Published in Curr Biol on June 24, 2010
Prorenin receptor is essential for normal podocyte structure and function. J Am Soc Nephrol (2011) 2.08
Multiple genes of the renin-angiotensin system are novel targets of Wnt/β-catenin signaling. J Am Soc Nephrol (2014) 1.21
Planar cell polarity signaling: coordination of cellular orientation across tissues. Wiley Interdiscip Rev Dev Biol (2013) 1.11
Molecular bioelectricity: how endogenous voltage potentials control cell behavior and instruct pattern regulation in vivo. Mol Biol Cell (2014) 1.11
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(Pro)renin receptor is crucial for Wnt/β-catenin-dependent genesis of pancreatic ductal adenocarcinoma. Sci Rep (2015) 0.81
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AGPAT9 suppresses cell growth, invasion and metastasis by counteracting acidic tumor microenvironment through KLF4/LASS2/V-ATPase signaling pathway in breast cancer. Oncotarget (2015) 0.81
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ATP6AP2/(pro)renin receptor contributes to glucose metabolism via stabilizing the pyruvate dehydrogenase E1 β subunit. J Biol Chem (2015) 0.77
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Regulation of Notch signaling and endocytosis by the Lgl neoplastic tumor suppressor. Cell Cycle (2015) 0.75
Identification of V-ATPase as a molecular sensor of SOX11-levels and potential therapeutic target for mantle cell lymphoma. BMC Cancer (2016) 0.75
Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. Nat Genet (2005) 6.67
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Nat Genet (2006) 5.36
Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. Nat Genet (2003) 5.24
The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proc Natl Acad Sci U S A (2006) 4.56
Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis. Nat Genet (2003) 4.14
Primary cilia regulate mTORC1 activity and cell size through Lkb1. Nat Cell Biol (2010) 3.55
Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest (2010) 3.44
Role of mTOR in podocyte function and diabetic nephropathy in humans and mice. J Clin Invest (2011) 2.90
TRPP2 and TRPV4 form a polymodal sensory channel complex. J Cell Biol (2008) 2.88
Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia. Am J Hum Genet (2008) 2.74
Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling. Mol Cell Biol (2003) 2.69
Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell (2012) 2.54
Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci U S A (2006) 2.16
Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. EMBO J (2005) 2.12
Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome. J Am Soc Nephrol (2009) 1.86
Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin. J Cell Sci (2008) 1.86
NEPH1 defines a novel family of podocin interacting proteins. FASEB J (2002) 1.85
Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1. J Am Soc Nephrol (2003) 1.83
Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains. Hum Mol Genet (2003) 1.70
The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth. J Cell Biol (2006) 1.66
Vertebrate kidney tubules elongate using a planar cell polarity-dependent, rosette-based mechanism of convergent extension. Nat Genet (2012) 1.62
Wnt signaling in polycystic kidney disease. J Am Soc Nephrol (2007) 1.58
Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development. Proc Natl Acad Sci U S A (2009) 1.57
On-demand strategy as an alternative to conventionally scheduled post-transplant immunoadsorptions after ABO-incompatible kidney transplantation. Nephrol Dial Transplant (2007) 1.47
The nephronophthisis gene product NPHP2/Inversin interacts with Aurora A and interferes with HDAC6-mediated cilia disassembly. Nephrol Dial Transplant (2013) 1.47
Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury. Autophagy (2012) 1.44
Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity. J Biol Chem (2008) 1.43
The carboxyl terminus of Neph family members binds to the PDZ domain protein zonula occludens-1. J Biol Chem (2003) 1.42
The retinitis pigmentosa GTPase regulator interacting protein 1 (RPGRIP1) links RPGR to the nephronophthisis protein network. Kidney Int (2010) 1.42
mTORC2 critically regulates renal potassium handling. J Clin Invest (2016) 1.40
Unraveling the role of podocyte turnover in glomerular aging and injury. J Am Soc Nephrol (2014) 1.36
Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia. EMBO J (2005) 1.35
ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3. Nat Genet (2013) 1.32
mTOR and rapamycin in the kidney: signaling and therapeutic implications beyond immunosuppression. Kidney Int (2010) 1.30
A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9. Biochem Biophys Res Commun (2006) 1.29
Gene expression profiling in polycythaemia vera: overexpression of transcription factor NF-E2. Br J Haematol (2005) 1.26
Genetic and physical interaction between the NPHP5 and NPHP6 gene products. Hum Mol Genet (2008) 1.26
Cilium-generated signaling: a cellular GPS? Curr Opin Nephrol Hypertens (2006) 1.21
TRPP2 channels regulate apoptosis through the Ca2+ concentration in the endoplasmic reticulum. EMBO J (2009) 1.21
Differential role of Rab proteins in ciliary trafficking: Rab23 regulates smoothened levels. J Cell Sci (2010) 1.20
NEPH2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases. J Am Soc Nephrol (2005) 1.19
Subcellular localization and trafficking of polycystins. Pflugers Arch (2005) 1.16
OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum. J Biol Chem (2007) 1.14
The polycystin-1 C-terminal fragment triggers branching morphogenesis and migration of tubular kidney epithelial cells. J Clin Invest (2002) 1.11
PRKCSH/80K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradation. Hum Mol Genet (2010) 1.10
Vps34 deficiency reveals the importance of endocytosis for podocyte homeostasis. J Am Soc Nephrol (2013) 1.09
Gene profiling of polycystic kidneys. Nephrol Dial Transplant (2006) 1.09
The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels. EMBO J (2006) 1.09
The German Chronic Kidney Disease (GCKD) study: design and methods. Nephrol Dial Transplant (2011) 1.09
Long-term outcome of ABO-incompatible living donor kidney transplantation based on antigen-specific desensitization. An observational comparative analysis. Nephrol Dial Transplant (2010) 1.08
Nephrocystin-4 is required for pronephric duct-dependent cloaca formation in zebrafish. Hum Mol Genet (2011) 1.07
A model organism approach: defining the role of Neph proteins as regulators of neuron and kidney morphogenesis. Hum Mol Genet (2010) 1.05
Neuronal expression and interaction with the synaptic protein CASK suggest a role for Neph1 and Neph2 in synaptogenesis. J Comp Neurol (2006) 1.05
Tyrosine phosphorylation modulates the activity of TRPV4 in response to defined stimuli. J Biol Chem (2008) 1.04
Regulation of ciliary polarity by the APC/C. Proc Natl Acad Sci U S A (2009) 1.03
ABO-incompatible kidney transplantation using antigen-specific immunoadsorption and rituximab: a single center experience. Xenotransplantation (2006) 1.02
The subcellular localization of TRPP2 modulates its function. J Am Soc Nephrol (2008) 1.02
Inversin relays Frizzled-8 signals to promote proximal pronephros development. Proc Natl Acad Sci U S A (2010) 1.02
Sensitive cilia set up the kidney. Nat Med (2007) 1.00
Von hippel-lindau: a tumor suppressor links microtubules to ciliogenesis and cancer development. Cancer Res (2007) 1.00
Ciliary calcium signaling is modulated by kidney injury molecule-1 (Kim1). Pflugers Arch (2007) 0.98
SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans. Genes Dev (2008) 0.98
Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha. J Biol Chem (2002) 0.98
The nuclear envelope protein Nesprin-2 has roles in cell proliferation and differentiation during wound healing. Nucleus (2012) 0.98
Therapeutic approaches in autosomal dominant polycystic kidney disease (ADPKD): is there light at the end of the tunnel? Nephrol Dial Transplant (2006) 0.96
Inversin, Wnt signaling and primary cilia. Differentiation (2011) 0.95
Flow modulates centriole movements in tubular epithelial cells. Pflugers Arch (2008) 0.91
Role of the polarity protein Scribble for podocyte differentiation and maintenance. PLoS One (2012) 0.90
Identification of a Protein Kinase C-dependent phosphorylation site involved in sensitization of TRPV4 channel. Biochem Biophys Res Commun (2009) 0.89
Increased expression of secreted frizzled-related protein 4 in polycystic kidneys. J Am Soc Nephrol (2008) 0.89
Drosophila ATP6AP2/VhaPRR functions both as a novel planar cell polarity core protein and a regulator of endosomal trafficking. EMBO J (2013) 0.89
Expression profiling on chronically rejected transplant kidneys. Transplantation (2003) 0.89
Host cell responses induced by hepatitis C virus binding. Hepatology (2006) 0.89
A complex of BBS1 and NPHP7 is required for cilia motility in zebrafish. PLoS One (2013) 0.88
N-wasp is required for stabilization of podocyte foot processes. J Am Soc Nephrol (2013) 0.87
Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia. J Biol Chem (2011) 0.87
The planar cell polarity (PCP) protein Diversin translocates to the nucleus to interact with the transcription factor AF9. Biochem Biophys Res Commun (2009) 0.87
Monitoring kidney and renal cyst volumes applying MR approaches on a rapamycin treated mouse model of ADPKD. MAGMA (2008) 0.85
YAP1 recruits c-Abl to protect angiomotin-like 1 from Nedd4-mediated degradation. PLoS One (2012) 0.85
aPKCλ/ι and aPKCζ contribute to podocyte differentiation and glomerular maturation. J Am Soc Nephrol (2013) 0.85
Kif3a guides microtubular dynamics, migration and lumen formation of MDCK cells. PLoS One (2013) 0.85
Interaction with the Bardet-Biedl gene product TRIM32/BBS11 modifies the half-life and localization of Glis2/NPHP7. J Biol Chem (2014) 0.84
Elevated expression of the V-ATPase C subunit triggers JNK-dependent cell invasion and overgrowth in a Drosophila epithelium. Dis Model Mech (2013) 0.83
Kidney injury molecule 1 (Kim1) is a novel ciliary molecule and interactor of polycystin 2. Biochem Biophys Res Commun (2007) 0.82
ABO-incompatible kidney transplantation-proposal of an intensified apheresis strategy for patients with high initial isoagglutinine titers. J Clin Apher (2007) 0.81
Functional and spatial analysis of C. elegans SYG-1 and SYG-2, orthologs of the Neph/nephrin cell adhesion module directing selective synaptogenesis. PLoS One (2011) 0.80
Novel concepts in understanding and management of glomerular proteinuria. Nephrol Dial Transplant (2002) 0.80
The Treatment of Autosomal Dominant Polycystic Kidney Disease. Dtsch Arztebl Int (2015) 0.80
Successful liver transplantation in a kidney and pancreas allograft recipient with fulminant herpes simplex virus type 2 hepatitis. Nephrol Dial Transplant (2007) 0.79
Thrombotic microangiopathy associated with unusual viral sequences in HIV-1-positive patients. Nephrol Dial Transplant (2004) 0.79
A short carboxy-terminal domain of polycystin-1 reorganizes the microtubular network and the endoplasmic reticulum. Exp Cell Res (2009) 0.79
cDNA microarray analysis of adaptive changes after renal ablation in a sclerosis-resistant mouse strain. Kidney Blood Press Res (2007) 0.79
TORC2 signaling antagonizes SKN-1 to induce C. elegans mesendodermal embryonic development. Dev Biol (2013) 0.79
Functional study of mammalian Neph proteins in Drosophila melanogaster. PLoS One (2012) 0.78
The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin. Development (2015) 0.78