Innate IL-17-producing cells: the sentinels of the immune system.

PubWeight™: 6.88‹?› | Rank: Top 1%

🔗 View Article (PMID 20559326)

Published in Nat Rev Immunol on June 18, 2010

Authors

Daniel J Cua1, Cristina M Tato

Author Affiliations

1: Merck Research Laboratories, DNAX Discovery Research, 901 California Avenue, Palo Alto, CA 94304, USA. daniel.cua@spcorp.com

Articles citing this

(truncated to the top 100)

Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol (2013) 7.10

Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol (2011) 6.96

Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature (2011) 6.43

Targeting IL-17 and TH17 cells in chronic inflammation. Nat Rev Drug Discov (2012) 4.70

IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells. Nat Med (2012) 4.38

CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut. Immunity (2010) 4.19

Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus. J Immunol (2011) 3.83

The microbiome in infectious disease and inflammation. Annu Rev Immunol (2012) 3.76

The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells. Immunity (2011) 3.32

The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing. Nat Rev Immunol (2014) 2.82

Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis. J Immunol (2011) 2.53

The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss. Nat Immunol (2012) 2.48

Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice. J Clin Invest (2012) 2.18

Cutting edge: Identification of a motile IL-17-producing gammadelta T cell population in the dermis. J Immunol (2011) 2.16

Autoimmune epididymoorchitis is essential to the pathogenesis of male-specific spondylarthritis in HLA-B27-transgenic rats. Arthritis Rheum (2012) 2.10

Th17 cells in immunity to Candida albicans. Cell Host Microbe (2012) 1.97

MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of RORγ⁺ regulatory T cells. Science (2015) 1.95

Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response. Trends Immunol (2013) 1.94

IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. Nat Immunol (2011) 1.94

Defective neutrophil recruitment in leukocyte adhesion deficiency type I disease causes local IL-17-driven inflammatory bone loss. Sci Transl Med (2014) 1.94

The IL-23-IL-17 axis in inflammatory arthritis. Nat Rev Rheumatol (2015) 1.89

Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2. Nat Immunol (2013) 1.88

Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis. Immunity (2014) 1.87

Recent advances in the IL-17 cytokine family. Curr Opin Immunol (2011) 1.86

Cutaneous immunosurveillance by self-renewing dermal gammadelta T cells. J Exp Med (2011) 1.85

IL-17RA signaling reduces inflammation and mortality during Trypanosoma cruzi infection by recruiting suppressive IL-10-producing neutrophils. PLoS Pathog (2012) 1.84

IL-17 family member cytokines: regulation and function in innate immunity. Cytokine Growth Factor Rev (2010) 1.76

Innate lymphoid cell interactions with microbiota: implications for intestinal health and disease. Immunity (2012) 1.73

Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential. Clin Sci (Lond) (2011) 1.73

The emerging role of IL-17 in the pathogenesis of psoriasis: preclinical and clinical findings. J Invest Dermatol (2012) 1.71

Polyclonal mucosa-associated invariant T cells have unique innate functions in bacterial infection. Infect Immun (2012) 1.69

IL-17 family: cytokines, receptors and signaling. Cytokine (2013) 1.66

Signaling of interleukin-17 family cytokines in immunity and inflammation. Cell Signal (2010) 1.66

Interleukin-17+CD8+ T cells are enriched in the joints of patients with psoriatic arthritis and correlate with disease activity and joint damage progression. Arthritis Rheumatol (2014) 1.66

Th17 cells in cancer: help or hindrance? Carcinogenesis (2011) 1.63

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses. Cell (2015) 1.63

Role of IL-17 and Th17 cells in herpes simplex virus-induced corneal immunopathology. J Immunol (2011) 1.53

The interleukin-17 cytokine family: critical players in host defence and inflammatory diseases. Immunology (2011) 1.53

IL-17 Expression by macrophages is associated with proliferative inflammatory atrophy lesions in prostate cancer patients. Int J Clin Exp Pathol (2011) 1.52

Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice. Proc Natl Acad Sci U S A (2016) 1.50

Innate immune cell-produced IL-17 sustains inflammation in bullous pemphigoid. J Invest Dermatol (2014) 1.47

Epidemiology of stress and asthma: from constricting communities and fragile families to epigenetics. Immunol Allergy Clin North Am (2011) 1.47

Mechanisms of obesity-induced inflammation and insulin resistance: insights into the emerging role of nutritional strategies. Front Endocrinol (Lausanne) (2013) 1.47

Elevating body temperature enhances hematopoiesis and neutrophil recovery after total body irradiation in an IL-1-, IL-17-, and G-CSF-dependent manner. Blood (2012) 1.46

IL-17 and TNF-α sustain neutrophil recruitment during inflammation through synergistic effects on endothelial activation. J Immunol (2012) 1.44

Defining the Roles of IFN-γ and IL-17A in Inflammation and Protection against Helicobacter pylori Infection. PLoS One (2015) 1.43

Thrombospondin-1 production is enhanced by Porphyromonas gingivalis lipopolysaccharide in THP-1 cells. PLoS One (2014) 1.42

Central Role of IL-23 and IL-17 Producing Eosinophils as Immunomodulatory Effector Cells in Acute Pulmonary Aspergillosis and Allergic Asthma. PLoS Pathog (2017) 1.39

Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells. Nat Immunol (2013) 1.38

IL-17 cytokines in immunity and inflammation. Emerg Microbes Infect (2013) 1.37

A comparison of mindfulness-based stress reduction and an active control in modulation of neurogenic inflammation. Brain Behav Immun (2012) 1.35

Activation of aryl hydrocarbon receptor (AhR) leads to reciprocal epigenetic regulation of FoxP3 and IL-17 expression and amelioration of experimental colitis. PLoS One (2011) 1.34

T-helper 17 cell cytokines and interferon type I: partners in crime in systemic lupus erythematosus? Arthritis Res Ther (2014) 1.34

Mechanisms controlling Th17 cytokine expression and host defense. J Leukoc Biol (2011) 1.33

Mucocutaneous candidiasis: the IL-17 pathway and implications for targeted immunotherapy. Arthritis Res Ther (2012) 1.33

The cytokine network of acute HIV infection: a promising target for vaccines and therapy to reduce viral set-point? PLoS Pathog (2011) 1.33

Metabolic control of the Treg/Th17 axis. Immunol Rev (2013) 1.26

IL-17-producing innate lymphoid cells are restricted to mucosal tissues and are depleted in SIV-infected macaques. Mucosal Immunol (2012) 1.26

Subcapsular sinus macrophage fragmentation and CD169+ bleb acquisition by closely associated IL-17-committed innate-like lymphocytes. PLoS One (2012) 1.24

Neutrophil cell surface receptors and their intracellular signal transduction pathways. Int Immunopharmacol (2013) 1.23

IL-17 in obesity and adipogenesis. Cytokine Growth Factor Rev (2010) 1.23

Coordinate regulation of neutrophil homeostasis by liver X receptors in mice. J Clin Invest (2011) 1.23

Neutrophils in innate and adaptive immunity. Semin Immunopathol (2013) 1.23

IL17A genetic variation is associated with altered susceptibility to Gram-positive infection and mortality of severe sepsis. Crit Care (2011) 1.23

Cytokine-induced cytokine production by conventional and innate lymphoid cells. Trends Immunol (2012) 1.22

T cell subsets and their signature cytokines in autoimmune and inflammatory diseases. Cytokine (2014) 1.21

Cross-talk between aryl hydrocarbon receptor and the inflammatory response: a role for nuclear factor-κB. J Biol Chem (2013) 1.21

Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25. Nat Immunol (2012) 1.20

Th17 cells confer long-term adaptive immunity to oral mucosal Candida albicans infections. Mucosal Immunol (2012) 1.20

Evidence for anti-inflammatory effects of C5a on the innate IL-17A/IL-23 axis. FASEB J (2011) 1.19

Transcription of Il17 and Il17f is controlled by conserved noncoding sequence 2. Immunity (2012) 1.18

TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic? Front Immunol (2012) 1.17

Review: The interleukin-23/interleukin-17 axis in spondyloarthritis pathogenesis: Th17 and beyond. Arthritis Rheumatol (2014) 1.17

The deubiquitinase A20 mediates feedback inhibition of interleukin-17 receptor signaling. Sci Signal (2013) 1.16

Oral-resident natural Th17 cells and γδ T cells control opportunistic Candida albicans infections. J Exp Med (2014) 1.14

Regulation and function of innate and adaptive interleukin-17-producing cells. EMBO Rep (2012) 1.14

B cells regulate neutrophilia during Mycobacterium tuberculosis infection and BCG vaccination by modulating the interleukin-17 response. PLoS Pathog (2013) 1.14

Cutting edge: Generation of colitogenic Th17 CD4 T cells is enhanced by IL-17+ γδ T cells. J Immunol (2011) 1.13

IL-22 is produced by innate lymphoid cells and limits inflammation in allergic airway disease. PLoS One (2011) 1.13

Paneth cell-derived interleukin-17A causes multiorgan dysfunction after hepatic ischemia and reperfusion injury. Hepatology (2011) 1.12

Th17 cells and IL-17 in protective immunity to vaginal candidiasis. PLoS One (2011) 1.12

Innate and adaptive immune responses against Staphylococcus aureus skin infections. Semin Immunopathol (2011) 1.12

Bispecific T-cells expressing polyclonal repertoire of endogenous γδ T-cell receptors and introduced CD19-specific chimeric antigen receptor. Mol Ther (2013) 1.09

Th17 cell accumulation is decreased during chronic experimental colitis by (n-3) PUFA in Fat-1 mice. J Nutr (2011) 1.08

CCR6 is required for epidermal trafficking of γδ-T cells in an IL-23-induced model of psoriasiform dermatitis. J Invest Dermatol (2012) 1.08

Action of RORs and their ligands in (patho)physiology. Trends Endocrinol Metab (2012) 1.08

Differential role of the interleukin-17 axis and neutrophils in resolution of inhalational anthrax. Infect Immun (2011) 1.07

Immunity and immune suppression in human ovarian cancer. Immunotherapy (2011) 1.07

Re-establishing immunological self-tolerance in autoimmune disease. Nat Med (2012) 1.06

Neutrophils in cancer: neutral no more. Nat Rev Cancer (2016) 1.06

IL-17 signaling in host defense against Candida albicans. Immunol Res (2011) 1.06

Staphylococcus aureus alpha toxin suppresses effective innate and adaptive immune responses in a murine dermonecrosis model. PLoS One (2013) 1.06

Role of interleukin 23 signaling in Clostridium difficile colitis. J Infect Dis (2013) 1.05

Transcriptomic and innate immune responses to Yersinia pestis in the lymph node during bubonic plague. Infect Immun (2010) 1.05

Induction of type I interferon signaling by Pseudomonas aeruginosa is diminished in cystic fibrosis epithelial cells. Am J Respir Cell Mol Biol (2012) 1.05

Loss and dysregulation of Th17 cells during HIV infection. Clin Dev Immunol (2013) 1.04

Experimental abdominal aortic aneurysm formation is mediated by IL-17 and attenuated by mesenchymal stem cell treatment. Circulation (2012) 1.04

Marking and quantifying IL-17A-producing cells in vivo. PLoS One (2012) 1.04

Early MyD88-dependent induction of interleukin-17A expression during Salmonella colitis. Infect Immun (2011) 1.04

Interleukin-23-mediated inflammation in Pseudomonas aeruginosa pulmonary infection. Infect Immun (2011) 1.04

Articles cited by this

(truncated to the top 100)

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell (2006) 33.94

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol (2005) 30.22

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity (2006) 29.29

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med (2005) 28.73

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science (2006) 27.49

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol (2005) 27.17

IL-17 and Th17 Cells. Annu Rev Immunol (2009) 23.02

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature (2003) 22.89

IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature (2007) 16.59

Interleukin-17 family members and inflammation. Immunity (2004) 16.16

IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol (2007) 14.99

Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med (2003) 14.60

Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem (2002) 14.34

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med (2006) 13.74

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med (2008) 12.68

Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity (2007) 12.12

IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol (2007) 10.71

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature (2008) 10.15

Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science (2006) 9.95

Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature (2008) 9.32

IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med (2008) 9.05

T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med (1996) 8.59

An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat Immunol (2003) 8.23

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nature (2008) 8.22

Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. Immunity (2009) 8.20

Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol (2000) 6.62

IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. Immunity (2001) 6.56

Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. Immunity (2008) 6.49

Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science (1999) 6.49

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature (2010) 6.44

Structure and signalling in the IL-17 receptor family. Nat Rev Immunol (2009) 6.38

Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J Exp Med (2005) 6.37

Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity (2009) 6.24

Enteric defensins are essential regulators of intestinal microbial ecology. Nat Immunol (2009) 6.10

Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. Immunity (2009) 6.05

Th17 and regulatory T cells in mediating and restraining inflammation. Cell (2010) 5.89

Requirement for RORgamma in thymocyte survival and lymphoid organ development. Science (2000) 5.78

Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity (2006) 5.40

Th17 cell differentiation: the long and winding road. Immunity (2008) 5.40

IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection. J Immunol (2006) 5.27

Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J Exp Med (2008) 4.95

Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells. Nat Immunol (2008) 4.94

Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin. Nat Immunol (2008) 4.78

IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem (2007) 4.77

Interleukin-17 and lung host defense against Klebsiella pneumoniae infection. Am J Respir Cell Mol Biol (2001) 4.56

Organogenesis of lymphoid tissues. Nat Rev Immunol (2003) 4.53

New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25. J Immunol (2002) 4.48

Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia. J Exp Med (2007) 4.47

Cutting edge: roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection. J Immunol (2003) 4.45

IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacille Calmette-Guerin infection. J Immunol (2007) 4.23

Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma. Immunity (2008) 4.21

IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger. J Immunol (2003) 4.13

Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production. J Immunol (2007) 4.11

Developing lymph nodes collect CD4+CD3- LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells. Immunity (1997) 4.10

In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells. J Exp Med (2008) 3.85

MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection. J Exp Med (2007) 3.79

CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. J Immunol (1993) 3.74

Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice. Clin Immunol (2004) 3.41

IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest (2010) 3.40

Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells. Proc Natl Acad Sci U S A (2008) 3.34

The roles of IL-17A in inflammatory immune responses and host defense against pathogens. Immunol Rev (2008) 3.32

IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury. J Clin Invest (2009) 3.30

Gammadelta T cells and the lymphoid stress-surveillance response. Immunity (2009) 3.23

Th17 cells and mucosal host defense. Semin Immunol (2007) 3.17

Interleukin-22-producing natural killer cells and lymphoid tissue inducer-like cells in mucosal immunity. Immunity (2009) 3.02

CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets. Nat Immunol (2009) 3.00

Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens. Immunology (2009) 2.92

Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion. J Immunol (2008) 2.90

IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors. J Exp Med (2010) 2.87

Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis. Hum Genet (2007) 2.78

Comparison of ustekinumab and etanercept for moderate-to-severe psoriasis. N Engl J Med (2010) 2.74

Crohn's disease and the NOD2 gene: a role for paneth cells. Gastroenterology (2003) 2.72

Protection of the intestinal mucosa by intraepithelial gamma delta T cells. Proc Natl Acad Sci U S A (2002) 2.69

Interleukin-17/interleukin-17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection. Infect Immun (2005) 2.66

Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells. J Exp Med (2010) 2.64

Exacerbation of collagen-induced arthritis by oligoclonal, IL-17-producing gamma delta T cells. J Immunol (2007) 2.62

Dual nature of the adaptive immune system in lampreys. Nature (2009) 2.53

An anti-inflammatory role for gamma delta T lymphocytes in acquired immunity to Mycobacterium tuberculosis. J Immunol (1997) 2.46

Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis. Immunity (2010) 2.32

The aryl hydrocarbon receptor in immunity. Trends Immunol (2009) 2.19

Claudins regulate the intestinal barrier in response to immune mediators. Gastroenterology (2000) 2.17

RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells. Immunity (1998) 2.15

Transcriptional regulatory networks in Th17 cell differentiation. Curr Opin Immunol (2009) 2.12

Dioxins: an overview. Environ Res (2006) 2.11

Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. J Immunol (2009) 1.93

The IL23R Arg381Gln non-synonymous polymorphism confers susceptibility to ankylosing spondylitis. Ann Rheum Dis (2008) 1.92

IL-7 receptor alpha+ CD3(-) cells in the embryonic intestine induces the organizing center of Peyer's patches. Int Immunol (1999) 1.91

Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions. Proc Natl Acad Sci U S A (1992) 1.88

Critical role of ROR-γt in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation. Proc Natl Acad Sci U S A (2008) 1.87

CCR6 and NK1.1 distinguish between IL-17A and IFN-gamma-producing gammadelta effector T cells. Eur J Immunol (2009) 1.83

Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells. Immunity (2007) 1.79

Mixed results with modulation of TH-17 cells in human autoimmune diseases. Nat Immunol (2009) 1.73

Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). Nat Genet (2010) 1.72

Microbial colonization drives expansion of IL-1 receptor 1-expressing and IL-17-producing gamma/delta T cells. Cell Host Microbe (2010) 1.71

IL-17 produced by Paneth cells drives TNF-induced shock. J Exp Med (2008) 1.71

Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells. Immunity (2002) 1.70

Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis. Arthritis Rheum (2009) 1.69

Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells. J Interferon Cytokine Res (1996) 1.65

Structural basis of receptor sharing by interleukin 17 cytokines. Nat Immunol (2009) 1.60

Interleukin 17-producing gamma delta T cells increased in patients with active pulmonary tuberculosis. Cell Mol Immunol (2008) 1.58

Articles by these authors

Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity (2007) 12.12

TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat Immunol (2007) 11.14

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol (2006) 7.89

Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling. Nature (2010) 7.50

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat Immunol (2009) 6.74

Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J Exp Med (2008) 4.95

Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum (2007) 3.06

IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells. J Immunol (2009) 2.39

Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals. J Exp Med (2007) 1.83

Immunology: what does it mean to be just 17? Nature (2006) 1.39

Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii. J Exp Med (2008) 1.33

How the immune system talks to itself: the varied role of synapses. Immunol Rev (2013) 0.92

Alternative lifestyles of T cells. Nat Immunol (2008) 0.80

Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection. medRxiv (2020) 0.75