PubRank

Thomas H Bugge

Author PubWeight™ 105.56‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes. Cancer Cell 2003 3.42
2 Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein. J Clin Invest 2003 3.41
3 Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis. Oncogene 2002 2.74
4 Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer. Cancer Metastasis Rev 2003 2.39
5 Loss of proteolytically processed filaggrin caused by epidermal deletion of Matriptase/MT-SP1. J Cell Biol 2003 2.08
6 Evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiation. J Biol Chem 2006 2.07
7 Proteolytic activation of the 1918 influenza virus hemagglutinin. J Virol 2009 2.05
8 Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation. Genes Dev 2005 1.92
9 Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation. Blood 2010 1.82
10 Role for the actomyosin complex in regulated exocytosis revealed by intravital microscopy. Proc Natl Acad Sci U S A 2011 1.74
11 Diphtheria toxin-murine granulocyte-macrophage colony-stimulating factor-induced hepatotoxicity is mediated by Kupffer cells. Mol Cancer Ther 2004 1.68
12 Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway. Am J Pathol 2009 1.62
13 uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion. J Cell Biol 2003 1.60
14 MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells. J Exp Med 2005 1.55
15 Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestine. Proc Natl Acad Sci U S A 2010 1.52
16 Co-localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase. J Cell Physiol 2007 1.51
17 MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D. J Biol Chem 2007 1.51
18 Matriptase: potent proteolysis on the cell surface. Mol Med 2006 1.47
19 Type II transmembrane serine proteases in development and disease. Int J Biochem Cell Biol 2007 1.45
20 Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent. J Clin Invest 2002 1.44
21 Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice. J Biol Chem 2007 1.44
22 Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy. J Cell Biol 2005 1.42
23 Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature. J Biol Chem 2007 1.41
24 Potent antitumor activity of a urokinase-activated engineered anthrax toxin. Proc Natl Acad Sci U S A 2003 1.38
25 Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice. Development 2009 1.38
26 Anthrax toxin: structures, functions and tumour targeting. Expert Opin Biol Ther 2003 1.32
27 Delineation of matriptase protein expression by enzymatic gene trapping suggests diverging roles in barrier function, hair formation, and squamous cell carcinogenesis. Am J Pathol 2006 1.32
28 Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity. J Biol Chem 2008 1.31
29 Membrane-anchored serine proteases in vertebrate cell and developmental biology. Annu Rev Cell Dev Biol 2011 1.26
30 Accelerated wound healing by mTOR activation in genetically defined mouse models. PLoS One 2010 1.25
31 Extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein/Endo180, cooperate in fibroblast-mediated collagen degradation. J Biol Chem 2007 1.25
32 Type II transmembrane serine proteases. Thromb Haemost 2003 1.25
33 uPARAP/endo180 directs lysosomal delivery and degradation of collagen IV. Exp Cell Res 2004 1.23
34 Complementary roles of intracellular and pericellular collagen degradation pathways in vivo. Mol Cell Biol 2007 1.22
35 Collagen dissolution by keratinocytes requires cell surface plasminogen activation and matrix metalloproteinase activity. J Biol Chem 2002 1.21
36 Imaging specific cell-surface proteolytic activity in single living cells. Nat Methods 2006 1.20
37 Loss of matriptase suppression underlies spint1 mutation-associated ichthyosis and postnatal lethality. Am J Pathol 2009 1.20
38 M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. J Cell Biol 2013 1.19
39 Mechanism of FGF23 processing in fibrous dysplasia. J Bone Miner Res 2012 1.17
40 Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin. Nat Biotechnol 2005 1.17
41 Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation. PLoS Genet 2012 1.16
42 Design, synthesis, and characterization of urokinase plasminogen-activator-sensitive near-infrared reporter. Chem Biol 2004 1.15
43 Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity. Biochem J 2005 1.13
44 Membrane-anchored serine proteases in health and disease. Prog Mol Biol Transl Sci 2011 1.13
45 The non-phagocytic route of collagen uptake: a distinct degradation pathway. J Biol Chem 2011 1.09
46 A matriptase-prostasin reciprocal zymogen activation complex with unique features: prostasin as a non-enzymatic co-factor for matriptase activation. J Biol Chem 2013 1.09
47 Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome. Nat Genet 2010 1.09
48 Mannose receptor 2 attenuates renal fibrosis. J Am Soc Nephrol 2011 1.04
49 Hepatocyte growth factor activator inhibitor-1 has a complex subcellular itinerary. Biochem J 2008 1.02
50 Matriptase-deficient mice exhibit ichthyotic skin with a selective shift in skin microbiota. J Invest Dermatol 2009 1.01
51 Transport via the transcytotic pathway makes prostasin available as a substrate for matriptase. J Biol Chem 2010 1.00
52 PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation. J Biol Chem 2013 0.99
53 A urokinase-activated recombinant anthrax toxin is selectively cytotoxic to many human tumor cell types. Mol Cancer Ther 2006 0.98
54 Increased expression of the collagen internalization receptor uPARAP/Endo180 in the stroma of head and neck cancer. J Histochem Cytochem 2006 0.98
55 Potent inhibition of tumor angiogenesis by the matrix metalloproteinase-activated anthrax lethal toxin: implications for broad anti-tumor efficacy. Cell Cycle 2008 0.96
56 Expression and genetic loss of function analysis of the HAT/DESC cluster proteases TMPRSS11A and HAT. PLoS One 2011 0.96
57 Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes. J Biol Chem 2004 0.96
58 Conditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration. Am J Pathol 2009 0.95
59 Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death. Bioorg Med Chem 2009 0.95
60 The glycosylphosphatidylinositol-anchored serine protease PRSS21 (testisin) imparts murine epididymal sperm cell maturation and fertilizing ability. Biol Reprod 2009 0.94
61 Matriptase protects against experimental colitis and promotes intestinal barrier recovery. Inflamm Bowel Dis 2011 0.94
62 The low density lipoprotein receptor-related protein modulates protease activity in the brain by mediating the cellular internalization of both neuroserpin and neuroserpin-tissue-type plasminogen activator complexes. J Biol Chem 2003 0.94
63 Hu/Mu ProtIn oligonucleotide microarray: dual-species array for profiling protease and protease inhibitor gene expression in tumors and their microenvironment. Mol Cancer Res 2007 0.91
64 Cytotoxicity of the matrix metalloproteinase-activated anthrax lethal toxin is dependent on gelatinase expression and B-RAF status in human melanoma cells. Mol Cancer Ther 2008 0.91
65 Hepatocyte growth factor activator inhibitor-2 prevents shedding of matriptase. Exp Cell Res 2013 0.91
66 Profibrinolytic effects of metalloproteinases during skin wound healing in the absence of plasminogen. J Invest Dermatol 2008 0.90
67 Inhibition of tumor angiogenesis by the matrix metalloproteinase-activated anthrax lethal toxin in an orthotopic model of anaplastic thyroid carcinoma. Mol Cancer Ther 2010 0.89
68 Urokinase-type plasminogen activator stimulation of monocyte matrix metalloproteinase-1 production is mediated by plasmin-dependent signaling through annexin A2 and inhibited by inactive plasmin. J Immunol 2007 0.89
69 Efficient targeting of head and neck squamous cell carcinoma by systemic administration of a dual uPA and MMP-activated engineered anthrax toxin. PLoS One 2011 0.86
70 A urokinase-activated recombinant diphtheria toxin targeting the granulocyte-macrophage colony-stimulating factor receptor is selectively cytotoxic to human acute myeloid leukemia blasts. Blood 2004 0.86
71 Capillary morphogenesis protein-2 is required for mouse parturition by maintaining uterine collagen homeostasis. Biochem Biophys Res Commun 2012 0.86
72 Antitumor efficacy of a urokinase activation-dependent anthrax toxin. Mol Cancer Ther 2006 0.85
73 Systematic urokinase-activated anthrax toxin therapy produces regressions of subcutaneous human non-small cell lung tumor in athymic nude mice. Cancer Res 2007 0.85
74 Differential actions of the endocytic collagen receptor uPARAP/Endo180 and the collagenase MMP-2 in bone homeostasis. PLoS One 2013 0.85
75 Endocytic collagen degradation: a novel mechanism involved in protection against liver fibrosis. J Pathol 2012 0.85
76 Matrix metalloproteinase-activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formation during in vitro morphogenesis. Mol Cancer Res 2009 0.84
77 Optical zymography for specific detection of urokinase plasminogen activator activity in biological samples. Anal Biochem 2005 0.83
78 Complex determinants in specific members of the mannose receptor family govern collagen endocytosis. J Biol Chem 2014 0.83
79 Detection of plasminogen activators in oral cancer by laser capture microdissection combined with zymography. Oral Oncol 2004 0.82
80 Plasminogen promotes sarcoma growth and suppresses the accumulation of tumor-infiltrating macrophages. Oncogene 2002 0.80
81 Anthrax target in macrophages unveiled. Nat Genet 2006 0.79
82 Localization of regulatory elements mediating constitutive and cytokine-stimulated plasminogen gene expression. J Biol Chem 2002 0.79
83 Imaging specific cell surface protease activity in living cells using reengineered bacterial cytotoxins. Methods Mol Biol 2009 0.79
84 Detection of active matriptase using a biotinylated chloromethyl ketone peptide. PLoS One 2013 0.78
85 Dissecting the urokinase activation pathway using urokinase-activated anthrax toxin. Methods Mol Biol 2009 0.77
86 Peptide toxins directed at the matrix dissolution systems of cancer cells. Protein Pept Lett 2002 0.76
87 Amalfi to Washington D. C.--twenty years of plasminogen activator research. Thromb Haemost 2005 0.75
88 Methods in molecular biology. Proteases and cancer. Methods and protocols. Preface. Methods Mol Biol 2009 0.75