Published in Science on January 30, 2009
Non-muscle myosin II takes centre stage in cell adhesion and migration. Nat Rev Mol Cell Biol (2009) 7.77
Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nat Rev Mol Cell Biol (2010) 7.27
The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol (2012) 6.07
Nanoscale architecture of integrin-based cell adhesions. Nature (2010) 5.88
Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate. Nat Mater (2010) 5.36
Collective cell guidance by cooperative intercellular forces. Nat Mater (2011) 4.64
alpha-Catenin as a tension transducer that induces adherens junction development. Nat Cell Biol (2010) 4.42
Mechanical integration of actin and adhesion dynamics in cell migration. Annu Rev Cell Dev Biol (2010) 4.06
Balancing forces: architectural control of mechanotransduction. Nat Rev Mol Cell Biol (2011) 3.87
Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation. J Cell Biol (2010) 3.56
Myosin II dynamics are regulated by tension in intercalating cells. Dev Cell (2009) 3.49
Material properties of the cell dictate stress-induced spreading and differentiation in embryonic stem cells. Nat Mater (2009) 3.30
Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner. J Cell Biol (2010) 3.25
Mechanical control of tissue and organ development. Development (2010) 3.18
Integrins in cell migration. Cold Spring Harb Perspect Biol (2011) 3.15
E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch. Proc Natl Acad Sci U S A (2012) 2.82
Stretchy proteins on stretchy substrates: the important elements of integrin-mediated rigidity sensing. Dev Cell (2010) 2.65
Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction. Proc Natl Acad Sci U S A (2009) 2.52
Mammary gland ECM remodeling, stiffness, and mechanosignaling in normal development and tumor progression. Cold Spring Harb Perspect Biol (2011) 2.48
Integrins and extracellular matrix in mechanotransduction. Cold Spring Harb Perspect Biol (2010) 2.36
Cell fate regulation by coupling mechanical cycles to biochemical signaling pathways. Curr Opin Cell Biol (2009) 2.33
Force probing surfaces of living cells to molecular resolution. Nat Chem Biol (2009) 2.28
Vinculin regulates the recruitment and release of core focal adhesion proteins in a force-dependent manner. Curr Biol (2013) 2.20
Talins and kindlins: partners in integrin-mediated adhesion. Nat Rev Mol Cell Biol (2013) 2.14
Actin machinery and mechanosensitivity in invadopodia, podosomes and focal adhesions. J Cell Sci (2009) 2.13
The switchable integrin adhesome. J Cell Sci (2010) 2.12
Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins. EMBO Rep (2011) 1.96
Evidence of a large-scale mechanosensing mechanism for cellular adaptation to substrate stiffness. Proc Natl Acad Sci U S A (2012) 1.94
Mechanotransduction and extracellular matrix homeostasis. Nat Rev Mol Cell Biol (2014) 1.94
New insights into the T cell synapse from single molecule techniques. Nat Rev Immunol (2011) 1.90
Strength dependence of cadherin-mediated adhesions. Biophys J (2010) 1.86
Mechanosensing through cooperative interactions between myosin II and the actin crosslinker cortexillin I. Curr Biol (2009) 1.86
Raver1 interactions with vinculin and RNA suggest a feed-forward pathway in directing mRNA to focal adhesions. Structure (2009) 1.77
Forcing form and function: biomechanical regulation of tumor evolution. Trends Cell Biol (2010) 1.77
Matrix elasticity, cytoskeletal forces and physics of the nucleus: how deeply do cells 'feel' outside and in? J Cell Sci (2010) 1.73
A hitchhiker's guide to mechanobiology. Dev Cell (2011) 1.72
Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrate. PLoS Comput Biol (2009) 1.69
Mechanisms of mechanical signaling in development and disease. J Cell Sci (2011) 1.67
Soft substrates promote homogeneous self-renewal of embryonic stem cells via downregulating cell-matrix tractions. PLoS One (2010) 1.67
Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions. Nat Cell Biol (2012) 1.66
Extracellular rigidity sensing by talin isoform-specific mechanical linkages. Nat Cell Biol (2015) 1.66
Mechanical regulation of signaling pathways in bone. Gene (2012) 1.65
United we stand: integrating the actin cytoskeleton and cell-matrix adhesions in cellular mechanotransduction. J Cell Sci (2012) 1.63
The hard life of soft cells. Cell Motil Cytoskeleton (2009) 1.61
Multiscale modeling of form and function. Science (2009) 1.60
Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions. Proc Natl Acad Sci U S A (2012) 1.59
Dynamics and regulation of contractile actin-myosin networks in morphogenesis. Curr Opin Cell Biol (2010) 1.59
New PI(4,5)P2- and membrane proximal integrin-binding motifs in the talin head control beta3-integrin clustering. J Cell Biol (2009) 1.58
Cells test substrate rigidity by local contractions on submicrometer pillars. Proc Natl Acad Sci U S A (2012) 1.58
Dynamic regulation of the structure and functions of integrin adhesions. Dev Cell (2013) 1.57
Actomyosin-generated tension controls the molecular kinetics of focal adhesions. J Cell Sci (2011) 1.57
Materials as stem cell regulators. Nat Mater (2014) 1.53
Mechanotransduction in vivo by repeated talin stretch-relaxation events depends upon vinculin. PLoS Biol (2011) 1.52
How vinculin regulates force transmission. Proc Natl Acad Sci U S A (2013) 1.51
The Structural Basis of Actin Organization by Vinculin and Metavinculin. J Mol Biol (2015) 1.50
The emerging role of forces in axonal elongation. Prog Neurobiol (2011) 1.50
Stable Force Balance between Epithelial Cells Arises from F-Actin Turnover. Dev Cell (2015) 1.49
Transcription upregulation via force-induced direct stretching of chromatin. Nat Mater (2016) 1.48
Integrin inactivators: balancing cellular functions in vitro and in vivo. Nat Rev Mol Cell Biol (2013) 1.45
Integrin-dependent force transmission to the extracellular matrix by α-actinin triggers adhesion maturation. Proc Natl Acad Sci U S A (2013) 1.44
Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch. Dev Cell (2015) 1.41
Early integrin binding to Arg-Gly-Asp peptide activates actin polymerization and contractile movement that stimulates outward translocation. Proc Natl Acad Sci U S A (2011) 1.40
Nanotopographical control of stem cell differentiation. J Tissue Eng (2010) 1.38
Cell adhesion strength is controlled by intermolecular spacing of adhesion receptors. Biophys J (2010) 1.37
Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis. EMBO J (2010) 1.36
Myosin IIA/IIB restrict adhesive and protrusive signaling to generate front-back polarity in migrating cells. J Cell Biol (2011) 1.36
Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation. Sci Rep (2014) 1.36
Mechanical strain stabilizes reconstituted collagen fibrils against enzymatic degradation by mammalian collagenase matrix metalloproteinase 8 (MMP-8). PLoS One (2010) 1.35
Phosphoinositide signaling regulates the exocyst complex and polarized integrin trafficking in directionally migrating cells. Dev Cell (2012) 1.35
Molecular mechanisms of cellular mechanosensing. Nat Mater (2013) 1.34
The secret life of α-catenin: moonlighting in morphogenesis. J Cell Biol (2011) 1.34
The C terminus of talin links integrins to cell cycle progression. J Cell Biol (2011) 1.33
Conformational changes and signaling in cell and matrix physics. Curr Biol (2009) 1.33
Force-dependent polymorphism in type IV pili reveals hidden epitopes. Proc Natl Acad Sci U S A (2010) 1.33
From mechanosensitivity to inflammatory responses: new players in the pathology of glaucoma. Curr Eye Res (2013) 1.31
Decoupling substrate stiffness, spread area, and micropost density: a close spatial relationship between traction forces and focal adhesions. Biophys J (2012) 1.30
PR65, the HEAT-repeat scaffold of phosphatase PP2A, is an elastic connector that links force and catalysis. Proc Natl Acad Sci U S A (2010) 1.30
The heel and toe of the cell's foot: a multifaceted approach for understanding the structure and dynamics of focal adhesions. Cell Motil Cytoskeleton (2009) 1.29
Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1. Eur J Cell Biol (2010) 1.29
Contractility modulates cell adhesion strengthening through focal adhesion kinase and assembly of vinculin-containing focal adhesions. J Cell Physiol (2010) 1.29
Molecular force transduction by ion channels: diversity and unifying principles. J Cell Sci (2012) 1.28
Using patterned supported lipid membranes to investigate the role of receptor organization in intercellular signaling. Nat Protoc (2011) 1.26
Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta1 integrins. Integr Biol (Camb) (2010) 1.23
The integrin adhesion complex changes its composition and function during morphogenesis of an epithelium. J Cell Sci (2009) 1.23
The alignment and fusion assembly of adipose-derived stem cells on mechanically patterned matrices. Biomaterials (2012) 1.23
Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions. Nat Cell Biol (2015) 1.23
Formin mDia1 senses and generates mechanical forces on actin filaments. Nat Commun (2013) 1.23
Mechanical derivation of functional myotubes from adipose-derived stem cells. Biomaterials (2011) 1.22
Mechanosensitivity and compositional dynamics of cell-matrix adhesions. EMBO Rep (2013) 1.22
Central region of talin has a unique fold that binds vinculin and actin. J Biol Chem (2010) 1.21
Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate. Cancer Res (2014) 1.21
Integrins in mechanotransduction. Curr Opin Cell Biol (2013) 1.21
Molecular tension sensors report forces generated by single integrin molecules in living cells. Nano Lett (2013) 1.21
Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation. J Struct Biol (2013) 1.19
RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover. J Biol Chem (2013) 1.19
Dynamic force-induced direct dissociation of protein complexes in a nuclear body in living cells. Nat Commun (2012) 1.18
Dynamic force sensing of filamin revealed in single-molecule experiments. Proc Natl Acad Sci U S A (2012) 1.17
Heart-specific stiffening in early embryos parallels matrix and myosin expression to optimize beating. Curr Biol (2013) 1.17
Mesenchymal stem cell durotaxis depends on substrate stiffness gradient strength. Biotechnol J (2013) 1.16
Molecular mechanochemistry: low force switch slows enzymatic cleavage of human type I collagen monomer. J Am Chem Soc (2011) 1.16
Force sensing by mechanical extension of the Src family kinase substrate p130Cas. Cell (2006) 7.35
Periodic lamellipodial contractions correlate with rearward actin waves. Cell (2004) 6.46
The relationship between force and focal complex development. J Cell Biol (2002) 6.26
The mechanical stability of ubiquitin is linkage dependent. Nat Struct Biol (2003) 4.66
Lamellipodial actin mechanically links myosin activity with adhesion-site formation. Cell (2007) 4.59
Membrane cholesterol, lateral mobility, and the phosphatidylinositol 4,5-bisphosphate-dependent organization of cell actin. Proc Natl Acad Sci U S A (2003) 4.34
Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse. Cell (2007) 3.92
Nonmuscle myosin IIA-dependent force inhibits cell spreading and drives F-actin flow. Biophys J (2006) 3.83
Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin. Nature (2003) 3.70
Talin depletion reveals independence of initial cell spreading from integrin activation and traction. Nat Cell Biol (2008) 3.62
Reverse engineering of the giant muscle protein titin. Nature (2002) 3.54
Linkage between ATP consumption and mechanical unfolding during the protein processing reactions of an AAA+ degradation machine. Cell (2003) 3.33
The unfolding kinetics of ubiquitin captured with single-molecule force-clamp techniques. Proc Natl Acad Sci U S A (2004) 3.18
Axonal mitochondrial transport and potential are correlated. J Cell Sci (2004) 3.15
The mechanical hierarchies of fibronectin observed with single-molecule AFM. J Mol Biol (2002) 3.09
Substrate rigidity and force define form through tyrosine phosphatase and kinase pathways. Trends Cell Biol (2006) 3.07
Live-cell super-resolution imaging with trimethoprim conjugates. Nat Methods (2010) 2.94
Single pilus motor forces exceed 100 pN. Proc Natl Acad Sci U S A (2002) 2.93
Force transduction by Triton cytoskeletons. J Cell Biol (2002) 2.83
Stretchy proteins on stretchy substrates: the important elements of integrin-mediated rigidity sensing. Dev Cell (2010) 2.65
Mitochondrial function and actin regulate dynamin-related protein 1-dependent mitochondrial fission. Curr Biol (2005) 2.54
Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction. Proc Natl Acad Sci U S A (2009) 2.52
Nanometer analysis of cell spreading on matrix-coated surfaces reveals two distinct cell states and STEPs. Biophys J (2004) 2.46
Activation of a signaling cascade by cytoskeleton stretch. Dev Cell (2004) 2.35
Cell fate regulation by coupling mechanical cycles to biochemical signaling pathways. Curr Opin Cell Biol (2009) 2.33
The mechanical integrin cycle. J Cell Sci (2009) 2.28
Basic mechanism of three-dimensional collagen fibre transport by fibroblasts. Nat Cell Biol (2005) 2.28
HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions. J Cell Sci (2007) 2.22
Talin1 is critical for force-dependent reinforcement of initial integrin-cytoskeleton bonds but not tyrosine kinase activation. J Cell Biol (2003) 2.18
Probing the chemistry of thioredoxin catalysis with force. Nature (2007) 2.17
RPTP-alpha acts as a transducer of mechanical force on alphav/beta3-integrin-cytoskeleton linkages. J Cell Biol (2003) 2.15
Cytoskeletal coherence requires myosin-IIA contractility. J Cell Sci (2010) 2.13
Force-dependent integrin-cytoskeleton linkage formation requires downregulation of focal complex dynamics by Shp2. EMBO J (2003) 2.03
Rigidity sensing at the leading edge through alphavbeta3 integrins and RPTPalpha. Biophys J (2005) 2.00
Force-dependent chemical kinetics of disulfide bond reduction observed with single-molecule techniques. Proc Natl Acad Sci U S A (2006) 1.95
Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology. EMBO J (2002) 1.94
In vivo protein labeling with trimethoprim conjugates: a flexible chemical tag. Nat Methods (2005) 1.85
Lateral membrane waves constitute a universal dynamic pattern of motile cells. Phys Rev Lett (2006) 1.85
Probing mechanical properties of living cells by atomic force microscopy with blunted pyramidal cantilever tips. Phys Rev E Stat Nonlin Soft Matter Phys (2005) 1.84
Contour length and refolding rate of a small protein controlled by engineered disulfide bonds. Biophys J (2006) 1.82
Mechanical unfolding intermediates observed by single-molecule force spectroscopy in a fibronectin type III module. J Mol Biol (2005) 1.79
Mechanical feedback between membrane tension and dynamics. Trends Cell Biol (2012) 1.75
Two distinct modes of myosin assembly and dynamics during epithelial wound closure. J Cell Biol (2007) 1.74
Quantification of cell edge velocities and traction forces reveals distinct motility modules during cell spreading. PLoS One (2008) 1.68
A force-dependent switch reverses type IV pilus retraction. Proc Natl Acad Sci U S A (2004) 1.61
Cells test substrate rigidity by local contractions on submicrometer pillars. Proc Natl Acad Sci U S A (2012) 1.58
Fibronectin rigidity response through Fyn and p130Cas recruitment to the leading edge. Mol Biol Cell (2006) 1.58
Dynamic phase transitions in cell spreading. Phys Rev Lett (2004) 1.56
Temporary increase in plasma membrane tension coordinates the activation of exocytosis and contraction during cell spreading. Proc Natl Acad Sci U S A (2011) 1.56
Tension in tubulovesicular networks of Golgi and endoplasmic reticulum membranes. Biophys J (2004) 1.55
Immediate-early signaling induced by E-cadherin engagement and adhesion. J Biol Chem (2007) 1.54
PEVK domain of titin: an entropic spring with actin-binding properties. J Struct Biol (2002) 1.49
Force generated by actomyosin contraction builds bridges between adhesive contacts. EMBO J (2010) 1.47
Integrin-dependent force transmission to the extracellular matrix by α-actinin triggers adhesion maturation. Proc Natl Acad Sci U S A (2013) 1.44
Force sensing and generation in cell phases: analyses of complex functions. J Appl Physiol (1985) (2005) 1.44
DNA transport into Bacillus subtilis requires proton motive force to generate large molecular forces. Nat Struct Mol Biol (2004) 1.43
Plasma membrane area increases with spread area by exocytosis of a GPI-anchored protein compartment. Mol Biol Cell (2009) 1.41
Differential matrix rigidity response in breast cancer cell lines correlates with the tissue tropism. PLoS One (2009) 1.40
Early integrin binding to Arg-Gly-Asp peptide activates actin polymerization and contractile movement that stimulates outward translocation. Proc Natl Acad Sci U S A (2011) 1.40
Finding the weakest link: exploring integrin-mediated mechanical molecular pathways. J Cell Sci (2012) 1.40
Visualization and quantification of mitochondrial dynamics in living animal cells. Methods Cell Biol (2007) 1.39
Mechanical design of the first proximal Ig domain of human cardiac titin revealed by single molecule force spectroscopy. J Mol Biol (2003) 1.39
RPTPalpha is required for rigidity-dependent inhibition of extension and differentiation of hippocampal neurons. J Cell Sci (2007) 1.38
Ligand binding modulates the mechanical stability of dihydrofolate reductase. Biophys J (2005) 1.35
Mechanical unfolding pathways of the enhanced yellow fluorescent protein revealed by single molecule force spectroscopy. J Biol Chem (2006) 1.35
An in vivo covalent TMP-tag based on proximity-induced reactivity. ACS Chem Biol (2009) 1.34
Optimized fluorescent trimethoprim derivatives for in vivo protein labeling. Chembiochem (2007) 1.34
Force-dependent polymorphism in type IV pili reveals hidden epitopes. Proc Natl Acad Sci U S A (2010) 1.33
Single-molecule paleoenzymology probes the chemistry of resurrected enzymes. Nat Struct Mol Biol (2011) 1.32
A new component in synaptic plasticity: upregulation of kinesin in the neurons of the gill-withdrawal reflex. Cell (2008) 1.32
Force propagation across cells: mechanical coherence of dynamic cytoskeletons. Curr Opin Cell Biol (2009) 1.31
Cell crawling mediates collective cell migration to close undamaged epithelial gaps. Proc Natl Acad Sci U S A (2012) 1.31
Nanolithographic control of the spatial organization of cellular adhesion receptors at the single-molecule level. Nano Lett (2011) 1.30
Simultaneous atomic force microscope and fluorescence measurements of protein unfolding using a calibrated evanescent wave. Proc Natl Acad Sci U S A (2004) 1.30
Chair-boat transitions in single polysaccharide molecules observed with force-ramp AFM. Proc Natl Acad Sci U S A (2002) 1.27
Trimers of the fibronectin cell adhesion domain localize to actin filament bundles and undergo rearward translocation. J Cell Sci (2002) 1.27
Expression of phosphatidylinositol (4,5) bisphosphate-specific pleckstrin homology domains alters direction but not the level of axonal transport of mitochondria. Mol Biol Cell (2003) 1.26
Single homopolypeptide chains collapse into mechanically rigid conformations. Proc Natl Acad Sci U S A (2009) 1.25
Signatures of hydrophobic collapse in extended proteins captured with force spectroscopy. Proc Natl Acad Sci U S A (2007) 1.24
Mapping cell-matrix stresses during stretch reveals inelastic reorganization of the cytoskeleton. Biophys J (2008) 1.23
Single-molecule force spectroscopy measurements of bond elongation during a bimolecular reaction. J Am Chem Soc (2008) 1.22
Stepwise unfolding of ankyrin repeats in a single protein revealed by atomic force microscopy. Biophys J (2005) 1.20
Dwell-time distribution analysis of polyprotein unfolding using force-clamp spectroscopy. Biophys J (2007) 1.17
Collapse dynamics of single proteins extended by force. Biophys J (2010) 1.16
The elasticity of individual titin PEVK exons measured by single molecule atomic force microscopy. J Biol Chem (2005) 1.16
Modulation of titin-based stiffness by disulfide bonding in the cardiac titin N2-B unique sequence. Biophys J (2009) 1.15
Direct evidence for coherent low velocity axonal transport of mitochondria. J Cell Biol (2006) 1.15
Retracted Solvent molecules bridge the mechanical unfolding transition state of a protein. Proc Natl Acad Sci U S A (2008) 1.14
Analysis of the local organization and dynamics of cellular actin networks. J Cell Biol (2013) 1.13
Natural selection for kinetic stability is a likely origin of correlations between mutational effects on protein energetics and frequencies of amino acid occurrences in sequence alignments. J Mol Biol (2006) 1.12
Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy. Nat Struct Mol Biol (2009) 1.11
Second-generation covalent TMP-tag for live cell imaging. J Am Chem Soc (2012) 1.11
Relation between protein stability, evolution and structure, as probed by carboxylic acid mutations. J Mol Biol (2004) 1.10
Force dependency of biochemical reactions measured by single-molecule force-clamp spectroscopy. Nat Protoc (2013) 1.08
The small GTPase R-Ras regulates organization of actin and drives membrane protrusions through the activity of PLCepsilon. J Cell Sci (2006) 1.07
Differential mechanical stability of filamin A rod segments. Biophys J (2011) 1.06