Neurokinin B stimulates GnRH release in the male monkey (Macaca mulatta) and is colocalized with kisspeptin in the arcuate nucleus.

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Published in Endocrinology on June 23, 2010

Authors

Suresh Ramaswamy1, Stephanie B Seminara, Barkat Ali, Philippe Ciofi, Nisar A Amin, Tony M Plant

Author Affiliations

1: Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

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Lack of association of hypogonadotropic genes with age at menarche: prospects for the future. J Clin Endocrinol Metab (2008) 0.75

Estradiol Up-Regulates Kisspeptin Expression in the Pre-Optic Area of Both the Male and Female Rhesus Monkey (Macaca mulatta): Implications for the Hypothalamic Control of Ovulation in Highly Evolved Primates. Neuroendocrinology (2016) 0.75

Corrigendum: SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome. Nat Genet (2017) 0.75