Published in J Virol on October 20, 2010
Adaptation of avian influenza A virus polymerase in mammals to overcome the host species barrier. J Virol (2013) 1.40
Key molecular factors in hemagglutinin and PB2 contribute to efficient transmission of the 2009 H1N1 pandemic influenza virus. J Virol (2012) 1.37
Two years after pandemic influenza A/2009/H1N1: what have we learned? Clin Microbiol Rev (2012) 1.31
Characterization in vitro and in vivo of a pandemic H1N1 influenza virus from a fatal case. PLoS One (2013) 1.30
Reassortment and mutation of the avian influenza virus polymerase PA subunit overcome species barriers. J Virol (2011) 1.28
PA residues in the 2009 H1N1 pandemic influenza virus enhance avian influenza virus polymerase activity in mammalian cells. J Virol (2011) 1.22
Selection on haemagglutinin imposes a bottleneck during mammalian transmission of reassortant H5N1 influenza viruses. Nat Commun (2013) 1.17
Unstable polymerase-nucleoprotein interaction is not responsible for avian influenza virus polymerase restriction in human cells. J Virol (2012) 1.14
Genomic and protein structural maps of adaptive evolution of human influenza A virus to increased virulence in the mouse. PLoS One (2011) 1.13
Characterization of an Avian Influenza Virus H9N2 Strain Isolated from a Wild Bird in Southern China. Genome Announc (2014) 1.06
PA-X decreases the pathogenicity of highly pathogenic H5N1 influenza A virus in avian species by inhibiting virus replication and host response. J Virol (2015) 1.04
Asparagine substitution at PB2 residue 701 enhances the replication, pathogenicity, and transmission of the 2009 pandemic H1N1 influenza A virus. PLoS One (2013) 1.01
Mutations in polymerase genes enhanced the virulence of 2009 pandemic H1N1 influenza virus in mice. PLoS One (2012) 1.00
Mouse-adapted H9N2 influenza A virus PB2 protein M147L and E627K mutations are critical for high virulence. PLoS One (2012) 0.99
Characterization of uncultivable bat influenza virus using a replicative synthetic virus. PLoS Pathog (2014) 0.98
Engineering temperature sensitive live attenuated influenza vaccines from emerging viruses. Vaccine (2012) 0.96
Implication of inflammatory macrophages, nuclear receptors, and interferon regulatory factors in increased virulence of pandemic 2009 H1N1 influenza A virus after host adaptation. J Virol (2012) 0.96
Emergence of mammalian species-infectious and -pathogenic avian influenza H6N5 virus with no evidence of adaptation. J Virol (2011) 0.95
Analysis of recombinant H7N9 wild-type and mutant viruses in pigs shows that the Q226L mutation in HA is important for transmission. J Virol (2014) 0.93
Identification of mammalian-adapting mutations in the polymerase complex of an avian H5N1 influenza virus. Nat Commun (2015) 0.91
Highly pathogenic avian influenza virus H5N1 controls type I IFN induction in chicken macrophage HD-11 cells: a polygenic trait that involves NS1 and the polymerase complex. Virol J (2012) 0.90
Naturally occurring mutations in the PA gene are key contributors to increased virulence of pandemic H1N1/09 influenza virus in mice. J Virol (2014) 0.89
Genomic polymorphism of the pandemic A (H1N1) influenza viruses correlates with viral replication, virulence, and pathogenicity in vitro and in vivo. PLoS One (2011) 0.89
Complete genome sequence of an H9N2 avian influenza virus isolated from egret in Lake Dongting wetland. J Virol (2012) 0.87
Universal influenza B virus genomic amplification facilitates sequencing, diagnostics, and reverse genetics. J Clin Microbiol (2014) 0.87
One health, multiple challenges: The inter-species transmission of influenza A virus. One Health (2015) 0.87
Reverse genetics plasmid for cloning unstable influenza A virus gene segments. J Virol Methods (2011) 0.86
Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza A virus that expresses an altered nucleoprotein sequence. PLoS One (2013) 0.84
Complete Genome Sequence of a Mixed-Subtype (H5N1 and H6N6) Avian Influenza Virus Isolated from a Duck in Hunan Province, China. Genome Announc (2014) 0.84
PB2-588I enhances 2009 H1N1 pandemic influenza virus virulence by increasing viral replication and exacerbating PB2 inhibition of beta interferon expression. J Virol (2013) 0.84
Synergistic Effect of S224P and N383D Substitutions in the PA of H5N1 Avian Influenza Virus Contributes to Mammalian Adaptation. Sci Rep (2015) 0.81
Amino acid changes in the influenza A virus PA protein that attenuate avian H5N1 viruses in mammals. J Virol (2014) 0.81
Mammalian adaptive mutations of the PA protein of highly pathogenic avian H5N1 influenza virus. J Virol (2015) 0.80
Heterogeneous virulence of pandemic 2009 influenza H1N1 virus in mice. Virol J (2012) 0.80
Sequencing viral genomes from a single isolated plaque. Virol J (2013) 0.79
Reversion of Cold-Adapted Live Attenuated Influenza Vaccine into a Pathogenic Virus. J Virol (2016) 0.78
PB2 segment promotes high-pathogenicity of H5N1 avian influenza viruses in mice. Front Microbiol (2015) 0.78
Host Adaptation and the Alteration of Viral Properties of the First Influenza A/H1N1pdm09 Virus Isolated in Japan. PLoS One (2015) 0.78
Identification of PB2 mutations responsible for the efficient replication of H5N1 influenza viruses in human lung epithelial cells. J Virol (2015) 0.78
Replication and transcription activities of ribonucleoprotein complexes reconstituted from avian H5N1, H1N1pdm09 and H3N2 influenza A viruses. PLoS One (2013) 0.78
Increased virulence of neuraminidase inhibitor-resistant pandemic H1N1 virus in mice: potential emergence of drug-resistant and virulent variants. Virulence (2013) 0.77
Additional Evidence That the Polymerase Subunits Contribute to the Viral Replication and the Virulence of H5N1 Avian Influenza Virus Isolates in Mice. PLoS One (2015) 0.75
In vitro exposure system for study of aerosolized influenza virus. Virology (2016) 0.75
Reduction of Neuraminidase Activity Exacerbates Disease in 2009 Pandemic Influenza Virus-Infected Mice. J Virol (2016) 0.75
Complete Genome Sequence of a Novel Reassortant H3N6 Avian Influenza Virus Isolated from Domestic Green-Winged Teal. Genome Announc (2013) 0.75
Multiple Natural Substitutions in Avian Influenza A Virus PB2 Facilitate Efficient Replication in Human Cells. J Virol (2016) 0.75
Characterization of Novel Reassortant Influenza A (H5N2) Viruses Isolated from Poultry in Eastern China, 2015. Front Microbiol (2017) 0.75
Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science (2001) 18.43
Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Science (2005) 17.19
In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses. Nature (2009) 14.59
A DNA transfection system for generation of influenza A virus from eight plasmids. Proc Natl Acad Sci U S A (2000) 12.16
A single amino acid in the PB2 gene of influenza A virus is a determinant of host range. J Virol (1993) 10.22
Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection. N Engl J Med (2010) 9.90
Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice. Science (2009) 8.61
Avian influenza (H5N1) viruses isolated from humans in Asia in 2004 exhibit increased virulence in mammals. J Virol (2005) 7.88
Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets. Science (2009) 7.80
The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host. Proc Natl Acad Sci U S A (2005) 7.39
Molecular basis of replication of duck H5N1 influenza viruses in a mammalian mouse model. J Virol (2005) 7.36
Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N. PLoS Pathog (2009) 6.09
A mouse model for the evaluation of pathogenesis and immunity to influenza A (H5N1) viruses isolated from humans. J Virol (1999) 6.03
PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in mice. Virology (2004) 5.96
Lethality to ferrets of H5N1 influenza viruses isolated from humans and poultry in 2004. J Virol (2005) 5.40
Pediatric hospitalizations associated with 2009 pandemic influenza A (H1N1) in Argentina. N Engl J Med (2009) 4.70
Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice. PLoS Pathog (2007) 4.49
The structural basis for cap binding by influenza virus polymerase subunit PB2. Nat Struct Mol Biol (2008) 4.33
Single-reaction genomic amplification accelerates sequencing and vaccine production for classical and Swine origin human influenza a viruses. J Virol (2009) 4.20
Adaptive strategies of the influenza virus polymerase for replication in humans. Proc Natl Acad Sci U S A (2009) 3.89
Biological and structural characterization of a host-adapting amino acid in influenza virus. PLoS Pathog (2010) 3.65
Interaction of polymerase subunit PB2 and NP with importin alpha1 is a determinant of host range of influenza A virus. PLoS Pathog (2008) 3.37
Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit. Nat Struct Mol Biol (2007) 3.13
Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian host. PLoS Pathog (2009) 2.62
Host determinant residue lysine 627 lies on the surface of a discrete, folded domain of influenza virus polymerase PB2 subunit. PLoS Pathog (2008) 2.60
The molecular basis of the pathogenicity of the Dutch highly pathogenic human influenza A H7N7 viruses. J Infect Dis (2007) 2.58
Selection of H5N1 influenza virus PB2 during replication in humans. J Virol (2009) 2.42
PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells. J Virol (2010) 2.35
Pattern of mutation in the genome of influenza A virus on adaptation to increased virulence in the mouse lung: identification of functional themes. Proc Natl Acad Sci U S A (2001) 2.25
Adaptation of pandemic H1N1 influenza viruses in mice. J Virol (2010) 2.22
Introduction of virulence markers in PB2 of pandemic swine-origin influenza virus does not result in enhanced virulence or transmission. J Virol (2010) 2.19
Functional domains of the influenza A virus PB2 protein: identification of NP- and PB1-binding sites. Virology (2004) 2.10
Recent H5N1 avian influenza A virus increases rapidly in virulence to mice after a single passage in mice. J Gen Virol (2006) 1.76
Structural basis of the influenza A virus RNA polymerase PB2 RNA-binding domain containing the pathogenicity-determinant lysine 627 residue. J Biol Chem (2009) 1.70
Comparison of the pathology caused by H1N1, H5N1, and H3N2 influenza viruses. Arch Med Res (2010) 1.70
A single-amino-acid substitution in a polymerase protein of an H5N1 influenza virus is associated with systemic infection and impaired T-cell activation in mice. J Virol (2009) 1.56
A new influenza A virus infection in turkeys II. A highly pathogenic variant, a/turkey/ontario 772/66. Can Vet J (1968) 1.54
Viral RNA polymerase complex promotes optimal growth of 1918 virus in the lower respiratory tract of ferrets. Proc Natl Acad Sci U S A (2008) 1.53
Progress in identifying virulence determinants of the 1918 H1N1 and the Southeast Asian H5N1 influenza A viruses. Antiviral Res (2008) 1.47
Sequences in influenza A virus PB2 protein that determine productive infection for an avian influenza virus in mouse and human cell lines. J Virol (2001) 1.42
Adaptation of an H7N7 equine influenza A virus in mice. J Gen Virol (2007) 1.41
Substitution of lysine at 627 position in PB2 protein does not change virulence of the 2009 pandemic H1N1 virus in mice. Virology (2010) 1.32
The PB2-E627K mutation attenuates viruses containing the 2009 H1N1 influenza pandemic polymerase. MBio (2010) 1.18
Pathogenicity of highly pathogenic avian H5N1 influenza A viruses isolated from humans between 2003 and 2008 in northern Vietnam. J Gen Virol (2010) 1.17
Lessons learned from reconstructing the 1918 influenza pandemic. J Infect Dis (2006) 1.17
Topological domains in mammalian genomes identified by analysis of chromatin interactions. Nature (2012) 18.23
The Genome sequence of the SARS-associated coronavirus. Science (2003) 16.68
Scope and impact of financial conflicts of interest in biomedical research: a systematic review. JAMA (2003) 16.08
Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution. Nature (2005) 11.99
Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines. Nature (2010) 10.66
Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature (2007) 10.40
Modelling schizophrenia using human induced pluripotent stem cells. Nature (2011) 7.41
A distinct lineage of influenza A virus from bats. Proc Natl Acad Sci U S A (2012) 6.27
Trends in survival after in-hospital cardiac arrest. N Engl J Med (2012) 5.67
Characterization of human metapneumoviruses isolated from patients in North America. J Infect Dis (2002) 5.64
Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning. Nat Med (2003) 5.45
Prognostic accuracy of day versus night ambulatory blood pressure: a cohort study. Lancet (2007) 5.21
A high-resolution map of the three-dimensional chromatin interactome in human cells. Nature (2013) 5.18
Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. Science (2006) 4.71
Widespread lateral gene transfer from intracellular bacteria to multicellular eukaryotes. Science (2007) 4.65
Human illness from avian influenza H7N3, British Columbia. Emerg Infect Dis (2004) 4.29
Comparative genomics of emerging human ehrlichiosis agents. PLoS Genet (2006) 4.23
Single-reaction genomic amplification accelerates sequencing and vaccine production for classical and Swine origin human influenza a viruses. J Virol (2009) 4.20
The evolutionary genetics and emergence of avian influenza viruses in wild birds. PLoS Pathog (2008) 4.17
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy improves survival of patients with peritoneal carcinomatosis from gastric cancer: final results of a phase III randomized clinical trial. Ann Surg Oncol (2011) 4.16
New world bats harbor diverse influenza A viruses. PLoS Pathog (2013) 4.10
Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina). J Am Coll Cardiol (2013) 3.90
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol Cell (2005) 3.89
Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada. PLoS Med (2010) 3.85
Long-term outcomes in elderly survivors of in-hospital cardiac arrest. N Engl J Med (2013) 3.85
Stochastic processes are key determinants of short-term evolution in influenza a virus. PLoS Pathog (2006) 3.82
Epigenomic analysis of multilineage differentiation of human embryonic stem cells. Cell (2013) 3.81
Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lung. Nat Biotechnol (2007) 3.54
Genome analysis linking recent European and African influenza (H5N1) viruses. Emerg Infect Dis (2007) 3.53
Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol Cell Biol (2003) 3.51
Genetic variants and risk of lung cancer in never smokers: a genome-wide association study. Lancet Oncol (2010) 3.49
Viral genome sequencing by random priming methods. BMC Genomics (2008) 3.48
AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling. Science (2008) 3.44
Ambulatory arterial stiffness index as a predictor of cardiovascular mortality in the Dublin Outcome Study. Hypertension (2006) 3.42
Human Bocavirus infection, Canada. Emerg Infect Dis (2006) 3.30
Pre-existing AAV capsid-specific CD8+ T cells are unable to eliminate AAV-transduced hepatocytes. Mol Ther (2007) 3.26
Multiple reassortment events in the evolutionary history of H1N1 influenza A virus since 1918. PLoS Pathog (2008) 3.25
Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy. Nature (2004) 3.24
A Pseudomonas syringae effector inactivates MAPKs to suppress PAMP-induced immunity in plants. Cell Host Microbe (2007) 3.15
The scale of population structure in Arabidopsis thaliana. PLoS Genet (2010) 3.12
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. J Cell Biol (2014) 3.12
Triple reassortant H3N2 influenza A viruses, Canada, 2005. Emerg Infect Dis (2006) 3.05
Genomic diversity of 2010 Haitian cholera outbreak strains. Proc Natl Acad Sci U S A (2012) 3.04
Label-free, normalized quantification of complex mass spectrometry data for proteomic analysis. Nat Biotechnol (2009) 3.01
Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature (2013) 3.00
Identification of a novel astrovirus (astrovirus VA1) associated with an outbreak of acute gastroenteritis. J Virol (2009) 2.96
Prognostic value of a microRNA signature in nasopharyngeal carcinoma: a microRNA expression analysis. Lancet Oncol (2012) 2.91
Novel avian influenza H7N3 strain outbreak, British Columbia. Emerg Infect Dis (2004) 2.90
Masked hypertension in diabetes mellitus: treatment implications for clinical practice. Hypertension (2013) 2.89
Pseudomonas syringae effector AvrPto blocks innate immunity by targeting receptor kinases. Curr Biol (2007) 2.84
Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow. Cell (2008) 2.84
Anterior chamber width measurement by high-speed optical coherence tomography. Ophthalmology (2005) 2.77
Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma. Nat Med (2013) 2.70
Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage. PLoS Genet (2005) 2.68
Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric. BMC Neurosci (2006) 2.68
Prognostic value of reading-to-reading blood pressure variability over 24 hours in 8938 subjects from 11 populations. Hypertension (2010) 2.64
Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer. Nat Med (2010) 2.62
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Nat Biotechnol (2004) 2.60
Clinical and molecular characterisation of hereditary dopamine transporter deficiency syndrome: an observational cohort and experimental study. Lancet Neurol (2010) 2.60
Component-specific effectiveness of trivalent influenza vaccine as monitored through a sentinel surveillance network in Canada, 2006-2007. J Infect Dis (2009) 2.59
A decade's studies on metastasis of hepatocellular carcinoma. J Cancer Res Clin Oncol (2003) 2.50
Effectiveness of AS03 adjuvanted pandemic H1N1 vaccine: case-control evaluation based on sentinel surveillance system in Canada, autumn 2009. BMJ (2011) 2.50
Correlation of IHC and FISH for ALK gene rearrangement in non-small cell lung carcinoma: IHC score algorithm for FISH. J Thorac Oncol (2011) 2.50
miR-301a as an NF-κB activator in pancreatic cancer cells. EMBO J (2010) 2.47
A coastal cline in sodium accumulation in Arabidopsis thaliana is driven by natural variation of the sodium transporter AtHKT1;1. PLoS Genet (2010) 2.45
The early diversification of influenza A/H1N1pdm. PLoS Curr (2009) 2.44
Prevention of stroke and myocardial infarction by amlodipine and Angiotensin receptor blockers: a quantitative overview. Hypertension (2007) 2.43
Two calcium-dependent protein kinases, CPK4 and CPK11, regulate abscisic acid signal transduction in Arabidopsis. Plant Cell (2007) 2.40
CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus. Proc Natl Acad Sci U S A (2004) 2.38
Whole-genome sequence analysis of Pseudomonas syringae pv. phaseolicola 1448A reveals divergence among pathovars in genes involved in virulence and transposition. J Bacteriol (2005) 2.38
Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Nat Biotechnol (2011) 2.37
Ambulatory blood pressure monitoring in 9357 subjects from 11 populations highlights missed opportunities for cardiovascular prevention in women. Hypertension (2011) 2.33
beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer. Cancer Cell (2002) 2.33
Novel, chimpanzee serotype 68-based adenoviral vaccine carrier for induction of antibodies to a transgene product. J Virol (2002) 2.31
Pathogenesis of avian influenza (H7) virus infection in mice and ferrets: enhanced virulence of Eurasian H7N7 viruses isolated from humans. J Virol (2007) 2.30
Prognostic value of isolated nocturnal hypertension on ambulatory measurement in 8711 individuals from 10 populations. J Hypertens (2010) 2.28
A transforming metal nanocomposite with large elastic strain, low modulus, and high strength. Science (2013) 2.28
A cross-sectional study of the microeconomic impact of cardiovascular disease hospitalization in four low- and middle-income countries. PLoS One (2011) 2.23
Positional cloning of the murine flavivirus resistance gene. Proc Natl Acad Sci U S A (2002) 2.22
Substantia nigra tangles are related to gait impairment in older persons. Ann Neurol (2006) 2.17
CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients. J Clin Invest (2010) 2.15
Role of health insurance in averting economic hardship in families after acute stroke in China. Stroke (2009) 2.13
Genome sequence of Synechococcus CC9311: Insights into adaptation to a coastal environment. Proc Natl Acad Sci U S A (2006) 2.13
Treatment of long-lasting persistent atrial fibrillation using minimally invasive surgery combined with irbesartan. Ann Thorac Surg (2011) 2.11
Sensitive and broadly reactive reverse transcription-PCR assays to detect novel paramyxoviruses. J Clin Microbiol (2008) 2.10
An overview of anthrax infection including the recently identified form of disease in injection drug users. Intensive Care Med (2012) 2.10
Molecular epidemiology of A/H3N2 and A/H1N1 influenza virus during a single epidemic season in the United States. PLoS Pathog (2008) 2.09
Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling. J Neurosci (2007) 2.09
Comparative assessment of scoring functions on a diverse test set. J Chem Inf Model (2009) 2.09
Predictive role of the nighttime blood pressure. Hypertension (2010) 2.07
Temporally structured metapopulation dynamics and persistence of influenza A H3N2 virus in humans. Proc Natl Acad Sci U S A (2011) 2.06
Potential bridges for HIV infection to men who have sex with men in Guangzhou, China. AIDS Behav (2006) 2.06
Urinary angiotensinogen excretion and ambulatory blood pressure. J Hypertens (2012) 2.04
The NLRP3 inflammasome promotes renal inflammation and contributes to CKD. J Am Soc Nephrol (2010) 2.04