PubRank

Patrick J Casey

Author PubWeight™ 79.27‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Post-prenylation-processing enzymes as new targets in oncogenesis. Nat Rev Cancer 2005 2.47
2 Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. Mol Cell 2005 2.36
3 Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J Mol Biol 2004 2.15
4 Overview of the Alliance for Cellular Signaling. Nature 2002 2.15
5 beta-Catenin is a Nek2 substrate involved in centrosome separation. Genes Dev 2007 1.96
6 Rap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier function. J Biol Chem 2005 1.84
7 Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. J Clin Invest 2004 1.81
8 Site-specific analysis of protein S-acylation by resin-assisted capture. J Lipid Res 2010 1.77
9 Reaction path of protein farnesyltransferase at atomic resolution. Nature 2002 1.63
10 A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells. Proc Natl Acad Sci U S A 2005 1.59
11 Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation. Mol Cell Biol 2002 1.56
12 The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. Proc Natl Acad Sci U S A 2006 1.54
13 A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion. J Biol Chem 2006 1.47
14 GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer. J Clin Invest 2007 1.47
15 Identification of a role for beta-catenin in the establishment of a bipolar mitotic spindle. J Biol Chem 2004 1.43
16 Activation of Rap1 promotes prostate cancer metastasis. Cancer Res 2009 1.41
17 Biologic functions of the G12 subfamily of heterotrimeric g proteins: growth, migration, and metastasis. Biochemistry 2007 1.39
18 A novel protein geranylgeranyltransferase-I inhibitor with high potency, selectivity, and cellular activity. J Biol Chem 2006 1.35
19 A small molecule inhibitor of isoprenylcysteine carboxymethyltransferase induces autophagic cell death in PC3 prostate cancer cells. J Biol Chem 2008 1.32
20 Structure of mammalian protein geranylgeranyltransferase type-I. EMBO J 2003 1.28
21 Androgen receptor activation by G(s) signaling in prostate cancer cells. J Biol Chem 2005 1.26
22 Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development. Cancer Cell 2005 1.23
23 Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate. Proc Natl Acad Sci U S A 2003 1.17
24 Pertussis-toxin-sensitive Galpha subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G-protein-channel complex. Mol Cell Neurosci 2005 1.16
25 Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin. J Biol Chem 2002 1.14
26 On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy. J Biol Chem 2003 1.10
27 MicroRNA-182 and microRNA-200a control G-protein subunit α-13 (GNA13) expression and cell invasion synergistically in prostate cancer cells. J Biol Chem 2013 1.07
28 Role of G12 proteins in oncogenesis and metastasis. Br J Pharmacol 2009 1.05
29 Galphaz negatively regulates insulin secretion and glucose clearance. J Biol Chem 2007 1.03
30 Selective uncoupling of G alpha 12 from Rho-mediated signaling. J Biol Chem 2005 1.03
31 Rho GTPase activity modulates Wnt3a/beta-catenin signaling. Cell Signal 2009 1.01
32 Kinetic studies of protein farnesyltransferase mutants establish active substrate conformation. Biochemistry 2003 1.00
33 Analysis of the kinetic mechanism of recombinant human isoprenylcysteine carboxylmethyltransferase (Icmt). BMC Biochem 2004 0.98
34 Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration. J Biol Chem 2009 0.97
35 Activation of Gz attenuates Rap1-mediated differentiation of PC12 cells. J Biol Chem 2002 0.96
36 Poly adenosine diphosphate-ribose polymerase inhibitor PJ34 abolishes systemic proinflammatory responses to thoracic aortic ischemia and reperfusion. J Am Coll Surg 2006 0.95
37 Conversion of protein farnesyltransferase to a geranylgeranyltransferase. Biochemistry 2006 0.94
38 High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors. J Biol Chem 2003 0.94
39 Pharmacological targeting of the mitochondrial phosphatase PTPMT1. J Pharmacol Exp Ther 2010 0.92
40 RHO methylation matters: a role for isoprenylcysteine carboxylmethyltransferase in cell migration and adhesion. Cell Adh Migr 2011 0.91
41 The regulator of G protein signaling domain of axin selectively interacts with Galpha12 but not Galpha13. Mol Pharmacol 2006 0.91
42 A global partnership in medical education between Duke University and the National University of Singapore. Acad Med 2008 0.91
43 Endoscopically assisted fasciotomy: description of technique and in vitro assessment of lower-leg compartment decompression. Am J Sports Med 2002 0.91
44 A role for Rac3 GTPase in the regulation of autophagy. J Biol Chem 2011 0.90
45 Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis. J Biol Chem 2011 0.90
46 Reciprocal signaling between the transcriptional co-factor Eya2 and specific members of the Galphai family. Mol Pharmacol 2004 0.89
47 Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe. Mol Cell Biol 2009 0.88
48 Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function. Methods Enzymol 2006 0.88
49 Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass. J Biol Chem 2012 0.87
50 A role for G(z) in pancreatic islet beta-cell biology. J Biol Chem 2005 0.87
51 The effects of systemic hypothermia on a murine model of thoracic aortic ischemia reperfusion. J Vasc Surg 2010 0.86
52 Growth hormone or insulin-like growth factor-I extends longevity of equine spermatozoa in vitro. Theriogenology 2002 0.86
53 Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver. J Biol Chem 2002 0.86
54 A prenylated p47phox-p67phox-Rac1 chimera is a Quintessential NADPH oxidase activator: membrane association and functional capacity. J Biol Chem 2010 0.84
55 Discovery of geranylgeranyltransferase-I inhibitors with novel scaffolds by the means of quantitative structure-activity relationship modeling, virtual screening, and experimental validation. J Med Chem 2009 0.84
56 Time-dependent inhibition of isoprenylcysteine carboxyl methyltransferase by indole-based small molecules. Biochemistry 2007 0.83
57 Analysis of the molecular interaction of the farnesyl moiety of transducin through the use of a photoreactive farnesyl analogue. Biochemistry 2004 0.83
58 Control of RhoA methylation by carboxylesterase I. J Biol Chem 2013 0.82
59 G12 signaling through c-Jun NH2-terminal kinase promotes breast cancer cell invasion. PLoS One 2011 0.82
60 Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation. J Biol Chem 2010 0.82
61 Effects of pharmacologic inhibition of protein geranylgeranyltransferase type I on aqueous humor outflow through the trabecular meshwork. Invest Ophthalmol Vis Sci 2008 0.82
62 Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt). Eur J Med Chem 2013 0.80
63 PJ34, a poly-ADP-ribose polymerase inhibitor, modulates visceral mitochondrial activity and CD14 expression following thoracic aortic ischemia-reperfusion. Am J Surg 2009 0.80
64 Amino derivatives of indole as potent inhibitors of isoprenylcysteine carboxyl methyltransferase. J Med Chem 2010 0.78
65 Interacting targets of the farnesyl of transducin gamma-subunit. Biochemistry 2008 0.78
66 Stereospecificity and kinetic mechanism of human prenylcysteine lyase, an unusual thioether oxidase. J Biol Chem 2002 0.78
67 Improved loading and cleavage methods for solid-phase synthesis using chlorotrityl resins: synthesis and testing of a library of 144 discrete chemicals as potential farnesyltransferase inhibitors. J Comb Chem 2004 0.78
68 The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly. J Biol Chem 2002 0.76
69 The effect of growth hormone (GH) and insulin-like growth factor-I (IGF-I) on in vitro maturation of equine oocytes. Zygote 2011 0.76
70 Quantitative structure-activity relationship (QSAR) of indoloacetamides as inhibitors of human isoprenylcysteine carboxyl methyltransferase. Bioorg Med Chem Lett 2006 0.75
71 Analysis of the regulation of microtubule dynamics by interaction of RGSZ1 (RGS20) with the neuronal stathmin, SCG10. Methods Enzymol 2004 0.75