Published in JAMA on June 23, 2010
Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12,064 survivors of myocardial infarction: a double-blind randomised trial. Lancet (2010) 4.23
Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals. Am J Clin Nutr (2014) 2.81
Influence of nitrous oxide anesthesia, B-vitamins, and MTHFR gene polymorphisms on perioperative cardiac events: the vitamins in nitrous oxide (VINO) randomized trial. Anesthesiology (2013) 2.39
Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50,000 individuals. Lancet (2013) 2.37
Reactive oxygen species in cardiovascular disease. Free Radic Biol Med (2011) 2.29
Fixed-dose combination therapy for the prevention of cardiovascular disease. Cochrane Database Syst Rev (2014) 2.24
Paradoxical absence of a prothrombotic phenotype in a mouse model of severe hyperhomocysteinemia. Blood (2011) 2.02
Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial. BMJ (2010) 1.89
Novel Biomarker of Oxidative Stress Is Associated With Risk of Death in Patients With Coronary Artery Disease. Circulation (2015) 1.69
Cancer risk with folic acid supplements: a systematic review and meta-analysis. BMJ Open (2012) 1.20
Limitations of observational evidence: implications for evidence-based dietary recommendations. Adv Nutr (2014) 1.19
Integrated stress response modulates cellular redox state via induction of cystathionine γ-lyase: cross-talk between integrated stress response and thiol metabolism. J Biol Chem (2012) 1.10
Combined methylmalonic acidemia and homocystinuria, cblC type. II. Complications, pathophysiology, and outcomes. J Inherit Metab Dis (2011) 1.06
Randomized multicenter investigation of folate plus vitamin B12 supplementation in schizophrenia. JAMA Psychiatry (2013) 1.02
Homocysteine and vascular disease: review of published results of the homocysteine-lowering trials. J Inherit Metab Dis (2010) 0.98
Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism and cognitive impairment: the health in men study. Mol Psychiatry (2011) 0.97
Effect of folic acid supplementation in pregnancy on preeclampsia: the folic acid clinical trial study. J Pregnancy (2013) 0.89
Micronutrient intake in relation to all-cause mortality in a prospective Danish cohort. Food Nutr Res (2012) 0.89
Effect of folic acid supplementation on cardiovascular outcomes: a systematic review and meta-analysis. PLoS One (2011) 0.89
Effect of long-term supplementation with folic acid and B vitamins on risk of depression in older women. Br J Psychiatry (2015) 0.85
Press releases issued by supplements industry organisations and non-industry organisations in response to publication of clinical research findings: a case-control study. PLoS One (2014) 0.82
Palm tocotrienol-rich fraction improves vascular proatherosclerotic changes in hyperhomocysteinemic rats. Evid Based Complement Alternat Med (2013) 0.82
Dietary supplements and disease prevention - a global overview. Nat Rev Endocrinol (2016) 0.81
Heme-dependent Metabolite Switching Regulates H2S Synthesis in Response to Endoplasmic Reticulum (ER) Stress. J Biol Chem (2016) 0.81
Water-soluble vitamins in people with low glomerular filtration rate or on dialysis: a review. Semin Dial (2013) 0.80
MTHFR C677T genotype and cardiovascular risk in a general population without mandatory folic acid fortification. Eur J Nutr (2014) 0.80
Effect of B-vitamin supplementation on stroke: a meta-analysis of randomized controlled trials. PLoS One (2013) 0.80
Managing cardiovascular risk in people with chronic kidney disease: a review of the evidence from randomized controlled trials. Ther Adv Chronic Dis (2011) 0.79
Activation of transsulfuration pathway by salvianolic acid a treatment: a homocysteine-lowering approach with beneficial effects on redox homeostasis in high-fat diet-induced hyperlipidemic rats. Nutr Metab (Lond) (2013) 0.79
Folic acid supplements and colorectal cancer risk: meta-analysis of randomized controlled trials. Sci Rep (2015) 0.79
Vitamin composition of ethnic foods commonly consumed in Europe. Food Nutr Res (2012) 0.79
Effect of B vitamin (folate, B6, and B12) supplementation on osteoporotic fracture and bone turnover markers: a meta-analysis. Med Sci Monit (2015) 0.78
Dietary methionine restriction in mice elicits an adaptive cardiovascular response to hyperhomocysteinemia. Sci Rep (2015) 0.78
Chronic hyperhomocysteinemia causes vascular remodelling by instigating vein phenotype in artery. Arch Physiol Biochem (2011) 0.78
Low-dose B vitamins supplementation ameliorates cardiovascular risk: a double-blind randomized controlled trial in healthy Chinese elderly. Eur J Nutr (2014) 0.78
Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc (2016) 0.78
A review of psoriasis, a known risk factor for cardiovascular disease and its impact on folate and homocysteine metabolism. J Nutr Metab (2012) 0.78
Rabbiteye blueberry prevents osteoporosis in ovariectomized rats. J Orthop Surg Res (2014) 0.78
Homocysteine-induced attenuation of vascular endothelium-dependent hyperalgesia in the rat. Neuroscience (2014) 0.77
Prognostic Value of Elevated Homocysteine Levels in Korean Patients with Coronary Artery Disease: A Propensity Score Matched Analysis. Korean Circ J (2016) 0.77
Remodeling in vein expresses arterial phenotype in hyperhomocysteinemia. Int J Physiol Pathophysiol Pharmacol (2011) 0.76
Update on the NCEP ATP-III emerging cardiometabolic risk factors. BMC Med (2014) 0.76
Herbal, vitamin, and mineral supplement use in patients enrolled in a cardiac rehabilitation program. J Cardiopulm Rehabil Prev (2012) 0.76
Efficacy of Supplementation with B Vitamins for Stroke Prevention: A Network Meta-Analysis of Randomized Controlled Trials. PLoS One (2015) 0.76
Association between B vitamins supplementation and risk of cardiovascular outcomes: a cumulative meta-analysis of randomized controlled trials. PLoS One (2014) 0.76
Predictors of residual cardiovascular risk in patients on statin therapy for primary prevention. Cardiology (2011) 0.76
Association of MTHFR C677T Genotype With Ischemic Stroke Is Confined to Cerebral Small Vessel Disease Subtype. Stroke (2016) 0.76
Mendelian randomisation study of the associations of vitamin B12 and folate genetic risk scores with blood pressure and fasting serum lipid levels in three Danish population-based studies. Eur J Clin Nutr (2016) 0.75
Large placebo-controlled RCT in myocardial infarction survivors finds that daily folic acid and vitamin B12 have no effect on risk of major vascular event. Evid Based Med (2010) 0.75
Effects of folic acid plus vitamin B12 vs placebo in myocardial infarction survivors. JAMA (2010) 0.75
Reduced folate and serum vitamin metabolites in patients with rectal carcinoma: an open-label feasibility study of pemetrexed with folic acid and vitamin B12 supplementation. Anticancer Drugs (2016) 0.75
Acute ascorbic acid infusion increases left ventricular diastolic function in postmenopausal women. Maturitas (2016) 0.75
Niacin or ezetimibe for patients with, or at risk of coronary heart disease. Clin Med Insights Cardiol (2010) 0.75
Deficiency of superoxide dismutase promotes cerebral vascular hypertrophy and vascular dysfunction in hyperhomocysteinemia. PLoS One (2017) 0.75
Optimum dose of vitamin D for disease prevention in older people: BEST-D trial of vitamin D in primary care. Osteoporos Int (2016) 0.75
The association between B vitamins supplementation and adverse cardiovascular events: a meta-analysis. Int J Clin Exp Med (2014) 0.75
Effect of vitamin B supplementation on cancer incidence, death due to cancer, and total mortality: A PRISMA-compliant cumulative meta-analysis of randomized controlled trials. Medicine (Baltimore) (2016) 0.75
Homocysteine-reducing B vitamins and ischemic heart disease: a separate-sample Mendelian randomization analysis. Eur J Clin Nutr (2016) 0.75
Prevention: B vitamins and CVD--failure to find a simple solution. Nat Rev Cardiol (2010) 0.75
Fixed-dose combination therapy for the prevention of cardiovascular disease. Cochrane Database Syst Rev (2012) 0.75
Association of TCN2 rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies. Am J Clin Nutr (2017) 0.75
Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet (2002) 40.37
Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet (2009) 26.09
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83
Mortality in relation to smoking: 50 years' observations on male British doctors. BMJ (2004) 24.88
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med (2008) 19.76
2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens (2013) 18.17
Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet (2007) 15.27
Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med (2013) 13.92
MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial. Lancet (2003) 13.69
Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet (2009) 13.64
2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J (2013) 12.73
C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Lancet (2009) 11.81
Major lipids, apolipoproteins, and risk of vascular disease. JAMA (2009) 10.58
A nationally representative case-control study of smoking and death in India. N Engl J Med (2008) 10.21
Effects of extended-release niacin with laropiprant in high-risk patients. N Engl J Med (2014) 9.25
Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies. Lancet (2011) 9.07
Genetic variants associated with Lp(a) lipoprotein level and coronary disease. N Engl J Med (2009) 8.73
Adult and child malaria mortality in India: a nationally representative mortality survey. Lancet (2010) 7.89
21st-century hazards of smoking and benefits of cessation in the United States. N Engl J Med (2013) 7.77
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA (2005) 7.35
The 21st century hazards of smoking and benefits of stopping: a prospective study of one million women in the UK. Lancet (2012) 7.28
Vitamin A supplementation every 6 months with retinol in 1 million pre-school children in north India: DEVTA, a cluster-randomised trial. Lancet (2013) 7.04
Smoking and mortality from tuberculosis and other diseases in India: retrospective study of 43000 adult male deaths and 35000 controls. Lancet (2003) 6.58
Meta-analysis of breast cancer outcomes in adjuvant trials of aromatase inhibitors versus tamoxifen. J Clin Oncol (2009) 6.51
Tobacco use in 3 billion individuals from 16 countries: an analysis of nationally representative cross-sectional household surveys. Lancet (2012) 6.49
Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals. Arch Intern Med (2010) 6.48
Blood pressure-lowering treatment based on cardiovascular risk: a meta-analysis of individual patient data. Lancet (2014) 6.23
Unravelling the fetal origins hypothesis: is there really an inverse association between birthweight and subsequent blood pressure? Lancet (2002) 5.91
Social inequalities in male mortality, and in male mortality from smoking: indirect estimation from national death rates in England and Wales, Poland, and North America. Lancet (2006) 5.70
Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality. JAMA (2009) 5.63
Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA (2005) 5.60
Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA (2009) 5.32
Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20536 people with cerebrovascular disease or other high-risk conditions. Lancet (2004) 5.19
Prospective study of one million deaths in India: rationale, design, and validation results. PLoS Med (2005) 5.05
Use of ramipril in preventing stroke: double blind randomised trial. BMJ (2002) 4.91
10-year stroke prevention after successful carotid endarterectomy for asymptomatic stenosis (ACST-1): a multicentre randomised trial. Lancet (2010) 4.73
Urinary sodium and potassium excretion and risk of cardiovascular events. JAMA (2011) 4.68
Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents. Lancet (2016) 4.49
Lipoprotein-associated phospholipase A(2) and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies. Lancet (2010) 4.46
Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12,064 survivors of myocardial infarction: a double-blind randomised trial. Lancet (2010) 4.23
Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: prospective cohort study of about 300,000 women in US SEER cancer registries. Lancet Oncol (2005) 4.21
Cost-effectiveness of simvastatin in people at different levels of vascular disease risk: economic analysis of a randomised trial in 20,536 individuals. Lancet (2005) 4.20
Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p. Hum Mol Genet (2007) 4.09
Alemtuzumab-based induction treatment versus basiliximab-based induction treatment in kidney transplantation (the 3C Study): a randomised trial. Lancet (2014) 4.05
Association of apolipoprotein E genotypes with lipid levels and coronary risk. JAMA (2007) 4.03
Alcohol and cause-specific mortality in Russia: a retrospective case-control study of 48,557 adult deaths. Lancet (2009) 4.01
New models for large prospective studies: is there a better way? Am J Epidemiol (2012) 3.85
Effects of blood pressure reduction in mild hypertension: a systematic review and meta-analysis. Ann Intern Med (2014) 3.81
Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174,000 participants in 27 randomised trials. Lancet (2015) 3.79
Principal results of the Controlled Onset Verapamil Investigation of Cardiovascular End Points (CONVINCE) trial. JAMA (2003) 3.71
Global effects of smoking, of quitting, and of taxing tobacco. N Engl J Med (2014) 3.64
Alcohol poisoning is a main determinant of recent mortality trends in Russia: evidence from a detailed analysis of mortality statistics and autopsies. Int J Epidemiol (2008) 3.56
UK cancer survival statistics. BMJ (2010) 3.44
Analyses of cancer data from three ezetimibe trials. N Engl J Med (2008) 3.44
Stages of the cigarette epidemic on entering its second century. Tob Control (2012) 2.98
Population deworming every 6 months with albendazole in 1 million pre-school children in North India: DEVTA, a cluster-randomised trial. Lancet (2013) 2.95
Lipids and lipoproteins and risk of different vascular events in the MRC/BHF Heart Protection Study. Circulation (2012) 2.90
China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up. Int J Epidemiol (2011) 2.82