Published in Nature on May 01, 2008
The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol (2012) 6.07
Plasticity of cell migration: a multiscale tuning model. J Cell Biol (2009) 5.82
One-dimensional topography underlies three-dimensional fibrillar cell migration. J Cell Biol (2009) 5.07
Random versus directionally persistent cell migration. Nat Rev Mol Cell Biol (2009) 4.99
The lymphatic vasculature in disease. Nat Med (2011) 4.20
Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited. J Cell Biol (2009) 4.04
Physical limits of cell migration: control by ECM space and nuclear deformation and tuning by proteolysis and traction force. J Cell Biol (2013) 3.77
Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish. Dev Cell (2010) 3.19
Intravital imaging. Cell (2011) 3.18
Integrins in cell migration. Cold Spring Harb Perspect Biol (2011) 3.15
Integrins in cell migration--the actin connection. J Cell Sci (2009) 2.88
Stromal cell contributions to the homeostasis and functionality of the immune system. Nat Rev Immunol (2009) 2.82
Nonpolarized signaling reveals two distinct modes of 3D cell migration. J Cell Biol (2012) 2.76
The ins and outs of leukocyte integrin signaling. Annu Rev Immunol (2009) 2.76
Breaching multiple barriers: leukocyte motility through venular walls and the interstitium. Nat Rev Mol Cell Biol (2010) 2.72
β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments. Nat Cell Biol (2013) 2.52
The filamins: organizers of cell structure and function. Cell Adh Migr (2011) 2.50
Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin. Immunity (2009) 2.50
Afferent lymph-derived T cells and DCs use different chemokine receptor CCR7-dependent routes for entry into the lymph node and intranodal migration. Nat Immunol (2011) 2.37
The impact of the extracellular matrix on inflammation. Nat Rev Immunol (2010) 2.30
Mechanisms and consequences of dendritic cell migration. Immunity (2008) 2.25
Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo. Nature (2013) 2.19
HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes. Nat Rev Immunol (2012) 2.18
Adaptive force transmission in amoeboid cell migration. Nat Cell Biol (2009) 2.17
Talins and kindlins: partners in integrin-mediated adhesion. Nat Rev Mol Cell Biol (2013) 2.14
gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis. Blood (2009) 2.07
Dictyostelium amoebae and neutrophils can swim. Proc Natl Acad Sci U S A (2010) 1.99
The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency. Nat Immunol (2008) 1.97
The vascular basement membrane as "soil" in brain metastasis. PLoS One (2009) 1.95
Force transmission in migrating cells. J Cell Biol (2010) 1.89
Matrix geometry determines optimal cancer cell migration strategy and modulates response to interventions. Nat Cell Biol (2013) 1.84
Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels. J Exp Med (2009) 1.83
Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA-regulated adhesions. Nat Immunol (2010) 1.82
Dasatinib inhibits proinflammatory functions of mature human neutrophils. Blood (2012) 1.75
Bringing up the rear: defining the roles of the uropod. Nat Rev Mol Cell Biol (2009) 1.74
Physical confinement alters tumor cell adhesion and migration phenotypes. FASEB J (2012) 1.74
CXCR3 chemokine receptor enables local CD8(+) T cell migration for the destruction of virus-infected cells. Immunity (2015) 1.73
CD44 mediates successful interstitial navigation by killer T cells and enables efficient antitumor immunity. Immunity (2008) 1.72
Reducing background fluorescence reveals adhesions in 3D matrices. Nat Cell Biol (2011) 1.69
DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity. J Exp Med (2014) 1.68
Cell mechanics control rapid transitions between blebs and lamellipodia during migration. Proc Natl Acad Sci U S A (2012) 1.67
At the leading edge of three-dimensional cell migration. J Cell Sci (2013) 1.66
DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses. Blood (2012) 1.63
DC mobilization from the skin requires docking to immobilized CCL21 on lymphatic endothelium and intralymphatic crawling. J Exp Med (2011) 1.63
The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment. J Exp Med (2014) 1.59
Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes. EMBO J (2009) 1.58
Reconstitution of an actin cortex inside a liposome. Biophys J (2009) 1.55
Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature (2009) 1.55
Distinct roles for paxillin and Hic-5 in regulating breast cancer cell morphology, invasion, and metastasis. Mol Biol Cell (2011) 1.54
Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease. Sci Signal (2011) 1.51
Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. Immunity (2012) 1.50
Discoidin domain receptor 2 regulates neutrophil chemotaxis in 3D collagen matrices. Blood (2012) 1.49
Integrin function in T-cell homing to lymphoid and nonlymphoid sites: getting there and staying there. Crit Rev Immunol (2009) 1.49
The role and regulation of blebs in cell migration. Curr Opin Cell Biol (2013) 1.48
New dimensions in cell migration. Nat Rev Mol Cell Biol (2012) 1.46
Chemokines in the immunopathogenesis of hepatitis C infection. Hepatology (2009) 1.46
Fascin Regulates Nuclear Movement and Deformation in Migrating Cells. Dev Cell (2016) 1.45
Impact of tumor cell cytoskeleton organization on invasiveness and migration: a microchannel-based approach. PLoS One (2010) 1.43
Stromal and hematopoietic cells in secondary lymphoid organs: partners in immunity. Immunol Rev (2013) 1.40
The Actin Filament-Binding Protein Coronin Regulates Motility in Plasmodium Sporozoites. PLoS Pathog (2016) 1.40
WNK1 kinase balances T cell adhesion versus migration in vivo. Nat Immunol (2016) 1.39
The role of phosphoinositide 3-kinases in neutrophil migration in 3D collagen gels. PLoS One (2015) 1.38
Characterization of zebrafish larval inflammatory macrophages. Dev Comp Immunol (2009) 1.37
Dendritic cell chemotaxis in 3D under defined chemokine gradients reveals differential response to ligands CCL21 and CCL19. Proc Natl Acad Sci U S A (2011) 1.36
Mechanisms and functions for the duration of intercellular contacts made by lymphocytes. Nat Rev Immunol (2009) 1.36
Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels. J Exp Med (2012) 1.33
Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II. Nat Immunol (2010) 1.33
Targeting tumor cell motility to prevent metastasis. Adv Drug Deliv Rev (2011) 1.32
Lymph node fibroblastic reticular cells in health and disease. Nat Rev Immunol (2015) 1.31
Perinuclear P granules are the principal sites of mRNA export in adult C. elegans germ cells. Development (2010) 1.29
Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1. Eur J Cell Biol (2010) 1.29
The role of the microenvironment in tumor growth and invasion. Prog Biophys Mol Biol (2011) 1.28
The peri-islet basement membrane, a barrier to infiltrating leukocytes in type 1 diabetes in mouse and human. Diabetes (2012) 1.27
Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells. Nat Cell Biol (2015) 1.27
A molecular switch for the orientation of epithelial cell polarization. Dev Cell (2014) 1.27
The regulatory role of cell mechanics for migration of differentiating myeloid cells. Proc Natl Acad Sci U S A (2009) 1.26
Inflammation-induced interstitial migration of effector CD4⁺ T cells is dependent on integrin αV. Nat Immunol (2013) 1.24
Neutrophil adhesion and chemotaxis depend on substrate mechanics. J Phys Condens Matter (2010) 1.21
Mechanisms of force generation and force transmission during interstitial leukocyte migration. EMBO Rep (2010) 1.21
Microfluidics-based devices: New tools for studying cancer and cancer stem cell migration. Biomicrofluidics (2011) 1.21
Role of WASP in cell polarity and podosome dynamics of myeloid cells. Eur J Cell Biol (2010) 1.20
Traction forces of neutrophils migrating on compliant substrates. Biophys J (2011) 1.20
Directional decisions during neutrophil chemotaxis inside bifurcating channels. Integr Biol (Camb) (2010) 1.20
Force transmission during adhesion-independent migration. Nat Cell Biol (2015) 1.19
Three-dimensional migration of macrophages requires Hck for podosome organization and extracellular matrix proteolysis. Blood (2009) 1.18
A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis. J Exp Med (2012) 1.18
Directed migration of mesenchymal cells: where signaling and the cytoskeleton meet. Curr Opin Cell Biol (2014) 1.17
MT1-MMP controls human mesenchymal stem cell trafficking and differentiation. Blood (2009) 1.17
Interstitial cell migration: integrin-dependent and alternative adhesion mechanisms. Cell Tissue Res (2009) 1.16
T cell migration, search strategies and mechanisms. Nat Rev Immunol (2016) 1.16
Impaired humoral immunity and tolerance in K14-VEGFR-3-Ig mice that lack dermal lymphatic drainage. J Immunol (2012) 1.15
Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes. Cell Mol Life Sci (2014) 1.15
Distinct roles for LFA-1 affinity regulation during T-cell adhesion, diapedesis, and interstitial migration in lymph nodes. Blood (2009) 1.15
Modulus-driven differentiation of marrow stromal cells in 3D scaffolds that is independent of myosin-based cytoskeletal tension. Biomaterials (2010) 1.14
Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments. Nat Commun (2016) 1.13
Molecular control of steady-state dendritic cell maturation and immune homeostasis. Annu Rev Immunol (2013) 1.13
The multiple faces of leukocyte interstitial migration. Semin Immunopathol (2014) 1.12
Cell motility: the integrating role of the plasma membrane. Eur Biophys J (2011) 1.11
Traversing the basement membrane in vivo: a diversity of strategies. J Cell Biol (2014) 1.11
Lifeact: a versatile marker to visualize F-actin. Nat Methods (2008) 12.23
Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing. J Exp Med (2005) 5.89
CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity (2004) 5.48
SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function. Cell (2008) 5.02
ILK, PINCH and parvin: the tIPP of integrin signalling. Nat Rev Mol Cell Biol (2006) 4.64
Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med (2008) 4.55
The tail of integrins, talin, and kindlins. Science (2009) 4.51
Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. Cell (2006) 4.43
Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells. J Exp Med (2006) 4.30
Calpain-mediated proteolysis of talin regulates adhesion dynamics. Nat Cell Biol (2004) 4.29
Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. Immunity (2011) 3.92
Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions. J Exp Med (2009) 3.79
Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin. Nature (2003) 3.70
Structural basis for vinculin activation at sites of cell adhesion. Nature (2004) 3.62
Talin depletion reveals independence of initial cell spreading from integrin activation and traction. Nat Cell Biol (2008) 3.62
Genetic and cell biological analysis of integrin outside-in signaling. Genes Dev (2009) 3.57
The structure and regulation of vinculin. Trends Cell Biol (2006) 3.52
Processive movement of MreB-associated cell wall biosynthetic complexes in bacteria. Science (2011) 3.47
Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces. Nat Immunol (2007) 3.41
Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position. Nature (2002) 3.35
Kindlin-2 controls bidirectional signaling of integrins. Genes Dev (2008) 3.15
The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation. Dev Cell (2006) 3.10
Mechanical modes of 'amoeboid' cell migration. Curr Opin Cell Biol (2009) 2.99
Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. J Exp Med (2007) 2.85
Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells. Nat Med (2009) 2.85
CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo. J Exp Med (2007) 2.81
Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. J Clin Invest (2008) 2.77
The structure of an integrin/talin complex reveals the basis of inside-out signal transduction. EMBO J (2009) 2.76
Breaching multiple barriers: leukocyte motility through venular walls and the interstitium. Nat Rev Mol Cell Biol (2010) 2.72
Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev (2003) 2.68
Chemokine requirements for B cell entry to lymph nodes and Peyer's patches. J Exp Med (2002) 2.68
Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells. Blood (2002) 2.61
CD103- and CD103+ bronchial lymph node dendritic cells are specialized in presenting and cross-presenting innocuous antigen to CD4+ and CD8+ T cells. J Immunol (2007) 2.61
Interstitial dendritic cell guidance by haptotactic chemokine gradients. Science (2013) 2.61
Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation. Nat Med (2006) 2.59
β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments. Nat Cell Biol (2013) 2.52
Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells. Nat Cell Biol (2008) 2.46
Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities. Development (2004) 2.44
Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo. J Exp Med (2007) 2.43
Afferent lymph-derived T cells and DCs use different chemokine receptor CCR7-dependent routes for entry into the lymph node and intranodal migration. Nat Immunol (2011) 2.37
The Kindlins: subcellular localization and expression during murine development. Exp Cell Res (2006) 2.36
Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon. Neuron (2003) 2.31
Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails. J Cell Sci (2009) 2.29
The integrin-actin connection, an eternal love affair. EMBO J (2003) 2.26
The Structure of the talin head reveals a novel extended conformation of the FERM domain. Structure (2010) 2.22
Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis. Genes Dev (2003) 2.21
Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells. Immunity (2010) 2.18
HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes. Nat Rev Immunol (2012) 2.18
Talin1 is critical for force-dependent reinforcement of initial integrin-cytoskeleton bonds but not tyrosine kinase activation. J Cell Biol (2003) 2.18
Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae. Dev Cell (2010) 2.17
Adaptive force transmission in amoeboid cell migration. Nat Cell Biol (2009) 2.17
Stromal mesenteric lymph node cells are essential for the generation of gut-homing T cells in vivo. J Exp Med (2008) 2.15
Talins and kindlins: partners in integrin-mediated adhesion. Nat Rev Mol Cell Biol (2013) 2.14
Induced bronchus-associated lymphoid tissue serves as a general priming site for T cells and is maintained by dendritic cells. J Exp Med (2009) 2.10
The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase! EMBO J (2009) 2.10
Tenomodulin is necessary for tenocyte proliferation and tendon maturation. Mol Cell Biol (2005) 2.10
Cdc42-dependent leading edge coordination is essential for interstitial dendritic cell migration. Blood (2009) 2.09
Alloantigen-specific de novo-induced Foxp3+ Treg revert in vivo and do not protect from experimental GVHD. Eur J Immunol (2009) 2.07
The role of laminin in embryonic cell polarization and tissue organization. Dev Cell (2003) 2.05
Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation. Blood (2010) 2.04
Beta1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance. Development (2004) 2.04
A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair. Development (2002) 2.04
Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma. Blood (2002) 2.03
Role of vinculin in regulating focal adhesion turnover. Eur J Cell Biol (2006) 2.03
Ena/VASP Is Required for neuritogenesis in the developing cortex. Neuron (2007) 2.01
Lifeact mice for studying F-actin dynamics. Nat Methods (2010) 2.00
Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals. Cell (2007) 2.00
Homing of mouse spermatogonial stem cells to germline niche depends on beta1-integrin. Cell Stem Cell (2008) 1.98
Central roles of alpha5beta1 integrin and fibronectin in vascular development in mouse embryos and embryoid bodies. Arterioscler Thromb Vasc Biol (2002) 1.97
Chemokine receptor CCR9 contributes to the localization of plasma cells to the small intestine. J Exp Med (2004) 1.97
Hyperplastic conotruncal endocardial cushions and transposition of great arteries in perlecan-null mice. Circ Res (2002) 1.96
Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins. EMBO Rep (2011) 1.96
Integrins in invasive growth. J Clin Invest (2002) 1.96
The role of integrin binding sites in fibronectin matrix assembly in vivo. Curr Opin Cell Biol (2008) 1.89
CCR6 and NK1.1 distinguish between IL-17A and IFN-gamma-producing gammadelta effector T cells. Eur J Immunol (2009) 1.83
Talin-dependent integrin activation is required for fibrin clot retraction by platelets. Blood (2010) 1.83
Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels. J Exp Med (2009) 1.83
The microanatomy of T-cell responses. Immunol Rev (2008) 1.82
The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. J Cell Biol (2007) 1.81
Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction. PLoS Genet (2008) 1.78
The structure of the C-terminal actin-binding domain of talin. EMBO J (2007) 1.77
ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability. J Exp Med (2006) 1.75
Plasma fibronectin promotes thrombus growth and stability in injured arterioles. Proc Natl Acad Sci U S A (2003) 1.74
Regulatory T cells interfere with the development of bronchus-associated lymphoid tissue. J Exp Med (2007) 1.74
Genetic analysis of beta1 integrin "activation motifs" in mice. J Cell Biol (2006) 1.73
Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle. EMBO J (2004) 1.73
CC chemokine receptor 7 and 9 double-deficient hematopoietic progenitors are severely impaired in seeding the adult thymus. Blood (2009) 1.73
Dendritic cells govern induction and reprogramming of polarized tissue-selective homing receptor patterns of T cells: important roles for soluble factors and tissue microenvironments. Eur J Immunol (2005) 1.73
Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography. Nat Cell Biol (2010) 1.72