Caspase-3 activation is required for reovirus-induced encephalitis in vivo.

PubWeight™: 0.89‹?›

🔗 View Article (PMC 3023174)

Published in J Neurovirol on July 01, 2010

Authors

J David Beckham1, Kathryn D Tuttle, Kenneth L Tyler

Author Affiliations

1: Department of Medicine, Division of Infectious Diseases, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado 80045, USA. david.beckham@ucdenver.edu

Articles citing this

Reovirus activates a caspase-independent cell death pathway. MBio (2013) 0.95

Daxx upregulation within the cytoplasm of reovirus-infected cells is mediated by interferon and contributes to apoptosis. J Virol (2013) 0.93

Apoptosis induced by mammalian reovirus is beta interferon (IFN) independent and enhanced by IFN regulatory factor 3- and NF-κB-dependent expression of Noxa. J Virol (2011) 0.93

A brain slice culture model of viral encephalitis reveals an innate CNS cytokine response profile and the therapeutic potential of caspase inhibition. Exp Neurol (2011) 0.92

The proapoptotic Bcl-2 protein Bax plays an important role in the pathogenesis of reovirus encephalitis. J Virol (2011) 0.90

Virus-induced transcriptional changes in the brain include the differential expression of genes associated with interferon, apoptosis, interleukin 17 receptor A, and glutamate signaling as well as flavivirus-specific upregulation of tRNA synthetases. MBio (2014) 0.89

Oncolytic reovirus preferentially induces apoptosis in KRAS mutant colorectal cancer cells, and synergizes with irinotecan. Oncotarget (2014) 0.83

Activation of innate immune responses in the central nervous system during reovirus myelitis. J Virol (2012) 0.79

Alpha-Synuclein Expression Restricts RNA Viral Infections in the Brain. J Virol (2015) 0.77

Viral gene expression potentiates reovirus-induced necrosis. Virology (2015) 0.77

Mitochondrial p53 Contributes to Reovirus-Induced Neuronal Apoptosis and Central Nervous System Injury in a Mouse Model of Viral Encephalitis. J Virol (2016) 0.76

Impact of caspase-1/11, -3, -7, or IL-1β/IL-18 deficiency on rabies virus-induced macrophage cell death and onset of disease. Cell Death Discov (2017) 0.75

Articles cited by this

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature (1996) 7.27

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol (1999) 6.24

Neurologic manifestations and outcome of West Nile virus infection. JAMA (2003) 4.61

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin. Cell (2006) 4.53

Japanese encephalitis. J Neurol Neurosurg Psychiatry (2000) 2.76

Executioner caspase-3 and caspase-7 are functionally distinct proteases. Proc Natl Acad Sci U S A (2008) 2.74

Outcome of and prognostic factors for herpes simplex encephalitis in adult patients: results of a multicenter study. Clin Infect Dis (2002) 2.71

Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway. Cell Death Differ (2009) 2.63

Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation. Nat Med (2000) 2.11

Serial killers: ordering caspase activation events in apoptosis. Cell Death Differ (1999) 1.97

Molecular basis of viral neurotropism: experimental reovirus infection. Neurology (1985) 1.94

Caspase 3-dependent cell death of neurons contributes to the pathogenesis of West Nile virus encephalitis. J Virol (2006) 1.86

Mutations in reovirus outer-capsid protein sigma3 selected during persistent infections of L cells confer resistance to protease inhibitor E64. J Virol (1997) 1.66

Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's disease. Am J Pathol (2008) 1.47

Reovirus-induced G(2)/M cell cycle arrest requires sigma1s and occurs in the absence of apoptosis. J Virol (2000) 1.31

Reovirus-induced apoptosis is preceded by increased cellular calpain activity and is blocked by calpain inhibitors. J Virol (1999) 1.30

Modulation of synaptic transmission by the BCL-2 family protein BCL-xL. J Neurosci (2003) 1.28

Reovirus variants selected during persistent infections of L cells contain mutations in the viral S1 and S4 genes and are altered in viral disassembly. J Virol (1997) 1.27

Reovirus-induced neuronal apoptosis is mediated by caspase 3 and is associated with the activation of death receptors. J Neurovirol (2002) 1.23

The epidemiology, clinical features, and long-term prognosis of Japanese encephalitis in central sarawak, malaysia, 1997-2005. Clin Infect Dis (2008) 1.16

Neuronal cell death in alphavirus encephalomyelitis. Curr Top Microbiol Immunol (2005) 1.12

Minocycline inhibits West Nile virus replication and apoptosis in human neuronal cells. J Antimicrob Chemother (2007) 1.11

Minocycline delays disease onset and mortality in reovirus encephalitis. Exp Neurol (2005) 1.11

Regional differences in viral growth and central nervous system injury correlate with apoptosis. J Virol (2004) 1.08

Pathogenesis of reovirus infections of the central nervous system. Curr Top Microbiol Immunol (1998) 1.03

Inhibition of apoptosis prevents West Nile virus induced cell death. BMC Microbiol (2007) 1.02

Novel strategy for treatment of viral central nervous system infection by using a cell-permeating inhibitor of c-Jun N-terminal kinase. J Virol (2007) 1.01

Central nervous system apoptosis in human herpes simplex virus and cytomegalovirus encephalitis. J Infect Dis (2002) 1.01

A piglet survival model of posthypoxic encephalopathy. Pediatr Res (1996) 0.99

Fas-mediated apoptotic signaling in the mouse brain following reovirus infection. J Virol (2009) 0.97

Reovirus infection of the CNS enhances iNOS expression in areas of virus-induced injury. Exp Neurol (2005) 0.94

Calpain-1 cleaves and activates caspase-7. J Biol Chem (2009) 0.94

Japanese encephalitis virus infection activates caspase-8 and -9 in a FADD-independent and mitochondrion-dependent manner. J Gen Virol (2008) 0.87

Prolonged replication in the mouse central nervous system of reoviruses isolated from persistently infected cell cultures. J Virol (1993) 0.87

Reovirus activates transforming growth factor beta and bone morphogenetic protein signaling pathways in the central nervous system that contribute to neuronal survival following infection. J Virol (2009) 0.86

Possible involvement of caspase-6 and -7 but not caspase-3 in the regulation of hypoxia-induced apoptosis in tube-forming endothelial cells. Exp Cell Res (2008) 0.85

Caspase-3 activity in hippocampal slices reflects changes in synaptic plasticity. Neurosci Behav Physiol (2008) 0.78

Articles by these authors

Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis. N Engl J Med (2005) 7.54

Does Toll-like receptor 3 play a biological role in virus infections? Virology (2004) 2.73

Naturally acquired West Nile virus encephalomyelitis in transplant recipients: clinical, laboratory, diagnostic, and neuropathological features. Arch Neurol (2004) 2.71

West Nile virus neuroinvasive disease. Ann Neurol (2006) 2.42

Rituximab-associated progressive multifocal leukoencephalopathy in rheumatoid arthritis. Arch Neurol (2011) 1.83

Herpesvirus infections of the nervous system. Nat Clin Pract Neurol (2007) 1.48

Molecular methods for diagnosis of viral encephalitis. Clin Microbiol Rev (2004) 1.42

Quantitative CSF PCR in Epstein-Barr virus infections of the central nervous system. Ann Neurol (2002) 1.38

MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts. EMBO J (2003) 1.27

Glutathione binding to the Bcl-2 homology-3 domain groove: a molecular basis for Bcl-2 antioxidant function at mitochondria. J Biol Chem (2007) 1.26

Dual infections of the central nervous system with Epstein-Barr virus. J Infect Dis (2004) 1.24

Reovirus-induced neuronal apoptosis is mediated by caspase 3 and is associated with the activation of death receptors. J Neurovirol (2002) 1.23

Bell's palsy--is glucocorticoid treatment enough? N Engl J Med (2007) 1.22

West Nile virus meningoencephalitis. Nat Clin Pract Neurol (2006) 1.22

Progressive multifocal leukoencephalopathy, efalizumab, and immunosuppression: a cautionary tale for dermatologists. Arch Dermatol (2009) 1.19

Apoptosis in animal models of virus-induced disease. Nat Rev Microbiol (2009) 1.19

Caspase inhibition protects against reovirus-induced myocardial injury in vitro and in vivo. J Virol (2004) 1.18

Reovirus-induced apoptosis requires mitochondrial release of Smac/DIABLO and involves reduction of cellular inhibitor of apoptosis protein levels. J Virol (2002) 1.18

Use of PCR for the diagnosis of herpesvirus infections of the central nervous system. J Clin Virol (2002) 1.17

Two distinct phases of virus-induced nuclear factor kappa B regulation enhance tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in virus-infected cells. J Biol Chem (2003) 1.14

JNK regulates the release of proapoptotic mitochondrial factors in reovirus-infected cells. J Virol (2004) 1.13

Minocycline delays disease onset and mortality in reovirus encephalitis. Exp Neurol (2005) 1.11

Recurrent dermatomal vesicular skin lesions: a clue to diagnosis of herpes simplex virus 2 meningitis. Arch Neurol (2003) 1.09

Regional differences in viral growth and central nervous system injury correlate with apoptosis. J Virol (2004) 1.08

The uninvited guest: JC virus infection of neurons in PML. Neurology (2003) 1.05

Reovirus-induced alterations in gene expression related to cell cycle regulation. J Virol (2002) 1.03

Progressive multifocal leukoencephalopathy: can we reduce risk in patients receiving biological immunomodulatory therapies? Ann Neurol (2010) 1.03

Impact of rituximab-associated B-cell defects on West Nile virus meningoencephalitis in solid organ transplant recipients. Clin Transplant (2009) 1.01

Novel strategy for treatment of viral central nervous system infection by using a cell-permeating inhibitor of c-Jun N-terminal kinase. J Virol (2007) 1.01

Progressive multifocal leukoencephalopathy and apoptosis of infected oligodendrocytes in the central nervous system of patients with and without AIDS. Arch Neurol (2002) 1.01

Central nervous system apoptosis in human herpes simplex virus and cytomegalovirus encephalitis. J Infect Dis (2002) 1.01

Reovirus-induced alteration in expression of apoptosis and DNA repair genes with potential roles in viral pathogenesis. J Virol (2003) 1.00

Fas-mediated apoptotic signaling in the mouse brain following reovirus infection. J Virol (2009) 0.97

West Nile virus growth is independent of autophagy activation. Virology (2012) 0.97

JAK-STAT signaling pathways are activated in the brain following reovirus infection. J Neurovirol (2007) 0.95

Novel nuclear herniations induced by nuclear localization of a viral protein. J Virol (2004) 0.95

Nonstructural protein sigma1s is a determinant of reovirus virulence and influences the kinetics and severity of apoptosis induction in the heart and central nervous system. J Virol (2005) 0.95

Reovirus infection of the CNS enhances iNOS expression in areas of virus-induced injury. Exp Neurol (2005) 0.94

Neuro-intensive care of patients with acute CNS infections. Neurotherapeutics (2012) 0.94

Progressive multifocal leukoencephalopathy and relapsing-remitting multiple sclerosis: a comparative study. Arch Neurol (2009) 0.93

Daxx upregulation within the cytoplasm of reovirus-infected cells is mediated by interferon and contributes to apoptosis. J Virol (2013) 0.93

A brain slice culture model of viral encephalitis reveals an innate CNS cytokine response profile and the therapeutic potential of caspase inhibition. Exp Neurol (2011) 0.92

Colorado surveillance program for chronic wasting disease transmission to humans: lessons from 2 highly suspicious but negative cases. Arch Neurol (2007) 0.92

Inhibition of Rac GTPase triggers a c-Jun- and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neurons. J Neurochem (2005) 0.91

Death receptor-mediated apoptotic signaling is activated in the brain following infection with West Nile virus in the absence of a peripheral immune response. J Virol (2013) 0.91

The proapoptotic Bcl-2 protein Bax plays an important role in the pathogenesis of reovirus encephalitis. J Virol (2011) 0.90

Disrupted glutamate transporter expression in the spinal cord with acute flaccid paralysis caused by West Nile virus infection. J Neuropathol Exp Neurol (2009) 0.90

Initial management of acute bacterial meningitis in adults: summary of IDSA guidelines. Rev Neurol Dis (2006) 0.90

Novel approaches and challenges to treatment of central nervous system viral infections. Ann Neurol (2013) 0.90

Virus-induced transcriptional changes in the brain include the differential expression of genes associated with interferon, apoptosis, interleukin 17 receptor A, and glutamate signaling as well as flavivirus-specific upregulation of tRNA synthetases. MBio (2014) 0.89

Through a glass, darkly: cerebrospinal fluid viral load measurements and the pathogenesis of human immunodeficiency virus infection of the central nervous system. Arch Neurol (2002) 0.86

Reovirus activates transforming growth factor beta and bone morphogenetic protein signaling pathways in the central nervous system that contribute to neuronal survival following infection. J Virol (2009) 0.86

Viral infections of the nervous system, 2002: update on diagnosis and treatment. Arch Neurol (2002) 0.86

Type I interferon signaling limits reoviral tropism within the brain and prevents lethal systemic infection. J Neurovirol (2011) 0.85

Experimental reovirus-induced acute flaccid paralysis and spinal motor neuron cell death. J Neuropathol Exp Neurol (2008) 0.83

Down-regulation of cFLIP following reovirus infection sensitizes human ovarian cancer cells to TRAIL-induced apoptosis. Apoptosis (2007) 0.81

TRAIL and inhibitors of apoptosis are opposing determinants for NF-kappaB-dependent, genotoxin-induced apoptosis of cancer cells. Oncogene (2002) 0.81

North American encephalitic arboviruses. Neurol Clin (2008) 0.81

Issues and updates in emerging neurologic viral infections. Semin Neurol (2011) 0.80

Cardiac cell-specific apoptotic and cytokine responses to reovirus infection: determinants of myocarditic phenotype. J Card Fail (2009) 0.79

Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by inhibition of Rac GTPase activity. J Biol Chem (2012) 0.79

Activation of innate immune responses in the central nervous system during reovirus myelitis. J Virol (2012) 0.79

Human herpesvirus 6 and multiple sclerosis: the continuing conundrum. J Infect Dis (2003) 0.78

Elevated CSF cytokines in the Jarisch-Herxheimer reaction of general paresis. JAMA Neurol (2013) 0.77

Type 3 reovirus neuroinvasion after intramuscular inoculation: viral genetic determinants of lethality and spinal cord infection. Virology (2002) 0.77

Reduplicative paramnesia in Morvan's syndrome. J Neurol Sci (2007) 0.77

The 50th birthday of progressive multifocal leukoencephalopathy: New insights into pathogenesis. Ann Neurol (2008) 0.76

PML therapy: "It's Déjà vu all over again". J Neurovirol (2013) 0.76

Arbovirus Infections. Continuum (Minneap Minn) (2015) 0.76

Infectious disease - developments in the field of Creutzfeldt-Jakob disease. Rev Neurol Dis (2007) 0.75

Bacterial meningitis: an urgent need for further progress to reduce mortality and morbidity. Neurology (2008) 0.75

Slice culture modeling of central nervous system (CNS) viral infection. Methods Mol Biol (2013) 0.75

Donald H. Gilden, MD (1937-2016). Neurology (2016) 0.75

2nd International Conference on Progressive Multifocal Leukoencephalopathy (PML) 2015: JCV virology, progressive multifocal leukoencephalopathy pathogenesis, diagnosis and risk stratification, and new approaches to prevention and treatment. J Neurovirol (2015) 0.75

Persistent neurobehavioral signs and symptoms following West Nile fever. J Neuropsychiatry Clin Neurosci (2008) 0.75