Published in J Nat Prod on July 23, 2010
Discovery of an unusual biosynthetic origin for circular proteins in legumes. Proc Natl Acad Sci U S A (2011) 1.16
Cyclotide discovery in Gentianales revisited-identification and characterization of cyclic cystine-knot peptides and their phylogenetic distribution in Rubiaceae plants. Biopolymers (2013) 1.10
Cyclotides associate with leaf vasculature and are the products of a novel precursor in petunia (Solanaceae). J Biol Chem (2012) 1.00
Anti-Streptococcal activity of Brazilian Amazon Rain Forest plant extracts presents potential for preventive strategies against dental caries. J Appl Oral Sci (2014) 0.96
Discovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants. J Biol Chem (2012) 0.91
Discovery of a linear cyclotide from the bracelet subfamily and its disulfide mapping by top-down mass spectrometry. J Biol Chem (2011) 0.90
Novel cyclotides and uncyclotides with highly shortened precursors from Chassalia chartacea and effects of methionine oxidation on bioactivities. J Biol Chem (2012) 0.86
Plant antimicrobial peptides as potential anticancer agents. Biomed Res Int (2015) 0.83
Induction of apoptotic effects of antiproliferative protein from the seeds of Borreria hispida on lung cancer (A549) and cervical cancer (HeLa) cell lines. Biomed Res Int (2014) 0.77
Inhibition of Human Prolyl Oligopeptidase Activity by the Cyclotide Psysol 2 Isolated from Psychotria solitudinum. J Nat Prod (2015) 0.77
Cyclotide structure-activity relationships: qualitative and quantitative approaches linking cytotoxic and anthelmintic activity to the clustering of physicochemical forces. PLoS One (2014) 0.76
Cyclotides Isolated from an Ipecac Root Extract Antagonize the Corticotropin Releasing Factor Type 1 Receptor. Front Pharmacol (2017) 0.75
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38
Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone. J Am Chem Soc (2003) 1.67
HIV-1 protease inhibitor induced oxidative stress suppresses glucose stimulated insulin release: protection with thymoquinone. Exp Biol Med (Maywood) (2009) 1.56
Distribution and evolution of circular miniproteins in flowering plants. Plant Cell (2008) 1.37
Cyclotides: a novel type of cytotoxic agents. Mol Cancer Ther (2002) 1.32
Potential of mesenchymal stem cells in gene therapy approaches for inherited and acquired diseases. Expert Opin Biol Ther (2005) 1.24
Neoplastic reprogramming of patient-derived adipose stem cells by prostate cancer cell-associated exosomes. Stem Cells (2014) 1.20
Cytotoxic cyclotides from Viola tricolor. J Nat Prod (2004) 1.18
Selective cytotoxicity evaluation in anticancer drug screening of fractionated plant extracts. J Biomol Screen (2002) 1.18
A continent of plant defense peptide diversity: cyclotides in Australian Hybanthus (Violaceae). Plant Cell (2005) 1.16
Prognostic significance of cytoplasmic SOX9 in invasive ductal carcinoma and metastatic breast cancer. Exp Biol Med (Maywood) (2011) 1.15
Anticancer and chemosensitizing abilities of cycloviolacin 02 from Viola odorata and psyle cyclotides from Psychotria leptothyrsa. Biopolymers (2010) 1.13
Antimicrobial and cytotoxic activity of agelasine and agelasimine analogs. Bioorg Med Chem (2007) 1.11
Biosynthesis, natural sources, dietary intake, pharmacokinetic properties, and biological activities of hydroxycinnamic acids. J Agric Food Chem (2012) 1.10
Cytotoxic effects of cardiac glycosides in colon cancer cells, alone and in combination with standard chemotherapeutic drugs. J Nat Prod (2009) 1.07
Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proc Natl Acad Sci U S A (2013) 1.07
The nuclear factor kappa-B signaling pathway as a therapeutic target against thyroid cancers. Thyroid (2012) 1.06
Combined X-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold. J Biol Chem (2009) 1.05
Expanding the ChemGPS chemical space with natural products. J Nat Prod (2005) 1.04
Variations in cyclotide expression in viola species. J Nat Prod (2004) 1.00
Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species. Exp Biol Med (Maywood) (2010) 1.00
Reversible antifouling effect of the cyclotide cycloviolacin O2 against barnacles. J Nat Prod (2004) 1.00
The cyclotide fingerprint in oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides. Chembiochem (2007) 0.99
MRP (ABCC) transporters-mediated efflux of anti-HIV drugs, saquinavir and zidovudine, from human endothelial cells. Exp Biol Med (Maywood) (2008) 0.99
Mechanism of action of cytotoxic cyclotides: cycloviolacin O2 disrupts lipid membranes. J Nat Prod (2007) 0.98
The cyclotide cycloviolacin O2 from Viola odorata has potent bactericidal activity against Gram-negative bacteria. J Antimicrob Chemother (2010) 0.97
Naturally occurring xanthones; latest investigations: isolation, structure elucidation and chemosystematic significance. Curr Med Chem (2009) 0.96
MicroRNA expression profiles in differentiated thyroid cancer, a review. Int J Clin Exp Med (2012) 0.95
Antifouling activity of bromotyrosine-derived sponge metabolites and synthetic analogues. Mar Biotechnol (NY) (2007) 0.94
Human fecal water inhibits COX-2 in colonic HT-29 cells: role of phenolic compounds. J Nutr (2005) 0.93
Novel strategies for isolation and characterization of cyclotides: the discovery of bioactive macrocyclic plant polypeptides in the Violaceae. Curr Protein Pept Sci (2004) 0.93
(+)-agelasine D: improved synthesis and evaluation of antibacterial and cytotoxic activities. J Nat Prod (2006) 0.91
Rediscovery of known natural compounds: nuisance or goldmine? Bioorg Med Chem (2005) 0.91
Silencing of mouse Aprt is a gradual process in differentiated cells. Mol Cell Biol (2003) 0.91
Synergistic inhibition of thyroid cancer by suppressing MAPK/PI3K/AKT pathways. J Surg Res (2013) 0.89
The traditional medical uses and cytotoxic activities of sixty-one Egyptian plants: discovery of an active cardiac glycoside from Urginea maritima. J Ethnopharmacol (2012) 0.89
Natural products in modern life science. Phytochem Rev (2010) 0.89
Molecular analysis of cocaine-induced endothelial dysfunction: role of endothelin-1 and nitric oxide. Cardiovasc Toxicol (2008) 0.89
Oxygenation of polyunsaturated long chain fatty acids by recombinant CYP4F8 and CYP4F12 and catalytic importance of Tyr-125 and Gly-328 of CYP4F8. Arch Biochem Biophys (2005) 0.89
Circular proteins from plants and fungi. J Biol Chem (2012) 0.89
Ultra-stable peptide scaffolds for protein engineering-synthesis and folding of the circular cystine knotted cyclotide cycloviolacin O2. Chembiochem (2008) 0.89
Chemistry and biology of cyclotides: circular plant peptides outside the box. J Nat Prod (2014) 0.89
Evaluation of toxicity and antitumor activity of cycloviolacin O2 in mice. Biopolymers (2010) 0.88
Primary and 3-D modelled structures of two cyclotides from Viola odorata. Phytochemistry (2003) 0.88
Cytoplasmic compartmentalization of SOX9 abrogates the growth arrest response of breast cancer cells that can be rescued by trichostatin A treatment. Cancer Biol Ther (2011) 0.88
Unconventional natural sources for future drug discovery. Drug Discov Today (2004) 0.88
Is COX-2 a perpetrator or a protector? Selective COX-2 inhibitors remain controversial. Acta Pharmacol Sin (2005) 0.87
Antifouling activity of brominated cyclopeptides from the marine sponge Geodia barretti. J Nat Prod (2004) 0.86
The conserved glu in the cyclotide cycloviolacin O2 has a key structural role. Chembiochem (2009) 0.86
Cyclotide proteins and precursors from the genus Gloeospermum: filling a blank spot in the cyclotide map of Violaceae. Phytochemistry (2009) 0.86
Functional versus chemical diversity: is biodiversity important for drug discovery? Trends Pharmacol Sci (2002) 0.86
Interlocking disulfides in circular proteins: toward efficient oxidative folding of cyclotides. Antioxid Redox Signal (2010) 0.86
Suppression of clonogenic potential of human bone marrow mesenchymal stem cells by HIV type 1: putative role of HIV type 1 tat protein and inflammatory cytokines. AIDS Res Hum Retroviruses (2002) 0.85
Cyclotide-membrane interactions: defining factors of membrane binding, depletion and disruption. Biochim Biophys Acta (2011) 0.85
Antifouling activity of synthesized peptide analogs of the sponge metabolite barettin. Peptides (2006) 0.84
Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands. J Nat Prod (2006) 0.84
Evaluation of the cyclooxygenase inhibiting effects of six major cannabinoids isolated from Cannabis sativa. Biol Pharm Bull (2011) 0.84
Constituents of Hypericum laricifolium and their cyclooxygenase (COX) enzyme activities. Chem Pharm Bull (Tokyo) (2003) 0.84
Zidovudine (AZT) treatment suppresses granulocyte-monocyte colony stimulating factor receptor type alpha (GM-CSFR alpha) gene expression in murine bone marrow cells. Life Sci (2002) 0.84
Rosiglitazone reduces serum homocysteine levels, smooth muscle proliferation, and intimal hyperplasia in Sprague-Dawley rats fed a high methionine diet. Metabolism (2005) 0.84
The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity. Phytochemistry (2008) 0.84
The nrf1 and nrf2 balance in oxidative stress regulation and androgen signaling in prostate cancer cells. Cancers (Basel) (2010) 0.83
Low-dose methylmercury-induced oxidative stress, cytotoxicity, and tau-hyperphosphorylation in human neuroblastoma (SH-SY5Y) cells. Environ Toxicol (2011) 0.83
Cyclotides from an extreme habitat: characterization of cyclic peptides from Viola abyssinica of the Ethiopian highlands. J Nat Prod (2011) 0.83
The impact of the 2007 ESC-ACC-AHA-WHF Universal definition on the incidence and classification of acute myocardial infarction: a retrospective cohort study. Int J Cardiol (2008) 0.82
The HIV-1 Tat protein enhances megakaryocytic commitment of K562 cells by facilitating CREB transcription factor coactivation by CBP. Exp Biol Med (Maywood) (2005) 0.82
Mesenchymal stem cell derived hematopoietic cells are permissive to HIV-1 infection. Retrovirology (2011) 0.82
Therapeutic effects of Nigella sativa on chronic HAART-induced hyperinsulinemia in rats. Can J Physiol Pharmacol (2009) 0.82
Ex vivo activity of cardiac glycosides in acute leukaemia. PLoS One (2011) 0.81
Specific increase in MDR1 mediated drug-efflux in human brain endothelial cells following co-exposure to HIV-1 and saquinavir. PLoS One (2013) 0.81
Biomedicine in the environment: cyclotides constitute potent natural toxins in plants and soil bacteria. Environ Toxicol Chem (2011) 0.81
A neutrophil multitarget functional bioassay to detect anti-inflammatory natural products. J Nat Prod (2002) 0.81
Synthesis, antimicrobial and antineoplastic activities for agelasine and agelasimine analogs with a beta-cyclocitral derived substituent. Arch Pharm (Weinheim) (2007) 0.81
Cycloviolacin O2 (CyO2) suppresses productive infection and augments the antiviral efficacy of nelfinavir in HIV-1 infected monocytic cells. Biopolymers (2013) 0.81
Recruitment in the field of Balanus improvisus and Mytilus edulis in response to the antifouling cyclopeptides barettin and 8,9-dihydrobarettin from the marine sponge Geodia barretti. Biofouling (2004) 0.81
Antifouling activity of the sponge metabolite agelasine D and synthesised analogs on Balanus improvisus. Biofouling (2008) 0.81
Chemical composition and repellency of essential oils from four medicinal plants against Ixodes ricinus nymphs (Acari: Ixodidae). J Med Entomol (2012) 0.81
Ligatoxin B, a new cytotoxic protein with a novel helix-turn-helix DNA-binding domain from the mistletoe Phoradendron liga. Biochem J (2002) 0.80