Stanley Nattel

Author PubWeight™ 316.79‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design: a report of the Heart Rhythm Society (HRS) Task Force on Catheter and Surgical Ablation of Atrial Fibrillation. Developed in partnership with the European Heart Rhythm Association (EHRA), a registered branch of the European Society of Cardiology (ESC) and the European Cardiac Arrhythmia Society (ECAS); and in collaboration with the American College of Cardiology (ACC), American Heart Association (AHA), the Asia Pacific Heart Rhythm Society (APHRS), and the Society of Thoracic Surgeons (STS). Endorsed by the governing bodies of the American College of Cardiology Foundation, the American Heart Association, the European Cardiac Arrhythmia Society, the European Heart Rhythm Association, the Society of Thoracic Surgeons, the Asia Pacific Heart Rhythm Society, and the Heart Rhythm Society. Heart Rhythm 2012 8.03
2 Rhythm control versus rate control for atrial fibrillation and heart failure. N Engl J Med 2008 6.17
3 2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design. Europace 2012 5.84
4 Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation. J Am Coll Cardiol 2008 4.01
5 Cardiac arrhythmogenic remodeling in a rat model of long-term intensive exercise training. Circulation 2010 3.72
6 Prevention of atrial fibrillation: report from a national heart, lung, and blood institute workshop. Circulation 2009 3.50
7 Focused 2012 update of the Canadian Cardiovascular Society atrial fibrillation guidelines: recommendations for stroke prevention and rate/rhythm control. Can J Cardiol 2012 2.96
8 Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart. J Physiol 2007 2.83
9 Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation 2012 2.58
10 Recent advances in the molecular pathophysiology of atrial fibrillation. J Clin Invest 2011 2.38
11 Atrial fibrillation promotion by endurance exercise: demonstration and mechanistic exploration in an animal model. J Am Coll Cardiol 2013 2.38
12 Calcium-handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure. Circ Arrhythm Electrophysiol 2008 2.37
13 Feedback remodeling of cardiac potassium current expression: a novel potential mechanism for control of repolarization reserve. Circulation 2008 2.34
14 2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design. J Interv Card Electrophysiol 2012 2.08
15 The clinical profile and pathophysiology of atrial fibrillation: relationships among clinical features, epidemiology, and mechanisms. Circ Res 2014 2.07
16 Differences in atrial versus ventricular remodeling in dogs with ventricular tachypacing-induced congestive heart failure. Cardiovasc Res 2004 2.06
17 Sinus node dysfunction and hyperpolarization-activated (HCN) channel subunit remodeling in a canine heart failure model. Cardiovasc Res 2005 2.02
18 Effects of simvastatin on the development of the atrial fibrillation substrate in dogs with congestive heart failure. Cardiovasc Res 2007 2.02
19 Atrial fibrillation pathophysiology: implications for management. Circulation 2011 2.01
20 Differential distribution of cardiac ion channel expression as a basis for regional specialization in electrical function. Circ Res 2002 2.00
21 Transmural action potential and ionic current remodeling in ventricles of failing canine hearts. Am J Physiol Heart Circ Physiol 2002 2.00
22 Ionic determinants of functional reentry in a 2-D model of human atrial cells during simulated chronic atrial fibrillation. Biophys J 2005 1.96
23 Intra-atrial pressure increases rate and organization of waves emanating from the superior pulmonary veins during atrial fibrillation. Circulation 2003 1.86
24 Decreased phosphorylation levels of cardiac myosin-binding protein-C in human and experimental heart failure. J Mol Cell Cardiol 2007 1.85
25 Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation. Circulation 2012 1.81
26 Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure. Genes Dev 2006 1.80
27 Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation. Cardiovasc Res 2010 1.74
28 Pioglitazone, a peroxisome proliferator-activated receptor-gamma activator, attenuates atrial fibrosis and atrial fibrillation promotion in rabbits with congestive heart failure. Heart Rhythm 2007 1.71
29 Role of angiotensin system and effects of its inhibition in atrial fibrillation: clinical and experimental evidence. Eur Heart J 2005 1.71
30 Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes. J Am Coll Cardiol 2013 1.68
31 Role of the autonomic nervous system in atrial fibrillation: pathophysiology and therapy. Circ Res 2014 1.68
32 Pulmonary vein reentry--properties and size matter: insights from a computational analysis. Heart Rhythm 2007 1.68
33 Improved outcome following restoration of sinus rhythm prior to catheter ablation of persistent atrial fibrillation: a comparative multicenter study. Heart Rhythm 2012 1.67
34 Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation. Circulation 2005 1.67
35 Substrate size as a determinant of fibrillatory activity maintenance in a mathematical model of canine atrium. Am J Physiol Heart Circ Physiol 2005 1.65
36 New antiarrhythmic drugs for treatment of atrial fibrillation. Lancet 2010 1.65
37 Dissociation between ionic remodeling and ability to sustain atrial fibrillation during recovery from experimental congestive heart failure. Circulation 2004 1.64
38 Differential behaviors of atrial versus ventricular fibroblasts: a potential role for platelet-derived growth factor in atrial-ventricular remodeling differences. Circulation 2008 1.61
39 Determinants of atrial fibrillation in an animal model of obesity and acute obstructive sleep apnea. Heart Rhythm 2012 1.59
40 Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability. Heart Rhythm 2010 1.59
41 Ca(2+)-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm. Circulation 2011 1.58
42 A proposal for new clinical concepts in the management of atrial fibrillation. Am Heart J 2012 1.57
43 In vivo electrophysiological effects of a selective slow delayed-rectifier potassium channel blocker in anesthetized dogs: potential insights into class III actions. Cardiovasc Res 2004 1.55
44 Maintenance of sinus rhythm and survival in patients with heart failure and atrial fibrillation. J Am Coll Cardiol 2010 1.55
45 Atrial fibrillation-associated minK38G/S polymorphism modulates delayed rectifier current and membrane localization. Cardiovasc Res 2005 1.54
46 Cholinergic atrial fibrillation in a computer model of a two-dimensional sheet of canine atrial cells with realistic ionic properties. Circ Res 2002 1.54
47 Changes in microRNA-1 expression and IK1 up-regulation in human atrial fibrillation. Heart Rhythm 2009 1.54
48 Differences in atrial fibrillation properties under vagal nerve stimulation versus atrial tachycardia remodeling. Heart Rhythm 2009 1.53
49 Molecular basis of funny current (If) in normal and failing human heart. J Mol Cell Cardiol 2008 1.53
50 Role of small-conductance calcium-activated potassium channels in atrial electrophysiology and fibrillation in the dog. Circulation 2013 1.51
51 Atrial fibrillation-associated remodeling does not promote atrial thrombus formation in canine models. Circ Arrhythm Electrophysiol 2012 1.50
52 MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation. J Clin Invest 2013 1.49
53 Left-to-right atrial inward rectifier potassium current gradients in patients with paroxysmal versus chronic atrial fibrillation. Circ Arrhythm Electrophysiol 2010 1.49
54 Involvement of lipid rafts and caveolae in cardiac ion channel function. Cardiovasc Res 2006 1.48
55 Region-specific gene expression profiles in the left atria of patients with valvular atrial fibrillation. Heart Rhythm 2012 1.47
56 Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression. Circ Res 2014 1.47
57 Differential effectiveness of pharmacological strategies to reveal dormant pulmonary vein conduction: a clinical-experimental correlation. Heart Rhythm 2011 1.45
58 Cellular electrophysiology of canine pulmonary vein cardiomyocytes: action potential and ionic current properties. J Physiol 2003 1.45
59 Role of T-type calcium channel subunits in post-myocardial infarction remodelling probed with genetically engineered mice. Cardiovasc Res 2011 1.44
60 Transmural expression of transient outward potassium current subunits in normal and failing canine and human hearts. J Physiol 2004 1.44
61 HERG K+ channel, a regulator of tumor cell apoptosis and proliferation. Cancer Res 2002 1.43
62 Cellular properties of C-terminal KCNH2 long QT syndrome mutations: description and divergence from clinical phenotypes. Heart Rhythm 2008 1.43
63 Novel molecular targets for atrial fibrillation therapy. Nat Rev Drug Discov 2012 1.42
64 Effect of simvastatin and antioxidant vitamins on atrial fibrillation promotion by atrial-tachycardia remodeling in dogs. Circulation 2004 1.41
65 Comparison of ion-channel subunit expression in canine cardiac Purkinje fibers and ventricular muscle. Circ Res 2002 1.41
66 Gender-related differences in ion-channel and transporter subunit expression in non-diseased human hearts. J Mol Cell Cardiol 2010 1.37
67 A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current. Is MiRP1 the missing link? J Physiol 2002 1.35
68 MicroRNA29: a mechanistic contributor and potential biomarker in atrial fibrillation. Circulation 2013 1.33
69 Novel approaches for pharmacological management of atrial fibrillation. Drugs 2009 1.32
70 Dynamic nature of atrial fibrillation substrate during development and reversal of heart failure in dogs. Circulation 2002 1.31
71 Pulmonary vein region ablation in experimental vagal atrial fibrillation: role of pulmonary veins versus autonomic ganglia. Circulation 2008 1.30
72 Changes in connexin expression and the atrial fibrillation substrate in congestive heart failure. Circ Res 2009 1.29
73 Potassium channel subunit remodeling in rabbits exposed to long-term bradycardia or tachycardia: discrete arrhythmogenic consequences related to differential delayed-rectifier changes. Circulation 2006 1.27
74 G protein-coupled receptor signalling in the cardiac nuclear membrane: evidence and possible roles in physiological and pathophysiological function. J Physiol 2011 1.27
75 Cellular signaling underlying atrial tachycardia remodeling of L-type calcium current. Circ Res 2008 1.27
76 Molecular basis of species-specific expression of repolarizing K+ currents in the heart. Am J Physiol Heart Circ Physiol 2003 1.27
77 Kir3-based inward rectifier potassium current: potential role in atrial tachycardia remodeling effects on atrial repolarization and arrhythmias. Circulation 2006 1.26
78 Connexins and atrial fibrillation: filling in the gaps. Circulation 2011 1.26
79 Evolution of the atrial fibrillation substrate in experimental congestive heart failure: angiotensin-dependent and -independent pathways. Cardiovasc Res 2003 1.25
80 Nuclear-delimited angiotensin receptor-mediated signaling regulates cardiomyocyte gene expression. J Biol Chem 2010 1.24
81 Atrial fibrillation and congestive heart failure: specific considerations at the intersection of two common and important cardiac disease sets. J Cardiovasc Electrophysiol 2002 1.24
82 Funny current downregulation and sinus node dysfunction associated with atrial tachyarrhythmia: a molecular basis for tachycardia-bradycardia syndrome. Circulation 2009 1.23
83 Mechanisms by which adenosine restores conduction in dormant canine pulmonary veins. Circulation 2010 1.23
84 Membrane cholesterol modulates Kv1.5 potassium channel distribution and function in rat cardiomyocytes. J Physiol 2007 1.22
85 Atrial cardiomyocyte tachycardia alters cardiac fibroblast function: a novel consideration in atrial remodeling. Cardiovasc Res 2007 1.22
86 Induction of heat shock response protects the heart against atrial fibrillation. Circ Res 2006 1.20
87 Animal models for atrial fibrillation: clinical insights and scientific opportunities. Europace 2009 1.20
88 Gene expression profile associated with chronic atrial fibrillation and underlying valvular heart disease in man. J Mol Cell Cardiol 2005 1.20
89 Role for MicroRNA-21 in atrial profibrillatory fibrotic remodeling associated with experimental postinfarction heart failure. Circ Arrhythm Electrophysiol 2012 1.20
90 Differential distribution of Kir2.1 and Kir2.3 subunits in canine atrium and ventricle. Am J Physiol Heart Circ Physiol 2002 1.18
91 Ranolazine: ion-channel-blocking actions and in vivo electrophysiological effects. Br J Pharmacol 2004 1.17
92 Characterization of the in vivo and in vitro electrophysiological effects of the novel antiarrhythmic agent AZD7009 in atrial and ventricular tissue of the dog. J Cardiovasc Pharmacol 2006 1.17
93 Ionic mechanisms limiting cardiac repolarization reserve in humans compared to dogs. J Physiol 2013 1.17
94 Contrasting gene expression profiles in two canine models of atrial fibrillation. Circ Res 2007 1.16
95 Canadian Cardiovascular Society atrial fibrillation guidelines 2010: rate and rhythm management. Can J Cardiol 2011 1.16
96 Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2. Am J Physiol Cell Physiol 2005 1.16
97 Calcium handling abnormalities in atrial fibrillation as a target for innovative therapeutics. J Cardiovasc Pharmacol 2008 1.15
98 Characterization of a hyperpolarization-activated time-dependent potassium current in canine cardiomyocytes from pulmonary vein myocardial sleeves and left atrium. J Physiol 2004 1.14
99 Time-dependent transients in an ionically based mathematical model of the canine atrial action potential. Am J Physiol Heart Circ Physiol 2002 1.14
100 Omega-3 polyunsaturated fatty acids prevent atrial fibrillation associated with heart failure but not atrial tachycardia remodeling. Circulation 2007 1.14
101 Mechanisms of atrial fibrillation termination by pure sodium channel blockade in an ionically-realistic mathematical model. Circ Res 2005 1.13
102 Remodelling of cardiac repolarization: how homeostatic responses can lead to arrhythmogenesis. Cardiovasc Res 2008 1.13
103 Ionic current abnormalities associated with prolonged action potentials in cardiomyocytes from diseased human right ventricles. Heart Rhythm 2004 1.12
104 Enalapril effects on atrial remodeling and atrial fibrillation in experimental congestive heart failure. Cardiovasc Res 2002 1.12
105 Barium block of Kir2 and human cardiac inward rectifier currents: evidence for subunit-heteromeric contribution to native currents. Cardiovasc Res 2003 1.12
106 Post-transcriptional alterations in the expression of cardiac Na+ channel subunits in chronic heart failure. J Mol Cell Cardiol 2004 1.11
107 KvLQT1 modulates the distribution and biophysical properties of HERG. A novel alpha-subunit interaction between delayed rectifier currents. J Biol Chem 2003 1.11
108 Impairment of HERG K(+) channel function by tumor necrosis factor-alpha: role of reactive oxygen species as a mediator. J Biol Chem 2004 1.10
109 Sex-based transmural differences in cardiac repolarization and ionic-current properties in canine left ventricles. Am J Physiol Heart Circ Physiol 2006 1.09
110 Atrial ionic remodeling induced by atrial tachycardia in the presence of congestive heart failure. Circulation 2004 1.09
111 Distinct contractile and molecular differences between two goat models of atrial dysfunction: AV block-induced atrial dilatation and atrial fibrillation. J Mol Cell Cardiol 2008 1.09
112 Atrial ischemia promotes atrial fibrillation in dogs. Circulation 2003 1.08
113 Clinical and mechanistic issues in early repolarization of normal variants and lethal arrhythmia syndromes. J Am Coll Cardiol 2010 1.07
114 Effects of antiarrhythmic drugs on fibrillation in the remodeled atrium: insights into the mechanism of the superior efficacy of amiodarone. Circulation 2003 1.06
115 Atrial fibrillation: basic mechanisms, remodeling and triggers. J Interv Card Electrophysiol 2005 1.05
116 Atrial tachycardia remodeling of pulmonary vein cardiomyocytes: comparison with left atrium and potential relation to arrhythmogenesis. Circulation 2005 1.05
117 Arrhythmogenic left atrial cellular electrophysiology in a murine genetic long QT syndrome model. Cardiovasc Res 2011 1.05
118 MicroRNA regulation and cardiac calcium signaling: role in cardiac disease and therapeutic potential. Circ Res 2014 1.05
119 Role of KATP channels in the maintenance of ventricular fibrillation in cardiomyopathic human hearts. Circ Res 2011 1.05
120 Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs. Circ Arrhythm Electrophysiol 2010 1.05
121 Mechanisms underlying rate-dependent remodeling of transient outward potassium current in canine ventricular myocytes. Circ Res 2008 1.03
122 Model-dependent effects of the gap junction conduction-enhancing antiarrhythmic peptide rotigaptide (ZP123) on experimental atrial fibrillation in dogs. Circulation 2007 1.02
123 Tissue-specific expression of two human Ca(v)1.2 isoforms under the control of distinct 5' flanking regulatory elements. FEBS Lett 2003 1.02
124 Spotlight on atrial fibrillation-the 'complete arrhythmia'. Cardiovasc Res 2002 1.01
125 Changes in I K, ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes. Cardiovasc Res 2007 1.01
126 Early and comprehensive management of atrial fibrillation: proceedings from the 2nd AFNET/EHRA consensus conference on atrial fibrillation entitled 'research perspectives in atrial fibrillation'. Europace 2009 1.01
127 Unique cardiac Purkinje fiber transient outward current β-subunit composition: a potential molecular link to idiopathic ventricular fibrillation. Circ Res 2013 1.00
128 Early and comprehensive management of atrial fibrillation: executive summary of the proceedings from the 2nd AFNET-EHRA consensus conference 'research perspectives in AF'. Eur Heart J 2009 1.00
129 Role of inflammation in atrial fibrillation pathophysiology and management. Circ J 2015 0.99
130 Atrial fibrillation: evidence for genetically determined disease. Curr Opin Cardiol 2008 0.99
131 Proteomic and metabolomic analysis of atrial profibrillatory remodelling in congestive heart failure. J Mol Cell Cardiol 2010 0.99
132 Kir2.4 and Kir2.1 K(+) channel subunits co-assemble: a potential new contributor to inward rectifier current heterogeneity. J Physiol 2002 0.98
133 Trafficking-deficient long QT syndrome mutation KCNQ1-T587M confers severe clinical phenotype by impairment of KCNH2 membrane localization: evidence for clinically significant IKr-IKs alpha-subunit interaction. Heart Rhythm 2009 0.98
134 Role of the Wnt-Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential. J Physiol 2012 0.98
135 Atrial-selective pharmacological therapy for atrial fibrillation: hype or hope? Curr Opin Cardiol 2009 0.98
136 Effects of a heat shock protein inducer on the atrial fibrillation substrate caused by acute atrial ischaemia. Cardiovasc Res 2008 0.98
137 A clinical approach to early repolarization. Circulation 2013 0.98
138 Mechanisms of atrial tachyarrhythmias associated with coronary artery occlusion in a chronic canine model. Circulation 2011 0.98
139 Properties of potassium currents in Purkinje cells of failing human hearts. Am J Physiol Heart Circ Physiol 2002 0.97
140 Pulmonary vein isolation using a pace-capture-guided versus an adenosine-guided approach: effect on dormant conduction and long-term freedom from recurrent atrial fibrillation--a prospective study. Circ Arrhythm Electrophysiol 2013 0.97
141 New insights into the mechanisms and management of atrial fibrillation. CMAJ 2002 0.96
142 Canine ventricular KCNE2 expression resides predominantly in Purkinje fibers. Circ Res 2003 0.96
143 Atrial-selective approaches for the treatment of atrial fibrillation. J Am Coll Cardiol 2008 0.96
144 Comparison of ion channel distribution and expression in cardiomyocytes of canine pulmonary veins versus left atrium. Cardiovasc Res 2005 0.96
145 Mechanisms of atrial fibrillation termination by rapidly unbinding Na+ channel blockers: insights from mathematical models and experimental correlates. Am J Physiol Heart Circ Physiol 2008 0.96
146 Cellular electrophysiology of atrial fibrillation. Cardiovasc Res 2002 0.96
147 Dofetilide block involves interactions with open and inactivated states of HERG channels. Pflugers Arch 2001 0.95
148 Impact of tissue geometry on simulated cholinergic atrial fibrillation: a modeling study. Chaos 2011 0.94
149 Prednisone prevents atrial fibrillation promotion by atrial tachycardia remodeling in dogs. Cardiovasc Res 2006 0.94
150 Normal function of HERG K+ channels expressed in HEK293 cells requires basal protein kinase B activity. FEBS Lett 2003 0.94
151 A high-fat diet increases risk of ventricular arrhythmia in female rats: enhanced arrhythmic risk in the absence of obesity or hyperlipidemia. J Appl Physiol (1985) 2010 0.93
152 The calcium/calmodulin/kinase system and arrhythmogenic afterdepolarizations in bradycardia-related acquired long-QT syndrome. Circ Arrhythm Electrophysiol 2009 0.93
153 Transforming growth factor-β and oxidative stress mediate tachycardia-induced cellular remodelling in cultured atrial-derived myocytes. Cardiovasc Res 2011 0.93
154 Roles of the left atrial roof and pulmonary veins in the anatomic substrate for persistent atrial fibrillation and ablation in a canine model. J Am Coll Cardiol 2010 0.91
155 The effect of vagally induced dispersion of action potential duration on atrial arrhythmogenesis. Heart Rhythm 2004 0.90
156 Differential protein kinase C isoform regulation and increased constitutive activity of acetylcholine-regulated potassium channels in atrial remodeling. Circ Res 2011 0.90
157 Minimizing repolarization-related proarrhythmic risk in drug development and clinical practice. Drugs 2010 0.90
158 Congestive heart failure effects on atrial fibroblast phenotype: differences between freshly-isolated and cultured cells. PLoS One 2012 0.90
159 Differential alterations of receptor densities of three muscarinic acetylcholine receptor subtypes and current densities of the corresponding K+ channels in canine atria with atrial fibrillation induced by experimental congestive heart failure. Cell Physiol Biochem 2004 0.90
160 Calpain mediates cardiac troponin degradation and contractile dysfunction in atrial fibrillation. J Mol Cell Cardiol 2008 0.90
161 Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome. Cardiovasc Res 2008 0.90
162 C-terminal domain of Kv4.2 and associated KChIP2 interactions regulate functional expression and gating of Kv4.2. J Biol Chem 2006 0.89
163 Heat shock proteins as molecular targets for intervention in atrial fibrillation. Cardiovasc Res 2008 0.89
164 A single residue in the S6 transmembrane domain governs the differential flecainide sensitivity of voltage-gated potassium channels. Mol Pharmacol 2005 0.89
165 Ion channel subunit expression changes in cardiac Purkinje fibers: a potential role in conduction abnormalities associated with congestive heart failure. Circ Res 2009 0.89
166 Single-channel recordings of a rapid delayed rectifier current in adult mouse ventricular myocytes: basic properties and effects of divalent cations. J Physiol 2004 0.89
167 Activation of histone deacetylase-6 induces contractile dysfunction through derailment of α-tubulin proteostasis in experimental and human atrial fibrillation. Circulation 2013 0.88
168 Effects of flecainide and quinidine on Kv4.2 currents: voltage dependence and role of S6 valines. Br J Pharmacol 2003 0.88
169 Effects of heart disease on cardiac ion current density versus current amplitude: important conceptual subtleties in the language of arrhythmogenic ion channel remodeling. Circ Res 2008 0.88
170 Atrial repolarization alternans as a path to atrial fibrillation. J Cardiovasc Electrophysiol 2012 0.87
171 Interactions between cardiac fibrosis spatial pattern and ionic remodeling on electrical wave propagation. Conf Proc IEEE Eng Med Biol Soc 2011 0.87
172 Pharmacological elimination of motion artifacts during optical imaging of cardiac tissues: is blebbistatin the answer? Heart Rhythm 2007 0.87
173 Atrial fibrillation compendium: historical context and detailed translational perspective on an important clinical problem. Circ Res 2014 0.87
174 Losartan prevents heart fibrosis induced by long-term intensive exercise in an animal model. PLoS One 2013 0.87
175 Local delivery of 17beta-estradiol improves reendothelialization and decreases inflammation after coronary stenting in a porcine model. Thromb Haemost 2005 0.86
176 Novel anti-arrhythmic drugs for atrial fibrillation management. Curr Vasc Pharmacol 2007 0.86
177 Cardiac pathways distinguish two epistatic modules enacting BP quantitative trait loci and candidate gene analysis. Hypertens Res 2009 0.86
178 Stem cells are not proarrhythmic: letting the genie out of the bottle. Circulation 2009 0.86
179 Effects of sustained beta-adrenergic stimulation on ionic currents of cultured adult guinea pig cardiomyocytes. Am J Physiol Heart Circ Physiol 2002 0.85
180 Wave block formation in homogeneous excitable media following premature excitations: dependence on restitution relations. Phys Rev E Stat Nonlin Soft Matter Phys 2005 0.85
181 Transcriptional profiling of ion channel genes in Brugada syndrome and other right ventricular arrhythmogenic diseases. Eur Heart J 2008 0.85
182 New insights into the molecular basis of atrial fibrillation: mechanistic and therapeutic implications. Cardiovasc Res 2011 0.84
183 In silico optimization of atrial fibrillation-selective sodium channel blocker pharmacodynamics. Biophys J 2012 0.84
184 Effects of inhibiting Na(+)/H(+)-exchange or angiotensin converting enzyme on atrial tachycardia-induced remodeling. Cardiovasc Res 2002 0.84
185 Effects of resveratrol (trans-3,5,4'-trihydroxystilbene) treatment on cardiac remodeling following myocardial infarction. J Pharmacol Exp Ther 2007 0.84
186 Potential mechanisms for the enhancement of HERG K+ channel function by phospholipid metabolites. Br J Pharmacol 2004 0.84
187 Marked differences between atrial and ventricular gene-expression remodeling in dogs with experimental heart failure. J Mol Cell Cardiol 2008 0.84
188 Intracrine endothelin signaling evokes IP3-dependent increases in nucleoplasmic Ca²⁺ in adult cardiac myocytes. J Mol Cell Cardiol 2013 0.83
189 The Kv4.2 N-terminal restores fast inactivation and confers KChlP2 modulatory effects on N-terminal-deleted Kv1.4 channels. Pflugers Arch 2004 0.83
190 CrossTalk proposal: Prolonged intense exercise training does lead to myocardial damage. J Physiol 2013 0.83
191 Proarrhythmic atrial calcium cycling in the diseased heart. Adv Exp Med Biol 2012 0.83
192 Regulation of cardiac nitric oxide signaling by nuclear β-adrenergic and endothelin receptors. J Mol Cell Cardiol 2013 0.82
193 Differential interactions of Na+ channel toxins with T-type Ca2+ channels. J Gen Physiol 2008 0.82
194 Calcium handling and atrial fibrillation. Wien Med Wochenschr 2012 0.82
195 Adenosine following pulmonary vein isolation to target dormant conduction elimination (ADVICE): methods and rationale. Can J Cardiol 2012 0.82
196 Voltage-clamp-based methods for the detection of constitutively active acetylcholine-gated I(K,ACh) channels in the diseased heart. Methods Enzymol 2010 0.82
197 Characterization of the cardiac KCNE1 gene promoter. Cardiovasc Res 2006 0.82
198 Defining "culprit mechanisms" in arrhythmogenic cardiac remodeling. Circ Res 2004 0.82
199 Exchange protein directly activated by cAMP mediates slow delayed-rectifier current remodeling by sustained β-adrenergic activation in guinea pig hearts. Circ Res 2014 0.82
200 Predicting the entrainment of reentrant cardiac waves using phase resetting curves. Phys Rev E Stat Nonlin Soft Matter Phys 2002 0.81
201 Nuclear factor of activated T cells mediates RhoA-induced fibronectin upregulation in glomerular podocytes. Am J Physiol Renal Physiol 2013 0.81
202 Comparison of Ca2+-handling properties of canine pulmonary vein and left atrial cardiomyocytes. Am J Physiol Heart Circ Physiol 2006 0.81
203 The pharmacological response of ischemia-related atrial fibrillation in dogs: evidence for substrate-specific efficacy. Cardiovasc Res 2007 0.81
204 Anthrax lethal factor activates K(+) channels to induce IL-1β secretion in macrophages. J Immunol 2011 0.81
205 Atrial fibrillation: therapy with omega-3 fatty acids-is the case closed? Nat Rev Cardiol 2011 0.81
206 Remodeling of Ca(2+)-handling by atrial tachycardia: evidence for a role in loss of rate-adaptation. Cardiovasc Res 2002 0.81
207 Distinct genomic replacements from Lewis correct diastolic dysfunction, attenuate hypertension, and reduce left ventricular hypertrophy in Dahl salt-sensitive rats. J Hypertens 2008 0.81
208 Nicotinamide adenine dinucleotide phosphate oxidase 4 mediates the differential responsiveness of atrial versus ventricular fibroblasts to transforming growth factor-β. Circ Arrhythm Electrophysiol 2013 0.81
209 The role of pulmonary veins vs. autonomic ganglia in different experimental substrates of canine atrial fibrillation. Cardiovasc Res 2010 0.81
210 Adenosine testing in atrial flutter ablation: unmasking of dormant conduction across the cavotricuspid isthmus and risk of recurrence. J Cardiovasc Electrophysiol 2013 0.81
211 Association of neonatal hypoxia with lasting changes in left ventricular gene expression: an animal model. J Thorac Cardiovasc Surg 2009 0.81
212 Identification of atrial tissue in pulmonary veins using intravascular ultrasound. J Am Soc Echocardiogr 2003 0.80
213 Exercise training as a treatment for heart failure: potential mechanisms and clinical implications. J Physiol 2009 0.80
214 Atrial structural remodeling as an antiarrhythmic target. J Cardiovasc Pharmacol 2008 0.80
215 The Past, Present, and Potential Future of Sodium Channel Block as an Atrial Fibrillation Suppressing Strategy. J Cardiovasc Pharmacol 2015 0.80
216 AMP-activated protein kinase: potential role in cardiac electrophysiology and arrhythmias. Circ Arrhythm Electrophysiol 2012 0.80
217 G-protein signaling and arrhythmogenic atrial remodeling: relevance to novel therapeutic targets in atrial fibrillation. Heart Rhythm 2008 0.80
218 Properties of a time-dependent potassium current in pig atrium: evidence for a role of kv1.5 in repolarization. J Pharmacol Exp Ther 2006 0.80
219 Age, gender, and supraventricular arrhythmias: roles of ion channels, connexins, and tissue architecture? Heart Rhythm 2004 0.80
220 Rate-dependence of atrial tachycardia effects on atrial refractoriness and atrial fibrillation maintenance. Cardiovasc Res 2008 0.79
221 Hypoxia in early life is associated with lasting changes in left ventricular structure and function at maturity in the rat. Int J Cardiol 2010 0.79
222 Management of atrial fibrillation in the year 2033: new concepts, tools, and applications leading to personalized medicine. Can J Cardiol 2013 0.79
223 Adrenergic control of a constitutively active acetylcholine-regulated potassium current in canine atrial cardiomyocytes. Cardiovasc Res 2007 0.79
224 Acute and chronic effects of cardiac resynchronization in patients developing heart failure with long-term pacemaker therapy for acquired complete atrioventricular block. Europace 2007 0.79
225 Pharmacological prevention of atrial tachycardia induced atrial remodeling as a potential therapeutic strategy. Pacing Clin Electrophysiol 2003 0.78
226 Insights into mechanisms linking cardiac hypertrophy and atrial fibrosis: evidence for a role of histone deacetylase in atrial fibrillation pathophysiology and therapy. J Mol Cell Cardiol 2008 0.78
227 Development of a computer algorithm for the detection of phase singularities and initial application to analyze simulations of atrial fibrillation. Chaos 2002 0.78
228 Arrhythmogenic right ventricular dysplasia type 1 and mutations in transforming growth factor beta3 gene regulatory regions: a breakthrough? Cardiovasc Res 2005 0.78
229 Drugs to promote sinus rhythm reversion and maintenance in atrial fibrillation--why amiodarone is better. Cardiovasc Drugs Ther 2003 0.78
230 T-type calcium current contributes to escape automaticity and governs the occurrence of lethal arrhythmias after atrioventricular block in mice. Circ Arrhythm Electrophysiol 2013 0.78
231 Consequences of atrial tachycardia-induced remodeling depend on the preexisting atrial substrate. Circulation 2002 0.78
232 Pulmonary vein cellular electrophysiology and atrial fibrillation: does basic research help us understand clinical pulmonary-vein arrhythmogenesis? Heart Rhythm 2005 0.78
233 Consequences of Atrial or Ventricular Tachypacing on the Heat Shock Proteins (HSP) level of Expression and Phosphorylation. Mcgill J Med 2009 0.78
234 Dormant pulmonary vein conduction unmasked by external electrical cardioversion. Heart Rhythm 2009 0.78
235 A mathematical model of human atrioventricular nodal function incorporating concealed conduction. Bull Math Biol 2002 0.78
236 Aldosterone antagonism and atrial fibrillation: time for clinical assessment? Eur Heart J 2005 0.77
237 Physiological versus pathological cardiac electrical remodelling: potential basis and relevance to clinical management. J Physiol 2010 0.77
238 Ultrarapid delayed rectifier K(+) current in H9c2 rat ventricular cell line: biophysical property and molecular identity. Cell Physiol Biochem 2002 0.77
239 Remodeling of cardiac inward-rectifier currents: an often-overlooked contributor to arrhythmogenic states. J Mol Cell Cardiol 2003 0.77
240 Human genetics: Lost anchors cost lives. Nature 2003 0.77
241 Isolation and study of cardiac nuclei from canine myocardium and adult ventricular myocytes. Methods Mol Biol 2015 0.77
242 Inward rectifier-funny current balance and spontaneous automaticity: cautionary notes for biologic pacemaker development. Heart Rhythm 2008 0.77
243 Novel targets for cardiac antiarrhythmic drug development. Curr Pharm Des 2005 0.77
244 Exercise training, inflammation and heart failure: working out to cool down. J Physiol 2010 0.77
245 Dronedarone in atrial fibrillation--Jekyll and Hyde? N Engl J Med 2011 0.77
246 Ventricular proarrhythmic effects of atrial fibrillation are modulated by depolarization and repolarization anomalies in patients with left ventricular dysfunction. Pacing Clin Electrophysiol 2009 0.76
247 Is atrial remodeling a viable target for prevention of atrial fibrillation recurrence? J Cardiovasc Electrophysiol 2004 0.76
248 F 16915 prevents heart failure-induced atrial fibrillation: a promising new drug as upstream therapy. Naunyn Schmiedebergs Arch Pharmacol 2014 0.76
249 Nestin is a marker of lung remodeling secondary to myocardial infarction and type I diabetes in the rat. J Cell Physiol 2015 0.76
250 Driver regions in atrial fibrillation associated with congestive heart failure: where are they, and what are they telling us? J Cardiovasc Electrophysiol 2005 0.76
251 Unique quantitative trait loci in synergy permanently improve diastolic dysfunction. Can J Cardiol 2013 0.76
252 Electrical storm: recent pathophysiological insights and therapeutic consequences. Basic Res Cardiol 2013 0.76
253 Prognostic significance of ventricular arrhythmias post-myocardial infarction. Can J Cardiol 2003 0.76
254 Pharmacotherapy for inherited arrhythmia syndromes: mechanistic basis, clinical trial evidence and practical application. Expert Rev Cardiovasc Ther 2015 0.75
255 Reply: Of mice and men: atrial fibrillation in veteran endurance runners. J Am Coll Cardiol 2013 0.75
256 Rebuttal from Eduard Guasch and Stanley Nattel. J Physiol 2013 0.75
257 Teasing out circadian variability in heart rate turbulence: A new approach to detecting biorhythms underlying cardiac function. Heart Rhythm 2006 0.75
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259 Are all sodium channel blockers created equal? Clinical-basic correlations based on observations in Brugada syndrome. Heart Rhythm 2005 0.75
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263 Role of constitutively active acetylcholine-mediated potassium current in atrial contractile dysfunction caused by atrial tachycardia remodelling. Europace 2010 0.75
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268 Preoperative atrial cardiomyocyte ionic currents and postoperative AF: important insights into what is not the mechanism. J Cardiovasc Electrophysiol 2006 0.75
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275 Inefficacy of a highly selective T-type calcium channel blocker in preventing atrial fibrillation related remodeling. J Cardiovasc Electrophysiol 2014 0.75
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277 Evolving developments in the therapeutics of atrial fibrillation: addressing an unmet need. J Cardiovasc Pharmacol 2008 0.75
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282 The pathology of atrial fibrillation in dogs. J Vet Cardiol 2005 0.75
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286 Anticoagulation for atrial fibrillation: state of the art and recommendations for a quickly moving target. Can J Cardiol 2013 0.75
287 Combining distinctive and novel loci doubles BP reduction, reverses diastolic dysfunction and mitigates LV hypertrophy. J Hypertens 2013 0.75
288 Corticosteroid use during pulmonary vein isolation is associated with a higher prevalence of dormant pulmonary vein conduction. Heart Rhythm 2013 0.75