Mendelian randomisation study of the associations of vitamin B12 and folate genetic risk scores with blood pressure and fasting serum lipid levels in three Danish population-based studies.

'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol (2003) 16.71

Effects of combination lipid therapy in type 2 diabetes mellitus. N Engl J Med (2010) 16.40

Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. N Engl J Med (2011) 15.30

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10

Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med (2006) 11.72

Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med (2006) 9.53

Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA (2002) 8.11

Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA (2004) 7.35

Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ (2002) 7.14

Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial. JAMA (2008) 5.92

MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA (2002) 5.29

Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial. JAMA (2007) 4.60

Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial. JAMA (2008) 4.49

A randomized non-pharmacological intervention study for prevention of ischaemic heart disease: baseline results Inter99. Eur J Cardiovasc Prev Rehabil (2003) 4.25

Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. Homocysteine Lowering Trialists' Collaboration. BMJ (1998) 3.81

Homocysteine metabolism. Annu Rev Nutr (1999) 3.75

Homocysteine and stroke: evidence on a causal link from mendelian randomisation. Lancet (2005) 3.60

Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial. JAMA (2010) 3.34

Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials. Lancet (2011) 2.35

Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study. JAMA (1995) 2.31

Use of allele scores as instrumental variables for Mendelian randomization. Int J Epidemiol (2013) 2.06

Homocysteine-lowering therapy and stroke risk, severity, and disability: additional findings from the HOPE 2 trial. Stroke (2009) 1.94

Meta-analysis of MTHFR 677C->T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate? BMJ (2005) 1.83

Dietary intake of folate and risk of stroke in US men and women: NHANES I Epidemiologic Follow-up Study. National Health and Nutrition Examination Survey. Stroke (2002) 1.69

Improvement in stroke mortality in Canada and the United States, 1990 to 2002. Circulation (2006) 1.58

Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials. Eur Heart J (2008) 1.52

Serum folate and homocysteine and the incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr (2004) 1.51

Folate intake and the risk of incident hypertension among US women. JAMA (2005) 1.49

Vitamin Intervention For Stroke Prevention trial: an efficacy analysis. Stroke (2005) 1.28

Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial. J Intern Med (2002) 1.23

Low dietary folate intake is associated with an excess incidence of acute coronary events: The Kuopio Ischemic Heart Disease Risk Factor Study. Circulation (2001) 1.16

Long-term homocysteine-lowering treatment with folic acid plus pyridoxine is associated with decreased blood pressure but not with improved brachial artery endothelium-dependent vasodilation or carotid artery stiffness: a 2-year, randomized, placebo-controlled trial. Arterioscler Thromb Vasc Biol (2001) 1.09

The association of alcohol and alcohol metabolizing gene variants with diabetes and coronary heart disease risk factors in a white population. PLoS One (2010) 1.08

The role of homocysteine-lowering B-vitamins in the primary prevention of cardiovascular disease. Cardiovasc Ther (2014) 1.07

Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets. PLoS Genet (2013) 1.04

Serum 25(OH)D and incident type 2 diabetes: a cohort study. Eur J Clin Nutr (2012) 1.04

HDL and endothelial protection. Br J Pharmacol (2013) 0.99

Low serum folate concentrations are associated with an excess incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study. Eur J Clin Nutr (2000) 0.95

Homocysteine-lowering interventions for preventing cardiovascular events. Cochrane Database Syst Rev (2015) 0.93

Contribution of thermolabile methylenetetrahydrofolate reductase variant to total plasma homocysteine levels in healthy men and women. Inter99 (2). Genet Epidemiol (2003) 0.87

HDL--is it too big to fail? Nat Rev Endocrinol (2013) 0.86

Low folate levels may be an atherogenic factor regardless of homocysteine levels in young healthy nonsmokers. Metabolism (2009) 0.85

Association of indoor air pollution with rhinitis symptoms, atopy and nitric oxide levels in exhaled air. Int Arch Allergy Immunol (2010) 0.84

Serum folate and risk for ischemic stroke. First National Health and Nutrition Examination Survey epidemiologic follow-up study. Stroke (1995) 0.84

L-folic acid supplementation in healthy postmenopausal women: effect on homocysteine and glycolipid metabolism. J Clin Endocrinol Metab (2005) 0.83

Folate intake and incidence of hypertension among American young adults: a 20-y follow-up study. Am J Clin Nutr (2012) 0.83

High-dose short-term folate administration modifies ambulatory blood pressure in postmenopausal women. A placebo-controlled study. Eur J Clin Nutr (2009) 0.81

Folate and cardiovascular disease: one size does not fit all. Lancet (2011) 0.80

MTHFR C677T genotype and cardiovascular risk in a general population without mandatory folic acid fortification. Eur J Nutr (2014) 0.80

Changes in lifestyle, biological risk factors and total homocysteine in relation to MTHFR C677T genotype: a 5-year follow-up study. Eur J Clin Nutr (2009) 0.79

Low-dose B vitamins supplementation ameliorates cardiovascular risk: a double-blind randomized controlled trial in healthy Chinese elderly. Eur J Nutr (2014) 0.78

Changes in lifestyle and total homocysteine in relation to MTHFR(C677T) genotype: the Inter99 study. Eur J Clin Nutr (2006) 0.78

Endothelial function in post-menopausal women: effect of folic acid supplementation. Hum Reprod (2004) 0.77

Biological cardiovascular risk factors and plasma homocysteine levels in the general Dutch population. Atherosclerosis (2001) 0.76

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. Nat Genet (2015) 1.28

The association of serum 25-OH vitamin D with atopy, asthma, and lung function in a prospective study of Danish adults. Clin Exp Allergy (2015) 0.85

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nat Commun (2017) 0.80

Tracking of body mass index from 7 to 69 years of age. Int J Obes (Lond) (2016) 0.78

Numerous Brugada syndrome-associated genetic variants have no effect on J-point elevation, syncope susceptibility, malignant cardiac arrhythmia, and all-cause mortality. Genet Med (2016) 0.76

Serum 25-hydroxyvitamin D and self-reported mental health status in adult Danes. Eur J Clin Nutr (2015) 0.75

Genetic Variations in the Human GPRC6A Receptor Control Cell Surface Expression and Function. J Biol Chem (2016) 0.75

Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium. Sci Rep (2017) 0.75

Association studies of genetic scores of serum vitamin B12 and folate levels with symptoms of depression and anxiety in two danish population studies. Eur J Clin Nutr (2017) 0.75

A functional IFN-λ4-generating DNA polymorphism could protect older asthmatic women from aeroallergen sensitization and associate with clinical features of asthma. Sci Rep (2017) 0.75