Published in Eur J Cell Biol on September 01, 2010
The Structure of the talin head reveals a novel extended conformation of the FERM domain. Structure (2010) 2.22
Talins and kindlins: partners in integrin-mediated adhesion. Nat Rev Mol Cell Biol (2013) 2.14
FAK promotes recruitment of talin to nascent adhesions to control cell motility. J Cell Biol (2012) 1.87
The tail of integrin activation. Trends Biochem Sci (2011) 1.62
A talin mutant that impairs talin-integrin binding in platelets decelerates αIIbβ3 activation without pathological bleeding. Blood (2014) 1.55
The C terminus of talin links integrins to cell cycle progression. J Cell Biol (2011) 1.33
Central region of talin has a unique fold that binds vinculin and actin. J Biol Chem (2010) 1.21
Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation. J Struct Biol (2013) 1.19
RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover. J Biol Chem (2013) 1.19
Subcellular localization of talin is regulated by inter-domain interactions. J Biol Chem (2012) 1.05
Mechanisms of talin-dependent integrin signaling and crosstalk. Biochim Biophys Acta (2013) 1.03
Talin1 regulates integrin turnover to promote embryonic epithelial morphogenesis. Mol Cell Biol (2011) 0.97
Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamics. PLoS One (2012) 0.97
Endothelial cell talin1 is essential for embryonic angiogenesis. Dev Biol (2010) 0.94
New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2. Eur J Cell Biol (2012) 0.91
Integrin adhesions: who's on first? What's on second? Connections between FAK and talin. Cell Adh Migr (2012) 0.90
Talin autoinhibition is required for morphogenesis. Curr Biol (2013) 0.88
A chemically-defined screening platform reveals behavioral similarities between primary human mesenchymal stem cells and endothelial cells. Integr Biol (Camb) (2012) 0.87
Talin determines the nanoscale architecture of focal adhesions. Proc Natl Acad Sci U S A (2015) 0.87
Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile. Biochem Biophys Res Commun (2012) 0.85
Integrin signaling in vascular function. Curr Opin Hematol (2012) 0.85
Contributions of talin-1 to glioma cell-matrix tensional homeostasis. J R Soc Interface (2011) 0.84
Myosin 1E localizes to actin polymerization sites in lamellipodia, affecting actin dynamics and adhesion formation. Biol Open (2013) 0.83
Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity. J Cell Biol (2016) 0.81
Both Talin-1 and Talin-2 correlate with malignancy potential of the human hepatocellular carcinoma MHCC-97 L cell. BMC Cancer (2016) 0.78
Induction of focal adhesions and motility in Drosophila S2 cells. Mol Biol Cell (2014) 0.77
Matrix metalloproteinase-9-dependent mechanisms of reduced contractility and increased stiffness in the aging heart. Proteomics Clin Appl (2015) 0.76
Talin Modulation by a Synthetic N-Acylurea Derivative Reduces Angiogenesis in Human Endothelial Cells. Int J Mol Sci (2017) 0.75
Stretching single talin rod molecules activates vinculin binding. Science (2009) 8.11
Talin binding to integrin beta tails: a final common step in integrin activation. Science (2003) 7.56
Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature (2008) 7.28
Structural basis of integrin activation by talin. Cell (2007) 5.37
The tail of integrins, talin, and kindlins. Science (2009) 4.51
Vinculin controls focal adhesion formation by direct interactions with talin and actin. J Cell Biol (2007) 4.28
Structural determinants of integrin recognition by talin. Mol Cell (2003) 4.20
Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin. Nature (2002) 4.03
A new protein of adhesion plaques and ruffling membranes. J Cell Biol (1983) 3.88
Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3. Curr Biol (2006) 3.81
Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin. Nature (2003) 3.70
Talin depletion reveals independence of initial cell spreading from integrin activation and traction. Nat Cell Biol (2008) 3.62
Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions. Nature (2002) 3.46
Integrin activation. J Cell Sci (2004) 3.02
Integrins in cell migration--the actin connection. J Cell Sci (2009) 2.88
Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. J Exp Med (2007) 2.85
The structure of an integrin/talin complex reveals the basis of inside-out signal transduction. EMBO J (2009) 2.76
Structural basis for the autoinhibition of talin in regulating integrin activation. Mol Cell (2008) 2.53
Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction. Proc Natl Acad Sci U S A (2009) 2.52
Biochemical and structural properties of the integrin-associated cytoskeletal protein talin. Annu Rev Biophys (2009) 2.47
Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo. J Exp Med (2007) 2.43
RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences. J Biol Chem (2008) 2.29
Conformation, localization, and integrin binding of talin depend on its interaction with phosphoinositides. J Biol Chem (2001) 2.25
Disruption of the talin gene arrests mouse development at the gastrulation stage. Dev Dyn (2000) 1.98
Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site. J Cell Sci (1996) 1.95
Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3. J Cell Biol (2008) 1.93
The N-terminal domains of talin cooperate with the phosphotyrosine binding-like domain to activate beta1 and beta3 integrins. J Biol Chem (2007) 1.89
Disruption of the talin gene compromises focal adhesion assembly in undifferentiated but not differentiated embryonic stem cells. J Cell Biol (1998) 1.79
The structure of the C-terminal actin-binding domain of talin. EMBO J (2007) 1.77
Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod. J Biol Chem (2005) 1.68
An interaction between integrin and the talin FERM domain mediates integrin activation but not linkage to the cytoskeleton. Nat Cell Biol (2006) 1.67
Specification of the direction of adhesive signaling by the integrin beta cytoplasmic domain. J Biol Chem (2005) 1.65
New PI(4,5)P2- and membrane proximal integrin-binding motifs in the talin head control beta3-integrin clustering. J Cell Biol (2009) 1.58
Characterization of an actin-binding site within the talin FERM domain. J Mol Biol (2004) 1.55
Microinjection of antibodies against talin inhibits the spreading and migration of fibroblasts. J Cell Sci (1992) 1.48
The structure of an interdomain complex that regulates talin activity. J Biol Chem (2009) 1.48
Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation. EMBO J (2010) 1.45
Properties of talin from chicken gizzard smooth muscle. J Biol Chem (1987) 1.40
Structural determinants of integrin binding to the talin rod. J Biol Chem (2009) 1.35
Down regulation of talin alters cell adhesion and the processing of the alpha 5 beta 1 integrin. J Cell Sci (1995) 1.33
Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes. J Clin Invest (2008) 1.33
The integrin binding site 2 (IBS2) in the talin rod domain is essential for linking integrin beta subunits to the cytoskeleton. J Biol Chem (2007) 1.28
The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation. J Mol Biol (2009) 1.25
Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions. Development (2009) 1.25
Spatial mapping of the neurite and soma proteomes reveals a functional Cdc42/Rac regulatory network. Proc Natl Acad Sci U S A (2008) 1.20
Talin phosphorylation sites mapped by mass spectrometry. J Cell Sci (2005) 1.19
Progressive myopathy and defects in the maintenance of myotendinous junctions in mice that lack talin 1 in skeletal muscle. Development (2008) 1.16
A C-terminal dimerization motif is required for focal adhesion targeting of Talin1 and the interaction of the Talin1 I/LWEQ module with F-actin. Biochemistry (2007) 1.13
Talin 2 is a large and complex gene encoding multiple transcripts and protein isoforms. FEBS J (2009) 1.06
Energy-filtered electron microscopy reveals that talin is a highly flexible protein composed of a series of globular domains. Eur J Biochem (1997) 1.05
Monoclonal antibodies recognizing the N- and C-terminal regions of talin disrupt actin stress fibers when microinjected into human fibroblasts. Cell Motil Cytoskeleton (1997) 1.04
The talin rod IBS2 alpha-helix interacts with the beta3 integrin cytoplasmic tail membrane-proximal helix by establishing charge complementary salt bridges. J Biol Chem (2008) 1.03
The N-terminal half of talin2 is sufficient for mouse development and survival. Biochem Biophys Res Commun (2005) 1.03
Control of high affinity interactions in the talin C terminus: how talin domains coordinate protein dynamics in cell adhesions. J Biol Chem (2009) 0.99
VEGFR1 (Flt1) regulates Rab4 recycling to control fibronectin polymerization and endothelial vessel branching. Traffic (2009) 0.94
Active genes dynamically colocalize to shared sites of ongoing transcription. Nat Genet (2004) 9.57
Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature (2008) 7.28
Calpain-mediated proteolysis of talin regulates adhesion dynamics. Nat Cell Biol (2004) 4.29
Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin. Nature (2003) 3.70
Structural basis for vinculin activation at sites of cell adhesion. Nature (2004) 3.62
Talin depletion reveals independence of initial cell spreading from integrin activation and traction. Nat Cell Biol (2008) 3.62
The structure and regulation of vinculin. Trends Cell Biol (2006) 3.52
RalGDS is required for tumor formation in a model of skin carcinogenesis. Cancer Cell (2005) 3.09
Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. J Exp Med (2007) 2.85
The structure of an integrin/talin complex reveals the basis of inside-out signal transduction. EMBO J (2009) 2.76
Raf proteins and cancer: B-Raf is identified as a mutational target. Biochim Biophys Acta (2003) 2.58
Replication and transcription: shaping the landscape of the genome. Nat Rev Genet (2005) 2.30
The Structure of the talin head reveals a novel extended conformation of the FERM domain. Structure (2010) 2.22
Talin1 is critical for force-dependent reinforcement of initial integrin-cytoskeleton bonds but not tyrosine kinase activation. J Cell Biol (2003) 2.18
Talin at a glance. J Cell Sci (2008) 2.16
Talins and kindlins: partners in integrin-mediated adhesion. Nat Rev Mol Cell Biol (2013) 2.14
Phytochromes B, D, and E act redundantly to control multiple physiological responses in Arabidopsis. Plant Physiol (2003) 2.05
Role of vinculin in regulating focal adhesion turnover. Eur J Cell Biol (2006) 2.03
The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2. Circ Res (2003) 1.92
Talin-dependent integrin activation is required for fibrin clot retraction by platelets. Blood (2010) 1.83
Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes. J Biol Chem (2009) 1.79
The structure of the C-terminal actin-binding domain of talin. EMBO J (2007) 1.77
Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle. EMBO J (2004) 1.73
Talin1 and Rap1 are critical for osteoclast function. Mol Cell Biol (2012) 1.68
Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod. J Biol Chem (2005) 1.68
Biochemical and functional characterization of the interaction between pentraxin 3 and C1q. Eur J Immunol (2003) 1.67
Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation. Blood (2012) 1.64
Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP. Nat Immunol (2002) 1.61
A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head. Structure (2005) 1.56
Characterization of an actin-binding site within the talin FERM domain. J Mol Biol (2004) 1.55
Human alpha-synemin interacts directly with vinculin and metavinculin. Biochem J (2008) 1.54
Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery. Nat Struct Mol Biol (2011) 1.53
Direct binding of C1q to apoptotic cells and cell blebs induces complement activation. Eur J Immunol (2002) 1.52
Mechanotransduction in vivo by repeated talin stretch-relaxation events depends upon vinculin. PLoS Biol (2011) 1.52
The structure of an interdomain complex that regulates talin activity. J Biol Chem (2009) 1.48
Noninvasive augmentation of microvessel number in patients with peripheral vascular disease. J Vasc Surg (2003) 1.45
Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation. EMBO J (2010) 1.45
Mutations in the huge Arabidopsis gene BIG affect a range of hormone and light responses. Plant J (2003) 1.42
Structural and dynamic characterization of a vinculin binding site in the talin rod. Biochemistry (2006) 1.40
Phosphatidylinositol phosphate kinase type 1gamma and beta1-integrin cytoplasmic domain bind to the same region in the talin FERM domain. J Biol Chem (2003) 1.37
V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a. EMBO Mol Med (2010) 1.36
Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo. J Biol Chem (2003) 1.36
Structural determinants of integrin binding to the talin rod. J Biol Chem (2009) 1.35
Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes. J Clin Invest (2008) 1.33
Structural basis for phosphatidylinositol phosphate kinase type Igamma binding to talin at focal adhesions. J Biol Chem (2004) 1.32
The region 3' to Xist mediates X chromosome counting and H3 Lys-4 dimethylation within the Xist gene. EMBO J (2004) 1.31
Paxillin associates with poly(A)-binding protein 1 at the dense endoplasmic reticulum and the leading edge of migrating cells. J Biol Chem (2001) 1.31
Integrin connections to the cytoskeleton through talin and vinculin. Biochem Soc Trans (2008) 1.30
The integrin binding site 2 (IBS2) in the talin rod domain is essential for linking integrin beta subunits to the cytoskeleton. J Biol Chem (2007) 1.28
The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation. J Mol Biol (2009) 1.25
Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions. Development (2009) 1.25
Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2. J Biol Chem (2007) 1.25
An essential role for talin during alpha(M)beta(2)-mediated phagocytosis. Mol Biol Cell (2007) 1.24
Lineage tracing of cardiac explant derived cells. PLoS One (2008) 1.22
Central region of talin has a unique fold that binds vinculin and actin. J Biol Chem (2010) 1.21
Structural diversity in integrin/talin interactions. Structure (2010) 1.20
Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation. J Struct Biol (2013) 1.19
RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover. J Biol Chem (2013) 1.19
The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor. Genes Dev (2011) 1.17
Carotid plaque instability and ischemic symptoms are linked to immaturity of microvessels within plaques. J Vasc Surg (2007) 1.16
The activity of the vinculin binding sites in talin is influenced by the stability of the helical bundles that make up the talin rod. J Biol Chem (2006) 1.15
The structure of the talin/integrin complex at a lipid bilayer: an NMR and MD simulation study. Structure (2010) 1.14
Further characterization of the interaction between the cytoskeletal proteins talin and vinculin. Biochem J (2002) 1.13
Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation. Proc Natl Acad Sci U S A (2013) 1.12
Structural and biophysical properties of the integrin-associated cytoskeletal protein talin. Biophys Rev (2009) 1.11