Atypical lipid composition in the purified relict plastid (apicoplast) of malaria parasites.

PubWeight™: 1.00‹?› | Rank: Top 15%

🔗 View Article (PMC 3645554)

Published in Proc Natl Acad Sci U S A on April 15, 2013

Authors

Cyrille Y Botté1, Yoshiki Yamaryo-Botté, Thusitha W T Rupasinghe, Kylie A Mullin, James I MacRae, Timothy P Spurck, Ming Kalanon, Melanie J Shears, Ross L Coppel, Paul K Crellin, Eric Maréchal, Malcolm J McConville, Geoffrey I McFadden

Author Affiliations

1: School of Botany, University of Melbourne, Parkville, VIC 3010, Australia. cyrille.botte@gmail.com

Articles citing this

Kinetic flux profiling elucidates two independent acetyl-CoA biosynthetic pathways in Plasmodium falciparum. J Biol Chem (2013) 0.96

Lipid synthesis in protozoan parasites: a comparison between kinetoplastids and apicomplexans. Prog Lipid Res (2013) 0.96

The neutral sphingomyelinase pathway regulates packaging of the prion protein into exosomes. J Biol Chem (2014) 0.95

The metabolic roles of the endosymbiotic organelles of Toxoplasma and Plasmodium spp. Curr Opin Microbiol (2013) 0.91

Serum lipids and lipoproteins in malaria--a systematic review and meta-analysis. Malar J (2013) 0.88

Enzymes involved in plastid-targeted phosphatidic acid synthesis are essential for Plasmodium yoelii liver-stage development. Mol Microbiol (2014) 0.86

Evolution of chloroplast transcript processing in Plasmodium and its chromerid algal relatives. PLoS Genet (2014) 0.85

Isoprenoid precursor biosynthesis is the essential metabolic role of the apicoplast during gametocytogenesis in Plasmodium falciparum. Eukaryot Cell (2014) 0.83

Light Remodels Lipid Biosynthesis in Nannochloropsis gaditana by Modulating Carbon Partitioning between Organelles. Plant Physiol (2016) 0.82

Profiling the Essential Nature of Lipid Metabolism in Asexual Blood and Gametocyte Stages of Plasmodium falciparum. Cell Host Microbe (2015) 0.82

Sugar activation and glycosylation in Plasmodium. Malar J (2015) 0.81

Lipid kinases are essential for apicoplast homeostasis in Toxoplasma gondii. Cell Microbiol (2014) 0.81

The intracellular parasite Toxoplasma gondii depends on the synthesis of long-chain and very long-chain unsaturated fatty acids not supplied by the host cell. Mol Microbiol (2015) 0.79

Plasmodium falciparum: multifaceted resistance to artemisinins. Malar J (2016) 0.78

Changes in lipid composition during sexual development of the malaria parasite Plasmodium falciparum. Malar J (2016) 0.78

Characterization of the Plasmodium falciparum and P. berghei glycerol 3-phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast. Cell Microbiol (2016) 0.76

Transcripts in the Plasmodium Apicoplast Undergo Cleavage at tRNAs and Editing, and Include Antisense Sequences. Protist (2016) 0.76

Discovery of compounds blocking the proliferation of Toxoplasma gondii and Plasmodium falciparum in a chemical space based on piperidinyl-benzimidazolone analogs. Antimicrob Agents Chemother (2014) 0.76

Systems Biology Approaches Applied to Regenerative Medicine. Curr Pathobiol Rep (2015) 0.75

Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal/Plant-Like Glycerol 3-Phosphate Acyltransferase. PLoS Pathog (2016) 0.75

Lipid response patterns in acute phase paediatric Plasmodium falciparum malaria. Metabolomics (2017) 0.75

Na+ Influx Induced by New Antimalarials Causes Rapid Alterations in the Cholesterol Content and Morphology of Plasmodium falciparum. PLoS Pathog (2016) 0.75

Plasmodium falciparum PfSET7: enzymatic characterization and cellular localization of a novel protein methyltransferase in sporozoite, liver and erythrocytic stage parasites. Sci Rep (2016) 0.75

Articles cited by this

Human malaria parasites in continuous culture. Science (1976) 59.70

Artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med (2009) 33.25

Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science (1999) 7.54

Towards complete cofactor arrangement in the 3.0 A resolution structure of photosystem II. Nature (2005) 6.40

A plastid organelle as a drug target in apicomplexan parasites. Nature (1997) 4.97

Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum. Proc Natl Acad Sci U S A (1998) 4.28

Stearoyl-acyl-carrier-protein desaturase from higher plants is structurally unrelated to the animal and fungal homologs. Proc Natl Acad Sci U S A (1991) 4.26

Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast. Nat Rev Microbiol (2004) 3.85

Plastid in human parasites. Nature (1996) 3.25

The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites. Cell Host Microbe (2008) 2.98

A common red algal origin of the apicomplexan, dinoflagellate, and heterokont plastids. Proc Natl Acad Sci U S A (2010) 2.41

Segregation of sphingolipids and sterols during formation of secretory vesicles at the trans-Golgi network. J Cell Biol (2009) 2.38

Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum. PLoS Biol (2011) 2.21

Structure of the lipophosphoglycan from Leishmania major. J Biol Chem (1990) 2.10

Development of the endoplasmic reticulum, mitochondrion and apicoplast during the asexual life cycle of Plasmodium falciparum. Mol Microbiol (2005) 2.02

The malaria parasite Plasmodium falciparum has only one pyruvate dehydrogenase complex, which is located in the apicoplast. Mol Microbiol (2005) 1.98

Apicoplast fatty acid synthesis is essential for organelle biogenesis and parasite survival in Toxoplasma gondii. Proc Natl Acad Sci U S A (2006) 1.93

Mechanisms of lipid transport involved in organelle biogenesis in plant cells. Annu Rev Cell Dev Biol (2009) 1.75

De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation. Cancer Res (2010) 1.59

Food vacuole-associated lipid bodies and heterogeneous lipid environments in the malaria parasite, Plasmodium falciparum. Mol Microbiol (2004) 1.57

The human malaria parasite Plasmodium falciparum possesses two distinct dihydrolipoamide dehydrogenases. Mol Microbiol (2005) 1.46

Membrane transporters in the relict plastid of malaria parasites. Proc Natl Acad Sci U S A (2006) 1.24

Compartmentation of redox metabolism in malaria parasites. PLoS Pathog (2010) 1.22

Apicoplast and mitochondrion in gametocytogenesis of Plasmodium falciparum. Eukaryot Cell (2008) 1.20

Phosphatidylinositol 3-phosphate, an essential lipid in Plasmodium, localizes to the food vacuole membrane and the apicoplast. Eukaryot Cell (2010) 1.16

Monogalactosyldiacylglycerol deficiency in Arabidopsis affects pigment composition in the prolamellar body and impairs thylakoid membrane energization and photoprotection in leaves. Plant Physiol (2008) 1.11

Insights into unique physiological features of neutral lipids in Apicomplexa: from storage to potential mediation in parasite metabolic activities. Int J Parasitol (2005) 1.10

Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii. J Biol Chem (2011) 1.09

Enzymes for heme biosynthesis are found in both the mitochondrion and plastid of the malaria parasite Plasmodium falciparum. Protist (2004) 1.08

Glycerophospholipid acquisition in Plasmodium - a puzzling assembly of biosynthetic pathways. Int J Parasitol (2010) 1.04

Organization, developmental dynamics, and evolution of plastid nucleoids. Int Rev Cytol (2003) 1.02

Phospholipid composition, cholesterol content and cholesterol exchange in Plasmodium falciparum-infected red cells. Mol Biochem Parasitol (1990) 1.00

Lipidomic analysis of Toxoplasma gondii reveals unusual polar lipids. Biochemistry (2007) 1.00

Phosphatidylinositol 3-monophosphate is involved in toxoplasma apicoplast biogenesis. PLoS Pathog (2011) 0.99

Oleic acid biosynthesis in Plasmodium falciparum: characterization of the stearoyl-CoA desaturase and investigation as a potential therapeutic target. PLoS One (2009) 0.98

Mitochondria and apicoplast of Plasmodium falciparum: behaviour on subcellular fractionation and the implication. Mitochondrion (2006) 0.98

Oleic acid is indispensable for intraerythrocytic proliferation of Plasmodium falciparum. Parasitology (2007) 0.96

Biogenesis of iron-sulphur clusters in amitochondriate and apicomplexan protists. Int J Parasitol (2002) 0.95

Identification of plant-like galactolipids in Chromera velia, a photosynthetic relative of malaria parasites. J Biol Chem (2011) 0.92

Membrane contact sites between apicoplast and ER in Toxoplasma gondii revealed by electron tomography. Traffic (2009) 0.92

Plasmodium falciparum apicoplast drugs: targets or off-targets? Chem Rev (2011) 0.92

Synthesis of chloroplast galactolipids in apicomplexan parasites. Eukaryot Cell (2002) 0.92

Critical regulation of galactolipid synthesis controls membrane differentiation and remodeling in distinct plant organs and following environmental changes. Prog Lipid Res (2011) 0.88

Cryo-electron tomography reveals four-membrane architecture of the Plasmodium apicoplast. Malar J (2013) 0.87

Neutral-lipid analysis reveals elevation of acylglycerols and lack of cholesterol esters in Plasmodium falciparum-infected erythrocytes. Eukaryot Cell (2003) 0.87

Ceramide mediates growth inhibition of the Plasmodium falciparum parasite. Cell Mol Life Sci (2003) 0.87

Metabolomic analysis of patient plasma yields evidence of plant-like α-linolenic acid metabolism in Plasmodium falciparum. J Infect Dis (2012) 0.86

Lipidomic analysis of Toxoplasma gondii tachyzoites rhoptries: further insights into the role of cholesterol. Biochem J (2008) 0.85

Subcellular localization and dynamics of a digalactolipid-like epitope in Toxoplasma gondii. J Lipid Res (2008) 0.84

Separation of DNA-containing organelles from Toxoplasma gondii by CZE. Electrophoresis (2010) 0.82

Purification and properties of recombinant Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase. J Biochem (2001) 0.82

Molecular characterization of Plasmodium falciparum S-adenosylmethionine synthetase. Biochem J (1999) 0.82

Genetic and transcriptional analysis of phosphoinositide-specific phospholipase C in Plasmodium. Exp Parasitol (2011) 0.80

The 2-methylcitrate cycle is implicated in the detoxification of propionate in Toxoplasma gondii. Mol Microbiol (2013) 0.79

A phosphatidylcholine-BODIPY 581/591 conjugate allows mapping of oxidative stress in P. falciparum-infected erythrocytes. Cytometry A (2009) 0.78

Articles by these authors

Genome sequence of the human malaria parasite Plasmodium falciparum. Nature (2002) 37.89

The Chlamydomonas genome reveals the evolution of key animal and plant functions. Science (2007) 11.15

Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast. Nat Rev Microbiol (2004) 3.85

Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes. Cell (2008) 3.80

MR1 presents microbial vitamin B metabolites to MAIT cells. Nature (2012) 3.71

Plastid evolution. Annu Rev Plant Biol (2008) 3.39

Localization of organellar proteins in Plasmodium falciparum using a novel set of transfection vectors and a new immunofluorescence fixation method. Mol Biochem Parasitol (2004) 3.13

Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum. Science (2003) 3.08

Genome reduction in Leptospira borgpetersenii reflects limited transmission potential. Proc Natl Acad Sci U S A (2006) 2.71

Phenotypic variation of Plasmodium falciparum merozoite proteins directs receptor targeting for invasion of human erythrocytes. EMBO J (2003) 2.56

The effects of anti-bacterials on the malaria parasite Plasmodium falciparum. Mol Biochem Parasitol (2007) 2.47

PlasmoDB: the Plasmodium genome resource. An integrated database providing tools for accessing, analyzing and mapping expression and sequence data (both finished and unfinished). Nucleic Acids Res (2002) 2.37

Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis. PLoS One (2008) 2.35

Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice. J Immunol (2006) 2.18

Bacterial CpG induces hyper-IgM production in CD27(+) memory B cells in primary biliary cirrhosis. Gastroenterology (2005) 2.17

Algal genomes reveal evolutionary mosaicism and the fate of nucleomorphs. Nature (2012) 2.15

VEGF-D promotes tumor metastasis by regulating prostaglandins produced by the collecting lymphatic endothelium. Cancer Cell (2012) 2.14

Deletion of interleukin-12p40 suppresses autoimmune cholangitis in dominant negative transforming growth factor beta receptor type II mice. Hepatology (2009) 2.11

Humans lack iGb3 due to the absence of functional iGb3-synthase: implications for NKT cell development and transplantation. PLoS Biol (2008) 2.08

Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease. Hepatology (2008) 2.05

Development of the endoplasmic reticulum, mitochondrion and apicoplast during the asexual life cycle of Plasmodium falciparum. Mol Microbiol (2005) 2.02

Identification of HLA-A2-restricted CD8(+) cytotoxic T cell responses in primary biliary cirrhosis: T cell activation is augmented by immune complexes cross-presented by dendritic cells. J Exp Med (2002) 2.00

The complete chloroplast genome of the chlorarachniophyte Bigelowiella natans: evidence for independent origins of chlorarachniophyte and euglenid secondary endosymbionts. Mol Biol Evol (2006) 1.99

The malaria parasite Plasmodium falciparum has only one pyruvate dehydrogenase complex, which is located in the apicoplast. Mol Microbiol (2005) 1.98

Distinct protein classes including novel merozoite surface antigens in Raft-like membranes of Plasmodium falciparum. J Biol Chem (2005) 1.95

SMP-1, a member of a new family of small myristoylated proteins in kinetoplastid parasites, is targeted to the flagellum membrane in Leishmania. Mol Biol Cell (2004) 1.95

Contribution of parasite proteins to altered mechanical properties of malaria-infected red blood cells. Blood (2002) 1.93

IL-2 receptor alpha(-/-) mice and the development of primary biliary cirrhosis. Hepatology (2006) 1.91

The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments. Immunity (2012) 1.89

MyD88 is essential for clearance of Leishmania major: possible role for lipophosphoglycan and Toll-like receptor 2 signaling. Eur J Immunol (2003) 1.82

Secretory pathway of trypanosomatid parasites. Microbiol Mol Biol Rev (2002) 1.81

Deletion of interleukin (IL)-12p35 induces liver fibrosis in dominant-negative TGFβ receptor type II mice. Hepatology (2013) 1.78

A Maurer's cleft-associated protein is essential for expression of the major malaria virulence antigen on the surface of infected red blood cells. J Cell Biol (2006) 1.73

Quantitation and phenotypic analysis of natural killer T cells in primary biliary cirrhosis using a human CD1d tetramer. Gastroenterology (2002) 1.72

Complete nucleotide sequence of the chlorarachniophyte nucleomorph: nature's smallest nucleus. Proc Natl Acad Sci U S A (2006) 1.70

Processing of an apicoplast leader sequence in Plasmodium falciparum and the identification of a putative leader cleavage enzyme. J Biol Chem (2002) 1.68

Identification and prioritization of merozoite antigens as targets of protective human immunity to Plasmodium falciparum malaria for vaccine and biomarker development. J Immunol (2013) 1.68

Lack of immunological or molecular evidence for a role of mouse mammary tumor retrovirus in primary biliary cirrhosis. Gastroenterology (2004) 1.67

Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis. J Clin Invest (2002) 1.65

Loss of nucleosomal DNA condensation coincides with appearance of a novel nuclear protein in dinoflagellates. Curr Biol (2012) 1.63

Metabolic maps and functions of the Plasmodium mitochondrion. FEMS Microbiol Rev (2006) 1.57

Hepatic IL-17 responses in human and murine primary biliary cirrhosis. J Autoimmun (2008) 1.57

Apotopes and the biliary specificity of primary biliary cirrhosis. Hepatology (2009) 1.55

Malaria and the red blood cell membrane. Semin Hematol (2004) 1.54

The apicoplast: a review of the derived plastid of apicomplexan parasites. Curr Issues Mol Biol (2005) 1.54

Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis. Hepatology (2010) 1.53

Liver-targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis. Hepatology (2006) 1.53

Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid. J Immunol (2005) 1.47

Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium. Hepatology (2003) 1.46

Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum. BMC Biol (2013) 1.46

The human malaria parasite Plasmodium falciparum possesses two distinct dihydrolipoamide dehydrogenases. Mol Microbiol (2005) 1.46

Adoptive transfer of CD8(+) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice. Hepatology (2008) 1.45

Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii. J Exp Med (2011) 1.43

Primary biliary cirrhosis is associated with altered hepatic microRNA expression. J Autoimmun (2009) 1.41

No TRAP, no invasion. Trends Parasitol (2008) 1.41

Identification of 2-nonynoic acid, a cosmetic component, as a potential trigger of primary biliary cirrhosis. J Autoimmun (2006) 1.41

Primary biliary cirrhosis. Lancet (2011) 1.37

The Leishmania-macrophage interaction: a metabolic perspective. Cell Microbiol (2007) 1.37

Altered monocyte responses to defined TLR ligands in patients with primary biliary cirrhosis. Hepatology (2005) 1.37

PimE is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of phosphatidylinositol mannoside in mycobacteria. J Biol Chem (2006) 1.36

Phosphate deprivation induces transfer of DGDG galactolipid from chloroplast to mitochondria. J Cell Biol (2004) 1.36

The apicoplast: a plastid in Plasmodium falciparum and other Apicomplexan parasites. Int Rev Cytol (2003) 1.34

Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphatase. Proc Natl Acad Sci U S A (2006) 1.34

Evidence that intracellular beta1-2 mannan is a virulence factor in Leishmania parasites. J Biol Chem (2003) 1.34

Function of the cytochrome bc1-aa3 branch of the respiratory network in mycobacteria and network adaptation occurring in response to its disruption. J Bacteriol (2005) 1.33

Secondary acylation of Klebsiella pneumoniae lipopolysaccharide contributes to sensitivity to antibacterial peptides. J Biol Chem (2007) 1.33

Therapeutic effect of cytotoxic T lymphocyte antigen 4/immunoglobulin on a murine model of primary biliary cirrhosis. Hepatology (2013) 1.33

LeishCyc: a biochemical pathways database for Leishmania major. BMC Syst Biol (2009) 1.32

Structure and metal-dependent mechanism of peptidoglycan deacetylase, a streptococcal virulence factor. Proc Natl Acad Sci U S A (2005) 1.31

Alveolins, a new family of cortical proteins that define the protist infrakingdom Alveolata. Mol Biol Evol (2008) 1.31

Surface determinants of Leishmania parasites and their role in infectivity in the mammalian host. Curr Mol Med (2004) 1.31

A dynamic programming approach for the alignment of signal peaks in multiple gas chromatography-mass spectrometry experiments. BMC Bioinformatics (2007) 1.29

Properties and prediction of mitochondrial transit peptides from Plasmodium falciparum. Mol Biochem Parasitol (2003) 1.28

Antibodies to Plasmodium falciparum and Plasmodium vivax merozoite surface protein 5 in Indonesia: species-specific and cross-reactive responses. J Infect Dis (2008) 1.28

The response of Nannochloropsis gaditana to nitrogen starvation includes de novo biosynthesis of triacylglycerols, a decrease of chloroplast galactolipids, and reorganization of the photosynthetic apparatus. Eukaryot Cell (2013) 1.28

Characterization of a membrane-associated rhoptry protein of Plasmodium falciparum. J Biol Chem (2003) 1.26

A type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum. Antimicrob Agents Chemother (2003) 1.26

A set of glycosylphosphatidyl inositol-anchored membrane proteins of Plasmodium falciparum is refractory to genetic deletion. Infect Immun (2006) 1.25

Membrane transporters in the relict plastid of malaria parasites. Proc Natl Acad Sci U S A (2006) 1.24

A sensitive bead assay for antimitochondrial antibodies: Chipping away at AMA-negative primary biliary cirrhosis. Hepatology (2007) 1.23

Mitochondrial metabolism of glucose and glutamine is required for intracellular growth of Toxoplasma gondii. Cell Host Microbe (2012) 1.22

Biosynthesis of mycobacterial phosphatidylinositol mannosides. Biochem J (2004) 1.22

Immunization with a xenobiotic 6-bromohexanoate bovine serum albumin conjugate induces antimitochondrial antibodies. J Immunol (2003) 1.21

Apicoplast and mitochondrion in gametocytogenesis of Plasmodium falciparum. Eukaryot Cell (2008) 1.20

The reductase that catalyzes mycolic motif synthesis is required for efficient attachment of mycolic acids to arabinogalactan. J Biol Chem (2007) 1.19

Mature parasite-infected erythrocyte surface antigen (MESA) of Plasmodium falciparum binds to the 30-kDa domain of protein 4.1 in malaria-infected red blood cells. Blood (2003) 1.19

Increased killing activity and decreased cytokine production in NK cells in patients with primary biliary cirrhosis. J Autoimmun (2006) 1.17

B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis. Gastroenterology (2008) 1.17

Sodium-dependent uptake of inorganic phosphate by the intracellular malaria parasite. Nature (2006) 1.16

IL-12/Th1 and IL-23/Th17 biliary microenvironment in primary biliary cirrhosis: implications for therapy. Hepatology (2014) 1.15

Modification of glycopeptidolipids by an O-methyltransferase of Mycobacterium smegmatis. Microbiology (2002) 1.15