancer. Surg Today (2011) 1.14
Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling. EMBO Mol Med (2013) 1.14
Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein. Biochem J (2003) 1.12
NAIP interacts with hippocalcin and protects neurons against calcium-induced cell death through caspase-3-dependent and -independent pathways. EMBO J (2000) 1.12
XIAP: cell death regulation meets copper homeostasis. Arch Biochem Biophys (2007) 1.10
A dimeric Smac/diablo peptide directly relieves caspase-3 inhibition by XIAP. Dynamic and cooperative regulation of XIAP by Smac/Diablo. J Biol Chem (2007) 1.07
Enhanced cytoprotective effects of the inhibitor of apoptosis protein cellular IAP1 through stabilization with TRAF2. J Biol Chem (2009) 1.05
IAPs: guardians of RIPK1. Cell Death Differ (2011) 1.03
Drosophila IAP1-mediated ubiquitylation controls activation of the initiator caspase DRONC independent of protein degradation. PLoS Genet (2011) 0.97
Estrogen suppresses uterine epithelial apoptosis by inducing birc1 expression. Mol Endocrinol (2007) 0.97
The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition. Biochem J (2005) 0.97
The BIR motifs mediate dominant interference and oligomerization of inhibitor of apoptosis Op-IAP. Mol Cell Biol (2000) 0.95
Influence of survivin and caspase-3 on cell apoptosis and prognosis in gastric carcinoma. World J Gastroenterol (2004) 0.93
Structural mechanisms of DIAP1 auto-inhibition and DIAP1-mediated inhibition of drICE. Nat Commun (2011) 0.87
CLL cells are resistant to smac mimetics because of an inability to form a ripoptosome complex. Cell Death Dis (2013) 0.83
XIAP associates with GSK3 and inhibits the promotion of intrinsic apoptotic signaling by GSK3. Cell Signal (2009) 0.83
Structural determinants of caspase-9 inhibition by the vaccinia virus protein, F1L. J Biol Chem (2011) 0.83
Crystal structure of the BIR1 domain of XIAP in two crystal forms. J Mol Biol (2007) 0.82
Evaluation of zinc (II) chelators for inhibiting p53-mediated apoptosis. Oncotarget (2013) 0.78
Apoptotic signaling in mouse odontogenesis. OMICS (2011) 0.77
Monomerization of cytosolic mature smac attenuates interaction with IAPs and potentiation of caspase activation. PLoS One (2010) 0.77
Identification of an Xiap-like pseudogene on mouse chromosome 7. PLoS One (2009) 0.76
The structure of XIAP BIR2: understanding the selectivity of the BIR domains. Acta Crystallogr D Biol Crystallogr (2013) 0.76
Inducing RNA interference in the arbovirus vector, Culicoides sonorensis. Insect Mol Biol (2014) 0.76
Transient pockets on XIAP-BIR2: toward the characterization of putative binding sites of small-molecule XIAP inhibitors. J Mol Model (2011) 0.76
Molecular signature of anastasis for reversal of apoptosis. F1000Res (2017) 0.75
Impact of inhibitor of apoptosis proteins on immune modulation and inflammation. Immunol Cell Biol (2016) 0.75
The sequence of the human genome. Science (2001) 101.55
Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care (1997) 23.95
Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci U S A (1990) 16.34
p21 is a universal inhibitor of cyclin kinases. Nature (1993) 15.55
Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci U S A (1996) 12.89
LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell (2001) 11.99
Socioeconomic factors, health behaviors, and mortality: results from a nationally representative prospective study of US adults. JAMA (1998) 11.90
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell (1995) 11.72
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature (2000) 11.49
The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell (1995) 9.82
Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. Science (1997) 9.73
Highly parallel SNP genotyping. Cold Spring Harb Symp Quant Biol (2003) 9.10
An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature (1994) 8.60
X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature (1996) 8.37
Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell (1997) 8.28
Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature (1998) 8.02
Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc Natl Acad Sci U S A (1997) 7.52
LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature (2001) 7.44
High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J Exp Med (2000) 7.38
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J Biol Chem (2001) 7.35
Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest (2001) 7.20
Discovering high-affinity ligands for proteins: SAR by NMR. Science (1996) 7.10
Control of p70 s6 kinase by kinase activity of FRAP in vivo. Nature (1995) 7.05
Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science (1995) 7.00
Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity (1995) 6.91
RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein. EMBO J (1998) 6.68
Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J Virol (1997) 6.61
Ecological degradation in protected areas: the case of Wolong Nature Reserve for giant pandas. Science (2001) 6.52
Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science (2001) 6.47
Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc Natl Acad Sci U S A (1980) 6.31
Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention. N Engl J Med (1999) 6.27
Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein. Science (1997) 6.10
Genome-wide search for genes affecting the risk for alcohol dependence. Am J Med Genet (1998) 6.04
Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma. Proc Natl Acad Sci U S A (1996) 6.00
Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science (1996) 5.92
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell (1997) 5.92
The cost effectiveness of combination antiretroviral therapy for HIV disease. N Engl J Med (2001) 5.89
The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae. Cell (2001) 5.86
Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein. Genes Dev (1994) 5.68
D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell (1992) 5.51
Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell (1996) 5.45
p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27. Curr Biol (1999) 5.40
Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. Br J Cancer (2001) 5.36
High-resolution inkjet printing of all-polymer transistor circuits. Science (2000) 5.35
Genetic diversity and disease control in rice. Nature (2000) 5.34
An essential role for Rac in Ras transformation. Nature (1995) 5.34
Capecitabine/cisplatin versus 5-fluorouracil/cisplatin as first-line therapy in patients with advanced gastric cancer: a randomised phase III noninferiority trial. Ann Oncol (2009) 5.08
Residual HIV-1 RNA in blood plasma of patients taking suppressive highly active antiretroviral therapy. JAMA (1999) 4.98
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci U S A (1999) 4.90
Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines. Proc Natl Acad Sci U S A (2001) 4.79
HMG-1 as a mediator of acute lung inflammation. J Immunol (2000) 4.78
Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell (1999) 4.76
Structure of the gene V protein of bacteriophage f1 determined by multiwavelength x-ray diffraction on the selenomethionyl protein. Proc Natl Acad Sci U S A (1994) 4.67
DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell (1995) 4.64
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice. Proc Natl Acad Sci U S A (2001) 4.62
Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms. Science (1999) 4.61
Secondary structure of the 5' nontranslated regions of hepatitis C virus and pestivirus genomic RNAs. Nucleic Acids Res (1992) 4.58
Familial transmission of substance use disorders. Arch Gen Psychiatry (1998) 4.57
Bcl-x(L) forms an ion channel in synthetic lipid membranes. Nature (1997) 4.55
Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells. J Exp Med (2000) 4.54
Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate. Nature (1994) 4.49
Human marrow stromal cell therapy for stroke in rat: neurotrophins and functional recovery. Neurology (2002) 4.45
Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43. Circ Res (2001) 4.38
Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. J Clin Invest (1997) 4.31
Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine. Nature (1999) 4.29
Demethylation-induced developmental pleiotropy in Arabidopsis. Science (1996) 4.25
Overland heroin trafficking routes and HIV-1 spread in south and south-east Asia. AIDS (2000) 4.24
Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc Natl Acad Sci U S A (1996) 4.20
Evolutionary analyses of the human genome. Nature (2001) 4.13
Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase. Arch Biochem Biophys (1992) 4.12
Gene expression profiles during the initial phase of salt stress in rice. Plant Cell (2001) 4.11
Fringe is a glycosyltransferase that modifies Notch. Nature (2000) 4.09
Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry. Biol Chem Hoppe Seyler (1994) 4.09
A structural basis for drug-induced long QT syndrome. Proc Natl Acad Sci U S A (2000) 4.06
14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol Cell (2000) 4.05
Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits. Nature (1994) 4.05
Effect of mobile phone intervention for diabetes on glycaemic control: a meta-analysis. Diabet Med (2011) 4.04
Aggregation-based crystal growth and microstructure development in natural iron oxyhydroxide biomineralization products. Science (2000) 4.03
Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways. J Cell Biol (2001) 3.92
Identification of a nuclear receptor that is activated by farnesol metabolites. Cell (1995) 3.92
Structural basis for the inhibition of caspase-3 by XIAP. Cell (2001) 3.91
B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection. J Exp Med (2000) 3.89
Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. FASEB J (2005) 3.84
Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB. Diabetes (2001) 3.83
Genetic analysis of BRCA1 function in a defined tumor cell line. Mol Cell (1999) 3.83
Two regulatory genes of the maize anthocyanin pathway are homologous: isolation of B utilizing R genomic sequences. Plant Cell (1989) 3.83
Three-dimensional solution structure of the 44 kDa ectodomain of SIV gp41. EMBO J (1998) 3.77
Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Cell (1999) 3.76
Submucosal endoscopic esophageal myotomy: a novel experimental approach for the treatment of achalasia. Endoscopy (2007) 3.75
Pooled exposure-response analyses and risk assessment for lung cancer in 10 cohorts of silica-exposed workers: an IARC multicentre study. Cancer Causes Control (2001) 3.74
Quantum ground state and single-phonon control of a mechanical resonator. Nature (2010) 3.71
Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation. Genes Dev (1993) 3.70
Unique response pathways are established by allosteric interactions among nuclear hormone receptors. Cell (1995) 3.70
XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair. Cell (2001) 3.66
Role of miR-143 targeting KRAS in colorectal tumorigenesis. Oncogene (2009) 3.64
mRNA decay mediated by two distinct AU-rich elements from c-fos and granulocyte-macrophage colony-stimulating factor transcripts: different deadenylation kinetics and uncoupling from translation. Mol Cell Biol (1995) 3.61