Published in J Cell Biol on August 11, 2008
Autosomal dominant polycystic kidney disease: the last 3 years. Kidney Int (2009) 3.66
Primary cilia regulate mTORC1 activity and cell size through Lkb1. Nat Cell Biol (2010) 3.55
Direct recording and molecular identification of the calcium channel of primary cilia. Nature (2013) 2.27
Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease. J Cell Biol (2008) 2.20
Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes. Arthritis Rheum (2009) 2.02
Structural and molecular basis of the assembly of the TRPP2/PKD1 complex. Proc Natl Acad Sci U S A (2009) 1.84
Molecular advances in autosomal dominant polycystic kidney disease. Adv Chronic Kidney Dis (2010) 1.77
Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia. Nat Methods (2013) 1.76
The primary cilium as a cellular signaling center: lessons from disease. Curr Opin Genet Dev (2009) 1.73
Contribution of TRPV1-TRPA1 interaction to the single channel properties of the TRPA1 channel. J Biol Chem (2010) 1.63
TRPV4 dysfunction promotes renal cystogenesis in autosomal recessive polycystic kidney disease. J Am Soc Nephrol (2013) 1.60
Molecular mechanism of TRP channels. Compr Physiol (2013) 1.58
The polycystin complex mediates Wnt/Ca(2+) signalling. Nat Cell Biol (2016) 1.49
A TRPM4-dependent current in murine renal primary cilia. Am J Physiol Renal Physiol (2015) 1.43
Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2. Nat Struct Mol Biol (2017) 1.40
Transient receptor potential channelopathies. Pflugers Arch (2010) 1.40
TRPC1 and TRPC6 channels cooperate with TRPV4 to mediate mechanical hyperalgesia and nociceptor sensitization. J Neurosci (2009) 1.38
Strategies targeting cAMP signaling in the treatment of polycystic kidney disease. J Am Soc Nephrol (2013) 1.33
Wild-type and brachyolmia-causing mutant TRPV4 channels respond directly to stretch force. J Biol Chem (2010) 1.32
Attenuated, flow-induced ATP release contributes to absence of flow-sensitive, purinergic Cai2+ signaling in human ADPKD cyst epithelial cells. Am J Physiol Renal Physiol (2009) 1.28
Expression and distribution of transient receptor potential (TRP) channels in bladder epithelium. Am J Physiol Renal Physiol (2010) 1.27
Transient receptor potential (TRP) channels: a clinical perspective. Br J Pharmacol (2014) 1.25
Primary cilium-dependent mechanosensing is mediated by adenylyl cyclase 6 and cyclic AMP in bone cells. FASEB J (2010) 1.20
A 3.5-nm structure of rat TRPV4 cation channel revealed by Zernike phase-contrast cryoelectron microscopy. J Biol Chem (2009) 1.20
Activation of Trpv4 reduces the hyperproliferative phenotype of cystic cholangiocytes from an animal model of ARPKD. Gastroenterology (2010) 1.20
TRPV3: time to decipher a poorly understood family member! J Physiol (2013) 1.18
A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J (2010) 1.18
The transient receptor potential channels TRPP2 and TRPC1 form a heterotetramer with a 2:2 stoichiometry and an alternating subunit arrangement. J Biol Chem (2009) 1.17
TRPV channels and vascular function. Acta Physiol (Oxf) (2010) 1.16
Regulation of transport in the connecting tubule and cortical collecting duct. Compr Physiol (2012) 1.16
The interplay between cell signalling and mechanics in developmental processes. Nat Rev Genet (2013) 1.13
Polycystins and renovascular mechanosensory transduction. Nat Rev Nephrol (2010) 1.13
Fluid flows and forces in development: functions, features and biophysical principles. Development (2012) 1.12
Cystic kidney disease: the role of Wnt signaling. Trends Mol Med (2010) 1.10
Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. Development (2010) 1.10
Polycystin-2 activation by inositol 1,4,5-trisphosphate-induced Ca2+ release requires its direct association with the inositol 1,4,5-trisphosphate receptor in a signaling microdomain. J Biol Chem (2010) 1.10
The role of transient receptor potential channels in kidney disease. Nat Rev Nephrol (2009) 1.08
Combined NGS approaches identify mutations in the intraflagellar transport gene IFT140 in skeletal ciliopathies with early progressive kidney Disease. Hum Mutat (2013) 1.07
A mechanosensitive ion channel regulating cell volume. Am J Physiol Cell Physiol (2010) 1.06
Defining features of the hair cell mechanoelectrical transducer channel. Pflugers Arch (2009) 1.05
Structural requirements for PACSIN/Syndapin operation during zebrafish embryonic notochord development. PLoS One (2009) 1.05
Swelling and eicosanoid metabolites differentially gate TRPV4 channels in retinal neurons and glia. J Neurosci (2014) 1.05
Depletion of intracellular Ca2+ stores stimulates the translocation of vanilloid transient receptor potential 4-c1 heteromeric channels to the plasma membrane. Arterioscler Thromb Vasc Biol (2010) 1.04
Function of transient receptor potential cation channel subfamily V member 4 (TRPV4) as a mechanical transducer in flow-sensitive segments of renal collecting duct system. J Biol Chem (2012) 1.03
The Role of TRP Proteins in Mast Cells. Front Immunol (2012) 1.02
Atomic force microscopy reveals the alternating subunit arrangement of the TRPP2-TRPV4 heterotetramer. Biophys J (2010) 1.01
A polycystin-centric view of cyst formation and disease: the polycystins revisited. Kidney Int (2015) 1.01
Mechanically induced osteogenic lineage commitment of stem cells. Stem Cell Res Ther (2013) 1.00
Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner. J Clin Invest (2015) 1.00
Epidermal growth factor-mediated proliferation and sodium transport in normal and PKD epithelial cells. Biochim Biophys Acta (2010) 1.00
Ciliar functions in the nephron. Pflugers Arch (2009) 0.99
Determinants of TRPV4 activity following selective activation by small molecule agonist GSK1016790A. PLoS One (2011) 0.99
TRPV4 and the regulation of vascular tone. J Cardiovasc Pharmacol (2013) 0.99
Cystic diseases of the kidney: ciliary dysfunction and cystogenic mechanisms. Pediatr Nephrol (2010) 0.98
Meckel-Gruber syndrome and the role of primary cilia in kidney, skeleton, and central nervous system development. Organogenesis (2013) 0.98
A method for measuring electrical signals in a primary cilium. Cilia (2012) 0.98
Smooth muscle cell transient receptor potential polycystin-2 (TRPP2) channels contribute to the myogenic response in cerebral arteries. J Physiol (2013) 0.97
Function and regulation of TRPP2 at the plasma membrane. Am J Physiol Renal Physiol (2009) 0.97
Structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach. Proc Natl Acad Sci U S A (2011) 0.94
TRPP2 and TRPV4 form an EGF-activated calcium permeable channel at the apical membrane of renal collecting duct cells. PLoS One (2013) 0.94
Loss of interneuron LTD and attenuated pyramidal cell LTP in Trpv1 and Trpv3 KO mice. Hippocampus (2013) 0.94
The ciliary flow sensor and polycystic kidney disease. Nephrol Dial Transplant (2013) 0.93
Molecular pathways and therapies in autosomal-dominant polycystic kidney disease. Physiology (Bethesda) (2015) 0.93
TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel. FASEB J (2014) 0.92
Purinergic activation of Ca2+-permeable TRPV4 channels is essential for mechano-sensitivity in the aldosterone-sensitive distal nephron. PLoS One (2011) 0.91
The primary cilium functions as a mechanical and calcium signaling nexus. Cilia (2015) 0.91
Primary cilia signaling mediates intraocular pressure sensation. Proc Natl Acad Sci U S A (2014) 0.91
A single amino acid residue constitutes the third dimerization domain essential for the assembly and function of the tetrameric polycystin-2 (TRPP2) channel. J Biol Chem (2011) 0.91
Protein kinase G inhibits flow-induced Ca2+ entry into collecting duct cells. J Am Soc Nephrol (2012) 0.91
Primary cilia and kidney injury: current research status and future perspectives. Am J Physiol Renal Physiol (2013) 0.90
Heteromerization of TRP channel subunits: extending functional diversity. Protein Cell (2010) 0.90
Expression of Arabidopsis MCA1 enhanced mechanosensitive channel activity in the Xenopus laevis oocyte plasma membrane. Plant Signal Behav (2012) 0.90
Vasopressin and disruption of calcium signalling in polycystic kidney disease. Nat Rev Nephrol (2015) 0.89
Drosophila sperm swim backwards in the female reproductive tract and are activated via TRPP2 ion channels. PLoS One (2011) 0.89
Polycystins and partners: proposed role in mechanosensitivity. J Physiol (2014) 0.89
Role of TRP channels in the cardiovascular system. Am J Physiol Heart Circ Physiol (2014) 0.88
Gene expression gradients along the tonotopic axis of the chicken auditory epithelium. J Assoc Res Otolaryngol (2011) 0.88
A TRPV4 channel C-terminal folding recognition domain critical for trafficking and function. J Biol Chem (2013) 0.88
Calcium-mediated mechanisms of cystic expansion. Biochim Biophys Acta (2010) 0.88
An acute rise in intraluminal pressure shifts the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide in human arterioles. Am J Physiol Heart Circ Physiol (2014) 0.88
Sensory functions of motile cilia and implication for bronchiectasis. Front Biosci (Schol Ed) (2012) 0.87
The primary cilium calcium channels and their role in flow sensing. Pflugers Arch (2014) 0.86
Shear stress-induced volume decrease in C11-MDCK cells by BK-alpha/beta4. Am J Physiol Renal Physiol (2010) 0.86
P2X4 receptors interact with both P2X2 and P2X7 receptors in the form of homotrimers. Br J Pharmacol (2011) 0.86
Kif3a guides microtubular dynamics, migration and lumen formation of MDCK cells. PLoS One (2013) 0.85
Pathophysiology of childhood polycystic kidney diseases: new insights into disease-specific therapy. Pediatr Res (2013) 0.84
Primary cilia: the chemical antenna regulating human adipose-derived stem cell osteogenesis. PLoS One (2013) 0.84
Purinergic signalling in the kidney in health and disease. Purinergic Signal (2013) 0.84
An intelligent nano-antenna: Primary cilium harnesses TRP channels to decode polymodal stimuli. Cell Calcium (2015) 0.83
Biomechanical force in blood development: extrinsic physical cues drive pro-hematopoietic signaling. Differentiation (2013) 0.83
A latent capacity of the C. elegans polycystins to disrupt sensory transduction is repressed by the single-pass ciliary membrane protein CWP-5. Dis Model Mech (2010) 0.83
Astrocyte contributions to flow/pressure-evoked parenchymal arteriole vasoconstriction. J Neurosci (2015) 0.83
A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7. J Biol Chem (2009) 0.83
Cellular functions of transient receptor potential channels. Int J Biochem Cell Biol (2010) 0.83
Novel insights into TRPV4 function in the kidney. Pflugers Arch (2012) 0.83
Transient receptor potential channels and regulation of lung endothelial permeability. Pulm Circ (2013) 0.82
The primary cilium as a novel extracellular sensor in bone. Front Endocrinol (Lausanne) (2012) 0.82
Apigenin, a plant-derived flavone, activates transient receptor potential vanilloid 4 cation channel. Br J Pharmacol (2012) 0.82
Discrete control of TRPV4 channel function in the distal nephron by protein kinases A and C. J Biol Chem (2013) 0.82
Cell polarity and cystic kidney disease. Pediatr Nephrol (2012) 0.82
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet (2003) 13.33
Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference. J Virol (2003) 6.21
Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell (2000) 5.73
Bending the MDCK cell primary cilium increases intracellular calcium. J Membr Biol (2001) 5.42
Heat-evoked activation of the ion channel, TRPV4. J Neurosci (2002) 4.69
Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents. Nature (2001) 4.28
A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney. Development (2004) 3.97
Abnormal osmotic regulation in trpv4-/- mice. Proc Natl Acad Sci U S A (2003) 3.87
Somatic inactivation of Pkd2 results in polycystic kidney disease. Cell (1998) 3.84
Impaired pressure sensation in mice lacking TRPV4. J Biol Chem (2003) 3.59
Combinatorial expression of TRPV channel proteins defines their sensory functions and subcellular localization in C. elegans neurons. Neuron (2002) 3.17
Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation. Nat Genet (1997) 3.06
Mechanisms of Disease: autosomal dominant and recessive polycystic kidney diseases. Nat Clin Pract Nephrol (2006) 2.95
Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells. J Biol Chem (2002) 2.87
Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2003) 2.50
TRPV4 calcium entry channel: a paradigm for gating diversity. Am J Physiol Cell Physiol (2004) 2.35
A simple methylene blue-azure II-basic fuchsin stain for epoxy-embedded tissue sections. Stain Technol (1974) 2.24
Molecular determinants of permeation through the cation channel TRPV4. J Biol Chem (2002) 2.24
Polycystin 1 is required for the structural integrity of blood vessels. Proc Natl Acad Sci U S A (2000) 2.23
Altered thermal selection behavior in mice lacking transient receptor potential vanilloid 4. J Neurosci (2005) 2.21
Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. EMBO J (2005) 2.12
Specific association of the gene product of PKD2 with the TRPC1 channel. Proc Natl Acad Sci U S A (1999) 2.09
Impaired osmotic sensation in mice lacking TRPV4. Am J Physiol Cell Physiol (2003) 2.00
Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion. Proc Natl Acad Sci U S A (2007) 1.72
PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4. J Biol Chem (2006) 1.71
Mechanoregulation of intracellular Ca2+ concentration is attenuated in collecting duct of monocilium-impaired orpk mice. Am J Physiol Renal Physiol (2005) 1.66
Dual role of the TRPV4 channel as a sensor of flow and osmolality in renal epithelial cells. Am J Physiol Renal Physiol (2007) 1.50
Polycystin-2 immunolocalization and function in zebrafish. J Am Soc Nephrol (2006) 1.50
TRP channels in C. elegans. Annu Rev Physiol (2006) 1.39
Polycystic kidney disease--the ciliary connection. Lancet (2003) 1.37
TRPV4 as a flow sensor in flow-dependent K+ secretion from the cortical collecting duct. Am J Physiol Renal Physiol (2006) 1.37
Differential activation of the volume-sensitive cation channel TRP12 (OTRPC4) and volume-regulated anion currents in HEK-293 cells. Pflugers Arch (2001) 1.36
The versatile nature of the calcium-permeable cation channel TRPP2. EMBO Rep (2006) 1.34
Loss of Bardet Biedl syndrome proteins causes defects in peripheral sensory innervation and function. Proc Natl Acad Sci U S A (2007) 1.32
Warm temperature-sensitive transient receptor potential vanilloid 4 (TRPV4) plays an essential role in thermal hyperalgesia. J Biol Chem (2004) 1.31
TRPP2 and autosomal dominant polycystic kidney disease. Biochim Biophys Acta (2007) 1.27
Homo- and heteromeric assembly of TRP channel subunits. Pflugers Arch (2005) 1.24
Renal expression of osmotically responsive cation channel TRPV4 is restricted to water-impermeant nephron segments. Am J Physiol Renal Physiol (2004) 1.23
Cellular activation triggered by the autosomal dominant polycystic kidney disease gene product PKD2. Mol Cell Biol (1999) 1.20
Subcellular localization and trafficking of polycystins. Pflugers Arch (2005) 1.16
The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels. EMBO J (2006) 1.09
PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2. J Biol Chem (2004) 1.07
Dynamic expression of the osmosensory channel trpv4 in multiple developing organs in zebrafish. Gene Expr Patterns (2006) 1.05
Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs. Mol Reprod Dev (2005) 1.04
Ciliary calcium signaling is modulated by kidney injury molecule-1 (Kim1). Pflugers Arch (2007) 0.98
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst (2005) 13.00
Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. Nat Genet (2005) 6.67
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature (2004) 5.76
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Nat Genet (2006) 5.36
Quantum dots versus organic dyes as fluorescent labels. Nat Methods (2008) 5.36
Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. Nat Genet (2003) 5.24
The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proc Natl Acad Sci U S A (2006) 4.56
Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. Nature (2003) 4.45
A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1. Nat Med (2007) 4.40
Somatic mutations of the HER2 kinase domain in lung adenocarcinomas. Cancer Res (2005) 4.25
Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis. Nat Genet (2003) 4.14
Primary cilia regulate mTORC1 activity and cell size through Lkb1. Nat Cell Biol (2010) 3.55
TRPA1 acts as a cold sensor in vitro and in vivo. Proc Natl Acad Sci U S A (2009) 3.46
Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest (2010) 3.44
PIK3CA mutations and copy number gains in human lung cancers. Cancer Res (2008) 3.42
Constitutive photomorphogenesis 1 and multiple photoreceptors control degradation of phytochrome interacting factor 3, a transcription factor required for light signaling in Arabidopsis. Plant Cell (2004) 3.31
PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats. Am J Hum Genet (2002) 3.21
TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption. J Biol Chem (2003) 3.15
Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem (2002) 3.14
PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell (2002) 3.09
TRP channels: an overview. Cell Calcium (2005) 2.98
Permeation and selectivity of TRP channels. Annu Rev Physiol (2006) 2.96
Role of mTOR in podocyte function and diabetic nephropathy in humans and mice. J Clin Invest (2011) 2.90
Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells. J Biol Chem (2002) 2.87
Bimodal action of menthol on the transient receptor potential channel TRPA1. J Neurosci (2007) 2.78
Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia. Am J Hum Genet (2008) 2.74
Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling. Mol Cell Biol (2003) 2.69
The OsTB1 gene negatively regulates lateral branching in rice. Plant J (2003) 2.69
Calcium absorption across epithelia. Physiol Rev (2005) 2.57
Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell (2012) 2.54
Heat activation of TRPM5 underlies thermal sensitivity of sweet taste. Nature (2005) 2.52
Sensing with TRP channels. Nat Chem Biol (2005) 2.51
TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli. Nat Chem Biol (2007) 2.48
TRPV4 calcium entry channel: a paradigm for gating diversity. Am J Physiol Cell Physiol (2004) 2.35
TRPM3 is a nociceptor channel involved in the detection of noxious heat. Neuron (2011) 2.31
Gating of TRP channels: a voltage connection? J Physiol (2005) 2.30
Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations. Proc Natl Acad Sci U S A (2002) 2.29
2-aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3. J Neurosci (2004) 2.27
Molecular determinants of permeation through the cation channel TRPV4. J Biol Chem (2002) 2.24
Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia. Nat Genet (2008) 2.24
The Ca2+-activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphate. EMBO J (2006) 2.22
Altered thermal selection behavior in mice lacking transient receptor potential vanilloid 4. J Neurosci (2005) 2.21
Voltage dependence of the Ca2+-activated cation channel TRPM4. J Biol Chem (2003) 2.21
Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding. J Clin Invest (2007) 2.19
Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci U S A (2006) 2.16
Retracted Aberrant methylation of Reprimo in human malignancies. Int J Cancer (2005) 2.13
The vanilloid transient receptor potential channel TRPV4: from structure to disease. Prog Biophys Mol Biol (2009) 2.13
TRPs in our senses. Curr Biol (2008) 2.12
Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. EMBO J (2005) 2.12
Notch signaling controls the differentiation of transporting epithelia and multiciliated cells in the zebrafish pronephros. Development (2007) 2.08
Phase II study of tofacitinib (CP-690,550) combined with methotrexate in patients with rheumatoid arthritis and an inadequate response to methotrexate. Arthritis Care Res (Hoboken) (2011) 2.06
Exploring the impact of climate on human longevity. Exp Gerontol (2012) 2.03
Mutations in the gene encoding the calcium-permeable ion channel TRPV4 produce spondylometaphyseal dysplasia, Kozlowski type and metatropic dysplasia. Am J Hum Genet (2009) 2.02
Pharmacology of vanilloid transient receptor potential cation channels. Mol Pharmacol (2009) 2.00
Impaired osmotic sensation in mice lacking TRPV4. Am J Physiol Cell Physiol (2003) 2.00
CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly of ciliary dynein arms. Nat Genet (2012) 1.99
Mechanical induction of lateral root initiation in Arabidopsis thaliana. Proc Natl Acad Sci U S A (2008) 1.98
A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo. J Am Soc Nephrol (2004) 1.97
Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex. EMBO J (2003) 1.97
Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. Proc Natl Acad Sci U S A (2010) 1.96
Assessment of epidermal growth factor receptor mutation by endobronchial ultrasound-guided transbronchial needle aspiration. Chest (2007) 1.93
From cilia to cyst. Nat Genet (2003) 1.92
TRPV3 and TRPV4 mediate warmth-evoked currents in primary mouse keratinocytes. J Biol Chem (2004) 1.88
Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome. J Am Soc Nephrol (2009) 1.86
Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin. J Cell Sci (2008) 1.86
NEPH1 defines a novel family of podocin interacting proteins. FASEB J (2002) 1.85
Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1. J Am Soc Nephrol (2003) 1.83
Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival. Oncogene (2004) 1.82
Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4. J Biol Chem (2004) 1.82
Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function. J Immunol (2008) 1.81
Outer pore architecture of a Ca2+-selective TRP channel. J Biol Chem (2004) 1.79
TRPV4-mediated calcium influx regulates terminal differentiation of osteoclasts. Cell Metab (2008) 1.79
Molecular advances in autosomal dominant polycystic kidney disease. Adv Chronic Kidney Dis (2010) 1.77
TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress. Am J Physiol Heart Circ Physiol (2009) 1.76
Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer. Cancer Res (2004) 1.74
Clinical implications of an implantable cardioverter-defibrillator in patients with vasospastic angina and lethal ventricular arrhythmia. J Am Coll Cardiol (2012) 1.73
Siblings of Okinawan centenarians share lifelong mortality advantages. J Gerontol A Biol Sci Med Sci (2006) 1.73
PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4. J Biol Chem (2006) 1.71
Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains. Hum Mol Genet (2003) 1.70
Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1. J Am Soc Nephrol (2010) 1.70
Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice. Cell Calcium (2005) 1.70
Spectrum of mutations in the gene for autosomal recessive polycystic kidney disease (ARPKD/PKHD1). J Am Soc Nephrol (2003) 1.70
The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Brain (2011) 1.70