Published in Neuropsychopharmacology on April 29, 2013
Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories--indications for novel treatments of addiction. Eur J Neurosci (2014) 1.18
Synaptic mechanisms underlying persistent cocaine craving. Nat Rev Neurosci (2016) 1.03
Astrocytic dysfunction and addiction: consequences of impaired glutamate homeostasis. Neuroscientist (2014) 0.99
Rodent models for compulsive alcohol intake. Alcohol (2014) 0.93
The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis. Pharmacol Rev (2016) 0.86
Differential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on nicotine versus cocaine self-administration and relapse in squirrel monkeys. Psychopharmacology (Berl) (2015) 0.84
How Preclinical Models Evolved to Resemble the Diagnostic Criteria of Drug Addiction. Biol Psychiatry (2015) 0.84
Chronic EtOH effects on putative measures of compulsive behavior in mice. Addict Biol (2015) 0.79
Cortical GluN2B deletion attenuates punished suppression of food reward-seeking. Psychopharmacology (Berl) (2015) 0.77
Glutamate carboxypeptidase II (GCPII) inhibitor 2-PMPA reduces rewarding effects of the synthetic cathinone MDPV in rats: a role for N-acetylaspartylglutamate (NAAG). Psychopharmacology (Berl) (2017) 0.76
Convergent functional genomics in addiction research - a translational approach to study candidate genes and gene networks. In Silico Pharmacol (2013) 0.76
New measurement criteria for studying alcohol drinking and relapse in rodents. In Silico Pharmacol (2013) 0.75
Presynaptic G Protein-Coupled Receptors: Gatekeepers of Addiction? Front Cell Neurosci (2016) 0.75
Nucleus accumbens injections of the mGluR2/3 agonist LY379268 increase cue-induced sucrose seeking following adult, but not adolescent sucrose self-administration. Neuroscience (2015) 0.75
Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings. Prog Mol Biol Transl Sci (2015) 0.75
From bench to bedside: mGluR2 positive allosteric modulators as medications to treat substance use disorders. Psychopharmacology (Berl) (2016) 0.75
Melatonin reduces motivation for cocaine self-administration and prevents relapse-like behavior in rats. Psychopharmacology (Berl) (2017) 0.75
Neurocircuitry of addiction. Neuropsychopharmacology (2010) 14.22
The neural basis of addiction: a pathology of motivation and choice. Am J Psychiatry (2005) 12.53
The glutamate homeostasis hypothesis of addiction. Nat Rev Neurosci (2009) 5.97
Transition from moderate to excessive drug intake: change in hedonic set point. Science (1998) 5.66
Evidence for addiction-like behavior in the rat. Science (2004) 5.19
High impulsivity predicts the switch to compulsive cocaine-taking. Science (2008) 4.76
Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse. Nat Neurosci (2003) 4.63
Behavioural assessment of drug reinforcement and addictive features in rodents: an overview. Addict Biol (2006) 3.94
A role of ventral tegmental area glutamate in contextual cue-induced relapse to heroin seeking. J Neurosci (2004) 2.23
Transition to addiction is associated with a persistent impairment in synaptic plasticity. Science (2010) 2.04
Preferential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on conditioned reinstatement versus primary reinforcement: comparison between cocaine and a potent conventional reinforcer. J Neurosci (2004) 1.99
Reversing cocaine-induced synaptic potentiation provides enduring protection from relapse. Proc Natl Acad Sci U S A (2010) 1.94
Metabotropic glutamate 2/3 receptors in the ventral tegmental area and the nucleus accumbens shell are involved in behaviors relating to nicotine dependence. J Neurosci (2007) 1.85
Activation of group II metabotropic glutamate receptors in the nucleus accumbens shell attenuates context-induced relapse to heroin seeking. Neuropsychopharmacology (2005) 1.79
The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaine- and food-seeking behavior in rats. Psychopharmacology (Berl) (2006) 1.74
Compulsive drug seeking by rats under punishment: effects of drug taking history. Psychopharmacology (Berl) (2007) 1.74
Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat. Neuroscience (1993) 1.69
Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4. J Neurosci (1993) 1.63
Behavioral and functional evidence of metabotropic glutamate receptor 2/3 and metabotropic glutamate receptor 5 dysregulation in cocaine-escalated rats: factor in the transition to dependence. Biol Psychiatry (2010) 1.63
Activation of group II metabotropic glutamate receptors attenuates both stress and cue-induced ethanol-seeking and modulates c-fos expression in the hippocampus and amygdala. J Neurosci (2006) 1.55
Systemic and central amygdala injections of the mGluR(2/3) agonist LY379268 attenuate the expression of incubation of cocaine craving. Biol Psychiatry (2006) 1.49
From controlled drug intake to loss of control: the irreversible development of drug addiction in the rat. Behav Brain Res (1995) 1.48
The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection. J Neurosci (2007) 1.38
Pattern of intake and drug craving predict the development of cocaine addiction-like behavior in rats. Biol Psychiatry (2008) 1.35
Enhanced cocaine responsiveness and impaired motor coordination in metabotropic glutamate receptor subtype 2 knockout mice. Proc Natl Acad Sci U S A (2005) 1.30
The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats. Neuropsychopharmacology (2010) 1.23
Rescue of infralimbic mGluR2 deficit restores control over drug-seeking behavior in alcohol dependence. J Neurosci (2013) 1.22
Neurocircuitry for modeling drug effects. Addict Biol (2012) 1.22
The mGluR2/3 agonist LY379268 attenuates context- and discrete cue-induced reinstatement of sucrose seeking but not sucrose self-administration in rats. Behav Brain Res (2006) 1.19
Prefrontal synaptic markers of cocaine addiction-like behavior in rats. Mol Psychiatry (2012) 1.17
The novel mGluR2/3 agonist LY379268 attenuates cue-induced reinstatement of heroin seeking. Neuroreport (2005) 1.15
Rats with extended access to cocaine exhibit increased stress reactivity and sensitivity to the anxiolytic-like effects of the mGluR 2/3 agonist LY379268 during abstinence. Neuropsychopharmacology (2007) 1.13
Systemic and central amygdala injections of the mGluR2/3 agonist LY379268 attenuate the expression of incubation of sucrose craving in rats. Behav Brain Res (2007) 1.11
Effects of the mGlu2/3 agonist LY379268 and the mGlu5 antagonist MTEP on ethanol seeking and reinforcement are differentially altered in rats with a history of ethanol dependence. Biol Psychiatry (2010) 1.08
Classical conditioning of a morphine abstinence phenomenon, reinforcement of opioid-drinking behavior and "relapse" in morphine-addicted rats. Psychopharmacologia (1967) 1.06
c-fos reduces corticosterone-mediated effects on neurotrophic factor expression in the rat hippocampal CA1 region. J Neurosci (2003) 1.05
Attenuation of methamphetamine seeking by the mGluR2/3 agonist LY379268 in rats with histories of restricted and escalated self-administration. Neuropharmacology (2012) 0.97
Enhanced sensitivity to attenuation of conditioned reinstatement by the mGluR 2/3 agonist LY379268 and increased functional activity of mGluR 2/3 in rats with a history of ethanol dependence. Neuropsychopharmacology (2011) 0.95
The metabotropic glutamate 2/3 receptor agonist LY379268 blocked nicotine-induced increases in nucleus accumbens shell dopamine only in the presence of a nicotine-associated context in rats. Neuropsychopharmacology (2011) 0.90
Regulation of cocaine-induced reinstatement by group II metabotropic glutamate receptors in the ventral tegmental area. Psychopharmacology (Berl) (2011) 0.84
(-)-2-oxa-4-aminobicylco[3.1.0]hexane-4,6-dicarboxylic acid (LY379268) and 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine (MTEP) similarly attenuate stress-induced reinstatement of cocaine seeking. Addict Biol (2011) 0.83
Drug specificity in extended access cocaine and heroin self-administration. Addict Biol (2011) 0.81
Behavioural assessment of drug reinforcement and addictive features in rodents: an overview. Addict Biol (2006) 3.94
Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill. Nat Neurosci (2009) 3.38
Genome-wide association study of alcohol dependence. Arch Gen Psychiatry (2009) 3.08
Withdrawal phenomena and dependence syndrome after the consumption of "spice gold". Dtsch Arztebl Int (2009) 2.94
Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc. Nat Neurosci (2009) 2.50
Cocaine sensitization and reward are under the influence of circadian genes and rhythm. Proc Natl Acad Sci U S A (2002) 2.40
Glutamate receptors on dopamine neurons control the persistence of cocaine seeking. Neuron (2008) 2.37
Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence. Biol Psychiatry (2007) 2.29
Stress-induced anhedonia in mice is associated with deficits in forced swimming and exploration. Neuropsychopharmacology (2004) 2.16
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. Proc Natl Acad Sci U S A (2011) 2.01
Adolescent impulsivity phenotypes characterized by distinct brain networks. Nat Neurosci (2012) 1.98
Regulation of monoamine oxidase A by circadian-clock components implies clock influence on mood. Curr Biol (2008) 1.97
Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS. J Neurosci (2003) 1.94
Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors. Science (2002) 1.93
Chronic intake of fermented floral nectar by wild treeshrews. Proc Natl Acad Sci U S A (2008) 1.89
mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior. Neuropsychopharmacology (2004) 1.83
Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians. Hepatology (2010) 1.65
Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance. Proc Natl Acad Sci U S A (2013) 1.64
Risk taking and the adolescent reward system: a potential common link to substance abuse. Am J Psychiatry (2011) 1.56
Ambiguous-cue interpretation is biased under stress- and depression-like states in rats. Neuropsychopharmacology (2009) 1.54
Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior. Arch Gen Psychiatry (2008) 1.39
The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection. J Neurosci (2007) 1.38
Influence of age at drinking onset on long-term ethanol self-administration with deprivation and stress phases. Alcohol Clin Exp Res (2005) 1.36
The glucocorticoid receptor as a potential target to reduce cocaine abuse. J Neurosci (2003) 1.34
Acamprosate: recent findings and future research directions. Alcohol Clin Exp Res (2008) 1.33
Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors. J Neurosci (2012) 1.29
The Ca(V)3.3 calcium channel is the major sleep spindle pacemaker in thalamus. Proc Natl Acad Sci U S A (2011) 1.26
Cannabinoid CB1 receptor antagonism reduces conditioned reinstatement of ethanol-seeking behavior in rats. Eur J Neurosci (2005) 1.25
Involvement of the AMPA receptor GluR-C subunit in alcohol-seeking behavior and relapse. J Neurosci (2006) 1.24
Rescue of infralimbic mGluR2 deficit restores control over drug-seeking behavior in alcohol dependence. J Neurosci (2013) 1.22
Neurocircuitry for modeling drug effects. Addict Biol (2012) 1.22
A comparative study on alcohol-preferring rat lines: effects of deprivation and stress phases on voluntary alcohol intake. Alcohol Clin Exp Res (2003) 1.21
Effect of acamprosate on magnetic resonance spectroscopy measures of central glutamate in detoxified alcohol-dependent individuals: a randomized controlled experimental medicine study. Arch Gen Psychiatry (2010) 1.21
Neurokinin 1 receptor and relative abundance of the short and long isoforms in the human brain. Eur J Neurosci (2003) 1.20
Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues. Neurosci Biobehav Rev (2009) 1.18
Translational magnetic resonance spectroscopy reveals excessive central glutamate levels during alcohol withdrawal in humans and rats. Biol Psychiatry (2011) 1.18
Effects of the circadian rhythm gene period 1 (per1) on psychosocial stress-induced alcohol drinking. Am J Psychiatry (2011) 1.15
The role of the NMDA receptor in alcohol relapse: a pharmacological mapping study using the alcohol deprivation effect. Neuropharmacology (2005) 1.15
Compulsive alcohol drinking in rodents. Addict Biol (2009) 1.15
Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat. Biol Psychiatry (2008) 1.14
Structure-activity studies on neuropeptide S: identification of the amino acid residues crucial for receptor activation. J Biol Chem (2006) 1.13
cDNA microarray analysis reveals novel candidate genes expressed in human peripheral blood following exhaustive exercise. Physiol Genomics (2005) 1.13
The effects of acamprosate and neramexane on cue-induced reinstatement of ethanol-seeking behavior in rat. Neuropsychopharmacology (2005) 1.12
Neuropeptide Y (NPY) suppresses yohimbine-induced reinstatement of alcohol seeking. Psychopharmacology (Berl) (2009) 1.12
The dopamine D3 receptor plays an essential role in alcohol-seeking and relapse. FASEB J (2006) 1.12
Reduced sensitivity to reward in CB1 knockout mice. Psychopharmacology (Berl) (2004) 1.11
Glutamatergic targets for new alcohol medications. Psychopharmacology (Berl) (2013) 1.10
Influence of age at drinking onset on the alcohol deprivation effect and stress-induced drinking in female rats. Pharmacol Biochem Behav (2006) 1.10
RASGRF2 regulates alcohol-induced reinforcement by influencing mesolimbic dopamine neuron activity and dopamine release. Proc Natl Acad Sci U S A (2012) 1.06
Rats with congenital learned helplessness respond less to sucrose but show no deficits in activity or learning. Behav Brain Res (2004) 1.05
Enhanced sucrose and cocaine self-administration and cue-induced drug seeking after loss of VGLUT2 in midbrain dopamine neurons in mice. J Neurosci (2011) 1.04
D-cycloserine facilitates extinction of conditioned alcohol-seeking behaviour in rats. Alcohol Alcohol (2008) 1.04
Circadian regulation of central ethanol sensitivity by the mPer2 gene. Addict Biol (2009) 1.03
Determinants of early alcohol use in healthy adolescents: the differential contribution of neuroimaging and psychological factors. Neuropsychopharmacology (2011) 1.03
NF-kappaB mediated glucocorticoid response in the inner ear after acoustic trauma. J Neurosci Res (2006) 1.02
Ethanol self-administration and reinstatement of ethanol-seeking behavior in Per1(Brdm1) mutant mice. Psychopharmacology (Berl) (2006) 1.01
Differential effects of the CRF-R1 antagonist GSK876008 on fear-potentiated, light- and CRF-enhanced startle suggest preferential involvement in sustained vs phasic threat responses. Neuropsychopharmacology (2008) 1.00
Social and structural housing conditions influence the development of a depressive-like phenotype in the learned helplessness paradigm in male mice. Behav Brain Res (2005) 1.00
Circadian expression of clock- and tumor suppressor genes in human oral mucosa. Cell Physiol Biochem (2010) 0.99
Glycine transporter-1 blockade leads to persistently reduced relapse-like alcohol drinking in rats. Biol Psychiatry (2010) 0.99
Fractalkine-upregulated milk-fat globule EGF factor-8 protein in cultured rat microglia. J Neuroimmunol (2005) 0.99
Functional magnetic resonance imaging reveals different neural substrates for the effects of orexin-1 and orexin-2 receptor antagonists. PLoS One (2011) 0.98
Stress triggers anhedonia in rats bred for learned helplessness. Behav Brain Res (2010) 0.97
Altered levels of glutamatergic receptors and Na+/K+ ATPase-α1 in the prefrontal cortex of subjects with schizophrenia. Schizophr Res (2011) 0.97
Importance of NO/cGMP signalling via cGMP-dependent protein kinase II for controlling emotionality and neurobehavioural effects of alcohol. Eur J Neurosci (2004) 0.96
Clock genes running amok. Clock genes and their role in drug addiction and depression. EMBO Rep (2007) 0.96
Cue-induced alcohol-seeking behaviour is reduced by disrupting the reconsolidation of alcohol-related memories. Psychopharmacology (Berl) (2009) 0.96
Reward sensitivity for a palatable food reward peaks during pubertal developmental in rats. Front Behav Neurosci (2010) 0.95
Cocaine-induced dopamine overflow within the nucleus accumbens measured by in vivo microdialysis: a meta-analysis. Synapse (2008) 0.95
Fractionation of spatial memory in GRM2/3 (mGlu2/mGlu3) double knockout mice reveals a role for group II metabotropic glutamate receptors at the interface between arousal and cognition. Neuropsychopharmacology (2011) 0.94
Glucocorticoid receptor and nuclear factor-kappa B interactions in restraint stress-mediated protection against acoustic trauma. Endocrinology (2006) 0.94
Candidate genes for alcohol dependence: animal studies. Alcohol Clin Exp Res (2003) 0.94
Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine. Proc Natl Acad Sci U S A (2008) 0.93
Inhibition of the casein-kinase-1-ε/δ/ prevents relapse-like alcohol drinking. Neuropsychopharmacology (2012) 0.93
Differential involvement of the opioid receptor antagonist naloxone in motivational and hedonic aspects of reward. Behav Brain Res (2009) 0.92
Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts. Biol Psychiatry (2003) 0.92
Loss of the serum response factor in the dopamine system leads to hyperactivity. FASEB J (2010) 0.92
Alcohol self-administration in two rat lines selectively bred for extremes in anxiety-related behavior. Neuropsychopharmacology (2002) 0.92
Structural synaptic elements are differentially regulated in superior temporal cortex of schizophrenia patients. Eur Arch Psychiatry Clin Neurosci (2012) 0.91
Effects of morphine withdrawal on micro-opioid receptor-stimulated guanylyl 5'-[gamma-[35S]thio]-triphosphate autoradiography in rat brain. Eur J Pharmacol (2002) 0.91
The effects of drugs of abuse on clock genes. Drug News Perspect (2008) 0.91
GSK1614343, a novel ghrelin receptor antagonist, produces an unexpected increase of food intake and body weight in rodents and dogs. Neuroendocrinology (2011) 0.91
Neuroimaging evidence of altered fronto-cortical and striatal function after prolonged cocaine self-administration in the rat. Neuropsychopharmacology (2011) 0.90
Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking. Neuropsychopharmacology (2011) 0.90
Incentive learning underlying cocaine-seeking requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons. J Neurosci (2010) 0.90
Genetic variation and brain gene expression in rodent models of alcoholism implications for medication development. Int Rev Neurobiol (2010) 0.90
The effects of lamotrigine on alcohol seeking and relapse. Neuropharmacology (2007) 0.90
The impact of acetylcholinesterase inhibitors on the extracellular acetylcholine concentrations in the adult rat brain: a meta-analysis. Synapse (2012) 0.89
Cluster and meta-analyses on factors influencing stress-induced alcohol drinking and relapse in rodents. Addict Biol (2014) 0.89
Altered hippocampal expression of glutamate receptors and transporters in GRM2 and GRM3 knockout mice. Synapse (2008) 0.88
Ethanol induces expression of the glutamate transporters EAAT1 and EAAT2 in organotypic cortical slice cultures. Alcohol Clin Exp Res (2004) 0.88