Published in J Biol Chem on February 03, 2007
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature (2007) 16.59
T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity (2007) 13.29
Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol (2010) 11.80
Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe (2008) 11.08
Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity (2008) 10.26
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity (2008) 9.61
Late developmental plasticity in the T helper 17 lineage. Immunity (2009) 8.81
Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature (2008) 8.17
Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity (2009) 6.87
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat Immunol (2009) 6.74
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell (2011) 5.63
Regulation of inflammatory responses by IL-17F. J Exp Med (2008) 5.56
A validated regulatory network for Th17 cell specification. Cell (2012) 4.82
Th17: the third member of the effector T cell trilogy. Curr Opin Immunol (2007) 4.78
IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem (2007) 4.77
Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3. J Exp Med (2008) 4.76
Follicular helper T cells: lineage and location. Immunity (2009) 4.75
Targeting IL-17 and TH17 cells in chronic inflammation. Nat Rev Drug Discov (2012) 4.70
TGF-beta: a master of all T cell trades. Cell (2008) 4.60
Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions. Nat Med (2011) 4.50
Th17 cells in human disease. Immunol Rev (2008) 4.27
Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5. Nat Immunol (2011) 3.91
Transcriptional regulation of Th17 cell differentiation. Semin Immunol (2007) 3.86
Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells. J Exp Med (2008) 3.85
Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity (2010) 3.52
CCR6 regulates the migration of inflammatory and regulatory T cells. J Immunol (2008) 3.51
Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science (2009) 3.47
Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. Immunity (2011) 3.40
Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway. Blood (2007) 3.33
IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells. Proc Natl Acad Sci U S A (2009) 3.31
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism. Nucl Recept Signal (2009) 3.19
IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A (2008) 3.04
gammadelta T cells: an important source of IL-17. Curr Opin Immunol (2008) 3.03
Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens. Immunology (2009) 2.92
JAK and STAT signaling molecules in immunoregulation and immune-mediated disease. Immunity (2012) 2.85
The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing. Nat Rev Immunol (2014) 2.82
Th17 cells: effector T cells with inflammatory properties. Semin Immunol (2007) 2.81
IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor. Immunity (2008) 2.78
An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells. Immunity (2011) 2.77
Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors. Immunol Rev (2010) 2.61
The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8. Immunity (2008) 2.55
Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase. Immunity (2009) 2.51
Novel signal transducer and activator of transcription 3 (STAT3) mutations, reduced T(H)17 cell numbers, and variably defective STAT3 phosphorylation in hyper-IgE syndrome. J Allergy Clin Immunol (2008) 2.50
Aiolos promotes TH17 differentiation by directly silencing Il2 expression. Nat Immunol (2012) 2.49
IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction. Nat Med (2012) 2.47
IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells. Proc Natl Acad Sci U S A (2007) 2.46
IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance. Nat Immunol (2015) 2.42
The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. J Exp Med (2009) 2.38
Role of Th1 and Th17 cells in organ-specific autoimmunity. J Autoimmun (2008) 2.35
TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease. J Exp Med (2008) 2.33
Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expression. Nat Immunol (2008) 2.31
Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases. J Immunol (2008) 2.22
A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory. Immunity (2011) 2.15
Emerging molecular insights into the interaction between probiotics and the host intestinal mucosa. Nat Rev Microbiol (2011) 2.15
Influenza A inhibits Th17-mediated host defense against bacterial pneumonia in mice. J Immunol (2010) 2.14
Genomic views of STAT function in CD4+ T helper cell differentiation. Nat Rev Immunol (2011) 2.09
Th1 and Th17 cells: adversaries and collaborators. Ann N Y Acad Sci (2010) 2.08
The transcription factor STAT3 is required for T helper 2 cell development. Immunity (2011) 2.03
Th17 cells in immunity to Candida albicans. Cell Host Microbe (2012) 1.97
STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation. J Immunol (2008) 1.97
Essentials of Th17 cell commitment and plasticity. Blood (2013) 1.95
A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma. Blood (2010) 1.89
Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation. J Exp Med (2009) 1.89
Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation. Semin Immunol (2007) 1.87
A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells. Clin Cancer Res (2008) 1.80
Translational mini-review series on Th17 cells: function and regulation of human T helper 17 cells in health and disease. Clin Exp Immunol (2009) 1.78
The myeloid differentiation factor 88 (MyD88) is required for CD4+ T cell effector function in a murine model of inflammatory bowel disease. J Immunol (2008) 1.75
Effector and regulatory T-cell subsets in autoimmunity and tissue inflammation. Scand J Immunol (2010) 1.70
Cellular and molecular basis for the regulation of inflammation by TGF-beta. J Biochem (2010) 1.69
TGF-beta promotes Th17 cell development through inhibition of SOCS3. J Immunol (2009) 1.66
From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited. Immunol Rev (2008) 1.65
Role of IL-17 and Th17 cells in liver diseases. Clin Dev Immunol (2010) 1.63
Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease. Nat Genet (2014) 1.62
Signal transduction pathways and transcriptional regulation in Th17 cell differentiation. Cytokine Growth Factor Rev (2010) 1.61
Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma. J Allergy Clin Immunol (2014) 1.61
A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3. Blood (2014) 1.58
Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response. J Immunol (2009) 1.57
Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma. Blood (2008) 1.56
CD4⁺T cells: differentiation and functions. Clin Dev Immunol (2012) 1.56
IL-17F: regulation, signaling and function in inflammation. Cytokine (2009) 1.56
Interleukin-17 and its expanding biological functions. Cell Mol Immunol (2010) 1.55
STAT3 in CD4+ T helper cell differentiation and inflammatory diseases. Cytokine (2009) 1.55
Tc17 CD8 T cells: functional plasticity and subset diversity. J Immunol (2009) 1.54
Cutting edge: in vitro generated Th17 cells maintain their cytokine expression program in normal but not lymphopenic hosts. J Immunol (2009) 1.54
Immunological decision-making: how does the immune system decide to mount a helper T-cell response? Immunology (2007) 1.54
Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation. J Clin Invest (2011) 1.54
Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis. Blood (2011) 1.50
The Th17 immune response is controlled by the Rel-RORγ-RORγ T transcriptional axis. J Exp Med (2011) 1.50
Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax. Proc Natl Acad Sci U S A (2010) 1.49
Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumonia. Am J Respir Cell Mol Biol (2008) 1.49
In colorectal cancer mast cells contribute to systemic regulatory T-cell dysfunction. Proc Natl Acad Sci U S A (2010) 1.47
T helper 17 cell heterogeneity and pathogenicity in autoimmune disease. Trends Immunol (2011) 1.47
Protein kinase CK2 governs the molecular decision between encephalitogenic TH17 cell and Treg cell development. Proc Natl Acad Sci U S A (2016) 1.42
T Helper 17/Regulatory T Cell Balance and Experimental Models of Peritoneal Dialysis-Induced Damage. Biomed Res Int (2015) 1.41
Molecular mechanisms of treg-mediated T cell suppression. Front Immunol (2012) 1.41
Th17 cells in immunity and autoimmunity. Clin Dev Immunol (2013) 1.40
Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation. Proc Natl Acad Sci U S A (2012) 1.40
Expansion of Th17 cells and functional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetes. Diabetes (2011) 1.39
Translational mini-review series on Th17 cells: induction of interleukin-17 production by regulatory T cells. Clin Exp Immunol (2009) 1.37
T helper17 cells are sufficient but not necessary to induce acute graft-versus-host disease. Biol Blood Marrow Transplant (2009) 1.37
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol (2005) 27.17
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature (2007) 14.28
T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity (2007) 13.29
Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity (2008) 10.26
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity (2008) 9.61
Somatic coding mutations in human induced pluripotent stem cells. Nature (2011) 9.50
Bcl6 mediates the development of T follicular helper cells. Science (2009) 8.50
Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity (2009) 6.87
Regulation of inflammatory responses by IL-17F. J Exp Med (2008) 5.56
T helper 17 cells promote cytotoxic T cell activation in tumor immunity. Immunity (2009) 4.69
Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions. Nat Med (2011) 4.50
Interleukin 25 promotes the initiation of proallergic type 2 responses. J Exp Med (2007) 3.91
The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol (2006) 3.76
IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. J Exp Med (2007) 3.66
Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature (2011) 3.56
CCR6 regulates the migration of inflammatory and regulatory T cells. J Immunol (2008) 3.51
Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells. Eur J Immunol (2009) 3.42
Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes. Cell Res (2006) 3.41
ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity. J Exp Med (2008) 3.39
B7S1, a novel B7 family member that negatively regulates T cell activation. Immunity (2003) 3.18
Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor. J Biol Chem (2006) 3.16
Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation. Immunity (2005) 3.14
Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation. J Biol Chem (2007) 3.14
Enhancer-mediated control of macrophage-specific arginase I expression. J Immunol (2004) 2.95
Toll-like receptor 2 signaling in CD4(+) T lymphocytes promotes T helper 17 responses and regulates the pathogenesis of autoimmune disease. Immunity (2010) 2.90
Characterization of mouse and human B7-H3 genes. J Immunol (2002) 2.86
Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex. Mol Cell Biol (2002) 2.70
Transcriptional regulation of th2 differentiation by inducible costimulator. Immunity (2003) 2.56
The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8. Immunity (2008) 2.55
HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. Oncogene (2005) 2.53
A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses. Cell Res (2007) 2.50
A critical role of neural-specific JNK3 for ischemic apoptosis. Proc Natl Acad Sci U S A (2003) 2.47
Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E. Immunity (2011) 2.39
Murine B7-H3 is a negative regulator of T cells. J Immunol (2004) 2.33
TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease. J Exp Med (2008) 2.33
A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity. Curr Biol (2010) 2.32
A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. Science (2012) 2.30
BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice. Clin Cancer Res (2012) 2.28
Stat5 tetramer formation is associated with leukemogenesis. Cancer Cell (2005) 2.26
Aberrant regulation of synovial T cell activation by soluble costimulatory molecules in rheumatoid arthritis. J Immunol (2006) 2.15
STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils. Blood (2006) 2.12
Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev (2003) 2.10
The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets. Nat Immunol (2011) 2.10
Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5. Nature (2004) 1.99
Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and 'emergency' hematopoiesis. Cytokine (2008) 1.95
Retracted Inducible costimulator is essential for collagen-induced arthritis. J Clin Invest (2003) 1.94
T-cell tolerance or function is determined by combinatorial costimulatory signals. EMBO J (2006) 1.92
General nature of the STAT3-activated anti-inflammatory response. J Immunol (2006) 1.90
IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNF-alpha in host macrophages. J Immunol (2005) 1.83
Regulation of IL-9 expression by IL-25 signaling. Nat Immunol (2010) 1.78
IL-17 family member cytokines: regulation and function in innate immunity. Cytokine Growth Factor Rev (2010) 1.76
B7-H3 is a potent inhibitor of human T-cell activation: No evidence for B7-H3 and TREML2 interaction. Eur J Immunol (2009) 1.71
Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells. Nat Immunol (2003) 1.70
Bcl6 expression specifies the T follicular helper cell program in vivo. J Exp Med (2012) 1.69
Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells. Proc Natl Acad Sci U S A (2012) 1.69
Signaling of interleukin-17 family cytokines in immunity and inflammation. Cell Signal (2010) 1.66
Arginine usage in mycobacteria-infected macrophages depends on autocrine-paracrine cytokine signaling. Sci Signal (2010) 1.66
Regulation and function of proinflammatory TH17 cells. Ann N Y Acad Sci (2008) 1.65
Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway. J Immunol (2007) 1.62
IL-17F: regulation, signaling and function in inflammation. Cytokine (2009) 1.56
Cutting edge: in vitro generated Th17 cells maintain their cytokine expression program in normal but not lymphopenic hosts. J Immunol (2009) 1.54
The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling. Semin Immunol (2004) 1.54
IL-6 signaling via the STAT3/SOCS3 pathway: functional analysis of the conserved STAT3 N-domain. Mol Cell Biochem (2006) 1.54
Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema. Sci Transl Med (2012) 1.54
Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis. EMBO Rep (2002) 1.52
STAT3 controls myeloid progenitor growth during emergency granulopoiesis. Blood (2010) 1.51
STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function. J Biol Chem (2012) 1.51
Cutting Edge: Programmed death (PD) ligand-1/PD-1 interaction is required for CD8+ T cell tolerance to tissue antigens. J Immunol (2006) 1.49
Regulation of T cell activation and tolerance by PDL2. Proc Natl Acad Sci U S A (2006) 1.46
BTNL2, a butyrophilin-like molecule that functions to inhibit T cell activation. J Immunol (2006) 1.45
CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-{kappa}B activation. Genes Dev (2007) 1.45