Published in Ann Surg on January 01, 2002
Tailoring to RB: tumour suppressor status and therapeutic response. Nat Rev Cancer (2008) 3.16
SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clin Cancer Res (2009) 2.44
Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumors. Am J Surg Pathol (2012) 1.71
Meta-analysis of immunohistochemical prognostic markers in resected pancreatic cancer. Br J Cancer (2011) 1.45
CDKN2A germline mutations in familial pancreatic cancer. Ann Surg (2002) 1.18
Stathmin 1 and p16(INK4A) are sensitive adjunct biomarkers for serous tubal intraepithelial carcinoma. Gynecol Oncol (2015) 1.00
Alterations of tumor suppressor gene p16INK4a in pancreatic ductal carcinoma. BMC Gastroenterol (2005) 0.97
Establishment and characterization of a new cell line, A99, from a primary small cell carcinoma of the pancreas. Pancreas (2011) 0.93
RhoT1 and Smad4 are correlated with lymph node metastasis and overall survival in pancreatic cancer. PLoS One (2012) 0.87
Expression of p57kip2, Rb protein and PCNA and their relationships with clinicopathology in human pancreatic cancer. World J Gastroenterol (2003) 0.87
Rationale for possible targeting of histone deacetylase signaling in cancer diseases with a special reference to pancreatic cancer. J Biomed Biotechnol (2010) 0.87
Preproenkephalin hypermethylation in the pure pancreatic juice compared with p53 mutation in the diagnosis of pancreatic carcinoma. J Gastroenterol (2006) 0.85
Prognostic significance of regulators of cell cycle and apoptosis, p16(INK4a), p53, and bcl-2 in primary mucosal melanomas of the head and neck. Head Neck Pathol (2011) 0.84
Can Molecular Biomarkers Change the Paradigm of Pancreatic Cancer Prognosis? Biomed Res Int (2016) 0.82
The molecular targets for the diagnosis and treatment of pancreatic cancer. Gut Liver (2010) 0.82
Does the WHO 2010 classification of pancreatic neuroendocrine neoplasms accurately characterize pancreatic neuroendocrine carcinomas? J Gastroenterol (2014) 0.80
Clinicopathological Significance of CDKN2A Promoter Hypermethylation Frequency with Pancreatic Cancer. Sci Rep (2015) 0.80
TGF-beta and p53 staining in CT-guided and endoscopic ultrasound fine-needle aspirates of pancreatic adenocarcinoma. Dig Dis Sci (2004) 0.79
Two distinct pathways of p16 gene inactivation in gallbladder cancer. World J Gastroenterol (2007) 0.77
Construction of targeted plasmid vector pcDNA3.1-Egr.1p-p16 and its expression in pancreatic cancer JF305 cells induced by radiation in vitro. World J Gastroenterol (2007) 0.77
Association of cyclin D1, p16 and retinoblastoma protein expressions with prognosis and metastasis of gallbladder carcinoma. World J Gastroenterol (2005) 0.77
Clinico-epigenetic combination including quantitative methylation value of DKK3 augments survival prediction of the patient with cervical cancer. J Cancer Res Clin Oncol (2012) 0.77
New tumor-associated antigen SC6 in pancreatic cancer. World J Gastroenterol (2005) 0.75
Association of MDM2 expression with shorter progression-free survival and overall survival in patients with advanced pancreatic cancer treated with gemcitabine-based chemotherapy. PLoS One (2017) 0.75
A genetic model for colorectal tumorigenesis. Cell (1990) 44.37
p53 mutations in human cancers. Science (1991) 31.96
Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A (1996) 29.54
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell (1998) 8.33
Tumor-suppressive pathways in pancreatic carcinoma. Cancer Res (1997) 4.54
Antioncogenes and human cancer. Proc Natl Acad Sci U S A (1993) 4.09
Pancreaticoduodenectomy for pancreatic adenocarcinoma: postoperative adjuvant chemoradiation improves survival. A prospective, single-institution experience. Ann Surg (1997) 3.90
Carcinoma of the pancreas: critical analysis of costs, results of resections, and the need for standardized reporting. J Am Coll Surg (1995) 3.83
Tests and estimates of allelic association in complex inheritance. Proc Natl Acad Sci U S A (1998) 2.78
The National Cancer Data Base report on pancreatic cancer. Cancer (1995) 2.77
Hypermethylation of multiple genes in pancreatic adenocarcinoma. Cancer Res (2000) 2.40
Collective review of small carcinomas of the pancreas. Ann Surg (1986) 2.24
Mdm2: keeping p53 under control. Oncogene (1997) 1.83
Pancreatic adenocarcinomas frequently show p53 gene mutations. Am J Pathol (1993) 1.80
Overexpression of p53 protein in adenocarcinoma of the pancreas. Am J Clin Pathol (1994) 1.79
Sensitivity of single-strand conformation polymorphism and heteroduplex method for mutation detection in the cystic fibrosis gene. Hum Mol Genet (1994) 1.62
The INK4a/ARF tumor suppressor: one gene--two products--two pathways. Trends Biochem Sci (1998) 1.59
MDM-2 oncoprotein overexpression, p53 gene mutation, and VEGF up-regulation in angiosarcomas. Am J Pathol (1998) 1.49
Absence of retinoblastoma protein expression in primary non-small cell lung carcinomas. Cancer Res (1991) 1.23
Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death. Nat Med (1997) 1.19
The p16-cyclin D1/CDK4-pRb pathway and clinical outcome in epithelial ovarian cancer. Clin Cancer Res (1999) 1.11
Molecular prognostic markers in pancreatic cancer. Cancer Control (2000) 1.10
MDM2 gene amplification and expression in non-small-cell lung cancer: immunohistochemical expression of its protein is a favourable prognostic marker in patients without p53 protein accumulation. Br J Cancer (1997) 1.07
Frequent codeletion of p16/MTS1 and p15/MTS2 and genetic alterations in p16/MTS1 in pancreatic tumors. Gastroenterology (1996) 1.05
Prognostic factors in resectable pancreatic cancer: p53 and bcl-2. J Gastrointest Surg (2000) 1.02
Absence of TP53 alterations in pheochromocytomas and medullary thyroid carcinomas. Genes Chromosomes Cancer (1997) 0.98
Frequent alterations of the tumor suppressor genes p53 and DCC in human pancreatic carcinoma. Gastroenterology (1994) 0.98
Frequent loss of p16 expression and its correlation with clinicopathological parameters in pancreatic carcinoma. Clin Cancer Res (1997) 0.97
Immunohistochemical p16INK4a analysis of archival tumors with deletion, hypermethylation, or mutation of the CDKN2/MTS1 gene. A comparison of four commercial antibodies. Appl Immunohistochem Mol Morphol (2000) 0.97
A molecular and immunohistochemical study of the MDM2 protein isoforms and p53 gene product in bronchogenic carcinoma. J Pathol (1996) 0.95
Cathepsin D, B and L circulating levels as prognostic markers of malignant progression. Anticancer Res (1996) 0.93
Frequent mutations of CDKN2 in primary pancreatic adenocarcinomas. Genes Chromosomes Cancer (1995) 0.92
Prognostic value of immunohistochemical expression of p53 in patients with pancreatic cancer. Oncology (1996) 0.92
Aberrant p16INK4 expression related to clinical stage and prognosis in patients with pancreatic cancer. Int J Oncol (1998) 0.90
Analysis of p53, p21WAF1, and TGF-beta1 in human ductal adenocarcinoma of the pancreas: TGF-beta1 protein expression predicts longer survival. Am J Clin Pathol (1998) 0.90
Surgical treatment of pancreatic cancer. The United States experience. Int J Pancreatol (1991) 0.90
Ki-67 and c-jun expression in pancreatic cancer: a prognostic marker? Oncol Rep (1999) 0.87
Reduced survival in patients with ductal pancreatic adenocarcinoma associated with CDKN2 mutation. J Natl Cancer Inst (1996) 0.87
The cell cycle-regulating transcription factors E2F-RB. Br J Cancer (1999) 0.86
Multiple primary tumors as an indicator for p16INK4a germline mutations in pancreatic cancer patients? Pancreas (2000) 0.85
P16INK4a expression adenovirus vector to suppress pancreas cancer cell proliferation. Clin Cancer Res (1999) 0.84
Adenovirus p16 gene therapy for prostate cancer. World J Urol (2000) 0.83
Multiple genetic alterations in hamster pancreatic ductal adenocarcinomas. Cancer Res (1995) 0.80
Molecular alterations associated with improved survival in pancreatic cancer patients treated with radiation or chemotherapy. J Hepatobiliary Pancreat Surg (1998) 0.79
Evaluation of UICC TNM classification for pancreatic cancer. A study of 228 patients. Int J Pancreatol (1997) 0.77
[The prognostic factors of pancreatic cancer--adhesion molecule CD44]. Gan To Kagaku Ryoho (1998) 0.77
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings. Ann Surg (2012) 19.78
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Genetics and beyond--the transcriptome of human monocytes and disease susceptibility. PLoS One (2010) 7.48
Statistical analysis of rare sequence variants: an overview of collapsing methods. Genet Epidemiol (2011) 6.18
Gene map of the extended human MHC. Nat Rev Genet (2004) 6.01
New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58
Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease. Circulation (2008) 5.20
New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet (2009) 5.12
Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nat Genet (2009) 4.63
The ubiquitin-specific protease USP28 is required for MYC stability. Nat Cell Biol (2007) 3.63
BRCA2 germline mutations in familial pancreatic carcinoma. J Natl Cancer Inst (2003) 3.37
Transoral thyroid and parathyroid surgery. Surg Endosc (2009) 3.31
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Predicting long-term outcome after acute ischemic stroke: a simple index works in patients from controlled clinical trials. Stroke (2008) 3.21
Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls. Circ Cardiovasc Genet (2010) 3.15
On safari to Random Jungle: a fast implementation of Random Forests for high-dimensional data. Bioinformatics (2010) 3.09
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature (2010) 2.88
FTO genotype is associated with phenotypic variability of body mass index. Nature (2012) 2.77
Candidate biomarkers for discrimination between infection and disease caused by Mycobacterium tuberculosis. J Mol Med (Berl) (2007) 2.69
Avoidance of mechanical ventilation by surfactant treatment of spontaneously breathing preterm infants (AMV): an open-label, randomised, controlled trial. Lancet (2011) 2.62
Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation study. PLoS One (2008) 2.37
Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages: a new cell biological concept. Lab Invest (2002) 2.33
Grasping molecular structures through publication-integrated 3D models. Trends Biochem Sci (2008) 2.26
SNP-based analysis of genetic substructure in the German population. Hum Hered (2006) 2.21
Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol (2010) 2.17
Association between c135G/A genotype and RET proto-oncogene germline mutations and phenotype of Hirschsprung's disease. Lancet (2002) 2.10
Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. JAMA (2009) 2.10
Next-generation phenotyping using the parkin example: time to catch up with genetics. JAMA Neurol (2013) 2.02
Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction. Circulation (2011) 1.96
Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia. Am J Hum Genet (2005) 1.94
Predicting functional outcome and survival after acute ischemic stroke. J Neurol (2002) 1.92
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nat Genet (2011) 1.92
Deregulated MYC expression induces dependence upon AMPK-related kinase 5. Nature (2012) 1.88
Association of a polymorphism of the ACVRL1 gene with sporadic arteriovenous malformations of the central nervous system. J Neurosurg (2006) 1.83
Triple target treatment (3T) is more effective than biofeedback alone for anal incontinence: the 3T-AI study. Dis Colon Rectum (2010) 1.81
The Indications for Laparoscopic Pancreatectomy. Dtsch Arztebl Int (2017) 1.71
A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease. Circ Cardiovasc Genet (2011) 1.63
EPIBLASTER-fast exhaustive two-locus epistasis detection strategy using graphical processing units. Eur J Hum Genet (2010) 1.62
Laryngoscopy in thyroid surgery--essential standard or unnecessary routine? Surgery (2007) 1.60
Opportunities and challenges for digital morphology. Biol Direct (2010) 1.60
The behaviour of random forest permutation-based variable importance measures under predictor correlation. BMC Bioinformatics (2010) 1.59
Usual ductal hyperplasia of the breast is a committed stem (progenitor) cell lesion distinct from atypical ductal hyperplasia and ductal carcinoma in situ. J Pathol (2002) 1.56
Ankylosing spondylitis: a beta2m-deposition disease? Trends Immunol (2003) 1.55
Sepsis syndrome and death in trauma patients are associated with variation in the gene encoding tumor necrosis factor. Crit Care Med (2008) 1.53
Genome-wide association study indicates two novel resistance loci for severe malaria. Nature (2012) 1.52
A pooled analysis of melanocytic nevus phenotype and the risk of cutaneous melanoma at different latitudes. Int J Cancer (2009) 1.51
Individual radiosensitivity measured with lymphocytes may predict the risk of acute reaction after radiotherapy. Int J Radiat Oncol Biol Phys (2008) 1.50
Human genetic resistance to Onchocerca volvulus: evidence for linkage to chromosome 2p from an autosome-wide scan. J Infect Dis (2008) 1.49
Outcome of surgery for primary hyperaldosteronism. World J Surg (2011) 1.47
Inactivation of Brca2 cooperates with Trp53(R172H) to induce invasive pancreatic ductal adenocarcinomas in mice: a mouse model of familial pancreatic cancer. Cancer Biol Ther (2011) 1.45
Call-associated acute fatigue in surgical residents--subjective perception or objective fact? A cross-sectional observational study to examine the influence of fatigue on surgical performance. World J Surg (2012) 1.43
Anterior chamber angle measurement with optical coherence tomography: intraobserver and interobserver variability. J Cataract Refract Surg (2006) 1.43
Combined inhibition of cellular pathways as a future therapeutic option in fatal anaplastic thyroid cancer. Endocrine (2012) 1.42
Effectiveness of radiochemotherapy on lymph node metastases in patients with stage IV oropharyngeal cancer. Oral Oncol (2004) 1.42
HLA-B27 misfolding is associated with aberrant intermolecular disulfide bond formation (dimerization) in the endoplasmic reticulum. J Biol Chem (2002) 1.41
Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans. PLoS Genet (2011) 1.40
Oligoclonal expansion of memory CD8+ T cells in cerebrospinal fluid from multiple sclerosis patients. Brain (2002) 1.37
Picking single-nucleotide polymorphisms in forests. BMC Proc (2007) 1.36
The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol. J Mol Med (Berl) (2008) 1.35
Lessons learned from Genetic Analysis Workshop 17: transitioning from genome-wide association studies to whole-genome statistical genetic analysis. Genet Epidemiol (2011) 1.34
Photodynamic diagnosis in non-muscle-invasive bladder cancer: a systematic review and cumulative analysis of prospective studies. Eur Urol (2009) 1.32
Airtightness of lung parenchyma without a closing suture after atypical resection using the Nd:YAG Laser LIMAX 120. Interact Cardiovasc Thorac Surg (2013) 1.32
Dual, HLA-B27 subtype-dependent conformation of a self-peptide. J Exp Med (2004) 1.31
Analyzing illumina gene expression microarray data from different tissues: methodological aspects of data analysis in the metaxpress consortium. PLoS One (2012) 1.31
Discovery and fine mapping of serum protein loci through transethnic meta-analysis. Am J Hum Genet (2012) 1.29
Splenic metastases in a large unselected autopsy series. Pathol Res Pract (2006) 1.26
Targeting FGFR/PDGFR/VEGFR impairs tumor growth, angiogenesis, and metastasis by effects on tumor cells, endothelial cells, and pericytes in pancreatic cancer. Mol Cancer Ther (2011) 1.26
Identification of genetic association of multiple rare variants using collapsing methods. Genet Epidemiol (2011) 1.26
Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies. Circ Cardiovasc Genet (2011) 1.26
Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11b(high)Gr1(low) macrophages. J Clin Invest (2011) 1.25
Genome-wide association study identifies a new locus for coronary artery disease on chromosome 10p11.23. Eur Heart J (2010) 1.25
Effectively incorporating selected multimedia content into medical publications. BMC Med (2011) 1.24
Deregulation of tumor angiogenesis and blockade of tumor growth in PPARbeta-deficient mice. EMBO J (2007) 1.24
Octreotide versus octreotide plus interferon-alpha in endocrine gastroenteropancreatic tumors: a randomized trial. Clin Gastroenterol Hepatol (2005) 1.23
Her-2/neu gene amplification and protein expression in primary male breast cancer. Breast Cancer Res Treat (2004) 1.23
Leaving the structural ivory tower, assisted by interactive 3D PDF. Trends Biochem Sci (2010) 1.19
Differential peptide dynamics is linked to major histocompatibility complex polymorphism. J Biol Chem (2004) 1.19
The songbird syrinx morphome: a three-dimensional, high-resolution, interactive morphological map of the zebra finch vocal organ. BMC Biol (2013) 1.18
CDKN2A germline mutations in familial pancreatic cancer. Ann Surg (2002) 1.18
Evaluation of the 4q32-34 locus in European familial pancreatic cancer. Cancer Epidemiol Biomarkers Prev (2006) 1.16
CD34+ fibrocytes, alpha-smooth muscle antigen-positive myofibroblasts, and CD117 expression in the stroma of invasive squamous cell carcinomas of the oral cavity, pharynx, and larynx. Virchows Arch (2004) 1.15
Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues. J Pathol (2012) 1.14
Tight junction-related structures in the absence of a lumen: occludin, claudins and tight junction plaque proteins in densely packed cell formations of stratified epithelia and squamous cell carcinomas. Eur J Cell Biol (2003) 1.13
Human Merkel cells--aspects of cell biology, distribution and functions. Eur J Cell Biol (2005) 1.13