Published in Immunity on August 01, 2006
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity (2008) 10.55
Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med (2006) 7.76
Inflammatory bowel disease. Annu Rev Immunol (2010) 7.10
Innate IL-17-producing cells: the sentinels of the immune system. Nat Rev Immunol (2010) 6.88
Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature (2010) 6.44
IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J Clin Invest (2008) 6.17
The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling. Nat Immunol (2010) 6.02
Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J Exp Med (2008) 5.25
Dendritic cells in intestinal immune regulation. Nat Rev Immunol (2008) 4.20
CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut. Immunity (2010) 4.19
The microbiome in infectious disease and inflammation. Annu Rev Immunol (2012) 3.76
Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytes. Immunity (2010) 3.59
Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity (2010) 3.52
Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology (2011) 3.52
Interleukin-23 drives intestinal inflammation through direct activity on T cells. Immunity (2010) 3.51
The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin Exp Immunol (2007) 3.51
Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells. Immunity (2013) 3.51
Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis. Immunity (2008) 3.40
Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum (2007) 3.06
Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis. J Clin Invest (2008) 3.00
Intestinal bacteria and the regulation of immune cell homeostasis. Annu Rev Immunol (2010) 2.85
Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues. Nat Immunol (2013) 2.82
Th17 cells: effector T cells with inflammatory properties. Semin Immunol (2007) 2.81
E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis. Immunity (2010) 2.78
IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease. J Exp Med (2011) 2.74
γδ T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism. Immunity (2010) 2.54
An antibiotic-responsive mouse model of fulminant ulcerative colitis. PLoS Med (2008) 2.50
The light and dark sides of intestinal intraepithelial lymphocytes. Nat Rev Immunol (2011) 2.46
Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells. J Exp Med (2008) 2.41
The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases. Cell Mol Immunol (2011) 2.26
Dendritic cells and cytokines in human inflammatory and autoimmune diseases. Cytokine Growth Factor Rev (2008) 2.13
IL-17 contributes to CD4-mediated graft-versus-host disease. Blood (2008) 2.07
Securing the immune tightrope: mononuclear phagocytes in the intestinal lamina propria. Nat Rev Immunol (2010) 2.02
Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of inflammatory bowel disease. Gastroenterology (2010) 2.01
GM-CSF mediates autoimmunity by enhancing IL-6-dependent Th17 cell development and survival. J Exp Med (2008) 1.99
The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells. Immunity (2012) 1.97
Dry eye as a mucosal autoimmune disease. Int Rev Immunol (2013) 1.85
LRRK2 is involved in the IFN-gamma response and host response to pathogens. J Immunol (2010) 1.85
Dendritic cells in intestinal homeostasis and disease. J Clin Invest (2009) 1.83
The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin. Annu Rev Pathol (2012) 1.80
Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. Nat Immunol (2011) 1.77
The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans. PLoS One (2011) 1.71
Interleukin-22: immunobiology and pathology. Annu Rev Immunol (2015) 1.60
GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science (2013) 1.58
The IL23 axis plays a key role in the pathogenesis of IBD. Gut (2007) 1.58
Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease. World J Gastroenterol (2007) 1.56
Regulation of interleukin-12/interleukin-23 production and the T-helper 17 response in humans. Immunol Rev (2008) 1.54
Experimental inflammatory bowel disease: insights into the host-microbiota dialog. Immunity (2011) 1.53
Inflammatory bowel disease, past, present and future: lessons from animal models. J Gastroenterol (2008) 1.48
Current and emerging therapeutic targets for IBD. Nat Rev Gastroenterol Hepatol (2017) 1.42
Th17 cells induce colitis and promote Th1 cell responses through IL-17 induction of innate IL-12 and IL-23 production. J Immunol (2011) 1.39
Both Th1 and Th17 are immunopathogenic but differ in other key biological activities. J Immunol (2008) 1.36
Mechanisms controlling Th17 cytokine expression and host defense. J Leukoc Biol (2011) 1.33
IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases. Nat Med (2015) 1.32
Adaptive immunity in the host-microbiota dialog. Mucosal Immunol (2010) 1.31
IL-17 producing CD4+ T cells mediate accelerated ischemia/reperfusion-induced injury in autoimmunity-prone mice. Clin Immunol (2008) 1.24
Systemic control of plasmacytoid dendritic cells by CD8+ T cells and commensal microbiota. J Immunol (2008) 1.24
Interleukin-23 secretion by donor antigen-presenting cells is critical for organ-specific pathology in graft-versus-host disease. Blood (2008) 1.24
Cutting edge: IFN-gamma is a negative regulator of IL-23 in murine macrophages and experimental colitis. J Immunol (2010) 1.23
IL-27 regulates homeostasis of the intestinal CD4+ effector T cell pool and limits intestinal inflammation in a murine model of colitis. J Immunol (2009) 1.21
Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome protein. Gastroenterology (2007) 1.21
CD4(+) T-cell subsets in intestinal inflammation. Immunol Rev (2013) 1.17
Interleukin-23 and T helper 17-type responses in intestinal inflammation: from cytokines to T-cell plasticity. Immunology (2011) 1.17
Review: The interleukin-23/interleukin-17 axis in spondyloarthritis pathogenesis: Th17 and beyond. Arthritis Rheumatol (2014) 1.17
STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation. Cell Res (2014) 1.15
Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity. J Clin Invest (2015) 1.14
Deletion of Foxp3+ regulatory T cells in genetically targeted mice supports development of intestinal inflammation. BMC Gastroenterol (2012) 1.13
Molecular control of steady-state dendritic cell maturation and immune homeostasis. Annu Rev Immunol (2013) 1.13
Characterising the mucosal and systemic immune responses to experimental human hookworm infection. PLoS Pathog (2012) 1.13
Dependence of intestinal granuloma formation on unique myeloid DC-like cells. J Clin Invest (2007) 1.12
Special regulatory T-cell review: Regulatory T cells and the intestinal tract--patrolling the frontier. Immunology (2008) 1.12
Unique and redundant functions of NKp46+ ILC3s in models of intestinal inflammation. J Exp Med (2015) 1.11
Development, regulation and functional capacities of Th17 cells. Semin Immunopathol (2010) 1.10
Interleukin-23 and Th17 cells in the control of gut inflammation. Mediators Inflamm (2009) 1.10
Advances in the pathogenesis and treatment of IBD. Clin Immunol (2009) 1.10
Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis. Proc Natl Acad Sci U S A (2015) 1.09
Innate and adaptive immunity in inflammatory bowel disease. World J Gastroenterol (2011) 1.09
IL-23R+ innate lymphoid cells induce colitis via interleukin-22-dependent mechanism. Mucosal Immunol (2013) 1.09
Inflammatory pathways of importance for management of inflammatory bowel disease. World J Gastroenterol (2014) 1.09
Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance. Nat Commun (2011) 1.08
IL-23 signaling enhances Th2 polarization and regulates allergic airway inflammation. Cell Res (2009) 1.08
Animal models of IBD: linkage to human disease. Curr Opin Pharmacol (2010) 1.08
Interleukin-23: as a drug target for autoimmune inflammatory diseases. Immunology (2012) 1.07
Impaired Bcl3 up-regulation leads to enhanced lipopolysaccharide-induced interleukin (IL)-23P19 gene expression in IL-10(-/-) mice. J Biol Chem (2008) 1.04
An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity. Mucosal Immunol (2010) 1.03
Inflammatory bowel disease: genetic and epidemiologic considerations. World J Gastroenterol (2008) 1.03
Fine-tuning of dendritic cell biology by the TNF superfamily. Nat Rev Immunol (2012) 1.02
c-Rel is essential for the development of innate and T cell-induced colitis. J Immunol (2008) 1.00
Dendritic cells: a critical player in cancer therapy? J Immunother (2008) 0.99
Pattern recognition receptor and autophagy gene variants are associated with development of antimicrobial antibodies in Crohn's disease. Inflamm Bowel Dis (2012) 0.98
Update on biologic pathways in inflammatory bowel disease and their therapeutic relevance. J Gastroenterol (2012) 0.98
Regulation of TH17 cells in the mucosal surfaces. J Allergy Clin Immunol (2009) 0.97
Intestinal dendritic cells in the pathogenesis of inflammatory bowel disease. World J Gastroenterol (2011) 0.96
Blocking TH17-polarizing cytokines by histone deacetylase inhibitors in vitro and in vivo. J Leukoc Biol (2008) 0.96
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners. Semin Immunopathol (2009) 0.96
IL-23 Contributes to Control of Chronic Helicobacter Pylori Infection and the Development of T Helper Responses in a Mouse Model. Front Immunol (2012) 0.94
Interleukin-17 regulation: an attractive therapeutic approach for asthma. Respir Res (2010) 0.93
The interleukin-23/interleukin-17 axis in spondyloarthritis. Curr Opin Rheumatol (2008) 0.93
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell (2006) 33.94
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med (2005) 28.73
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med (2007) 15.17
Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med (2003) 14.60
Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol (2007) 12.76
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest (2006) 11.89
TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat Immunol (2007) 11.14
Innate lymphoid cells--a proposal for uniform nomenclature. Nat Rev Immunol (2013) 7.94
Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med (2006) 7.76
Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling. Nature (2010) 7.50
Understanding the IL-23-IL-17 immune pathway. Trends Immunol (2005) 6.79
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat Immunol (2009) 6.74
Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature (2010) 6.44
Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature (2011) 6.43
Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. Immunity (2009) 6.05
CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J Exp Med (2003) 6.00
Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol (2011) 5.98
Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J Immunol (2003) 5.94
IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. J Exp Med (2006) 5.76
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med (2006) 5.63
Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level. Eur J Immunol (2005) 5.43
Th17 cell differentiation: the long and winding road. Immunity (2008) 5.40
In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J Exp Med (2002) 5.28
Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu Rev Immunol (2007) 4.90
IL-12 and IL-23: master regulators of innate and adaptive immunity. Immunol Rev (2004) 4.78
Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. J Clin Invest (2006) 4.77
Essential role for CD103 in the T cell-mediated regulation of experimental colitis. J Exp Med (2005) 4.47
Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation. Immunol Rev (2006) 4.40
IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells. Nat Med (2012) 4.38
T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells. J Exp Med (2005) 4.28
Dendritic cells in intestinal immune regulation. Nat Rev Immunol (2008) 4.20
Characterization of Foxp3+CD4+CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis. J Immunol (2006) 4.04
Regulatory T cells and intestinal homeostasis. Immunol Rev (2005) 3.82
Regulatory lymphocytes and intestinal inflammation. Annu Rev Immunol (2009) 3.80
Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans. J Exp Med (2008) 3.74
IL-25 regulates Th17 function in autoimmune inflammation. J Exp Med (2007) 3.69
Nod2 is required for the regulation of commensal microbiota in the intestine. Proc Natl Acad Sci U S A (2009) 3.58
Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity (2010) 3.52
Interleukin-23 drives intestinal inflammation through direct activity on T cells. Immunity (2010) 3.51
Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo. J Immunol (2006) 3.42
Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis. Immunity (2008) 3.40
Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract. J Exp Med (2006) 3.36
Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury. Nat Med (2009) 3.32
Regulatory T cells reinforce intestinal homeostasis. Immunity (2009) 3.27
E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis. Immunity (2010) 2.78
IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease. J Exp Med (2011) 2.74
Dysregulated hematopoietic stem and progenitor cell activity promotes interleukin-23-driven chronic intestinal inflammation. Immunity (2012) 2.72
Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine. J Exp Med (2008) 2.63
Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1. Immunity (2007) 2.61
Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population. Proc Natl Acad Sci U S A (2008) 2.57
Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model. J Exp Med (2013) 2.50
Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling. J Exp Med (2009) 2.41
IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells. J Immunol (2009) 2.39
IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12. J Immunol (2004) 2.37
Emerging challenges in regulatory T cell function and biology. Science (2007) 2.11
IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells. J Exp Med (2012) 2.11
Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: control by CD4+ regulatory T cells and IL-10. J Immunol (2003) 2.08
Why caregivers of people with dementia and memory loss don't use services. Int J Geriatr Psychiatry (2005) 2.06
Expression of Toll-like receptor 2 (TLR2), TLR4, and CD14 in biopsy samples of patients with inflammatory bowel diseases: upregulated expression of TLR2 in terminal ileum of patients with ulcerative colitis. J Histochem Cytochem (2007) 2.06
The interleukin-23 axis in intestinal inflammation. Immunol Rev (2008) 2.06
Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of inflammatory bowel disease. Gastroenterology (2010) 2.01
Depletion of CD25+ regulatory cells uncovers immune responses to shared murine tumor rejection antigens. Eur J Immunol (2002) 1.88
Telomere dysfunction causes sustained inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2011) 1.87
Foxp3(+) regulatory T cells promote T helper 17 cell development in vivo through regulation of interleukin-2. Immunity (2011) 1.87
Association of the R92Q TNFRSF1A mutation and extracranial deep vein thrombosis in patients with Behçet's disease. Arthritis Rheum (2005) 1.85
Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells. Blood (2011) 1.83
Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice. Cancer Immun (2002) 1.80
Epidermal growth factor reduces the development of necrotizing enterocolitis in a neonatal rat model. Am J Physiol Gastrointest Liver Physiol (2002) 1.75
Plasma adiponectin levels are associated with insulin resistance, but do not predict future risk of coronary heart disease in women. J Clin Endocrinol Metab (2005) 1.74
Segmented filamentous bacteria in a defined bacterial cocktail induce intestinal inflammation in SCID mice reconstituted with CD45RBhigh CD4+ T cells. Inflamm Bowel Dis (2007) 1.73
Microbiota, disease, and back to health: a metastable journey. Sci Transl Med (2012) 1.70
The link between IL-23 and Th17 cell-mediated immune pathologies. Semin Immunol (2007) 1.68
Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically. Cancer Cell (2013) 1.67
IL-17 regulates adipogenesis, glucose homeostasis, and obesity. J Immunol (2010) 1.67
Critical influence of natural regulatory CD25+ T cells on the fate of allografts in the absence of immunosuppression. Transplantation (2005) 1.66
The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. Immunity (2010) 1.64
OX40 is required for regulatory T cell-mediated control of colitis. J Exp Med (2010) 1.62