Published in Phytochemistry on October 30, 2009
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Theta-defensins prevent HIV-1 Env-mediated fusion by binding gp41 and blocking 6-helix bundle formation. J Biol Chem (2006) 1.54
The engineering of an orally active conotoxin for the treatment of neuropathic pain. Angew Chem Int Ed Engl (2010) 1.54
Circular proteins--no end in sight. Trends Biochem Sci (2002) 1.53
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Twists, knots, and rings in proteins. Structural definition of the cyclotide framework. J Biol Chem (2002) 1.46
Biosynthesis of circular proteins in plants. Plant J (2007) 1.39
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Distribution and evolution of circular miniproteins in flowering plants. Plant Cell (2008) 1.37
Engineering stable peptide toxins by means of backbone cyclization: stabilization of the alpha-conotoxin MII. Proc Natl Acad Sci U S A (2005) 1.37
Functional analysis of the alpha-defensin disulfide array in mouse cryptdin-4. J Biol Chem (2004) 1.36
Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design. Biochem J (2006) 1.35
Alpha-selenoconotoxins, a new class of potent alpha7 neuronal nicotinic receptor antagonists. J Biol Chem (2006) 1.34
Cyclotides: a novel type of cytotoxic agents. Mol Cancer Ther (2002) 1.32
Albumins and their processing machinery are hijacked for cyclic peptides in sunflower. Nat Chem Biol (2011) 1.31
Cyclotides as templates in drug design. Drug Discov Today (2009) 1.31
Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation. J Neurosci (2008) 1.29
The synthesis, structural characterization, and receptor specificity of the alpha-conotoxin Vc1.1. J Biol Chem (2006) 1.28
Plant cyclotides disrupt epithelial cells in the midgut of lepidopteran larvae. Proc Natl Acad Sci U S A (2008) 1.28
Discovery, structure and biological activities of cyclotides. Adv Drug Deliv Rev (2009) 1.26
The three-dimensional solution structure of NaD1, a new floral defensin from Nicotiana alata and its application to a homology model of the crop defense protein alfAFP. J Mol Biol (2003) 1.26
Conopeptide characterization and classifications: an analysis using ConoServer. Toxicon (2010) 1.26
Isolation, solution structure, and insecticidal activity of kalata B2, a circular protein with a twist: do Möbius strips exist in nature? Biochemistry (2005) 1.24
Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds. Blood (2011) 1.24
Alanine scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity. J Biol Chem (2008) 1.24
A novel plant protein-disulfide isomerase involved in the oxidative folding of cystine knot defense proteins. J Biol Chem (2007) 1.19
The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transporters. J Biol Chem (2012) 1.19
Conotoxins: natural product drug leads. Nat Prod Rep (2009) 1.19
Cytotoxic cyclotides from Viola tricolor. J Nat Prod (2004) 1.18
Cyclotides: natural, circular plant peptides that possess significant activity against gastrointestinal nematode parasites of sheep. Biochemistry (2008) 1.18
Selective cytotoxicity evaluation in anticancer drug screening of fractionated plant extracts. J Biomol Screen (2002) 1.18
Engineering stabilized vascular endothelial growth factor-A antagonists: synthesis, structural characterization, and bioactivity of grafted analogues of cyclotides. J Med Chem (2008) 1.17
Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins. J Biol Chem (2004) 1.16
A continent of plant defense peptide diversity: cyclotides in Australian Hybanthus (Violaceae). Plant Cell (2005) 1.16
Discovery of an unusual biosynthetic origin for circular proteins in legumes. Proc Natl Acad Sci U S A (2011) 1.16
Insecticidal plant cyclotides and related cystine knot toxins. Toxicon (2006) 1.16
Discovery of cyclotides in the fabaceae plant family provides new insights into the cyclization, evolution, and distribution of circular proteins. ACS Chem Biol (2011) 1.14
Linearization of a naturally occurring circular protein maintains structure but eliminates hemolytic activity. Biochemistry (2003) 1.14
Anticancer and chemosensitizing abilities of cycloviolacin 02 from Viola odorata and psyle cyclotides from Psychotria leptothyrsa. Biopolymers (2010) 1.13
The cyclic cystine knot miniprotein MCoTI-II is internalized into cells by macropinocytosis. Int J Biochem Cell Biol (2007) 1.13
A novel conotoxin inhibitor of Kv1.6 channel and nAChR subtypes defines a new superfamily of conotoxins. Biochemistry (2006) 1.12
Structures of muO-conotoxins from Conus marmoreus. I nhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons. J Biol Chem (2004) 1.12
The biological activity of the prototypic cyclotide kalata b1 is modulated by the formation of multimeric pores. J Biol Chem (2009) 1.12
Identification and characterization of a new family of cell-penetrating peptides: cyclic cell-penetrating peptides. J Biol Chem (2011) 1.12
Retrocyclin-2: structural analysis of a potent anti-HIV theta-defensin. Biochemistry (2007) 1.11
Biosynthesis, natural sources, dietary intake, pharmacokinetic properties, and biological activities of hydroxycinnamic acids. J Agric Food Chem (2012) 1.10
Cyclotide discovery in Gentianales revisited-identification and characterization of cyclic cystine-knot peptides and their phylogenetic distribution in Rubiaceae plants. Biopolymers (2013) 1.10
Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activity. J Biol Chem (2010) 1.09
Disulfide mapping of the cyclotide kalata B1. Chemical proof of the cystic cystine knot motif. J Biol Chem (2003) 1.09
Structural and functional characterization of the conserved salt bridge in mammalian paneth cell alpha-defensins: solution structures of mouse CRYPTDIN-4 and (E15D)-CRYPTDIN-4. J Biol Chem (2006) 1.08
Studies on the membrane interactions of the cyclotides kalata B1 and kalata B6 on model membrane systems by surface plasmon resonance. Anal Biochem (2005) 1.07
The role of the cyclic peptide backbone in the anti-HIV activity of the cyclotide kalata B1. FEBS Lett (2004) 1.07
Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proc Natl Acad Sci U S A (2013) 1.07
Discovery, synthesis, and structure-activity relationships of conotoxins. Chem Rev (2014) 1.07
Disulfide folding pathways of cystine knot proteins. Tying the knot within the circular backbone of the cyclotides. J Biol Chem (2002) 1.06
Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis. J Nat Prod (2007) 1.06
Decoding the membrane activity of the cyclotide kalata B1: the importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities. J Biol Chem (2011) 1.06
Bioactive cystine knot proteins. Curr Opin Chem Biol (2011) 1.05
Backbone cyclised peptides from plants show molluscicidal activity against the rice pest Pomacea canaliculata (golden apple snail). J Agric Food Chem (2008) 1.05
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Combined X-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold. J Biol Chem (2009) 1.05
Design and characterization of novel antimicrobial peptides, R-BP100 and RW-BP100, with activity against Gram-negative and Gram-positive bacteria. Biochim Biophys Acta (2012) 1.04
Enzymatic cyclization of a potent bowman-birk protease inhibitor, sunflower trypsin inhibitor-1, and solution structure of an acyclic precursor peptide. J Biol Chem (2003) 1.04
Tissue-specific expression of head-to-tail cyclized miniproteins in Violaceae and structure determination of the root cyclotide Viola hederacea root cyclotide1. Plant Cell (2004) 1.03
Structure-activity relationships of alpha-conotoxins targeting neuronal nicotinic acetylcholine receptors. Eur J Biochem (2004) 1.02
Structure of Petunia hybrida defensin 1, a novel plant defensin with five disulfide bonds. Biochemistry (2003) 1.02
A comparison of the self-association behavior of the plant cyclotides kalata B1 and kalata B2 via analytical ultracentrifugation. J Biol Chem (2003) 1.02
Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides. J Biol Chem (2008) 1.02
Circular proteins and mechanisms of cyclization. Biopolymers (2010) 1.02
Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence. J Biol Chem (2002) 1.01
Variations in cyclotide expression in viola species. J Nat Prod (2004) 1.00
Cyclic peptides arising by evolutionary parallelism via asparaginyl-endopeptidase-mediated biosynthesis. Plant Cell (2012) 1.00
A novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability. Biochem J (2006) 1.00
Cyclotides associate with leaf vasculature and are the products of a novel precursor in petunia (Solanaceae). J Biol Chem (2012) 1.00
Analysis and classification of circular proteins in CyBase. Biopolymers (2010) 1.00
The cyclotide fingerprint in oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides. Chembiochem (2007) 0.99
Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3. J Biol Chem (2005) 0.99
Insights into the molecular evolution of oxytocin receptor ligand binding. Biochem Soc Trans (2013) 0.99
Isolation, characterization, and bioactivity of cyclotides from the Micronesian plant Psychotria leptothyrsa. J Nat Prod (2010) 0.98
Discovery and characterization of a linear cyclotide from Viola odorata: implications for the processing of circular proteins. J Mol Biol (2006) 0.98
Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels. J Biol Chem (2002) 0.98
Solving the alpha-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antagonists. J Am Chem Soc (2010) 0.98
Mechanism of action of cytotoxic cyclotides: cycloviolacin O2 disrupts lipid membranes. J Nat Prod (2007) 0.98