Published in Proc Natl Acad Sci U S A on March 01, 1994
Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier Disease. J Clin Invest (1995) 2.20
Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target. Proc Natl Acad Sci U S A (2005) 1.91
The metabolism and anti-atherogenic properties of HDL. J Lipid Res (2008) 1.74
Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice. J Clin Invest (1995) 1.73
Cardioprotective functions of HDLs. J Lipid Res (2013) 1.29
Centripetal cholesterol flux from extrahepatic organs to the liver is independent of the concentration of high density lipoprotein-cholesterol in plasma. Proc Natl Acad Sci U S A (1996) 1.06
Pathway of biogenesis of apolipoprotein E-containing HDL in vivo with the participation of ABCA1 and LCAT. Biochem J (2007) 1.06
A unified scheme for initiation and conformational adaptation of human apolipoprotein E N-terminal domain upon lipoprotein binding and for receptor binding activity. J Biol Chem (2009) 1.03
Phenotype-dependent differences in apolipoprotein E metabolism and in cholesterol homeostasis in human monocyte-derived macrophages. J Clin Invest (1998) 1.00
Self-assembly of HEK cell-secreted ApoE particles resembles ApoE enrichment of lipoproteins as a ligand for the LDL receptor-related protein. Biochemistry (2006) 0.99
Effects of the apolipoprotein E polymorphism on uptake and transfer of cell-derived cholesterol in plasma. J Clin Invest (1995) 0.90
Cholesterol efflux potential of sera from mice expressing human cholesteryl ester transfer protein and/or human apolipoprotein AI. J Clin Invest (1995) 0.90
Studies of gene variants related to inflammation, oxidative stress, dyslipidemia, and obesity: implications for a nutrigenetic approach. J Obes (2011) 0.89
Low-dose expression of a human apolipoprotein E transgene in macrophages restores cholesterol efflux capacity of apolipoprotein E-deficient mouse plasma. Proc Natl Acad Sci U S A (1998) 0.87
Biophysical analysis of apolipoprotein E3 variants linked with development of type III hyperlipoproteinemia. PLoS One (2011) 0.83
Thermodynamic and structural destabilization of apoE3 by hereditary mutations associated with the development of lipoprotein glomerulopathy. J Lipid Res (2012) 0.83
Response of lipid, lipoprotein-cholesterol, and electrophoretic characteristics of lipoproteins following a single bout of aerobic exercise in women. Eur J Appl Physiol (2008) 0.81
Triacylglycerol-rich lipoproteins alter the secretion, and the cholesterol-effluxing function, of apolipoprotein E-containing lipoprotein particles from human (THP-1) macrophages. Biochem J (2001) 0.79
Genetic variation and atherosclerosis. Curr Genomics (2008) 0.79
Residues Leu261, Trp264, and Phe265 account for apolipoprotein E-induced dyslipidemia and affect the formation of apolipoprotein E-containing high-density lipoprotein. Biochemistry (2007) 0.79
Interaction between VLDL and phosphatidylcholine liposomes generates new γ-LpE-like particles. Lipids (2014) 0.75
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science (1988) 13.54
Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science (1992) 11.83
Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell (1992) 10.97
Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc Natl Acad Sci U S A (1992) 5.75
High-density lipoprotein--the clinical implications of recent studies. N Engl J Med (1989) 5.70
High density lipoprotein metabolism. J Lipid Res (1984) 2.85
Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets. Proc Natl Acad Sci U S A (1985) 2.59
Biochemical and genetic studies of the apoprotein E secreted by mouse macrophages and human monocytes. J Biol Chem (1982) 2.19
Plasma high density lipoproteins. Metabolism and relationship to atherogenesis. J Clin Invest (1990) 2.08
Early incorporation of cell-derived cholesterol into pre-beta-migrating high-density lipoprotein. Biochemistry (1988) 1.97
Type III hyperlipoproteinemia associated with apolipoprotein E deficiency. Science (1981) 1.84
Marked reduction of high density lipoprotein cholesterol in mice genetically modified to lack apolipoprotein A-I. Proc Natl Acad Sci U S A (1992) 1.71
A molecular defect causing fish eye disease: an amino acid exchange in lecithin-cholesterol acyltransferase (LCAT) leads to the selective loss of alpha-LCAT activity. Proc Natl Acad Sci U S A (1991) 1.69
Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: structure of low and high density lipoproteins as revealed by elctron microscopy. J Clin Invest (1971) 1.63
Cholesterol transport between cells and high-density lipoproteins. Biochim Biophys Acta (1991) 1.62
Differential phenotypic expression by three mutant alleles in familial lecithin:cholesterol acyltransferase deficiency. Lancet (1991) 1.56
A young type III hyperlipoproteinemic patient associated with apolipoprotein E deficiency. Metabolism (1989) 1.28
Apolipoprotein E deficiency with a depressed mRNA of normal size. Atherosclerosis (1991) 1.23
A frameshift mutation in the human apolipoprotein A-I gene causes high density lipoprotein deficiency, partial lecithin: cholesterol-acyltransferase deficiency, and corneal opacities. J Clin Invest (1991) 1.16
Regulation of macrophage apolipoprotein E gene expression by cholesterol. J Lipid Res (1989) 1.10
Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: physical and chemical studies of low and high density lipoproteins. J Clin Invest (1971) 1.07
Apolipoprotein E prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits. J Clin Invest (1992) 1.01
Two different allelic mutations in the lecithin-cholesterol acyltransferase gene associated with the fish eye syndrome. Lecithin-cholesterol acyltransferase (Thr123----Ile) and lecithin-cholesterol acyltransferase (Thr347----Met). J Clin Invest (1992) 0.99
Genetic and phenotypic heterogeneity in familial lecithin: cholesterol acyltransferase (LCAT) deficiency. Six newly identified defective alleles further contribute to the structural heterogeneity in this disease. J Clin Invest (1993) 0.99
Cell-derived unesterified cholesterol cycles between different HDLs and LDL for its effective esterification in plasma. Arterioscler Thromb (1993) 0.98
AIMilano apoprotein identification of the complete kindred and evidence of a dominant genetic transmission. Am J Hum Genet (1985) 0.95
Apolipoprotein A-I variants. Naturally occurring substitutions of proline residues affect plasma concentration of apolipoprotein A-I. J Clin Invest (1989) 0.93
Evidence for the distribution of apolipoprotein E between lipoprotein classes in human normocholesterolemic plasma and for the origin of unassociated apolipoprotein E (Lp-E). J Lipid Res (1984) 0.89
Promotion of sterol efflux and net transport by apolipoprotein E in lecithin:cholesterol acyltransferase deficiency. Metabolism (1982) 0.87
Regulation of apolipoprotein E secretion by high density lipoprotein 3 in mouse macrophages. J Lipid Res (1991) 0.83
[The enzymatic analysis of sphingomyelin in HDL (author's transl)]. J Clin Chem Clin Biochem (1982) 0.80
An economical assay for HDL phosphatidyl choline. J Clin Chem Clin Biochem (1983) 0.78
The transcriptional landscape of the mammalian genome. Science (2005) 37.63
Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science (1992) 11.83
Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1. Nat Genet (1999) 7.04
Targetted correction of a mutant HPRT gene in mouse embryonic stem cells. Nature (1988) 6.12
Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci U S A (1996) 5.94
Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc Natl Acad Sci U S A (1992) 5.75
Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA (2005) 5.60
Transcription profiling-based identification of Staphylococcus aureus genes regulated by the agr and/or sarA loci. J Bacteriol (2001) 5.57
Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2. Proc Natl Acad Sci U S A (1997) 5.54
Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400. Nature (1989) 5.02
A statistical method for flagging weak spots improves normalization and ratio estimates in microarrays. Physiol Genomics (2001) 4.50
Stress: a factor to be considered in heterotrophic microorganism enumeration from aquatic environments. Appl Microbiol (1974) 4.03
The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases. Eur J Epidemiol (2007) 3.81
Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression. Arterioscler Thromb (1994) 3.75
Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. J Clin Invest (1998) 3.71
Regulation of blood pressure by the type 1A angiotensin II receptor gene. Proc Natl Acad Sci U S A (1995) 3.54
Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia. Proc Natl Acad Sci U S A (1995) 3.51
Genetic control of blood pressure and the angiotensinogen locus. Proc Natl Acad Sci U S A (1995) 3.46
Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways. J Clin Invest (2001) 3.24
Targeted mutation of the Hprt gene in mouse embryonic stem cells. Proc Natl Acad Sci U S A (1988) 3.20
Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis. J Biol Chem (1997) 3.04
Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. Proc Natl Acad Sci U S A (1997) 2.99
Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virus. Am J Pathol (2000) 2.98
Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc Natl Acad Sci U S A (2000) 2.96
Single-copy transgenic mice with chosen-site integration. Proc Natl Acad Sci U S A (1996) 2.84
Three-dimensional structure of the alkaline protease of Pseudomonas aeruginosa: a two-domain protein with a calcium binding parallel beta roll motif. EMBO J (1993) 2.80
High-density lipoprotein cholesterol as a predictor of coronary heart disease risk. The PROCAM experience and pathophysiological implications for reverse cholesterol transport. Atherosclerosis (1996) 2.70
Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells. Proc Natl Acad Sci U S A (1989) 2.59
Ser-His-Glu triad forms the catalytic site of the lipase from Geotrichum candidum. Nature (1991) 2.57
Predicting progression to AIDS: combined usefulness of CD4 lymphocyte counts and p24 antigenemia. Am J Med (1990) 2.56
Severe impairment in early host defense against Candida albicans in mice deficient in myeloperoxidase. Infect Immun (1999) 2.38
Apolipoprotein E polymorphism and coronary artery disease. Arteriosclerosis (1983) 2.37
A coagulation factor IX-deficient mouse model for human hemophilia B. Blood (1997) 2.36
Absence of CC chemokine receptor-2 reduces atherosclerosis in apolipoprotein E-deficient mice. Atherosclerosis (1999) 2.35
Intracellular signalling: PDK1--a kinase at the hub of things. Curr Biol (1999) 2.31
The evolution of multigene families: human haptoglobin genes. Annu Rev Genet (1986) 2.21
Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease. J Clin Invest (1999) 2.21
Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II. Proc Natl Acad Sci U S A (1998) 2.17
The molecular pathology of lecithin:cholesterol acyltransferase (LCAT) deficiency syndromes. J Lipid Res (1997) 2.14
Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption. J Exp Med (1999) 2.13
Recombination and balanced chromosome polymorphism suggested by DNA sequences 5' to the human delta-globin gene. Proc Natl Acad Sci U S A (1983) 2.11
Duplication within the haptoglobin Hp2 gene. Nature (1984) 2.08
High density lipoproteins and arteriosclerosis. Role of cholesterol efflux and reverse cholesterol transport. Arterioscler Thromb Vasc Biol (2001) 2.03
Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice. J Clin Invest (2001) 2.03
Hepatic failure in a case of multiple myeloma-associated amyloidosis (kappa-AL) J Gastroenterol (1995) 2.01
A mouse model for beta 0-thalassemia. Proc Natl Acad Sci U S A (1995) 2.01
Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor. Science (2000) 2.01
Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like element. J Biol Chem (1985) 2.00
LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors. Neuropharmacology (1998) 1.98
Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption. J Clin Invest (1994) 1.98
The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins. Proc Natl Acad Sci U S A (1994) 1.97
Apolipoprotein AI transgene corrects apolipoprotein E deficiency-induced atherosclerosis in mice. J Clin Invest (1994) 1.93
Accurate modification of a chromosomal plasmid by homologous recombination in human cells. Proc Natl Acad Sci U S A (1987) 1.93
Integrin and cadherin synergy regulates contact inhibition of migration and motile activity. J Cell Biol (1998) 1.91
KCNE1 mutations cause jervell and Lange-Nielsen syndrome. Nat Genet (1997) 1.90
Detection of herpes simplex viral DNA in the iridocorneal endothelial syndrome. Arch Ophthalmol (1994) 1.88
Blockade of Angiotensin II type-1 receptor reduces oxidative stress in adipose tissue and ameliorates adipocytokine dysregulation. Kidney Int (2006) 1.87
Mutagenically separated PCR (MS-PCR): a highly specific one step procedure for easy mutation detection. Nucleic Acids Res (1993) 1.85
Apo E structure determines VLDL clearance and atherosclerosis risk in mice. J Clin Invest (1999) 1.85
Enhanced atherosclerosis and kidney dysfunction in eNOS(-/-)Apoe(-/-) mice are ameliorated by enalapril treatment. J Clin Invest (2000) 1.84
Lipoprotein(a) further increases the risk of coronary events in men with high global cardiovascular risk. J Am Coll Cardiol (2001) 1.80
Multicentre study of a new enzymatic method of cholesterol determination. J Clin Chem Clin Biochem (1984) 1.77
Risk of recurrent venous thrombosis in children with combined prothrombotic risk factors. Blood (2001) 1.75
Lipoprotein(a) is an independent risk factor for myocardial infarction at a young age. Clin Chem (1990) 1.75
Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene. Nat Genet (2000) 1.71
Marked reduction of high density lipoprotein cholesterol in mice genetically modified to lack apolipoprotein A-I. Proc Natl Acad Sci U S A (1992) 1.71
Targeted disruption of the mouse sphingolipid activator protein gene: a complex phenotype, including severe leukodystrophy and wide-spread storage of multiple sphingolipids. Hum Mol Genet (1996) 1.70
Cutting edge: Role of C-C chemokine receptor 5 in organ-specific and innate immunity to Cryptococcus neoformans. J Immunol (1999) 1.69
A molecular defect causing fish eye disease: an amino acid exchange in lecithin-cholesterol acyltransferase (LCAT) leads to the selective loss of alpha-LCAT activity. Proc Natl Acad Sci U S A (1991) 1.69
Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease. Am J Pathol (1998) 1.67
Phospholipase D1: a key factor for the exocytotic machinery in neuroendocrine cells. EMBO J (2001) 1.67
Granular corneal dystrophy with homozygous mutations in the kerato-epithelin gene. Am J Ophthalmol (1998) 1.66
Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene. J Biol Chem (1998) 1.65
Exaggerated response to endotoxin in mice lacking the Duffy antigen/receptor for chemokines (DARC). Blood (2000) 1.65
Bacterial interactions in dental biofilm development. J Dent Res (2009) 1.63
C-reactive protein and the severity of atherosclerosis in myocardial infarction patients with stable angina pectoris. Eur Heart J (2000) 1.63
Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2. J Clin Invest (1998) 1.61
Cell-specific signal transduction of parathyroid hormone (PTH)-related protein through stably expressed recombinant PTH/PTHrP receptors in vascular smooth muscle cells. Endocrinology (1996) 1.61
Defects in the generation of IFN-gamma are overcome to control infection with Leishmania donovani in CC chemokine receptor (CCR) 5-, macrophage inflammatory protein-1 alpha-, or CCR2-deficient mice. J Immunol (1999) 1.61
Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. J Neurosci (1998) 1.61
Gene targeting approaches to complex genetic diseases: atherosclerosis and essential hypertension. Proc Natl Acad Sci U S A (1995) 1.58
Defective peroxisomal catabolism of branched fatty acyl coenzyme A in mice lacking the sterol carrier protein-2/sterol carrier protein-x gene function. Genes Dev (1998) 1.58
Cloning and characterization of the Bacteroides fragilis metalloprotease toxin gene. Infect Immun (1997) 1.58
Responses of carotid artery in mice deficient in expression of the gene for endothelial NO synthase. Am J Physiol (1998) 1.57
A novel frameshift mutation in PMP22 accounts for hereditary neuropathy with liability to pressure palsies. Neurology (1997) 1.56
7-Dehydrocholesterol-dependent proteolysis of HMG-CoA reductase suppresses sterol biosynthesis in a mouse model of Smith-Lemli-Opitz/RSH syndrome. J Clin Invest (2001) 1.55
Hypertriglyceridemia and elevated lipoprotein(a) are risk factors for major coronary events in middle-aged men. Am J Cardiol (1996) 1.55
Activation of a cell-cycle-regulated histone gene by the oncogenic transcription factor IRF-2. Nature (1995) 1.54
Congenital neuromuscular disease with uniform type 1 fiber and RYR1 mutation. Neurology (2007) 1.53
Stigmatization and shame: consequences of caring for HIV/AIDS patients in China. AIDS Care (2007) 1.53
Fibrinogen and factor VII in the prediction of coronary risk. Results from the PROCAM study in healthy men. Arterioscler Thromb (1994) 1.52
Natural CD8+CD122+ T cells are more potent in suppression of allograft rejection than CD4+CD25+ regulatory T cells. Am J Transplant (2013) 1.52
Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene. J Biol Chem (1996) 1.51
Effective control of Epstein-Barr virus-related hemophagocytic lymphohistiocytosis with immunochemotherapy. Histiocyte Society. Blood (1999) 1.51
Swine lipoproteins and atherosclerosis. Changes in the plasma lipoproteins and apoproteins induced by cholesterol feeding. Biochemistry (1975) 1.50