Adaptation of pandemic H1N1 influenza viruses in mice.

PubWeight™: 2.22‹?› | Rank: Top 2%

🔗 View Article (PMC 2918990)

Published in J Virol on June 30, 2010

Authors

Natalia A Ilyushina1, Alexey M Khalenkov, Jon P Seiler, Heather L Forrest, Nicolai V Bovin, Henju Marjuki, Subrata Barman, Robert G Webster, Richard J Webby

Author Affiliations

1: Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee 38105-3678, USA.

Articles citing this

PB2 residue 158 is a pathogenic determinant of pandemic H1N1 and H5 influenza a viruses in mice. J Virol (2010) 1.91

The viral nucleoprotein determines Mx sensitivity of influenza A viruses. J Virol (2011) 1.51

Antibody pressure by a human monoclonal antibody targeting the 2009 pandemic H1N1 virus hemagglutinin drives the emergence of a virus with increased virulence in mice. MBio (2012) 1.43

Adaptation of avian influenza A virus polymerase in mammals to overcome the host species barrier. J Virol (2013) 1.40

Two years after pandemic influenza A/2009/H1N1: what have we learned? Clin Microbiol Rev (2012) 1.31

Reassortment and mutation of the avian influenza virus polymerase PA subunit overcome species barriers. J Virol (2011) 1.28

Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein. PLoS Pathog (2013) 1.24

PA residues in the 2009 H1N1 pandemic influenza virus enhance avian influenza virus polymerase activity in mammalian cells. J Virol (2011) 1.22

Effect of D222G mutation in the hemagglutinin protein on receptor binding, pathogenesis and transmissibility of the 2009 pandemic H1N1 influenza virus. PLoS One (2011) 1.21

Mutations in PA, NP, and HA of a pandemic (H1N1) 2009 influenza virus contribute to its adaptation to mice. Virus Res (2011) 1.21

Unstable polymerase-nucleoprotein interaction is not responsible for avian influenza virus polymerase restriction in human cells. J Virol (2012) 1.14

Genomic and protein structural maps of adaptive evolution of human influenza A virus to increased virulence in the mouse. PLoS One (2011) 1.13

Influenza A virus exacerbates Staphylococcus aureus pneumonia in mice by attenuating antimicrobial peptide production. J Infect Dis (2013) 1.11

Immunogenicity and efficacy of flagellin-fused vaccine candidates targeting 2009 pandemic H1N1 influenza in mice. PLoS One (2011) 1.05

Multifunctional adaptive NS1 mutations are selected upon human influenza virus evolution in the mouse. PLoS One (2012) 1.03

Combinations of favipiravir and peramivir for the treatment of pandemic influenza A/California/04/2009 (H1N1) virus infections in mice. Antiviral Res (2012) 1.00

Mutations in polymerase genes enhanced the virulence of 2009 pandemic H1N1 influenza virus in mice. PLoS One (2012) 1.00

Mouse-adapted H9N2 influenza A virus PB2 protein M147L and E627K mutations are critical for high virulence. PLoS One (2012) 0.99

The potential of avian H1N1 influenza A viruses to replicate and cause disease in mammalian models. PLoS One (2012) 0.99

Preclinical activity of VX-787, a first-in-class, orally bioavailable inhibitor of the influenza virus polymerase PB2 subunit. Antimicrob Agents Chemother (2014) 0.96

Implication of inflammatory macrophages, nuclear receptors, and interferon regulatory factors in increased virulence of pandemic 2009 H1N1 influenza A virus after host adaptation. J Virol (2012) 0.96

Comparable fitness and transmissibility between oseltamivir-resistant pandemic 2009 and seasonal H1N1 influenza viruses with the H275Y neuraminidase mutation. J Virol (2012) 0.94

Pathogenicity and transmissibility of North American triple reassortant swine influenza A viruses in ferrets. PLoS Pathog (2012) 0.94

Tissue tropism of swine influenza viruses and reassortants in ex vivo cultures of the human respiratory tract and conjunctiva. J Virol (2011) 0.93

The PA-gene-mediated lethal dissemination and excessive innate immune response contribute to the high virulence of H5N1 avian influenza virus in mice. J Virol (2012) 0.91

Characterization of innate responses to influenza virus infection in a novel lung type I epithelial cell model. J Gen Virol (2013) 0.91

Systems approaches to influenza-virus host interactions and the pathogenesis of highly virulent and pandemic viruses. Semin Immunol (2012) 0.88

Phenotypic differences in virulence and immune response in closely related clinical isolates of influenza A 2009 H1N1 pandemic viruses in mice. PLoS One (2013) 0.88

Protection against divergent influenza H1N1 virus by a centralized influenza hemagglutinin. PLoS One (2011) 0.87

Decreased serologic response in vaccinated military recruits during 2011 correspond to genetic drift in concurrent circulating pandemic A/H1N1 viruses. PLoS One (2012) 0.86

A plant-produced H1N1 trimeric hemagglutinin protects mice from a lethal influenza virus challenge. Hum Vaccin Immunother (2013) 0.86

Analysis of adaptation mutants in the hemagglutinin of the influenza A(H1N1)pdm09 virus. PLoS One (2013) 0.85

Rapid emergence of a virulent PB2 E627K variant during adaptation of highly pathogenic avian influenza H7N7 virus to mice. Virol J (2013) 0.85

Mast cells and influenza a virus: association with allergic responses and beyond. Front Immunol (2015) 0.85

Adenovirus-vectored drug-vaccine duo as a rapid-response tool for conferring seamless protection against influenza. PLoS One (2011) 0.84

Treatment of oseltamivir-resistant influenza A (H1N1) virus infections in mice with antiviral agents. Antiviral Res (2012) 0.84

The PA and HA gene-mediated high viral load and intense innate immune response in the brain contribute to the high pathogenicity of H5N1 avian influenza virus in mallard ducks. J Virol (2013) 0.84

Antimycotic-antibiotic amphotericin B promotes influenza virus replication in cell culture. J Virol (2011) 0.83

Exacerbation of influenza virus infections in mice by intranasal treatments and implications for evaluation of antiviral drugs. Antimicrob Agents Chemother (2012) 0.83

Fecal influenza in mammals: selection of novel variants. J Virol (2013) 0.82

Characterization of an artificial swine-origin influenza virus with the same gene combination as H1N1/2009 virus: a genesis clue of pandemic strain. PLoS One (2011) 0.82

A combination of HA and PA mutations enhances virulence in a mouse-adapted H6N6 influenza A virus. J Virol (2014) 0.82

Hemagglutinin 222D/G polymorphism facilitates fast intra-host evolution of pandemic (H1N1) 2009 influenza A viruses. PLoS One (2014) 0.82

Asthma increases susceptibility to heterologous but not homologous secondary influenza. J Virol (2014) 0.82

Amino acid changes in the influenza A virus PA protein that attenuate avian H5N1 viruses in mammals. J Virol (2014) 0.81

A comprehensive collection of systems biology data characterizing the host response to viral infection. Sci Data (2014) 0.81

Crucial role of PA in virus life cycle and host adaptation of influenza A virus. Med Microbiol Immunol (2014) 0.80

Novel roles of focal adhesion kinase in cytoplasmic entry and replication of influenza A viruses. J Virol (2014) 0.80

Mouse adaptation of influenza B virus increases replication in the upper respiratory tract and results in droplet transmissibility in ferrets. Sci Rep (2015) 0.80

Mammalian adaptive mutations of the PA protein of highly pathogenic avian H5N1 influenza virus. J Virol (2015) 0.80

Heterogeneous virulence of pandemic 2009 influenza H1N1 virus in mice. Virol J (2012) 0.80

Both influenza hemagglutinin and polymerase acidic genes are important for delayed pandemic 2009 H1N1 virus clearance in the ferret model. Virology (2012) 0.80

A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response. PLoS Pathog (2016) 0.79

Host Adaptation and the Alteration of Viral Properties of the First Influenza A/H1N1pdm09 Virus Isolated in Japan. PLoS One (2015) 0.78

Antigen sparing and enhanced protection using a novel rOv-ASP-1 adjuvant in aqueous formulation with influenza vaccines. Vaccine (2014) 0.78

Q&A: H1N1 pandemic influenza--what's new? BMC Biol (2010) 0.77

A(H1N1)pdm09 hemagglutinin D222G and D222N variants are frequently harbored by patients requiring extracorporeal membrane oxygenation and advanced respiratory assistance for severe A(H1N1)pdm09 infection. Influenza Other Respir Viruses (2013) 0.77

Increased virulence of neuraminidase inhibitor-resistant pandemic H1N1 virus in mice: potential emergence of drug-resistant and virulent variants. Virulence (2013) 0.77

Effect of AcHERV-GmCSF as an Influenza Virus Vaccine Adjuvant. PLoS One (2015) 0.77

Error-prone pcr-based mutagenesis strategy for rapidly generating high-yield influenza vaccine candidates. Virology (2015) 0.76

Enhanced humoral response to influenza vaccine in aged mice with a novel adjuvant, rOv-ASP-1. Vaccine (2016) 0.76

Differential Biphasic Transcriptional Host Response Associated with Coevolution of Hemagglutinin Quasispecies of Influenza A Virus. Front Microbiol (2016) 0.75

The Ability of a Non-Egg Adapted (Cell-Like) A(H1N1)pdm09 Virus to Egg-Adapt at HA Loci Other than 222 and 223 and Its Effect on the Yield of Viral Protein. PLoS One (2016) 0.75

The PA Endonuclease Inhibitor RO-7 Protects Mice from Lethal Challenge with Influenza A or B Viruses. Antimicrob Agents Chemother (2017) 0.75

A North American H7N3 Influenza Virus Supports Reassortment with 2009 Pandemic H1N1 and Induces Disease in Mice without Prior Adaptation. J Virol (2016) 0.75

Additional Evidence That the Polymerase Subunits Contribute to the Viral Replication and the Virulence of H5N1 Avian Influenza Virus Isolates in Mice. PLoS One (2015) 0.75

Centralized Consensus Hemagglutinin Genes Induce Protective Immunity against H1, H3 and H5 Influenza Viruses. PLoS One (2015) 0.75

Phenotypic and Genetic Characterization of Avian Influenza H5N2 Viruses with Intra- and Inter-Duck Variations in Taiwan. PLoS One (2015) 0.75

Molecular determinants of influenza virus pathogenesis in mice. Curr Top Microbiol Immunol (2014) 0.75

Canine H3N8 influenza vaccines partially protect mice against the canine H3N2 strain currently circulating in the United States. Vaccine (2016) 0.75

Reduction of Neuraminidase Activity Exacerbates Disease in 2009 Pandemic Influenza Virus-Infected Mice. J Virol (2016) 0.75

A zanamivir dimer with prophylactic and enhanced therapeutic activity against influenza viruses. J Antimicrob Chemother (2014) 0.75

Enterovirus D68 in Critically Ill Children: A Comparison With Pandemic H1N1 Influenza. Pediatr Crit Care Med (2016) 0.75

Activation of coagulation and tissue fibrin deposition in experimental influenza in ferrets. BMC Microbiol (2014) 0.75

Serum amyloid A (SAA) is an early biomarker of influenza virus disease in BALB/c, C57BL/2, Swiss-Webster, and DBA.2 mice. Antiviral Res (2016) 0.75

Analysis of the Contrasting Pathogenicities Induced by the D222G Mutation in 1918 and 2009 Pandemic Influenza A Viruses. J Chem Theory Comput (2015) 0.75

Calcium phosphate nanoparticle (CaPNP) for dose-sparing of inactivated whole virus pandemic influenza A (H1N1) 2009 vaccine in mice. Vaccine (2017) 0.75

Influenza A Virus PA Antagonizes Interferon-β by Interacting with Interferon Regulatory Factor 3. Front Immunol (2017) 0.75

Generation and characterization of interferon-lambda 1-resistant H1N1 influenza A viruses. PLoS One (2017) 0.75

Articles cited by this

Evolution and ecology of influenza A viruses. Microbiol Rev (1992) 39.99

Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. Science (2009) 25.61

Universal primer set for the full-length amplification of all influenza A viruses. Arch Virol (2001) 21.17

Swine influenza A (H1N1) infection in two children--Southern California, March-April 2009. MMWR Morb Mortal Wkly Rep (2009) 17.76

In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses. Nature (2009) 14.59

The structure and function of the hemagglutinin membrane glycoprotein of influenza virus. Annu Rev Biochem (1987) 11.99

A single amino acid in the PB2 gene of influenza A virus is a determinant of host range. J Virol (1993) 10.22

Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice. Science (2009) 8.61

Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets. Science (2009) 7.80

The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host. Proc Natl Acad Sci U S A (2005) 7.39

Molecular basis of replication of duck H5N1 influenza viruses in a mammalian mouse model. J Virol (2005) 7.36

PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in mice. Virology (2004) 5.96

The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04. J Exp Med (2006) 5.94

Influenza A virus PB1-F2 protein contributes to viral pathogenesis in mice. J Virol (2006) 4.74

STUDIES ON THE MECHANISM OF ADAPTATION OF INFLUENZA VIRUS TO MICE. J Exp Med (1947) 4.62

A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicity. Proc Natl Acad Sci U S A (2008) 3.99

Plaque inhibition assay for drug susceptibility testing of influenza viruses. Antimicrob Agents Chemother (1980) 3.60

Influenza virus receptor specificity and cell tropism in mouse and human airway epithelial cells. J Virol (2006) 3.60

Receptor-binding specificity of pandemic influenza A (H1N1) 2009 virus determined by carbohydrate microarray. Nat Biotechnol (2009) 3.07

Assessment of signs of influenza illness in the ferret model. J Virol Methods (1989) 3.07

Pathogenicity of influenza virus. Microbiol Rev (1980) 2.80

A single-amino-acid substitution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in mice. J Virol (2007) 2.80

A solid-phase enzyme-linked assay for influenza virus receptor-binding activity. J Virol Methods (1992) 2.32

Probing of the receptor-binding sites of the H1 and H3 influenza A and influenza B virus hemagglutinins by synthetic and natural sialosides. Virology (1993) 2.27

Pattern of mutation in the genome of influenza A virus on adaptation to increased virulence in the mouse lung: identification of functional themes. Proc Natl Acad Sci U S A (2001) 2.25

Effects of low- and high-passage influenza virus infection in normal and nude mice. Infect Immun (1977) 2.24

"Ambisense" approach for the generation of influenza A virus: vRNA and mRNA synthesis from one template. Virology (2000) 2.22

Studies on the pathogenesis of influenza virus pneumonia in mice. J Pathol Bacteriol (1962) 2.16

Fine mapping of the subunit binding sites of influenza virus RNA polymerase. Microbiol Immunol (2002) 1.90

Increased virulence of a mouse-adapted variant of influenza A/FM/1/47 virus is controlled by mutations in genome segments 4, 5, 7, and 8. J Virol (1990) 1.84

Changes in the hemagglutinin molecule of influenza type A (H3N2) virus associated with increased virulence for mice. Arch Virol (1997) 1.82

The influenza virus variant A/FM/1/47-MA possesses single amino acid replacements in the hemagglutinin, controlling virulence, and in the matrix protein, controlling virulence as well as growth. J Virol (1994) 1.81

The polymerase acidic protein gene of influenza a virus contributes to pathogenicity in a mouse model. J Virol (2009) 1.68

The pathogenesis of infections of the mouse caused by virulent and avirulent variants of an influenza virus. J Med Microbiol (1975) 1.65

Synthesis of polymeric neoglycoconjugates based on N-substituted polyacrylamides. Glycoconj J (1993) 1.56

Virulence of influenza A virus for mouse lung. Virus Genes (1997) 1.53

Genetic analysis of mouse-adapted influenza A virus identifies roles for the NA, PB1, and PB2 genes in virulence. Virus Res (1999) 1.51

Experimental evolution of human influenza virus H3 hemagglutinin in the mouse lung identifies adaptive regions in HA1 and HA2. J Virol (2008) 1.47

Adaptation of an H7N7 equine influenza A virus in mice. J Gen Virol (2007) 1.41

Human-like receptor specificity does not affect the neuraminidase-inhibitor susceptibility of H5N1 influenza viruses. PLoS Pathog (2008) 1.37

Adaptation of human influenza H3N2 virus in a mouse pneumonitis model: insights into viral virulence, tissue tropism and host pathogenesis. Microbes Infect (2008) 1.19

Changes in the antigenic specificity of influenza hemagglutinin in the course of adaptation to mice. Virology (1984) 1.11

The destruction of type 2 pneumocytes by airborne influenza PR8-A virus; its effect on surfactant and lecithin content of the pneumonic lesions of mice. Chest (1975) 1.11

Multiple amino acid substitutions are involved in the adaptation of H9N2 avian influenza virus to mice. Vet Microbiol (2009) 1.03

Structure and sequence analysis of influenza A virus nucleoprotein. Sci China C Life Sci (2009) 1.00

Studies on the genetic basis of human influenza A virus adaptation to mice: degrees of virulence of reassortants with defined genetic content. Arch Virol (1989) 0.97

Studies on the genetic determinants of influenza virus pathogenicity for mice with the use of reassortants between mouse-adapted and non-adapted variants of the same virus strain. Arch Virol (1986) 0.93

Recombination of influenza A strains with fowl plague virus can change pneumotropism for mice to a generalized infection with involvement of the central nervous system. Virology (1980) 0.91

Influenza virus: association of mouse-lung virulence with plaque formation in mouse kidney cells. Intervirology (1976) 0.81

Articles by these authors

Large-scale sequence analysis of avian influenza isolates. Science (2006) 9.87

Lethal H5N1 influenza viruses escape host anti-viral cytokine responses. Nat Med (2002) 9.47

Molecular basis of replication of duck H5N1 influenza viruses in a mammalian mouse model. J Virol (2005) 7.36

Are we ready for pandemic influenza? Science (2003) 7.20

The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04. J Exp Med (2006) 5.94

Lethality to ferrets of H5N1 influenza viruses isolated from humans and poultry in 2004. J Virol (2005) 5.40

Reemerging H5N1 influenza viruses in Hong Kong in 2002 are highly pathogenic to ducks. J Virol (2004) 5.17

Investigation of outbreaks of highly pathogenic H5N1 avian influenza in waterfowl and wild birds in Hong Kong in late 2002. Avian Pathol (2004) 5.08

Human infection with an avian H9N2 influenza A virus in Hong Kong in 2003. J Clin Microbiol (2005) 5.04

Influenza A viruses of migrating wild aquatic birds in North America. Vector Borne Zoonotic Dis (2004) 4.89

The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity (2009) 4.51

Eight-plasmid system for rapid generation of influenza virus vaccines. Vaccine (2002) 4.45

Dating the emergence of pandemic influenza viruses. Proc Natl Acad Sci U S A (2009) 4.36

Dynamic T cell migration program provides resident memory within intestinal epithelium. J Exp Med (2010) 4.09

Detection of influenza viruses resistant to neuraminidase inhibitors in global surveillance during the first 3 years of their use. Antimicrob Agents Chemother (2006) 4.02

Inefficient transmission of H5N1 influenza viruses in a ferret contact model. J Virol (2007) 3.79

TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection. Proc Natl Acad Sci U S A (2009) 3.70

Gain-of-function experiments on H7N9. Science (2013) 3.67

MERS coronaviruses in dromedary camels, Egypt. Emerg Infect Dis (2014) 3.64

The genesis and source of the H7N9 influenza viruses causing human infections in China. Nature (2013) 3.60

Cross-reactive neuraminidase antibodies afford partial protection against H5N1 in mice and are present in unexposed humans. PLoS Med (2007) 3.57

Immunization with reverse-genetics-produced H5N1 influenza vaccine protects ferrets against homologous and heterologous challenge. J Infect Dis (2006) 3.28

The influenza virus gene pool in a poultry market in South central china. Virology (2003) 3.25

Neuraminidase inhibitor-resistant influenza viruses may differ substantially in fitness and transmissibility. Antimicrob Agents Chemother (2005) 3.04

Domestic ducks and H5N1 influenza epidemic, Thailand. Emerg Infect Dis (2006) 2.98

Influenza in migratory birds and evidence of limited intercontinental virus exchange. PLoS Pathog (2007) 2.94

Assembly and budding of influenza virus. Virus Res (2004) 2.90

Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs. J Virol (2005) 2.88

Neuraminidase inhibitor-resistant recombinant A/Vietnam/1203/04 (H5N1) influenza viruses retain their replication efficiency and pathogenicity in vitro and in vivo. J Virol (2007) 2.77

Distribution of amantadine-resistant H5N1 avian influenza variants in Asia. J Infect Dis (2006) 2.76

Identification of H2N3 influenza A viruses from swine in the United States. Proc Natl Acad Sci U S A (2007) 2.73

Virulence may determine the necessary duration and dosage of oseltamivir treatment for highly pathogenic A/Vietnam/1203/04 influenza virus in mice. J Infect Dis (2005) 2.72

Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection. Proc Natl Acad Sci U S A (2007) 2.63

Structure of antigenic sites on the haemagglutinin molecule of H5 avian influenza virus and phenotypic variation of escape mutants. J Gen Virol (2002) 2.63

Studies of H5N1 influenza virus infection of pigs by using viruses isolated in Vietnam and Thailand in 2004. J Virol (2005) 2.56

Pathogenic and antigenic properties of phylogenetically distinct reassortant H3N2 swine influenza viruses cocirculating in the United States. J Clin Microbiol (2003) 2.55

H3N2 influenza virus transmission from swine to turkeys, United States. Emerg Infect Dis (2004) 2.53

The influenza virus enigma. Cell (2009) 2.48

Persistent host markers in pandemic and H5N1 influenza viruses. J Virol (2007) 2.42

Multiple reassortment between pandemic (H1N1) 2009 and endemic influenza viruses in pigs, United States. Emerg Infect Dis (2011) 2.42

Long-term evolution and transmission dynamics of swine influenza A virus. Nature (2011) 2.39

Epitope mapping of the hemagglutinin molecule of a highly pathogenic H5N1 influenza virus by using monoclonal antibodies. J Virol (2007) 2.39

Comparative sequence analysis of the symbiosis island of Mesorhizobium loti strain R7A. J Bacteriol (2002) 2.37

Avian flu: Gain-of-function experiments on H7N9. Nature (2013) 2.32

Influenza: emergence and control. J Virol (2004) 2.31

Swine outbreak of pandemic influenza A virus on a Canadian research farm supports human-to-swine transmission. Clin Infect Dis (2011) 2.28

Pause on avian flu transmission research. Science (2012) 2.24

Glycan array screening reveals a candidate ligand for Siglec-8. J Biol Chem (2004) 2.24

Detection of influenza virus resistance to neuraminidase inhibitors by an enzyme inhibition assay. Antiviral Res (2002) 2.22

Passive immunoprophylaxis and therapy with humanized monoclonal antibody specific for influenza A H5 hemagglutinin in mice. Respir Res (2006) 2.15

Pathogenesis of Hong Kong H5N1 influenza virus NS gene reassortants in mice: the role of cytokines and B- and T-cell responses. J Gen Virol (2005) 2.15

Retracted The NS1 gene of H5N1 influenza viruses circumvents the host anti-viral cytokine responses. Virus Res (2004) 2.15

Protection and compensation in the influenza virus-specific CD8+ T cell response. Proc Natl Acad Sci U S A (2003) 2.13

Role of specific hemagglutinin amino acids in the immunogenicity and protection of H5N1 influenza virus vaccines. Proc Natl Acad Sci U S A (2005) 2.13

Changes in H5N1 influenza virus hemagglutinin receptor binding domain affect systemic spread. Proc Natl Acad Sci U S A (2008) 2.11

Diversity of influenza viruses in swine and the emergence of a novel human pandemic influenza A (H1N1). Influenza Other Respir Viruses (2009) 2.11

Combination chemotherapy, a potential strategy for reducing the emergence of drug-resistant influenza A variants. Antiviral Res (2006) 2.11

Ducks: the "Trojan horses" of H5N1 influenza. Influenza Other Respir Viruses (2009) 2.10

Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice. J Virol (2009) 2.08

Role of quail in the interspecies transmission of H9 influenza A viruses: molecular changes on HA that correspond to adaptation from ducks to chickens. J Virol (2003) 2.07

Influenza virus morphogenesis and budding. Virus Res (2009) 2.07

Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets. Proc Natl Acad Sci U S A (2011) 2.04

Efficacy of oseltamivir therapy in ferrets inoculated with different clades of H5N1 influenza virus. Antimicrob Agents Chemother (2007) 2.03

Flow-enhanced adhesion regulated by a selectin interdomain hinge. J Cell Biol (2006) 2.02

Association of RIG-I with innate immunity of ducks to influenza. Proc Natl Acad Sci U S A (2010) 1.98

Bivalent role of the phosphatidylinositol-3-kinase (PI3K) during influenza virus infection and host cell defence. Cell Microbiol (2006) 1.94

Rescue of influenza B virus from eight plasmids. Proc Natl Acad Sci U S A (2002) 1.92

Indications that live poultry markets are a major source of human H5N1 influenza virus infection in China. J Virol (2011) 1.85

Efficacy of H5 influenza vaccines produced by reverse genetics in a lethal mouse model. J Infect Dis (2005) 1.83

Isolation of a novel swine influenza virus from Oklahoma in 2011 which is distantly related to human influenza C viruses. PLoS Pathog (2013) 1.83

Molecular determinants within the surface proteins involved in the pathogenicity of H5N1 influenza viruses in chickens. J Virol (2004) 1.83

Tumor necrosis factor alpha exerts powerful anti-influenza virus effects in lung epithelial cells. J Virol (2002) 1.82

Oseltamivir-resistant pandemic H1N1/2009 influenza virus possesses lower transmissibility and fitness in ferrets. PLoS Pathog (2010) 1.81

Intravenous zanamivir for oseltamivir-resistant 2009 H1N1 influenza. N Engl J Med (2009) 1.79