Published in IUBMB Life on August 01, 2010
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RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science (2009) 9.29
Involvement of microRNA in AU-rich element-mediated mRNA instability. Cell (2005) 9.01
Activation and signaling of the p38 MAP kinase pathway. Cell Res (2005) 5.48
PRAK is essential for ras-induced senescence and tumor suppression. Cell (2007) 4.30
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat Immunol (2003) 4.15
MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. Science (2002) 3.78
Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression. Immunity (2007) 3.38
Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways. Immunity (2008) 2.62
Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells (2003) 2.28
Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis. Cell Res (2013) 2.26
XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization. Mol Cell (2007) 2.21
Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels. Neuron (2004) 2.17
Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice. J Clin Invest (2008) 2.15
p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation. Cell (2006) 2.06
Autophagy contributes to caspase-independent macrophage cell death. J Biol Chem (2006) 1.87
Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation. J Biol Chem (2006) 1.86
GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. Science (2012) 1.84
Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest (2009) 1.80
Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J (2004) 1.79
Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins. Immunity (2010) 1.78
Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation. J Immunol (2008) 1.68
Glucocorticoids synergistically enhance nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via a negative cross-talk with p38 MAP kinase. J Biol Chem (2002) 1.67
The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence. Cancer Res (2010) 1.60
Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nat Cell Biol (2011) 1.59
Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-kappa B ligand signaling. J Biol Chem (2002) 1.59
Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages. Nat Immunol (2007) 1.57
Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein. J Biol Chem (2004) 1.48
Diverse sequence determinants control human and mouse receptor interacting protein 3 (RIP3) and mixed lineage kinase domain-like (MLKL) interaction in necroptotic signaling. J Biol Chem (2013) 1.48
Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J (2006) 1.47
Inhibition of p38 MAPK by glucocorticoids via induction of MAPK phosphatase-1 enhances nontypeable Haemophilus influenzae-induced expression of toll-like receptor 2. J Biol Chem (2002) 1.44
Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3. Blood (2005) 1.44
A role of RIP3-mediated macrophage necrosis in atherosclerosis development. Cell Rep (2013) 1.44
MicroRNAs and cardiovascular diseases. FEBS J (2011) 1.41
Calcineurin negatively regulates TLR-mediated activation pathways. J Immunol (2007) 1.33
Distinct effects of p38alpha deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel disease. Gastroenterology (2010) 1.31
Regulation of PRAK subcellular location by p38 MAP kinases. Mol Biol Cell (2003) 1.30
The p38 and JNK pathways cooperate to trans-activate vitamin D receptor via c-Jun/AP-1 and sensitize human breast cancer cells to vitamin D(3)-induced growth inhibition. J Biol Chem (2002) 1.29
TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling. J Biol Chem (2005) 1.28
ERK promotes hydrogen peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells. Am J Physiol Renal Physiol (2006) 1.27
Characterization of a neurotrophin signaling mechanism that mediates neuron survival in a temporally specific pattern. J Neurosci (2003) 1.27
Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi. Proc Natl Acad Sci U S A (2010) 1.27
Sensitizing anthrax lethal toxin-resistant macrophages to lethal toxin-induced killing by tumor necrosis factor-alpha. J Biol Chem (2002) 1.26
Synergistic activation of NF-kappaB by nontypeable Haemophilus influenzae and tumor necrosis factor alpha. Proc Natl Acad Sci U S A (2004) 1.25
Multiple activation mechanisms of p38alpha mitogen-activated protein kinase. J Biol Chem (2006) 1.25
MAPK signaling in inflammation-associated cancer development. Protein Cell (2010) 1.23
TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1. J Biol Chem (2002) 1.21
Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes. J Exp Med (2013) 1.21
Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages. J Immunol (2008) 1.20
Multiple death pathways in TNF-treated fibroblasts: RIP3- and RIP1-dependent and independent routes. Cell Res (2011) 1.20
p38 isoforms have opposite effects on AP-1-dependent transcription through regulation of c-Jun. The determinant roles of the isoforms in the p38 MAPK signal specificity. J Biol Chem (2002) 1.19
Activation of p38 alpha MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilization. J Biol Chem (2002) 1.19
p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanisms. J Biol Chem (2009) 1.19
Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA(1), p42 and p38alpha. Biochim Biophys Acta (2007) 1.18
RISC-target interaction: cleavage and translational suppression. Biochim Biophys Acta (2008) 1.18
Distinct requirements for p38alpha and c-Jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death. J Biol Chem (2004) 1.18
A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Dev Cell (2007) 1.16
p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation. Mol Cell Biol (2007) 1.15
Phosphatidylinositol ether lipid analogues that inhibit AKT also independently activate the stress kinase, p38alpha, through MKK3/6-independent and -dependent mechanisms. J Biol Chem (2007) 1.14
Rac1-MKK3-p38-MAPKAPK2 pathway promotes urokinase plasminogen activator mRNA stability in invasive breast cancer cells. J Biol Chem (2002) 1.13
Axin determines cell fate by controlling the p53 activation threshold after DNA damage. Nat Cell Biol (2009) 1.13
Nod1-dependent control of tumor growth. Proc Natl Acad Sci U S A (2006) 1.13
Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics (2012) 1.13
Orphan nuclear receptor Nur77 is involved in caspase-independent macrophage cell death. J Exp Med (2003) 1.11
p38 MAP kinase activation mediates gamma-globin gene induction in erythroid progenitors. Exp Hematol (2003) 1.11
Smad3 mediates transforming growth factor-beta-induced collagenase-3 (matrix metalloproteinase-13) expression in human gingival fibroblasts. Evidence for cross-talk between Smad3 and p38 signaling pathways. J Biol Chem (2002) 1.11
Essential role of p38gamma in K-Ras transformation independent of phosphorylation. J Biol Chem (2005) 1.11
Susceptibility of lysosomes to rupture is a determinant for plasma membrane disruption in tumor necrosis factor alpha-induced cell death. Mol Cell Biol (2003) 1.10
p38 MAPK activation selectively induces cell death in K-ras-mutated human colon cancer cells through regulation of vitamin D receptor. J Biol Chem (2004) 1.10
Determinants of public T cell responses. Cell Res (2012) 1.09
Inflammatory signaling and cellular senescence. Cell Signal (2008) 1.08
Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte. Circ Res (2010) 1.08
Receptor-interacting protein (RIP) kinase family. Cell Mol Immunol (2010) 1.07
Differentiation state-selective roles of p38 isoforms in human intestinal epithelial cell anoikis. Gastroenterology (2002) 1.07
Glucocorticoids synergize with IL-1beta to induce TLR2 expression via MAP Kinase Phosphatase-1-dependent dual Inhibition of MAPK JNK and p38 in epithelial cells. BMC Mol Biol (2004) 1.07
The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes. Mol Cell Biol (2008) 1.06
Extracellular signal-regulated kinase activation mediates mitochondrial dysfunction and necrosis induced by hydrogen peroxide in renal proximal tubular cells. J Pharmacol Exp Ther (2008) 1.05
New components of the necroptotic pathway. Protein Cell (2012) 1.04
Recombinatorial biases and convergent recombination determine interindividual TCRβ sharing in murine thymocytes. J Immunol (2012) 1.04
Phosphorylation of Raptor by p38beta participates in arsenite-induced mammalian target of rapamycin complex 1 (mTORC1) activation. J Biol Chem (2011) 1.04
A novel function of p38-regulated/activated kinase in endothelial cell migration and tumor angiogenesis. Mol Cell Biol (2011) 1.03
Activation of the p38 MAP kinase pathway is required for foam cell formation from macrophages exposed to oxidized LDL. APMIS (2002) 1.03
Determinants that control the specific interactions between TAB1 and p38alpha. Mol Cell Biol (2006) 1.02
p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2. Cancer Res (2003) 1.01
GSNO reductase and beta2-adrenergic receptor gene-gene interaction: bronchodilator responsiveness to albuterol. Pharmacogenet Genomics (2010) 1.00
Mitochondrial proteins Bnip3 and Bnip3L are involved in anthrax lethal toxin-induced macrophage cell death. J Biol Chem (2007) 1.00
p38 kinase-mediated transactivation of the epidermal growth factor receptor is required for dedifferentiation of renal epithelial cells after oxidant injury. J Biol Chem (2005) 0.99
Beta-actin is required for mitochondria clustering and ROS generation in TNF-induced, caspase-independent cell death. J Cell Sci (2004) 0.99
Estrogen receptor inhibits c-Jun-dependent stress-induced cell death by binding and modifying c-Jun activity in human breast cancer cells. J Biol Chem (2003) 0.98
Oxidative stress-induced inhibition of adrenal steroidogenesis requires participation of p38 mitogen-activated protein kinase signaling pathway. J Endocrinol (2008) 0.98
Rin GTPase couples nerve growth factor signaling to p38 and b-Raf/ERK pathways to promote neuronal differentiation. J Biol Chem (2005) 0.97
The role of the p38 pathway in adaptive immunity. Cell Mol Immunol (2007) 0.96
Determinants that control the distinct subcellular localization of p38alpha-PRAK and p38beta-PRAK complexes. J Biol Chem (2008) 0.95
Epithelial p38alpha controls immune cell recruitment in the colonic mucosa. PLoS Pathog (2010) 0.95
AMP as a low-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation. Cell Metab (2013) 0.95
Selecting, testing and understanding probiotic microorganisms. FEMS Immunol Med Microbiol (2006) 0.94
Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation. J Biol Chem (2003) 0.94