Published in Proc Natl Acad Sci U S A on June 01, 1991
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse. Proc Natl Acad Sci U S A (2003) 3.93
ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice. J Clin Invest (2011) 2.54
Lecithin: cholesterol acyltransferase--from biochemistry to role in cardiovascular disease. Curr Opin Endocrinol Diabetes Obes (2009) 1.29
A plasma lipoprotein containing only apolipoprotein E and with gamma mobility on electrophoresis releases cholesterol from cells. Proc Natl Acad Sci U S A (1994) 1.13
An intronic mutation in a lariat branchpoint sequence is a direct cause of an inherited human disorder (fish-eye disease). J Clin Invest (1996) 1.08
Fish eye syndrome: a molecular defect in the lecithin-cholesterol acyltransferase (LCAT) gene associated with normal alpha-LCAT-specific activity. Implications for classification and prognosis. J Clin Invest (1993) 1.02
Two different allelic mutations in the lecithin-cholesterol acyltransferase gene associated with the fish eye syndrome. Lecithin-cholesterol acyltransferase (Thr123----Ile) and lecithin-cholesterol acyltransferase (Thr347----Met). J Clin Invest (1992) 0.99
Genetic and phenotypic heterogeneity in familial lecithin: cholesterol acyltransferase (LCAT) deficiency. Six newly identified defective alleles further contribute to the structural heterogeneity in this disease. J Clin Invest (1993) 0.99
Lipoproteins, cholesterol homeostasis and cardiac health. Int J Biol Sci (2009) 0.97
High density lipoprotein cholesterol: an evolving target of therapy in the management of cardiovascular disease. Vasc Health Risk Manag (2008) 0.97
A unique genetic and biochemical presentation of fish-eye disease. J Clin Invest (1995) 0.93
Markedly accelerated catabolism of apolipoprotein A-II (ApoA-II) and high density lipoproteins containing ApoA-II in classic lecithin: cholesterol acyltransferase deficiency and fish-eye disease. J Clin Invest (1994) 0.91
Apolipoprotein A-I Q[-2]X causing isolated apolipoprotein A-I deficiency in a family with analphalipoproteinemia. J Clin Invest (1994) 0.87
Characterization of apolipoprotein A-I- and A-II-containing lipoproteins in a new case of high density lipoprotein deficiency resembling Tangier disease and their effects on intracellular cholesterol efflux. J Clin Invest (1993) 0.87
An apoA-I mimetic peptide increases LCAT activity in mice through increasing HDL concentration. Int J Biol Sci (2009) 0.85
A physiologically based in silico kinetic model predicting plasma cholesterol concentrations in humans. J Lipid Res (2012) 0.85
Segregation of LIPG, CETP, and GALNT2 mutations in Caucasian families with extremely high HDL cholesterol. PLoS One (2012) 0.85
Nonsynonymous polymorphic sites in the apolipoprotein (apo) A-IV gene are associated with changes in the concentration of apo B- and apo A-I-containing lipoproteins in a normal population. Am J Hum Genet (1992) 0.82
Lipid oxidation in carriers of lecithin:cholesterol acyltransferase gene mutations. Arterioscler Thromb Vasc Biol (2012) 0.77
Familial lecithin-cholesterol acyltransferase (LCAT) deficiency; a differential of proteinuria. J Nephropathol (2015) 0.75
Clinical and histopathological features of a suspected case of fish-eye disease. Jpn J Ophthalmol (2012) 0.75
Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem (1972) 95.79
Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science (1985) 95.08
Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus. Proc Natl Acad Sci U S A (1988) 18.72
High-density lipoprotein--the clinical implications of recent studies. N Engl J Med (1989) 5.70
Single bilayer liposomes prepared without sonication. Biochim Biophys Acta (1973) 3.83
Early incorporation of cell-derived cholesterol into pre-beta-migrating high-density lipoprotein. Biochemistry (1988) 1.97
Characterization of proteoliposomes containing apoprotein A-I: a new substrate for the measurement of lecithin: cholesterol acyltransferase activity. J Lipid Res (1982) 1.48
Designed diagnostic restriction fragment length polymorphisms for the detection of point mutations in ras oncogenes. Oncogene Res (1989) 1.45
Human lecithin-cholesterol acyltransferase gene: complete gene sequence and sites of expression. Nucleic Acids Res (1986) 1.28
DNA inversion within the apolipoproteins AI/CIII/AIV-encoding gene cluster of certain patients with premature atherosclerosis. Proc Natl Acad Sci U S A (1987) 1.28
Cholesterol net transport, esterification, and transfer in human hyperlipidemic plasma. J Clin Invest (1983) 1.25
A frameshift mutation in the human apolipoprotein A-I gene causes high density lipoprotein deficiency, partial lecithin: cholesterol-acyltransferase deficiency, and corneal opacities. J Clin Invest (1991) 1.16
Familial apolipoprotein A-I, C-III, and A-IV deficiency and premature atherosclerosis due to deletion of a gene complex on chromosome 11. J Biol Chem (1989) 1.16
Human plasma lecithin-cholesterol acyltransferase. An elucidation of the catalytic mechanism. J Biol Chem (1986) 1.15
Radioimmunoassay of human plasma lecithin-cholesterol acyltransferase. J Clin Invest (1981) 1.09
Simplified turbidimetric determination of apolipoproteins A-I, A-II and B using a microtitre method. J Clin Chem Clin Biochem (1988) 1.04
Human plasma lecithin-cholesterol acyltransferase. The vicinal nature of cysteine 31 and cysteine 184 in the catalytic site. J Biol Chem (1988) 1.00
Lecithin: cholesterol acyltransferase and the regulation of endogenous cholesterol transport. Adv Lipid Res (1983) 1.00
Lecithin:cholesterol acyltransferase. Functional regions and a structural model of the enzyme. J Biol Chem (1987) 0.99
Hypoalphalipoproteinemia resembling fish eye disease. Acta Med Scand (1987) 0.97
Lymphocyte reactivity in patients with carcinoma of the breast and large bowel. Br J Cancer (1975) 0.93
Mechanism of transfer of LDL-derived free cholesterol to HDL subfractions in human plasma. Biochemistry (1990) 0.92
Paradoxical esterification of plasma cholesterol in fish eye disease. Acta Med Scand (1985) 0.86
Cyclic A.M.P. and arrhythmias revisited. Lancet (1978) 0.83
Dextran sulfate-Mg2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol. Clin Chem (1982) 9.77
Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med (2001) 7.69
Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nat Genet (1999) 7.30
Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1. Nat Genet (1999) 7.04
Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B. N Engl J Med (1990) 6.43
Biodegradation of trichloroethylene and involvement of an aromatic biodegradative pathway. Appl Environ Microbiol (1987) 5.73
Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA (2005) 5.60
Effects of adaptation on biodegradation rates in sediment/water cores from estuarine and freshwater environments. Appl Environ Microbiol (1980) 5.09
A comprehensive evaluation of the heparin-manganese precipitation procedure for estimating high density lipoprotein cholesterol. J Lipid Res (1978) 4.84
Aerobic metabolism of trichloroethylene by a bacterial isolate. Appl Environ Microbiol (1986) 4.19
The role of a common variant of the cholesteryl ester transfer protein gene in the progression of coronary atherosclerosis. The Regression Growth Evaluation Statin Study Group. N Engl J Med (1998) 3.97
The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases. Eur J Epidemiol (2007) 3.81
Novel pathway of toluene catabolism in the trichloroethylene-degrading bacterium g4. Appl Environ Microbiol (1989) 3.53
Phenol and trichloroethylene degradation by Pseudomonas cepacia G4: kinetics and interactions between substrates. Appl Environ Microbiol (1990) 3.43
Comparison of p-Nitrophenol Biodegradation in Field and Laboratory Test Systems. Appl Environ Microbiol (1984) 2.85
Trichloroethylene metabolism by microorganisms that degrade aromatic compounds. Appl Environ Microbiol (1988) 2.81
High-density lipoprotein cholesterol as a predictor of coronary heart disease risk. The PROCAM experience and pathophysiological implications for reverse cholesterol transport. Atherosclerosis (1996) 2.70
Anaerobic Degradation of Chloroaromatic Compounds in Aquatic Sediments under a Variety of Enrichment Conditions. Appl Environ Microbiol (1989) 2.69
Changes in plasma lipids and lipoproteins in overweight men during weight loss through dieting as compared with exercise. N Engl J Med (1988) 2.65
Characterization of anaerobic dechlorinating consortia derived from aquatic sediments. Appl Environ Microbiol (1989) 2.57
Isolation and characterization of a fluoranthene-utilizing strain of Pseudomonas paucimobilis. Appl Environ Microbiol (1990) 2.48
Review of first 5 years of screening for familial hypercholesterolaemia in the Netherlands. Lancet (2001) 2.45
Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol (2001) 2.42
Apolipoprotein E polymorphism and coronary artery disease. Arteriosclerosis (1983) 2.37
Caffeinated and decaffeinated coffee effects on plasma lipoprotein cholesterol, apolipoproteins, and lipase activity: a controlled, randomized trial. Am J Clin Nutr (1991) 2.18
The molecular pathology of lecithin:cholesterol acyltransferase (LCAT) deficiency syndromes. J Lipid Res (1997) 2.14
Lipid lowering and plaque regression. New insights into prevention of plaque disruption and clinical events in coronary disease. Circulation (1993) 2.11
[Atherosclerosis partly due to local vasculitis]. Ned Tijdschr Geneeskd (1994) 2.05
High density lipoproteins and arteriosclerosis. Role of cholesterol efflux and reverse cholesterol transport. Arterioscler Thromb Vasc Biol (2001) 2.03
Mutations in the ABC1 gene in familial HDL deficiency with defective cholesterol efflux. Lancet (1999) 2.02
Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes. J Clin Invest (2000) 1.98
[Statins: possibly more than just lowering of the lipid level]. Ned Tijdschr Geneeskd (2000) 1.97
KCNE1 mutations cause jervell and Lange-Nielsen syndrome. Nat Genet (1997) 1.90
Mutagenically separated PCR (MS-PCR): a highly specific one step procedure for easy mutation detection. Nucleic Acids Res (1993) 1.85
Nevirapine-containing antiretroviral therapy in HIV-1 infected patients results in an anti-atherogenic lipid profile. AIDS (2001) 1.81
Lipoprotein(a) further increases the risk of coronary events in men with high global cardiovascular risk. J Am Coll Cardiol (2001) 1.80
Effect of the number of apolipoprotein(a) kringle 4 domains on immunochemical measurements of lipoprotein(a). Clin Chem (1995) 1.80
Multicentre study of a new enzymatic method of cholesterol determination. J Clin Chem Clin Biochem (1984) 1.77
A partial cDNA clone for human apolipoprotein B. Proc Natl Acad Sci U S A (1985) 1.76
The measurement of apolipoprotein A-I and A-II levels in men and women by immunoassay. J Clin Invest (1977) 1.75
Risk of recurrent venous thrombosis in children with combined prothrombotic risk factors. Blood (2001) 1.75
Lipoprotein(a) is an independent risk factor for myocardial infarction at a young age. Clin Chem (1990) 1.75
Effects of lowering elevated LDL cholesterol on the cardiovascular risk of lipoprotein(a). JAMA (1995) 1.74
Apoproteins B and A-I and coronary artery disease in humans. Arteriosclerosis (1984) 1.73
Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease. Circulation (2001) 1.71
First-trimester prenatal diagnosis for Huntington's disease with DNA probes. Lancet (1987) 1.70
Characterization of lipoprotein particles isolated by immunoaffinity chromatography. Particles containing A-I and A-II and particles containing A-I but no A-II. J Biol Chem (1984) 1.70
Increased exercise level and plasma lipoprotein concentrations: a one-year, randomized, controlled study in sedentary, middle-aged men. Metabolism (1983) 1.69
Heparin--Mn2+ quantitation of high-density-lipoprotein cholesterol: an ultrafiltration procedure for lipemic samples. Clin Chem (1978) 1.67
Effects of oral folic acid supplementation on endothelial function in familial hypercholesterolemia. A randomized placebo-controlled trial. Circulation (1999) 1.66
Multi-laboratory comparison of three heparin-Mn2+ precipitation procedures for estimating cholesterol in high-density lipoprotein. Clin Chem (1978) 1.63
C-reactive protein and the severity of atherosclerosis in myocardial infarction patients with stable angina pectoris. Eur Heart J (2000) 1.63
Phylogenetic and physiological comparisons of PAH-degrading bacteria from geographically diverse soils. Antonie Van Leeuwenhoek (1997) 1.60
Action of a fluoranthene-utilizing bacterial community on polycyclic aromatic hydrocarbon components of creosote. Appl Environ Microbiol (1989) 1.58
Defective peroxisomal catabolism of branched fatty acyl coenzyme A in mice lacking the sterol carrier protein-2/sterol carrier protein-x gene function. Genes Dev (1998) 1.58
Differential phenotypic expression by three mutant alleles in familial lecithin:cholesterol acyltransferase deficiency. Lancet (1991) 1.56
A novel frameshift mutation in PMP22 accounts for hereditary neuropathy with liability to pressure palsies. Neurology (1997) 1.56
Quantitation of apolipoprotein A-I of human plasma high density lipoprotein. Metabolism (1976) 1.55
Hypertriglyceridemia and elevated lipoprotein(a) are risk factors for major coronary events in middle-aged men. Am J Cardiol (1996) 1.55
Complete cDNA encoding human phospholipid transfer protein from human endothelial cells. J Biol Chem (1994) 1.53
Use of a reference material proposed by the International Federation of Clinical Chemistry and Laboratory Medicine to evaluate analytical methods for the determination of plasma lipoprotein(a). Clin Chem (2000) 1.52
Fibrinogen and factor VII in the prediction of coronary risk. Results from the PROCAM study in healthy men. Arterioscler Thromb (1994) 1.52
Swine lipoproteins and atherosclerosis. Changes in the plasma lipoproteins and apoproteins induced by cholesterol feeding. Biochemistry (1975) 1.50
Long-term cholesterol-lowering effects of 4 fat-restricted diets in hypercholesterolemic and combined hyperlipidemic men. The Dietary Alternatives Study. JAMA (1997) 1.50
Comparison of prostate-specific antigen (PSA) measured by four combinations of free PSA and total PSA assays. Clin Chem (1997) 1.50
Characterization of proteoliposomes containing apoprotein A-I: a new substrate for the measurement of lecithin: cholesterol acyltransferase activity. J Lipid Res (1982) 1.48
Homozygous Tangier disease and cardiovascular disease. Atherosclerosis (1994) 1.48
Hemostasis in normotensive and hypertensive men: results of the PROCAM study. The prospective cardiovascular Münster study. J Hypertens (1998) 1.48
D-dimers in relation to the severity of arteriosclerosis in patients with stable angina pectoris after myocardial infarction. Eur Heart J (1999) 1.48
Association of the GPIa C807T and GPIIIa PlA1/A2 polymorphisms with premature myocardial infarction in men. Eur Heart J (2002) 1.47
Molecular genetics and gene expression in atherosclerosis. Int J Cardiol (2001) 1.46
Plasma lipoproteins in familial combined hyperlipidemia and monogenic familial hypertriglyceridemia. J Lipid Res (1983) 1.46
Genotypic interaction and gender specificity of common genetic variants in the p53/mdm2 network in Crohn's disease. Digestion (2010) 1.45
Quantification of high-density-lipoprotein cholesterol by precipitation with phosphotungstic acid/MgCl2. Clin Chem (1983) 1.45
Plasminogen activator inhibitor-1 4G/4G-genotype is associated with cerebral sinus thrombosis in factor V Leiden carriers. Thromb Haemost (1998) 1.43
Suppression of endothelial cell apoptosis by high density lipoproteins (HDL) and HDL-associated lysosphingolipids. J Biol Chem (2001) 1.43
Systemic inflammation as a risk factor for atherothrombosis. Rheumatology (Oxford) (2007) 1.43
Low-density lipoproteins inhibit the Na+/H+ antiport in human platelets. A novel mechanism enhancing platelet activity in hypercholesterolemia. Circulation (1997) 1.43
Adenovirus-mediated rescue of lipoprotein lipase-deficient mice. Lipolysis of triglyceride-rich lipoproteins is essential for high density lipoprotein maturation in mice. J Biol Chem (2001) 1.43
Gel isoelectric focusing method for specific diagnosis of familial hyperlipoproteinemia type 3. Clin Chem (1979) 1.43
Differences in Lp[a] concentrations and apo[a] polymorphs between black and white Americans. J Lipid Res (1996) 1.42
A major insertion accounts for a significant proportion of mutations underlying human lipoprotein lipase deficiency. Proc Natl Acad Sci U S A (1989) 1.41
Isolation and characterization of a phospholipid transfer protein (LTP-II) from human plasma. J Lipid Res (1988) 1.41
Identification of oxidized low-density lipoprotein in human serum by NMR spectroscopy. Clin Sci (Lond) (1998) 1.40
A polymorphic DNA marker that represents a conserved expressed sequence in the region of the Huntington disease gene. Am J Hum Genet (1988) 1.39
Measurement of prostate-specific antigen: no advantage to ultrasensitive assays? J Natl Cancer Inst (1996) 1.39
[Primary and secondary prevention of coronary heart disease. A position paper of the International Task Force for the Prevention of Coronary Heart Disease]. Dtsch Med Wochenschr (2000) 1.39
Fatty acids promote translocation of CTP:phosphocholine cytidylyltransferase to the endoplasmic reticulum and stimulate rat hepatic phosphatidylcholine synthesis. J Biol Chem (1983) 1.38
Isolation of prostate-derived single cells and cell clusters from human peripheral blood. Cancer Res (1996) 1.37
[Postmenopausal estrogen substitution and the risk of atherosclerotic heart and vascular diseases]. Ned Tijdschr Geneeskd (1992) 1.37
[Familial hypercholesterolemia: recognition and prevention of cardiac complications at a young age]. Ned Tijdschr Geneeskd (2000) 1.36
The effects of subfractions of high density lipoprotein on cholesterol efflux from cultured fibroblasts. Regulation of low density lipoprotein receptor activity. J Biol Chem (1981) 1.36
Thermolabile methylenetetrahydrofolate reductase in coronary artery disease. Circulation (1997) 1.35