Published in Nat Genet on April 24, 2005
Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell (2009) 18.31
The primary cilium: a signalling centre during vertebrate development. Nat Rev Genet (2010) 8.81
Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol (2009) 6.66
HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Cell (2007) 6.50
The vertebrate primary cilium in development, homeostasis, and disease. Cell (2009) 5.29
Cilia and developmental signaling. Annu Rev Cell Dev Biol (2007) 4.88
Polycystic kidney disease. Annu Rev Med (2009) 4.78
A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1. Nat Med (2007) 4.40
Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells. Nat Genet (2008) 3.84
Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation. Immunity (2007) 3.58
Planar cell polarity signaling: from fly development to human disease. Annu Rev Genet (2008) 3.43
Mechanistic insights into Bardet-Biedl syndrome, a model ciliopathy. J Clin Invest (2009) 3.19
Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia. Hum Mol Genet (2008) 3.14
Ciliopathies: an expanding disease spectrum. Pediatr Nephrol (2011) 2.95
Wnt5a functions in planar cell polarity regulation in mice. Dev Biol (2007) 2.85
Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis. Nat Genet (2009) 2.84
FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair. Nat Genet (2012) 2.74
Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia. Am J Hum Genet (2008) 2.74
Dual and opposing roles of primary cilia in medulloblastoma development. Nat Med (2009) 2.73
Nephronophthisis: disease mechanisms of a ciliopathy. J Am Soc Nephrol (2008) 2.66
Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell (2012) 2.54
Functional analyses of variants reveal a significant role for dominant negative and common alleles in oligogenic Bardet-Biedl syndrome. Proc Natl Acad Sci U S A (2010) 2.45
Subcellular spatial regulation of canonical Wnt signalling at the primary cilium. Nat Cell Biol (2011) 2.40
Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. Nat Cell Biol (2010) 2.37
Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL. Nat Cell Biol (2008) 2.34
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet (2008) 2.29
Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning. Nature (2010) 2.23
Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease. J Cell Biol (2008) 2.20
Loss of oriented cell division does not initiate cyst formation. J Am Soc Nephrol (2009) 2.20
Bardet-Biedl syndrome: beyond the cilium. Pediatr Nephrol (2007) 2.14
Primary cilia and signaling pathways in mammalian development, health and disease. Nephron Physiol (2009) 2.09
Planar cell polarity signaling: the developing cell's compass. Cold Spring Harb Perspect Biol (2009) 2.02
Secreted and transmembrane wnt inhibitors and activators. Cold Spring Harb Perspect Biol (2013) 2.01
Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia. Genes Dev (2011) 1.94
A role for Alström syndrome protein, alms1, in kidney ciliogenesis and cellular quiescence. PLoS Genet (2006) 1.90
WNT/beta-catenin signaling in nephron progenitors and their epithelial progeny. Kidney Int (2008) 1.86
Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy. Nat Med (2009) 1.86
Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet-Biedl syndrome. Proc Natl Acad Sci U S A (2008) 1.78
Molecular advances in autosomal dominant polycystic kidney disease. Adv Chronic Kidney Dis (2010) 1.77
Wnt3a links left-right determination with segmentation and anteroposterior axis elongation. Development (2005) 1.76
Intraflagellar transport proteins are essential for cilia formation and for planar cell polarity. J Am Soc Nephrol (2010) 1.74
The primary cilium as a cellular signaling center: lessons from disease. Curr Opin Genet Dev (2009) 1.73
Advances in the pathogenesis and treatment of polycystic kidney disease. Curr Opin Nephrol Hypertens (2009) 1.73
The role of primary cilia in neuronal function. Neurobiol Dis (2010) 1.69
T-cell factor/β-catenin activity is suppressed in two different models of autosomal dominant polycystic kidney disease. Kidney Int (2011) 1.69
Planar cell polarity: coordinating morphogenetic cell behaviors with embryonic polarity. Dev Cell (2011) 1.64
A metabolomics approach using juvenile cystic mice to identify urinary biomarkers and altered pathways in polycystic kidney disease. Am J Physiol Renal Physiol (2010) 1.63
Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling. Hum Mol Genet (2008) 1.62
Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models. Nat Med (2010) 1.62
Planar cell polarity signaling in vertebrates. Bioessays (2007) 1.62
Ciliary and centrosomal defects associated with mutation and depletion of the Meckel syndrome genes MKS1 and MKS3. Hum Mol Genet (2009) 1.61
Modeling human disease in humans: the ciliopathies. Cell (2011) 1.60
A quest for the mechanism regulating global planar cell polarity of tissues. Trends Cell Biol (2009) 1.60
Cilia in the CNS: the quiet organelle claims center stage. Neuron (2011) 1.59
Mechanism and evolution of cytosolic Hedgehog signal transduction. Development (2010) 1.58
Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development. Proc Natl Acad Sci U S A (2009) 1.57
NEK1 mutations cause short-rib polydactyly syndrome type majewski. Am J Hum Genet (2011) 1.56
Pronephric tubulogenesis requires Daam1-mediated planar cell polarity signaling. J Am Soc Nephrol (2011) 1.55
Development of the bile ducts: essentials for the clinical hepatologist. J Hepatol (2012) 1.55
Inversin modulates the cortical actin network during mitosis. Am J Physiol Cell Physiol (2013) 1.52
Molecular regulation of kidney development: is the answer blowing in the Wnt? Pediatr Nephrol (2007) 1.52
Cilia in vertebrate development and disease. Development (2012) 1.50
Polycystin-1 induces cell migration by regulating phosphatidylinositol 3-kinase-dependent cytoskeletal rearrangements and GSK3beta-dependent cell cell mechanical adhesion. Mol Biol Cell (2007) 1.47
Convergent extension movements and ciliary function are mediated by ofd1, a zebrafish orthologue of the human oral-facial-digital type 1 syndrome gene. Hum Mol Genet (2008) 1.46
Primary cilia are not required for normal canonical Wnt signaling in the mouse embryo. PLoS One (2009) 1.44
Cilia in the nervous system: linking cilia function and neurodevelopmental disorders. Curr Opin Neurol (2011) 1.43
The ciliary transition zone: from morphology and molecules to medicine. Trends Cell Biol (2012) 1.43
Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo. Proc Natl Acad Sci U S A (2014) 1.41
Linking cilia to Wnts. Nat Genet (2005) 1.40
Building it up and taking it down: the regulation of vertebrate ciliogenesis. Dev Dyn (2008) 1.38
Planar cell polarity signaling, cilia and polarized ciliary beating. Curr Opin Cell Biol (2010) 1.37
Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localization of polycystin-2 in vivo and in vitro. Hum Mol Genet (2006) 1.36
The Oak Ridge Polycystic Kidney mouse: modeling ciliopathies of mice and men. Dev Dyn (2008) 1.36
BBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypes. Hum Mol Genet (2012) 1.33
Strategies targeting cAMP signaling in the treatment of polycystic kidney disease. J Am Soc Nephrol (2013) 1.33
Mutations in zebrafish leucine-rich repeat-containing six-like affect cilia motility and result in pronephric cysts, but have variable effects on left-right patterning. Development (2009) 1.31
The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis. Hum Mol Genet (2010) 1.30
Nephronophthisis. Pediatr Nephrol (2010) 1.28
Functional aspects of primary cilia in signaling, cell cycle and tumorigenesis. Cilia (2013) 1.28
Nephronophthisis. Eur J Hum Genet (2008) 1.27
Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes. Development (2010) 1.26
Genetic and physical interaction between the NPHP5 and NPHP6 gene products. Hum Mol Genet (2008) 1.26
Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis: summary statement of a first National Institutes of Health/Office of Rare Diseases conference. J Pediatr (2006) 1.26
HEF1-aurora A interactions: points of dialog between the cell cycle and cell attachment signaling networks. Cell Cycle (2006) 1.25
Planar cell polarity: keeping hairs straight is not so simple. Cold Spring Harb Perspect Biol (2010) 1.24
Renal primary cilia lengthen after acute tubular necrosis. J Am Soc Nephrol (2009) 1.23
Understanding ciliated epithelia: the power of Xenopus. Genesis (2011) 1.23
Primary cilia in planar cell polarity regulation of the inner ear. Curr Top Dev Biol (2008) 1.23
An essential role for dermal primary cilia in hair follicle morphogenesis. J Invest Dermatol (2008) 1.22
Molecular pathways: the role of primary cilia in cancer progression and therapeutics with a focus on Hedgehog signaling. Clin Cancer Res (2012) 1.20
Wnt/β-catenin signaling directly regulates Foxj1 expression and ciliogenesis in zebrafish Kupffer's vesicle. Development (2011) 1.20
Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy. J Clin Invest (2010) 1.20
Zebrafish colgate/hdac1 functions in the non-canonical Wnt pathway during axial extension and in Wnt-independent branchiomotor neuron migration. Mech Dev (2007) 1.19
Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos. EMBO J (2011) 1.19
Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome. Dis Model Mech (2010) 1.18
Line up and listen: Planar cell polarity regulation in the mammalian inner ear. Semin Cell Dev Biol (2009) 1.18
A role for planar cell polarity signaling in angiogenesis. Angiogenesis (2008) 1.18
Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by degrading Dishevelled-1 at the plasma membrane. J Biol Chem (2010) 1.18
Nephrocystin-3 is required for ciliary function in zebrafish embryos. Am J Physiol Renal Physiol (2010) 1.17
Shaping the mammalian auditory sensory organ by the planar cell polarity pathway. Int J Dev Biol (2007) 1.17
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet (2003) 13.33
Convergence of Wnt, beta-catenin, and cadherin pathways. Science (2004) 13.13
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev Cell (2003) 7.93
Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature (1994) 6.57
The promise and perils of Wnt signaling through beta-catenin. Science (2002) 6.11
Bending the MDCK cell primary cilium increases intracellular calcium. J Membr Biol (2001) 5.42
Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. Nat Genet (2003) 5.24
Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Development (2003) 3.08
Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction. Dev Biol (2003) 2.86
Beta-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos. Mech Dev (1996) 2.72
Early development of polycystic kidney disease in transgenic mice expressing an activated mutant of the beta-catenin gene. Oncogene (2001) 2.63
Frizzled6 controls hair patterning in mice. Proc Natl Acad Sci U S A (2004) 2.54
The polycystic kidney disease 1 gene product modulates Wnt signaling. J Biol Chem (1999) 2.37
Effect of flow and stretch on the [Ca2+]i response of principal and intercalated cells in cortical collecting duct. Am J Physiol Renal Physiol (2003) 2.25
The ankyrin repeat protein Diego mediates Frizzled-dependent planar polarization. Dev Cell (2001) 2.08
The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling. Genes Dev (2002) 2.02
From cilia to cyst. Nat Genet (2003) 1.92
Cloning of inv, a gene that controls left/right asymmetry and kidney development. Nature (1998) 1.90
Inversin, a novel gene in the vertebrate left-right axis pathway, is partially deleted in the inv mouse. Nat Genet (1998) 1.83
Diego interacts with Prickle and Strabismus/Van Gogh to localize planar cell polarity complexes. Development (2004) 1.80
Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium. J Biol Chem (2004) 1.77
Expression analyses and interaction with the anaphase promoting complex protein Apc2 suggest a role for inversin in primary cilia and involvement in the cell cycle. Hum Mol Genet (2002) 1.62
Inversin forms a complex with catenins and N-cadherin in polarized epithelial cells. Mol Biol Cell (2002) 1.37
The homeobox genes vox and vent are redundant repressors of dorsal fates in zebrafish. Development (2001) 1.27
Renal development: perspectives on a Wnt-dependent process. Semin Cell Dev Biol (2003) 1.13
Direct binding of Lef1 to sites in the boz promoter may mediate pre-midblastula-transition activation of boz expression. Dev Dyn (2003) 1.07
[Studies on fetal urine secretion]. Gynaecologia (1955) 1.02
Destruction with a box: substrate recognition by the anaphase-promoting complex. Mol Cell (2004) 0.94
A mammalian microRNA expression atlas based on small RNA library sequencing. Cell (2007) 34.03
When cilia go bad: cilia defects and ciliopathies. Nat Rev Mol Cell Biol (2007) 8.28
Ciliopathies. N Engl J Med (2011) 6.28
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Nat Genet (2006) 5.36
Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. Nat Genet (2003) 5.24
The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proc Natl Acad Sci U S A (2006) 4.56
Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis. Nat Genet (2003) 4.14
Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility. Nat Rev Genet (2007) 3.88
Planar cell polarity signalling couples cell division and morphogenesis during neurulation. Nature (2006) 3.80
Primary cilia regulate mTORC1 activity and cell size through Lkb1. Nat Cell Biol (2010) 3.55
Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest (2010) 3.44
Planar cell polarity signaling: from fly development to human disease. Annu Rev Genet (2008) 3.43
Ischemic preconditioning for prevention of contrast medium-induced nephropathy: randomized pilot RenPro Trial (Renal Protection Trial). Circulation (2012) 3.42
Pilot study of extracorporeal removal of soluble fms-like tyrosine kinase 1 in preeclampsia. Circulation (2011) 3.33
Planar cell polarization: an emerging model points in the right direction. Annu Rev Cell Dev Biol (2005) 3.10
Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol Cell (2003) 3.06
HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. Curr Biol (2009) 2.98
Role of mTOR in podocyte function and diabetic nephropathy in humans and mice. J Clin Invest (2011) 2.90
TRPP2 and TRPV4 form a polymodal sensory channel complex. J Cell Biol (2008) 2.88
Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia. Am J Hum Genet (2008) 2.74
Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling. Mol Cell Biol (2003) 2.69
Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. J Am Soc Nephrol (2008) 2.69
Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease. Dev Cell (2006) 2.64
Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell (2012) 2.54
The apical determinants aPKC and dPatj regulate Frizzled-dependent planar cell polarity in the Drosophila eye. Cell (2005) 2.38
Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci U S A (2006) 2.16
Nde1-mediated inhibition of ciliogenesis affects cell cycle re-entry. Nat Cell Biol (2011) 2.15
Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. EMBO J (2005) 2.12
Prickle and Strabismus form a functional complex to generate a correct axis during planar cell polarity signaling. EMBO J (2003) 2.09
Deep brain photoreceptors control light-seeking behavior in zebrafish larvae. Curr Biol (2012) 2.05
The zebrafish fleer gene encodes an essential regulator of cilia tubulin polyglutamylation. Mol Biol Cell (2007) 2.05
The slit diaphragm: a signaling platform to regulate podocyte function. Curr Opin Nephrol Hypertens (2005) 2.02
A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish. Development (2002) 2.00
Nephrin mutations can cause childhood-onset steroid-resistant nephrotic syndrome. J Am Soc Nephrol (2008) 1.94
Cilia proteins control cerebellar morphogenesis by promoting expansion of the granule progenitor pool. J Neurosci (2007) 1.92
Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin. J Cell Sci (2008) 1.86
Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome. J Am Soc Nephrol (2009) 1.86
PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndrome. J Clin Invest (2010) 1.85
NEPH1 defines a novel family of podocin interacting proteins. FASEB J (2002) 1.85
Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1. J Am Soc Nephrol (2003) 1.83
Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization. Nat Cell Biol (2009) 1.80
Diego interacts with Prickle and Strabismus/Van Gogh to localize planar cell polarity complexes. Development (2004) 1.80
Nephrocystin specifically localizes to the transition zone of renal and respiratory cilia and photoreceptor connecting cilia. J Am Soc Nephrol (2006) 1.79
The planar polarity gene strabismus regulates convergent extension movements in Xenopus. EMBO J (2002) 1.76
Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains. Hum Mol Genet (2003) 1.70
Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding. Nat Cell Biol (2005) 1.69
roundabout4 is essential for angiogenesis in vivo. Proc Natl Acad Sci U S A (2005) 1.69
Pou5f1-dependent EGF expression controls E-cadherin endocytosis, cell adhesion, and zebrafish epiboly movements. Dev Cell (2013) 1.69
The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth. J Cell Biol (2006) 1.66
RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome. Cell Metab (2008) 1.64
Vertebrate kidney tubules elongate using a planar cell polarity-dependent, rosette-based mechanism of convergent extension. Nat Genet (2012) 1.62
Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics. J Clin Invest (2011) 1.60
A quest for the mechanism regulating global planar cell polarity of tissues. Trends Cell Biol (2009) 1.60
Wnt signaling in polycystic kidney disease. J Am Soc Nephrol (2007) 1.58
Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development. Curr Biol (2007) 1.58
Comprehensive catecholaminergic projectome analysis reveals single-neuron integration of zebrafish ascending and descending dopaminergic systems. Nat Commun (2011) 1.57
Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development. Proc Natl Acad Sci U S A (2009) 1.57
The frizzled extracellular domain is a ligand for Van Gogh/Stbm during nonautonomous planar cell polarity signaling. Dev Cell (2008) 1.55
Cooperative control of Drosophila immune responses by the JNK and NF-kappaB signaling pathways. EMBO J (2006) 1.53
Severe mental retardation with breathing abnormalities (Pitt-Hopkins syndrome) is caused by haploinsufficiency of the neuronal bHLH transcription factor TCF4. Hum Mol Genet (2007) 1.52
Phosphatase-defective LEOPARD syndrome mutations in PTPN11 gene have gain-of-function effects during Drosophila development. Hum Mol Genet (2008) 1.50
Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nat Immunol (2011) 1.49
vglut2 and gad expression reveal distinct patterns of dual GABAergic versus glutamatergic cotransmitter phenotypes of dopaminergic and noradrenergic neurons in the zebrafish brain. J Comp Neurol (2014) 1.48
On-demand strategy as an alternative to conventionally scheduled post-transplant immunoadsorptions after ABO-incompatible kidney transplantation. Nephrol Dial Transplant (2007) 1.47
The nephronophthisis gene product NPHP2/Inversin interacts with Aurora A and interferes with HDAC6-mediated cilia disassembly. Nephrol Dial Transplant (2013) 1.47
Regulation of Lethal giant larvae by Dishevelled. Nature (2005) 1.47
Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury. Autophagy (2012) 1.44
Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity. J Biol Chem (2008) 1.43
The retinitis pigmentosa GTPase regulator interacting protein 1 (RPGRIP1) links RPGR to the nephronophthisis protein network. Kidney Int (2010) 1.42