Published in Nat Rev Neurol on June 08, 2010
The role of inflammation in epilepsy. Nat Rev Neurol (2010) 3.89
Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain. J Neurochem (2011) 1.82
Neuroprotective strategies involving ROS in Alzheimer disease. Free Radic Biol Med (2010) 1.57
How do immune cells support and shape the brain in health, disease, and aging? J Neurosci (2013) 1.51
Brain regeneration in physiology and pathology: the immune signature driving therapeutic plasticity of neural stem cells. Physiol Rev (2011) 1.40
Physical activity and inflammatory markers over 10 years: follow-up in men and women from the Whitehall II cohort study. Circulation (2012) 1.25
Microglia function in Alzheimer's disease. Front Pharmacol (2012) 1.17
The resolution of neuroinflammation in neurodegeneration: leukocyte recruitment via the choroid plexus. EMBO J (2013) 1.16
Inflammatory T helper 17 cells promote depression-like behavior in mice. Biol Psychiatry (2012) 1.05
GABA is an effective immunomodulatory molecule. Amino Acids (2011) 1.03
Iron deposits in the chronically inflamed central nervous system and contributes to neurodegeneration. Cell Mol Life Sci (2013) 1.02
Abnormal changes in NKT cells, the IGF-1 axis, and liver pathology in an animal model of ALS. PLoS One (2011) 1.00
Mechanisms of altered redox regulation in neurodegenerative diseases--focus on S--glutathionylation. Antioxid Redox Signal (2012) 1.00
Immune cell trafficking from the brain maintains CNS immune tolerance. J Clin Invest (2014) 0.98
Telomere shortening in neurological disorders: an abundance of unanswered questions. Trends Neurosci (2014) 0.96
Anti-inflammatory effects of spermidine in lipopolysaccharide-stimulated BV2 microglial cells. J Biomed Sci (2012) 0.96
Variable neuroendocrine-immune dysfunction in individuals with unfavorable outcome after severe traumatic brain injury. Brain Behav Immun (2014) 0.95
The privileged immunity of immune privileged organs: the case of the eye. Front Immunol (2012) 0.95
A conceptual revolution in the relationships between the brain and immunity. Brain Behav Immun (2010) 0.95
Treating depression and depression-like behavior with physical activity: an immune perspective. Front Psychiatry (2013) 0.95
Modulation of adult-born neurons in the inflamed hippocampus. Front Cell Neurosci (2013) 0.94
Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways. Mol Cell Neurosci (2015) 0.94
Microarray and pathway analysis reveal distinct mechanisms underlying cannabinoid-mediated modulation of LPS-induced activation of BV-2 microglial cells. PLoS One (2013) 0.94
CCAAT/enhancer binding protein-δ expression by dendritic cells regulates CNS autoimmune inflammatory disease. J Neurosci (2011) 0.93
Chemokine receptor CXCR2: physiology regulator and neuroinflammation controller? J Neuroimmunol (2012) 0.93
Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology. J Neuroinflammation (2012) 0.91
Finding a better drug for epilepsy: antiinflammatory targets. Epilepsia (2012) 0.91
Regulation by glycogen synthase kinase-3 of inflammation and T cells in CNS diseases. Front Mol Neurosci (2011) 0.90
Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer's-like cognitive decline. J Clin Invest (2014) 0.89
How can we improve clinical trials in amyotrophic lateral sclerosis? Nat Rev Neurol (2011) 0.89
Immune responses in age-related macular degeneration and a possible long-term therapeutic strategy for prevention. Am J Ophthalmol (2014) 0.88
Involvement of NT3 and P75(NTR) in photoreceptor degeneration following selective Müller cell ablation. J Neuroinflammation (2013) 0.87
Functional macrophage heterogeneity in a mouse model of autoimmune central nervous system pathology. J Immunol (2013) 0.86
Interacting chemokine signals regulate dendritic cells in acute brain injury. PLoS One (2014) 0.82
RNA sequencing reveals distinct mechanisms underlying BET inhibitor JQ1-mediated modulation of the LPS-induced activation of BV-2 microglial cells. J Neuroinflammation (2015) 0.82
Dendritic cells and multiple sclerosis: disease, tolerance and therapy. Int J Mol Sci (2012) 0.82
6-Shogaol, an active compound of ginger, protects dopaminergic neurons in Parkinson's disease models via anti-neuroinflammation. Acta Pharmacol Sin (2013) 0.82
Challenges facing translational research organizations in China: a qualitative multiple case study. J Transl Med (2013) 0.81
Non-steroidal anti-inflammatory drugs and amyotrophic lateral sclerosis: results from five prospective cohort studies. Amyotroph Lateral Scler (2012) 0.80
Migration of blood cells to β-amyloid plaques in Alzheimer's disease. Exp Gerontol (2015) 0.80
Intravenous infusion of nerve growth factor-secreting monocytes supports the survival of cholinergic neurons in the nucleus basalis of Meynert in hypercholesterolemia Brown-Norway rats. J Neurosci Res (2013) 0.80
Intravenous infusion of monocytes isolated from 2-week-old mice enhances clearance of Beta-amyloid plaques in an Alzheimer mouse model. PLoS One (2015) 0.79
'As above, so below' examining the interplay between emotion and the immune system. Immunology (2014) 0.79
Astrocytes modulate the polarization of CD4+ T cells to Th1 cells. PLoS One (2014) 0.79
Molecular and genetic inflammation networks in major human diseases. Mol Biosyst (2016) 0.79
Mechanisms of neural and behavioral dysfunction in Alzheimer's disease. Mol Neurobiol (2011) 0.78
Fingolimod: A Disease-Modifier Drug in a Mouse Model of Amyotrophic Lateral Sclerosis. Neurotherapeutics (2016) 0.78
The neurobiology of brain injury. Cerebrum (2012) 0.78
Neuroimmunomodulation in unipolar depression: a focus on chronobiology and chronotherapeutics. J Neural Transm (Vienna) (2012) 0.78
Th2-polarised PrP-specific transgenic T-cells confer partial protection against murine scrapie. PLoS Pathog (2011) 0.78
The generation of NGF-secreting primary rat monocytes: a comparison of different transfer methods. J Immunol Methods (2013) 0.77
Better immunity in later life: a position paper. Age (Dordr) (2014) 0.77
Are there roles for brain cell senescence in aging and neurodegenerative disorders? Biogerontology (2014) 0.76
Inflammatory status of transmigrating primary rat monocytes in a novel perfusion model simulating blood flow. J Neuroimmunol (2013) 0.76
Taking the Perspective that a Depressive State Reflects Inflammation: Implications for the Use of Antidepressants. Front Psychol (2012) 0.76
Glycans in sera of amyotrophic lateral sclerosis patients and their role in killing neuronal cells. PLoS One (2012) 0.76
Increased susceptibility to oxidative death of lymphocytes from Alzheimer patients correlates with dementia severity. Curr Alzheimer Res (2014) 0.76
Modulation of neuroinflammation and pathology in the 5XFAD mouse model of Alzheimer's disease using a biased and selective beta-1 adrenergic receptor partial agonist. Neuropharmacology (2017) 0.75
In Vivo Non-Invasive Tracking of Macrophage Recruitment to Experimental Stroke. PLoS One (2016) 0.75
Abnormalities in chemokine levels in schizophrenia and their clinical correlates. Schizophr Res (2016) 0.75
Aspirin use associated with amyotrophic lateral sclerosis: a total population-based case-control study. J Epidemiol (2014) 0.75
Neonatal Bacillus Calmette-Guérin vaccination alleviates lipopolysaccharide-induced neurobehavioral impairments and neuroinflammation in adult mice. Mol Med Rep (2016) 0.75
T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer's Disease: Potential Pools of New Biomarkers. J Immunol Res (2017) 0.75
Myeloid Dendritic Cells are Potential Players in Human Neurodegenerative Diseases. Front Immunol (2015) 0.75
The multi-target effects of CNI-1493: convergence of anti-amylodogenic and anti-inflammatory properties in animal models of Alzheimer's disease. Mol Med (2016) 0.75
Overview of Traumatic Brain Injury: An Immunological Context. Brain Sci (2017) 0.75
TNFα affects CREB-mediated neuroprotective signaling pathways of synaptic plasticity in neurons as revealed by proteomics and phospho-proteomics. Oncotarget (2017) 0.75
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science (2002) 49.51
Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci (2007) 11.11
Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins. Nat Med (2007) 6.80
Molecular biology of amyotrophic lateral sclerosis: insights from genetics. Nat Rev Neurosci (2006) 6.53
Inflammation in Alzheimer disease: driving force, bystander or beneficial response? Nat Med (2006) 6.15
Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial. Lancet Neurol (2007) 5.46
Inflammation in neurodegenerative disease--a double-edged sword. Neuron (2002) 4.95
Three or more routes for leukocyte migration into the central nervous system. Nat Rev Immunol (2003) 4.76
Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood. Nat Neurosci (2006) 4.30
Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature (2002) 4.21
Activation of microglial cells by beta-amyloid protein and interferon-gamma. Nature (1995) 4.18
Immune activation in brain aging and neurodegeneration: too much or too little? Neuron (2009) 3.76
Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice. PLoS Med (2009) 3.68
Trial of celecoxib in amyotrophic lateral sclerosis. Ann Neurol (2006) 3.39
Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nat Med (2008) 3.15
Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat Med (1999) 3.13
CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS. Proc Natl Acad Sci U S A (2008) 2.72
Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort. Neurology (2009) 2.32
Anti-inflammatory drugs and Alzheimer disease. Lancet (1990) 2.31
T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS. Proc Natl Acad Sci U S A (2008) 2.26
Biomarkers of Alzheimer disease in plasma. NeuroRx (2004) 2.02
Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia. FASEB J (2004) 2.00
Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1. Proc Natl Acad Sci U S A (2006) 1.92
T cell deficiency leads to cognitive dysfunction: implications for therapeutic vaccination for schizophrenia and other psychiatric conditions. Proc Natl Acad Sci U S A (2004) 1.91
Ineffective phagocytosis of amyloid-beta by macrophages of Alzheimer's disease patients. J Alzheimers Dis (2005) 1.88
Can the immune system be harnessed to repair the CNS? Nat Rev Neurosci (2008) 1.83
Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice. PLoS One (2008) 1.65
CD4-positive T lymphocytes provide a neuroimmunological link in the control of adult hippocampal neurogenesis. J Immunol (2009) 1.59
Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears beta-amyloid in a mouse model of Alzheimer disease. J Clin Invest (2005) 1.45
Taking advantage of the systemic immune system to cure brain diseases. Neuron (2009) 1.31
From bone marrow to microglia: barriers and avenues. Trends Immunol (2008) 1.25
Selective ablation of bone marrow-derived dendritic cells increases amyloid plaques in a mouse Alzheimer's disease model. Eur J Neurosci (2007) 1.24
MyD88-deficient bone marrow cells accelerate onset and reduce survival in a mouse model of amyotrophic lateral sclerosis. J Cell Biol (2007) 1.24
Immunity and cognition: what do age-related dementia, HIV-dementia and 'chemo-brain' have in common? Trends Immunol (2008) 1.23
Dual effect of CD4+CD25+ regulatory T cells in neurodegeneration: a dialogue with microglia. Proc Natl Acad Sci U S A (2004) 1.22
Protective autoimmunity functions by intracranial immunosurveillance to support the mind: The missing link between health and disease. Mol Psychiatry (2010) 1.21
Polymorphisms in inflammatory genes and the risk of Alzheimer disease. Arch Neurol (2001) 1.13
Protective autoimmunity against the enemy within: fighting glutamate toxicity. Trends Neurosci (2003) 1.10
Altered lymphocyte distribution in Alzheimer's disease. J Psychiatr Res (2006) 1.08
Intense immunosuppression in patients with rapidly worsening multiple sclerosis: treatment guidelines for the clinician. Lancet Neurol (2008) 1.07
Vaccination as a novel approach for treating depressive behavior. Biol Psychiatry (2008) 1.03
Attenuation of AD-like neuropathology by harnessing peripheral immune cells: local elevation of IL-10 and MMP-9. J Neurochem (2009) 1.02
Thymic involution, a co-morbidity factor in amyotrophic lateral sclerosis. J Cell Mol Med (2010) 0.91
Immune senescence and brain aging: can rejuvenation of immunity reverse memory loss? Trends Neurosci (2009) 0.86
Microglial NO induces delayed neuronal death following acute injury in the striatum. Eur J Neurosci (1998) 0.81
Toll-like receptors modulate adult hippocampal neurogenesis. Nat Cell Biol (2007) 4.00
The bright side of the glial scar in CNS repair. Nat Rev Neurosci (2009) 2.34
Two faces of chondroitin sulfate proteoglycan in spinal cord repair: a role in microglia/macrophage activation. PLoS Med (2008) 1.28
Genetic manipulation of CD74 in mouse strains of different backgrounds can result in opposite responses to central nervous system injury. J Immunol (2007) 0.84