Published in J Biol Chem on August 17, 2010
PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis. Cancer Res (2011) 1.43
PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans. J Lipid Res (2012) 1.23
Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation. Diabetes (2013) 1.22
Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A. Proc Natl Acad Sci U S A (2013) 1.07
Rosiglitazone-induced mitochondrial biogenesis in white adipose tissue is independent of peroxisome proliferator-activated receptor γ coactivator-1α. PLoS One (2011) 1.05
The diverse role of the PPARγ coactivator 1 family of transcriptional coactivators in cancer. Semin Cell Dev Biol (2012) 1.02
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Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium. PLoS One (2012) 1.00
PGC-1α improves glucose homeostasis in skeletal muscle in an activity-dependent manner. Diabetes (2012) 0.99
PGC-1α induces mitochondrial and myokine transcriptional programs and lipid droplet and glycogen accumulation in cultured human skeletal muscle cells. PLoS One (2012) 0.93
Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology. Semin Immunopathol (2013) 0.93
A role for adipose tissue de novo lipogenesis in glucose homeostasis during catch-up growth: a Randle cycle favoring fat storage. Diabetes (2012) 0.92
Impact of oxidative stress on exercising skeletal muscle. Biomolecules (2015) 0.91
Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle. J Biol Chem (2011) 0.91
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Complex Coordination of Cell Plasticity by a PGC-1α-controlled Transcriptional Network in Skeletal Muscle. Front Physiol (2015) 0.84
Molecular signatures of amyotrophic lateral sclerosis disease progression in hind and forelimb muscles of an SOD1(G93A) mouse model. Antioxid Redox Signal (2012) 0.84
The coactivator PGC-1α regulates skeletal muscle oxidative metabolism independently of the nuclear receptor PPARβ/δ in sedentary mice fed a regular chow diet. Diabetologia (2014) 0.82
Arctigenin efficiently enhanced sedentary mice treadmill endurance. PLoS One (2011) 0.81
Multiparity leads to obesity and inflammation in mothers and obesity in male offspring. Am J Physiol Endocrinol Metab (2011) 0.81
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Parkin in the regulation of fat uptake and mitochondrial biology: emerging links in the pathophysiology of Parkinson's disease. Curr Opin Lipidol (2012) 0.80
The single nucleotide polymorphism Gly482Ser in the PGC-1α gene impairs exercise-induced slow-twitch muscle fibre transformation in humans. PLoS One (2015) 0.79
Transcriptome analysis of post-hatch breast muscle in legacy and modern broiler chickens reveals enrichment of several regulators of myogenic growth. PLoS One (2015) 0.79
Effects of Testosterone and Evoked Resistance Exercise after Spinal Cord Injury (TEREX-SCI): study protocol for a randomised controlled trial. BMJ Open (2017) 0.78
Exercise Increases and Browns Muscle Lipid in High-Fat Diet-Fed Mice. Front Endocrinol (Lausanne) (2016) 0.77
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miR-34a(-/-) mice are susceptible to diet-induced obesity. Obesity (Silver Spring) (2016) 0.75
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Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice. Diabetologia (2014) 0.75
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell (1999) 19.48
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AMPK and PPARdelta agonists are exercise mimetics. Cell (2008) 6.39
The role of exercise and PGC1alpha in inflammation and chronic disease. Nature (2008) 5.31
PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription. Proc Natl Acad Sci U S A (2006) 5.28
Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1. FASEB J (2002) 4.75
Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J Clin Endocrinol Metab (2001) 4.53
Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. J Biol Chem (2003) 4.12
Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake. J Appl Physiol (1985) (2008) 3.54
Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects. Diabetes (1999) 2.86
Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proc Natl Acad Sci U S A (2008) 2.49
A role for the transcriptional coactivator PGC-1alpha in muscle refueling. J Biol Chem (2007) 2.19
Exercise-induced increase in muscle insulin sensitivity. J Appl Physiol (1985) (2005) 2.16
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Intramyocellular lipid content in type 2 diabetes patients compared with overweight sedentary men and highly trained endurance athletes. Am J Physiol Endocrinol Metab (2004) 1.32
High-fat diet, muscular lipotoxicity and insulin resistance. Proc Nutr Soc (2007) 1.32
Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: essential role in fatty acid oxidation. Am J Physiol Endocrinol Metab (2005) 1.29
Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletes. J Appl Physiol (1985) (2010) 1.26
The exercise pill--too good to be true? N Engl J Med (2008) 1.14
Training high--living low: changes of aerobic performance and muscle structure with training at simulated altitude. Int J Sports Med (2001) 1.08
Dual modulation of both lipid oxidation and synthesis by peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in cultured myotubes. FASEB J (2009) 1.01
Plasma membrane fatty acid-binding protein and mitochondrial glutamic-oxaloacetic transaminase of rat liver are related. Proc Natl Acad Sci U S A (1990) 0.99
Effect of 10 days of physical inactivity on glucose tolerance in master athletes. J Appl Physiol (1985) (1990) 0.97
Can exercise mimetics substitute for exercise? Cell Metab (2008) 0.94
Significant intramyocellular lipid use during prolonged cycling in endurance-trained males as assessed by three different methodologies. Am J Physiol Endocrinol Metab (2007) 0.94
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In vivo evaluation of the effects of continuous exercise on skeletal muscle triglycerides in trained humans. Lipids (2000) 0.92
Incorporation of [6-3H] glucose into lipid, protein, RNA and DNA of slices of differentiating rat cerebral cortex. J Neurochem (1971) 0.91
Dietary whey protein downregulates fatty acid synthesis in the liver, but upregulates it in skeletal muscle of exercise-trained rats. Nutrition (2005) 0.91
Increased gene expression of lipogenic enzymes and glucose transporter in white adipose tissue of suckling and weaned obese Zucker rats. Biochem J (1991) 0.86
Effects of short-term detraining on measures of obesity and glucose tolerance in elite athletes. J Sports Sci (2008) 0.85
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Effect of 2-month detraining on body composition and insulin sensitivity in young female dancers. Int J Obes (Lond) (2006) 0.80
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Rapid down-regulation of mitochondrial fat metabolism in human muscle after training cessation is dissociated from changes in insulin sensitivity. FEBS Lett (2009) 0.79
In appreciation of Sir Philip Randle: the glucose-fatty acid cycle. Br J Nutr (2007) 0.78
Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab (2005) 11.66
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell (2006) 10.18
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci U S A (2007) 8.23
Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc Natl Acad Sci U S A (2004) 6.53
PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription. Proc Natl Acad Sci U S A (2006) 5.28
Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metab (2005) 4.65
Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell (2005) 4.04
Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proc Natl Acad Sci U S A (2008) 2.49
Association between statin-associated myopathy and skeletal muscle damage. CMAJ (2009) 2.41
Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Genes Dev (2004) 2.39
Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells. Proc Natl Acad Sci U S A (2006) 2.26
Allometric scaling of maximal metabolic rate in mammals: muscle aerobic capacity as determinant factor. Respir Physiol Neurobiol (2004) 2.14
A fundamental system of cellular energy homeostasis regulated by PGC-1alpha. Proc Natl Acad Sci U S A (2007) 1.79
Origin of renal myofibroblasts in the model of unilateral ureter obstruction in the rat. Histochem Cell Biol (2008) 1.77
Impact of working memory training on memory performance in old-old adults. Psychol Aging (2008) 1.74
NUBIScan, an in silico approach for prediction of nuclear receptor response elements. Mol Endocrinol (2002) 1.67
Scaling functions to body size: theories and facts. J Exp Biol (2005) 1.53
A hypoxia complement differentiates the muscle response to endurance exercise. Exp Physiol (2010) 1.53
Vascular remodeling by intussusceptive angiogenesis. Cell Tissue Res (2003) 1.49
Exercise-induced maximal metabolic rate scales with muscle aerobic capacity. J Exp Biol (2005) 1.46
Exercise training in normobaric hypoxia in endurance runners. I. Improvement in aerobic performance capacity. J Appl Physiol (1985) (2006) 1.45
Correlation of atrophy and fatty infiltration on strength and integrity of rotator cuff repairs: a study in thirteen patients. J Shoulder Elbow Surg (2007) 1.34
SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice. Aging (Albany NY) (2010) 1.32
The peroxisome proliferator-activated receptor γ coactivator 1α/β (PGC-1) coactivators repress the transcriptional activity of NF-κB in skeletal muscle cells. J Biol Chem (2012) 1.32
Exercise training in normobaric hypoxia in endurance runners. III. Muscular adjustments of selected gene transcripts. J Appl Physiol (1985) (2006) 1.29
Exercise training in normobaric hypoxia in endurance runners. II. Improvement of mitochondrial properties in skeletal muscle. J Appl Physiol (1985) (2005) 1.22
Neer Award 2007: Reversion of structural muscle changes caused by chronic rotator cuff tears using continuous musculotendinous traction. An experimental study in sheep. J Shoulder Elbow Surg (2008) 1.22
A pathomechanical concept explains muscle loss and fatty muscular changes following surgical tendon release. J Orthop Res (2004) 1.17
Acclimatization of skeletal muscle mitochondria to high-altitude hypoxia during an ascent of Everest. FASEB J (2011) 1.15
Regulation of Foxo-1 and the angiopoietin-2/Tie2 system by shear stress. FEBS Lett (2007) 1.14
Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism. J Biol Chem (2006) 1.12
Excessive erythrocytosis compromises the blood-endothelium interface in erythropoietin-overexpressing mice. J Physiol (2011) 1.11
PGC-1α and myokines in the aging muscle - a mini-review. Gerontology (2010) 1.09
Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A. Proc Natl Acad Sci U S A (2013) 1.07
New aspects of altitude adaptation in Tibetans: a proteomic approach. FASEB J (2004) 1.06
Remodeling of calcium handling in skeletal muscle through PGC-1α: impact on force, fatigability, and fiber type. Am J Physiol Cell Physiol (2011) 1.05
RANTES (regulated on activation, normal T cell expressed and secreted), inflammation, obesity, and the metabolic syndrome. Circulation (2007) 1.04
Transcriptional reprogramming and ultrastructure during atrophy and recovery of mouse soleus muscle. Physiol Genomics (2004) 1.04
Eccentric exercise in coronary patients: central hemodynamic and metabolic responses. Med Sci Sports Exerc (2003) 1.04
Tumor recovery by angiogenic switch from sprouting to intussusceptive angiogenesis after treatment with PTK787/ZK222584 or ionizing radiation. Am J Pathol (2008) 1.03
Transcriptional adaptations of lipid metabolism in tibialis anterior muscle of endurance-trained athletes. Physiol Genomics (2003) 1.03
Prolonged unloading of rat soleus muscle causes distinct adaptations of the gene profile. FASEB J (2002) 1.02
The corepressor NCoR1 antagonizes PGC-1α and estrogen-related receptor α in the regulation of skeletal muscle function and oxidative metabolism. Mol Cell Biol (2012) 1.02
Content of intramyocellular lipids derived by electron microscopy, biochemical assays, and (1)H-MR spectroscopy. J Appl Physiol (1985) (2002) 1.01
Differential gene and protein expression in abluminal sprouting and intraluminal splitting forms of angiogenesis. Clin Sci (Lond) (2006) 1.01
Effect of calpain and proteasome inhibition on Ca2+-dependent proteolysis and muscle histopathology in the mdx mouse. FASEB J (2008) 1.01
PGC-1α improves glucose homeostasis in skeletal muscle in an activity-dependent manner. Diabetes (2012) 0.99
The transcriptional coactivator PGC-1α is dispensable for chronic overload-induced skeletal muscle hypertrophy and metabolic remodeling. Proc Natl Acad Sci U S A (2013) 0.99
Excessive erythrocytosis in adult mice overexpressing erythropoietin leads to hepatic, renal, neuronal, and muscular degeneration. Am J Physiol Regul Integr Comp Physiol (2006) 0.98
Block training periodization in alpine skiing: effects of 11-day HIT on VO2max and performance. Eur J Appl Physiol (2010) 0.98
Macrophages and dendritic cells express tight junction proteins and exchange particles in an in vitro model of the human airway wall. Immunobiology (2010) 0.97
Performing at extreme altitude: muscle cellular and subcellular adaptations. Eur J Appl Physiol (2003) 0.97
Diesel exhaust particles modulate the tight junction protein occludin in lung cells in vitro. Part Fibre Toxicol (2009) 0.96
Different response to eccentric and concentric training in older men and women. Eur J Appl Physiol (2009) 0.94
Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function. Proc Natl Acad Sci U S A (2011) 0.94
The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals. Nucl Recept (2004) 0.93
Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology. Semin Immunopathol (2013) 0.93
Statin therapy and the expression of genes that regulate calcium homeostasis and membrane repair in skeletal muscle. Am J Pathol (2010) 0.93
PGC-1 coactivators and the regulation of skeletal muscle fiber-type determination. Cell Metab (2011) 0.93
Electric pulse stimulation of cultured murine muscle cells reproduces gene expression changes of trained mouse muscle. PLoS One (2010) 0.93
Disruption of the histidine triad nucleotide-binding hint2 gene in mice affects glycemic control and mitochondrial function. Hepatology (2013) 0.91
ApoE-/- PGC-1α-/- mice display reduced IL-18 levels and do not develop enhanced atherosclerosis. PLoS One (2010) 0.91
LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver. J Lipid Res (2005) 0.91
Endurance training modulates the muscular transcriptome response to acute exercise. Pflugers Arch (2005) 0.91
Effects of dietary fat on muscle substrates, metabolism, and performance in athletes. Med Sci Sports Exerc (2003) 0.91
The San Francisco declaration on research assessment. J Exp Biol (2013) 0.90
Long-term administration of L-carnitine to humans: effect on skeletal muscle carnitine content and physical performance. Clin Chim Acta (2002) 0.89
Transcriptional reprogramming during reloading of atrophied rat soleus muscle. Am J Physiol Regul Integr Comp Physiol (2005) 0.89
Coordinated balancing of muscle oxidative metabolism through PGC-1α increases metabolic flexibility and preserves insulin sensitivity. Biochem Biophys Res Commun (2011) 0.89
Identification of the xenosensors regulating human 5-aminolevulinate synthase. Proc Natl Acad Sci U S A (2004) 0.89
Phenotype of capillaries in skeletal muscle of nNOS-knockout mice. Am J Physiol Regul Integr Comp Physiol (2013) 0.88
Molecular mechanisms of muscle plasticity with exercise. Compr Physiol (2011) 0.88
Effect of GH on human skeletal muscle lipid metabolism in GH deficiency. Am J Physiol Endocrinol Metab (2008) 0.87
The synergistic action of a VEGF-receptor tyrosine-kinase inhibitor and a sensitizing PDGF-receptor blocker depends upon the stage of vascular maturation. Microcirculation (2008) 0.87
Ultrastructural changes in diaphragm neuromuscular junctions in a severe mouse model for Spinal Muscular Atrophy and their prevention by bifunctional U7 snRNA correcting SMN2 splicing. Neuromuscul Disord (2010) 0.86
The angiotensin converting enzyme insertion/deletion polymorphism alters the response of muscle energy supply lines to exercise. Eur J Appl Physiol (2013) 0.86
The impact of antioxidant supplements and endurance exercise on genes of the carbohydrate and lipid metabolism in skeletal muscle of mice. Cell Biochem Funct (2012) 0.86
Is hypoxia training good for muscles and exercise performance? Prog Cardiovasc Dis (2010) 0.85
Annexins as cell-type-specific markers in the developing chicken chorionallantoic membrane. Cell Tissue Res (2005) 0.85
Lethal toxin of Clostridium sordellii is associated with fatal equine atypical myopathy. Vet Microbiol (2010) 0.85
Hypoxia refines plasticity of mitochondrial respiration to repeated muscle work. Eur J Appl Physiol (2013) 0.84
Different molecular and structural adaptations with eccentric and conventional strength training in elderly men and women. Gerontology (2011) 0.84
PGC-1α determines light damage susceptibility of the murine retina. PLoS One (2012) 0.83
Transcriptional profiling of tissue plasticity: role of shifts in gene expression and technical limitations. J Appl Physiol (1985) (2005) 0.83
For a pragmatic approach to exercise studies. J Appl Physiol (1985) (2010) 0.83
Vascular endothelial growth factor is expressed in endothelial cells isolated from skeletal muscles of nitric oxide synthase knockout mice during prazosin-induced angiogenesis. Biochem Biophys Res Commun (2002) 0.83
The coactivator PGC-1α regulates skeletal muscle oxidative metabolism independently of the nuclear receptor PPARβ/δ in sedentary mice fed a regular chow diet. Diabetologia (2014) 0.82
Biologically relevant sex differences for fitness-related parameters in active octogenarians. Eur J Appl Physiol (2007) 0.82
Hypoxia-induced gene activity in disused oxidative muscle. Adv Exp Med Biol (2006) 0.82
Decrease in VEGF expression induces intussusceptive vascular pruning. Arterioscler Thromb Vasc Biol (2011) 0.82