Published in Drug Metab Dispos on June 15, 2010
Human α/β hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver. J Biol Chem (2012) 0.75
Observation of Clinically Relevant Drug Interaction in Chimeric Mice with Humanized Livers: The Case of Valproic Acid and Carbapenem Antibiotics. Eur J Drug Metab Pharmacokinet (2017) 0.75
Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature (2009) 4.98
Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite. Drug Metab Dispos (2010) 3.06
T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice. FEBS Lett (2003) 2.52
Provision of a voluntary exercise environment enhances running activity and prevents obesity in Snark-deficient mice. Am J Physiol Endocrinol Metab (2009) 1.56
Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation. Mol Cell (2009) 1.51
Evaluation of pharmacogenetic algorithm for warfarin dose requirements in Japanese patients. Circ J (2010) 1.49
Incidental focal FDG uptake in heart is a lighthouse for considering cardiac screening. Ann Nucl Med (2013) 1.41
Activity of capuramycin analogues against Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium intracellulare in vitro and in vivo. J Antimicrob Chemother (2004) 1.41
Giant cell arteritis with polymyalgia rheumatica associated with influenza vaccination. J Dermatol (2011) 1.39
A new APE1/Ref-1-dependent pathway leading to reduction of NF-kappaB and AP-1, and activation of their DNA-binding activity. Nucleic Acids Res (2008) 1.22
OATP1B1, OATP1B3, and mrp2 are involved in hepatobiliary transport of olmesartan, a novel angiotensin II blocker. Drug Metab Dispos (2006) 1.19
Structural analysis of obscurin gene in hypertrophic cardiomyopathy. Biochem Biophys Res Commun (2007) 1.19
A site-specific, multiplexed kinase activity assay using stable-isotope dilution and high-resolution mass spectrometry. Proc Natl Acad Sci U S A (2009) 1.17
p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling. J Biol Chem (2009) 1.16
Blood flow restriction by low compressive force prevents disuse muscular weakness. J Sci Med Sport (2010) 1.14
Comparison of enzymatic properties between hPADI2 and hPADI4. Biochem Biophys Res Commun (2005) 1.14
Structure-based targeting of bioactive proteins into cypovirus polyhedra and application to immobilized cytokines for mammalian cell culture. Biomaterials (2009) 1.13
Wasting mechanisms in muscular dystrophy. Int J Biochem Cell Biol (2013) 1.07
A possible mechanism for the differences in efficiency and variability of active metabolite formation from thienopyridine antiplatelet agents, prasugrel and clopidogrel. Drug Metab Dispos (2009) 1.05
CS-8958, a prodrug of the novel neuraminidase inhibitor R-125489, demonstrates a favorable long-retention profile in the mouse respiratory tract. Antimicrob Agents Chemother (2009) 1.04
Analytical method for determination of disaccharides derived from keratan sulfates in human serum and plasma by high-performance liquid chromatography/turbo-ionspray ionization tandem mass spectrometry. Biomed Chromatogr (2007) 1.03
Novel extrahepatic cytochrome P450s. Toxicol Appl Pharmacol (2005) 1.01
Metabolic syndrome among pre- and post-menopausal rural women in Bangladesh: result from a population-based study. BMC Res Notes (2013) 0.96
Novel non-systemic inhibitor of ileal apical Na+-dependent bile acid transporter reduces serum cholesterol levels in hamsters and monkeys. Eur J Pharmacol (2006) 0.96
Regulatory circuitry of TWEAK-Fn14 system and PGC-1α in skeletal muscle atrophy program. FASEB J (2013) 0.96
Mass spectrometric analysis of type 1 inositol 1,4,5-trisphosphate receptor ubiquitination. J Biol Chem (2008) 0.95
Preliminary results of intensity-modulated radiation therapy with helical tomotherapy for prostate cancer. J Cancer Res Clin Oncol (2012) 0.94
Covalent binding and tissue distribution/retention assessment of drugs associated with idiosyncratic drug toxicity. Drug Metab Dispos (2008) 0.93
Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene. EMBO J (2009) 0.92
Predicting the severity of systemic inflammatory response syndrome (SIRS)-associated coagulopathy with hemostatic molecular markers and vascular endothelial injury markers. J Trauma (2007) 0.92
Prevalence of metabolic syndrome among rural Bangladeshi women. Diabetes Res Clin Pract (2011) 0.91
A zone classification system for risk assessment of idiosyncratic drug toxicity using daily dose and covalent binding. Drug Metab Dispos (2009) 0.91
Foods and beverages in relation to urothelial cancer: case-control study in Japan. Int J Urol (2004) 0.91
Changes in muscle temperature induced by 434 MHz microwave hyperthermia. Br J Sports Med (2007) 0.90
Association of age at menarche with metabolic syndrome and its components in rural Bangladeshi women. Nutr Metab (Lond) (2012) 0.90
Matrix metalloproteinase-9 inhibition improves proliferation and engraftment of myogenic cells in dystrophic muscle of mdx mice. PLoS One (2013) 0.90
Mechanism-based inhibition of human cytochrome P450 2B6 by ticlopidine, clopidogrel, and the thiolactone metabolite of prasugrel. Drug Metab Dispos (2008) 0.89
Identification of cytochrome P450 3A4 modification site with reactive metabolite using linear ion trap-Fourier transform mass spectrometry. Chem Res Toxicol (2007) 0.89
Predictability of idiosyncratic drug toxicity risk for carboxylic acid-containing drugs based on the chemical stability of acyl glucuronide. Drug Metab Dispos (2010) 0.88
Distribution of KAI-9803, a novel δ-protein kinase C inhibitor, after intravenous administration to rats. Drug Metab Dispos (2011) 0.88
Ethylene glycol monomethyl ether-induced toxicity is mediated through the inhibition of flavoprotein dehydrogenase enzyme family. Toxicol Sci (2010) 0.88
Human carboxymethylenebutenolidase as a bioactivating hydrolase of olmesartan medoxomil in liver and intestine. J Biol Chem (2010) 0.87
Naftopidil, a selective alpha-1 adrenoceptor antagonist, inhibits growth of human prostate cancer cells by G1 cell cycle arrest. Int J Cancer (2008) 0.87
Anti-HIV-1 activities and pharmacokinetics of new arylpiperazinyl fluoroquinolones. Bioorg Med Chem Lett (2002) 0.87
11C-methionine PET of acute myocardial infarction. J Nucl Med (2009) 0.86
Markers of electrophilic stress caused by chemically reactive metabolites in human hepatocytes. Drug Metab Dispos (2008) 0.86
Value of FDG-PET/CT using unfractionated heparin for managing primary cardiac lymphoma and several key findings. J Nucl Cardiol (2011) 0.86
Stunned myocardium in transient left ventricular apical ballooning: a serial study of dual I-123 BMIPP and Tl-201 SPECT. J Nucl Cardiol (2008) 0.86
Preliminary analysis of risk factors for late rectal toxicity after helical tomotherapy for prostate cancer. J Radiat Res (2013) 0.85
Effects of voluntary wheel running on satellite cells in the rat plantaris muscle. J Sports Sci Med (2009) 0.84
Interaction of angiotensin II type 1 receptor blockers with P-gp substrates in Caco-2 cells and hMDR1-expressing membranes. Life Sci (2009) 0.84
Re-evaluating the potentials and limitations of (99m)Tc-aprotinin scintigraphy for amyloid imaging. Am J Nucl Med Mol Imaging (2013) 0.84
TWEAK promotes exercise intolerance by decreasing skeletal muscle oxidative phosphorylation capacity. Skelet Muscle (2013) 0.84
Long fasting is effective in inhibiting physiological myocardial 18F-FDG uptake and for evaluating active lesions of cardiac sarcoidosis. EJNMMI Res (2014) 0.84
Human pharmacokinetic prediction of UDP-glucuronosyltransferase substrates with an animal scale-up approach. Drug Metab Dispos (2011) 0.83
Metabolism-dependent hepatotoxicity of amodiaquine in glutathione-depleted mice. Arch Toxicol (2009) 0.83
In vivo pharmacodynamic activity of tomopenem (formerly CS-023) against Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus in a murine thigh infection model. Antimicrob Agents Chemother (2010) 0.83
Glutaredoxin and thioredoxin can be involved in producing the pharmacologically active metabolite of a thienopyridine antiplatelet agent, prasugrel. Drug Metab Dispos (2010) 0.82
Efficacy of heparin loading during an 18F-FDG PET/CT examination to search for cardiac sarcoidosis activity. Clin Nucl Med (2013) 0.82
Protein identification by peptide mass fingerprinting and peptide sequence tagging with alternating scans of nano-liquid chromatography/infrared multiphoton dissociation Fourier transform ion cyclotron resonance mass spectrometry. J Mass Spectrom (2003) 0.81
Identification of a metabolizing enzyme in human kidney by proteomic correlation profiling. Mol Cell Proteomics (2013) 0.81
Culture period-dependent change of function and expression of ATP-binding cassette transporters in Caco-2 cells. Drug Metab Dispos (2009) 0.81
Histone H1 expression in human prostate cancer tissues and cell lines. Pathol Int (2011) 0.81
Heat stress enhances mTOR signaling after resistance exercise in human skeletal muscle. J Physiol Sci (2011) 0.80
Enhancement of the inhibitory activity of oatp antisense oligonucleotides by incorporation of 2'-O,4'-C-ethylene-bridged nucleic acids (ENA) without a loss of subtype selectivity. Biochemistry (2004) 0.80
The long-term results with delayed-combined androgen blockade therapy in local or locally advanced prostate cancer. Jpn J Clin Oncol (2012) 0.80
Risk assessment for drug-drug interaction caused by metabolism-based inhibition of CYP3A using automated in vitro assay systems and its application in the early drug discovery process. Drug Metab Dispos (2007) 0.80
Metabolic stability and uptake by human hepatocytes of pitavastatin, a new inhibitor of HMG-CoA reductase. Arzneimittelforschung (2004) 0.80
Neural cell adhesion molecule 2 as a target molecule for prostate and breast cancer gene therapy. Cancer Sci (2011) 0.80
Reproducibility and validity of the Japanese version of the Western Ontario Rotator Cuff Index. J Orthop Sci (2013) 0.80
Metabolism of ticlopidine in rats: identification of the main biliary metabolite as a glutathione conjugate of ticlopidine S-oxide. Drug Metab Dispos (2009) 0.80
Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling. Sci Rep (2013) 0.80
Amyloid imaging mismatch. Clin Nucl Med (2012) 0.79
Purification and identification of activating enzymes of CS-0777, a selective sphingosine 1-phosphate receptor 1 modulator, in erythrocytes. J Biol Chem (2011) 0.79
In vivo antisense activity of ENA oligonucleotides targeting PTP1B mRNA in comparison of that of 2'-MOE-modified oligonucleotides. Nucleic Acids Symp Ser (Oxf) (2007) 0.79
Direct comparison of in vivo antisense activity of ENA oligonucleotides targeting PTP1B mRNA with that of 2'-O-(2-methoxy)ethyl-modified oligonucleotides. Oligonucleotides (2006) 0.79
Whey protein intake after resistance exercise activates mTOR signaling in a dose-dependent manner in human skeletal muscle. Eur J Appl Physiol (2014) 0.79
Disruption of components of vascular endothelial growth factor angiogenic signalling system in metabolic syndrome. Findings from a study conducted in rural Bangladeshi women. Thromb Haemost (2013) 0.79
Effect of ion suppression on judgment of enzyme inhibition and avoidance of error by utilizing a stable isotope-labeled probe substrate: example of CYP3A4 inhibition with [13C4,15N] labeled midazolam as a substrate. Drug Metab Pharmacokinet (2007) 0.79
Ticlopidine-induced hepatotoxicity in a GSH-depleted rat model. Arch Toxicol (2010) 0.78
Effects of proprioceptive neuromuscular facilitation stretching and static stretching on maximal voluntary contraction. J Strength Cond Res (2013) 0.78
Glutathione S-transferase pi trapping method for generation and characterization of drug-protein adducts in human liver microsomes using liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal (2012) 0.78
Biotransformation of prasugrel, a novel thienopyridine antiplatelet agent, to the pharmacologically active metabolite. Drug Metab Dispos (2010) 0.78
Fiber-type specific expression of α-actinin isoforms in rat skeletal muscle. Biochem Biophys Res Commun (2012) 0.78
Inhibition mechanism of carbapenem antibiotics on acylpeptide hydrolase, a key enzyme in the interaction with valproic acid. Xenobiotica (2011) 0.78
Effects of Microwave Hyperthermia at Two Different Frequencies (434 and 2450 MHz) on Human Muscle Temperature. J Sports Sci Med (2008) 0.77
[Solitary fibrous tumor of a kidney: a case report]. Hinyokika Kiyo (2008) 0.77
A cross-sectional survey of blood pressure of a coastal city's resident victims of the 2011 Tohoku tsunami. Am J Hypertens (2013) 0.77