Published in J Nucleic Acids on July 25, 2010
From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs). Angew Chem Int Ed Engl (2016) 0.82
Contrasting enantioselective DNA preference: chiral helical macrocyclic lanthanide complex binding to DNA. Nucleic Acids Res (2012) 0.79
CHEMICAL SELECTIVITY OF NUCLEOBASE ADDUCTION RELATIVE TO IN VIVO MUTATION SITES ON EXON 7 FRAGMENT OF P53 TUMOR SUPPRESSOR GENE. Chem Sci (2015) 0.78
Protein Recognition in Drug-Induced DNA Alkylation: When the Moonlight Protein GAPDH Meets S23906-1/DNA Minor Groove Adducts. Int J Mol Sci (2015) 0.77
Stress-induced DNA damage: a case study in diffuse large B-cell lymphoma. J R Soc Interface (2014) 0.75
Next-generation bis-locked nucleic acids with stacking linker and 2'-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes. Nucleic Acids Res (2016) 0.75
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA (2002) 80.37
Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. Nature (1953) 47.27
Predicting DNA duplex stability from the base sequence. Proc Natl Acad Sci U S A (1986) 21.73
The Biological Actions and Therapeutic Applications of the B-Chloroethyl Amines and Sulfides. Science (1946) 18.24
Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. Annu Rev Biochem (1997) 9.83
The DNA replication fork in eukaryotic cells. Annu Rev Biochem (1998) 6.66
Mechanisms of helicase-catalyzed DNA unwinding. Annu Rev Biochem (1996) 5.81
Repair of DNA interstrand cross-links. Mutat Res (2001) 3.92
Strong minor groove base conservation in sequence logos implies DNA distortion or base flipping during replication and transcription initiation. Nucleic Acids Res (2001) 3.77
DNA modification and cancer. Annu Rev Biochem (1981) 3.67
Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism. Nature (2008) 3.62
Structural requirements for the binding of ethidium to nucleic acids. Biochim Biophys Acta (1966) 3.44
The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix. Nature (2008) 3.28
Mechanical separation of the complementary strands of DNA. Proc Natl Acad Sci U S A (1997) 3.25
Formation and repair of interstrand cross-links in DNA. Chem Rev (2006) 2.91
Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct. Proc Natl Acad Sci U S A (1996) 2.57
Loss of DNA mismatch repair in acquired resistance to cisplatin. Cancer Res (1996) 2.37
Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA. Nature (2008) 2.30
Structure of the DNA repair enzyme endonuclease IV and its DNA complex: double-nucleotide flipping at abasic sites and three-metal-ion catalysis. Cell (1999) 2.14
HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease. Proc Natl Acad Sci U S A (1994) 2.12
Cross-talk between nucleotide excision and homologous recombination DNA repair pathways in the mechanism of action of antitumor trabectedin. Cancer Res (2006) 1.94
The biology of eukaryotic promoter prediction--a review. Comput Chem (1999) 1.93
New metal complexes as potential therapeutics. Curr Opin Chem Biol (2003) 1.89
Nucleic acid helix-coil transitions mediated by helix-unwinding proteins from calf thymus. J Biol Chem (1976) 1.75
High base pair opening rates in tracts of GC base pairs. J Biol Chem (1999) 1.73
DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata. Biochemistry (1996) 1.73
Flipping of alkylated DNA damage bridges base and nucleotide excision repair. Nature (2009) 1.70
DNA unwinding produced by site-specific intrastrand cross-links of the antitumor drug cis-diamminedichloroplatinum(II). Biochemistry (1991) 1.68
Solution conformation of the major adduct between the carcinogen (+)-anti-benzo[a]pyrene diol epoxide and DNA. Proc Natl Acad Sci U S A (1992) 1.65
Opening of nucleic-acid double strands by helicases: active versus passive opening. Phys Rev E Stat Nonlin Soft Matter Phys (2005) 1.62
Poor base stacking at DNA lesions may initiate recognition by many repair proteins. DNA Repair (Amst) (2006) 1.61
Dynamic opening of DNA during the enzymatic search for a damaged base. Nat Struct Mol Biol (2004) 1.60
DNA dynamically directs its own transcription initiation. Nucleic Acids Res (2004) 1.59
Energetics of the strand separation transition in superhelical DNA. J Mol Biol (1992) 1.53
NMR solution structure of a DNA dodecamer duplex containing a cis-diammineplatinum(II) d(GpG) intrastrand cross-link, the major adduct of the anticancer drug cisplatin. Biochemistry (1998) 1.48
Sites of predicted stress-induced DNA duplex destabilization occur preferentially at regulatory loci. Proc Natl Acad Sci U S A (1993) 1.48
Platinum complexes as anticancer agents. Recent Pat Anticancer Drug Discov (2006) 1.45
Sequence-dependent elastic properties of DNA. J Mol Biol (2000) 1.43
The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin. Chem Biol (1996) 1.42
DNA modifications by antitumor platinum and ruthenium compounds: their recognition and repair. Prog Nucleic Acid Res Mol Biol (2002) 1.39
Sequence-dependent base pair opening in DNA double helix. Biophys J (2006) 1.38
Intercalators as anticancer drugs. Curr Pharm Des (2001) 1.36
DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy. DNA Repair (Amst) (2007) 1.36
Interaction of daunomycin and its derivatives with DNA. Biochim Biophys Acta (1972) 1.34
Crystal structure of a double-stranded DNA containing a cisplatin interstrand cross-link at 1.63 A resolution: hydration at the platinated site. Nucleic Acids Res (1999) 1.33
Duplex destabilization in superhelical DNA is predicted to occur at specific transcriptional regulatory regions. J Mol Biol (1996) 1.32
Structure and mechanism for DNA lesion recognition. Cell Res (2008) 1.30
Strand opening by the UvrA(2)B complex allows dynamic recognition of DNA damage. EMBO J (1999) 1.29
Studies on the structure of mouse helix-destabilizing protein-1. DNA binding and controlled proteolysis with trypsin. J Biol Chem (1980) 1.28
The human DNA repair factor XPC-HR23B distinguishes stereoisomeric benzo[a]pyrenyl-DNA lesions. EMBO J (2007) 1.28
The major metabolite of equilin, 4-hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-hydroxyequilenin-o-quinone. Chem Res Toxicol (1999) 1.26
DNA interactions of monofunctional organometallic ruthenium(II) antitumor complexes in cell-free media. Biochemistry (2003) 1.25
DNA binding mode of ruthenium complexes and relationship to tumor cell toxicity. Drug Resist Updat (2006) 1.25
Sequence-dependent distortions induced in DNA by monofunctional platinum(II) binding. Biochemistry (1992) 1.24
Role of high mobility group (HMG) chromatin proteins in DNA repair. DNA Repair (Amst) (2005) 1.24
Solution conformation of the (+)-cis-anti-[BP]dG adduct in a DNA duplex: intercalation of the covalently attached benzo[a]pyrenyl ring into the helix and displacement of the modified deoxyguanosine. Biochemistry (1993) 1.24
Ruthenium complexes as anticancer agents. Curr Med Chem (2006) 1.22
Detection of estrogen DNA-adducts in human breast tumor tissue and healthy tissue by combined nano LC-nano ES tandem mass spectrometry. J Am Soc Mass Spectrom (2003) 1.21
Alkylation of 2'-deoxynucleosides and DNA by the Premarin metabolite 4-hydroxyequilenin semiquinone radical. Chem Res Toxicol (1998) 1.20
DNA bending by the human damage recognition complex XPC-HR23B. DNA Repair (Amst) (2003) 1.20
Influence of cisplatin intrastrand crosslinking on the conformation, thermal stability, and energetics of a 20-mer DNA duplex. Proc Natl Acad Sci U S A (1996) 1.20
A model for initial DNA lesion recognition by NER and MMR based on local conformational flexibility. DNA Repair (Amst) (2004) 1.17
DNA structural dynamics: longitudinal breathing as a possible mechanism for the B in equilibrium Z transition. Nucleic Acids Res (1983) 1.16
Role of quinoids in estrogen carcinogenesis. Chem Res Toxicol (1998) 1.15
DNA conformational change produced by the site-specific interstrand cross-link of trans-diamminedichloroplatinum(II). Biochemistry (1993) 1.15
An aromatic sensor with aversion to damaged strands confers versatility to DNA repair. PLoS Biol (2007) 1.13
Nonhistone proteins HMG1 and HMG2 unwind DNA double helix. Nucleic Acids Res (1979) 1.13
Hierarchy of DNA damage recognition in Escherichia coli nucleotide excision repair. Biochemistry (2001) 1.11
Extending nature's leads: the anticancer agent ellipticine. Curr Med Chem Anticancer Agents (2004) 1.11
The sequence dependence of human nucleotide excision repair efficiencies of benzo[a]pyrene-derived DNA lesions: insights into the structural factors that favor dual incisions. J Mol Biol (2009) 1.10
Molecular dynamics of a kappaB DNA element: base flipping via cross-strand intercalative stacking in a microsecond-scale simulation. Nucleic Acids Res (2008) 1.10
Equine estrogen metabolite 4-hydroxyequilenin induces DNA damage in the rat mammary tissues: formation of single-strand breaks, apurinic sites, stable adducts, and oxidized bases. Chem Res Toxicol (2001) 1.09
Intercalative binding of ellipticine to DNA. Cancer Res (1975) 1.09
Processive translocation mechanism of the human Bloom's syndrome helicase along single-stranded DNA. Nucleic Acids Res (2010) 1.08
Conserved DNA structures in origins of replication. Nucleic Acids Res (1990) 1.07
Quinoids, quinoid radicals, and phenoxyl radicals formed from estrogens and antiestrogens. Toxicology (2002) 1.06
Resonant and localized breathing modes in terminal regions of the DNA double helix. Biophys J (1981) 1.06
Role of base flipping in specific recognition of damaged DNA by repair enzymes. J Mol Biol (2002) 1.05
AlkB demethylases flip out in different ways. DNA Repair (Amst) (2008) 1.05
Atomistic view of base flipping in DNA. Philos Trans A Math Phys Eng Sci (2004) 1.05
Differing roles of the N- and C-terminal zinc fingers in human immunodeficiency virus nucleocapsid protein-enhanced nucleic acid annealing. J Biol Chem (2003) 1.04
Nonhistone chromosomal protein HMG 1 interactions with DNA. Fluorescence and thermal denaturation studies. J Biol Chem (1985) 1.04
Thermostability of double-stranded deoxyribonucleic acids: effects of covalent additions of a psoralen. Biochemistry (1986) 1.04
Base flipping in nucleotide excision repair. J Biol Chem (2005) 1.02
Conformation of DNA modified at a d(GG) or a d(AG) site by the antitumor drug cis-diamminedichloroplatinum(II). Biochemistry (1989) 1.01
Mechanism of monofunctional and bifunctional alkylation of DNA by mitomycin C. Biochemistry (1988) 1.00
Base sequence-independent distorsions induced by interstrand cross-links in cis-diamminedichloroplatinum (II)-modified DNA. Nucleic Acids Res (1994) 1.00
HMG domain proteins induce sharp bends in cisplatin-modified DNA. Biochemistry (1994) 1.00
Solution structures of psoralen monoadducted and cross-linked DNA oligomers by NMR spectroscopy and restrained molecular dynamics. Biochemistry (1995) 1.00
Sequence sensitivity of breathing dynamics in heteropolymer DNA. Phys Rev Lett (2006) 1.00
DNA sequence context modulates the impact of a cisplatin 1,2-d(GpG) intrastrand cross-link on the conformational and thermodynamic properties of duplex DNA. J Mol Biol (2000) 0.99
Base selectivity and effects of sequence and DNA secondary structure on the formation of covalent adducts derived from the equine estrogen metabolite 4-hydroxyequilenin. Chem Res Toxicol (2005) 0.99
The cost of DNA bending. Trends Biochem Sci (2009) 0.98
Human testis-determining factor SRY binds to the major DNA adduct of cisplatin and a putative target sequence with comparable affinities. Biochemistry (1998) 0.98
Conformation of DNA modified by monofunctional Ru(II) arene complexes: recognition by DNA binding proteins and repair. Relationship to cytotoxicity. Chem Biol (2005) 0.98
Correlations between scaffold/matrix attachment region (S/MAR) binding activity and DNA duplex destabilization energy. J Mol Biol (2005) 0.98
DNA mismatch-specific base flipping by a bisacridine macrocycle. Chembiochem (2003) 0.98
Dynamic two-stage mechanism of versatile DNA damage recognition by xeroderma pigmentosum group C protein. Mutat Res (2009) 0.97
Damage detection and base flipping in direct DNA alkylation repair. Chembiochem (2009) 0.96
Exocyclic amino groups of flanking guanines govern sequence-dependent adduct conformations and local structural distortions for minor groove-aligned benzo[a]pyrenyl-guanine lesions in a GG mutation hotspot context. Nucleic Acids Res (2007) 0.96
Synthesis, antitumor activity, and mechanism of action of benzo[a]pyrano[3,2-h]acridin-7-one analogues of acronycine. J Med Chem (2006) 1.12
Direct inhibition of the DNA-binding activity of POU transcription factors Pit-1 and Brn-3 by selective binding of a phenyl-furan-benzimidazole dication. Nucleic Acids Res (2008) 1.04
Design of DNA minor groove binding diamidines that recognize GC base pair sequences: a dimeric-hinge interaction motif. J Am Chem Soc (2007) 1.02
DNA minor groove induced dimerization of heterocyclic cations: compound structure, binding affinity, and specificity for a TTAA site. J Mol Biol (2010) 0.96
Antitumor activity, X-ray crystal structure, and DNA binding properties of thiocoraline A, a natural bisintercalating thiodepsipeptide. J Med Chem (2007) 0.95
Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines. Nucleic Acids Res (2012) 0.95
Water-mediated binding of agents that target the DNA minor groove. J Am Chem Soc (2011) 0.94
Generation of replication-dependent double-strand breaks by the novel N2-G-alkylator S23906-1. Cancer Res (2006) 0.84
Novel stable camptothecin derivatives replacing the E-ring lactone by a ketone function are potent inhibitors of topoisomerase I and promising antitumor drugs. Mol Pharmacol (2007) 0.84
The unusual monomer recognition of guanine-containing mixed sequence DNA by a dithiophene heterocyclic diamidine. Biochemistry (2014) 0.82
Synthesis and biological evaluation of N-substituted benzo[c]phenanthrolines and benzo[c]phenanthrolinones as antiproliferative agents. Eur J Med Chem (2011) 0.81
Structure-dependent binding of arylimidamides to the DNA minor groove. Chembiochem (2013) 0.81
Further insight into the DNA recognition mechanism of trabectedin from the differential affinity of its demethylated analogue ecteinascidin ET729 for the triplet DNA binding site CGA. J Med Chem (2006) 0.81
Novel substituted benzothiophene and thienothiophene carboxanilides and quinolones: synthesis, photochemical synthesis, DNA-binding properties, antitumor evaluation and 3D-derived QSAR analysis. J Med Chem (2012) 0.80
Protein recognition of the S23906-1-DNA adduct by nuclear proteins: direct involvement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Biochem J (2013) 0.79
Photochemical electrocyclisation of 3-vinylindoles to pyrido[2,3-a]-, pyrido[4,3-a]- and thieno[2,3-a]-carbazoles: design, synthesis, DNA binding and antitumor cell cytotoxicity. Eur J Med Chem (2009) 0.78
Structure-activity relationships and mechanism of action of antitumor bis 8-hydroxyquinoline substituted benzylamines. Eur J Med Chem (2009) 0.78
Amino- and glycoconjugates of pyrido[4,3,2-kl]acridine. Synthesis, antitumor activity, and DNA binding. Bioorg Med Chem (2006) 0.78
Novel diamidino-substituted derivatives of phenyl benzothiazolyl and dibenzothiazolyl furans and thiophenes: synthesis, antiproliferative and DNA binding properties. J Med Chem (2010) 0.77
Rebeccamycin derivatives as dual DNA-damaging agents and potent checkpoint kinase 1 inhibitors. Mol Pharmacol (2008) 0.77
In vitro anticancer activity, toxicity and structure-activity relationships of phyllostictine A, a natural oxazatricycloalkenone produced by the fungus Phyllosticta cirsii. Toxicol Appl Pharmacol (2011) 0.77
Synthesis and biological activities of 7-aza rebeccamycin analogues bearing the sugar moiety on the nitrogen of the pyridine ring. Bioorg Med Chem (2006) 0.77
New anticancer active and selective phenylene-bisbenzothiazoles: synthesis, antiproliferative evaluation and DNA binding. Eur J Med Chem (2013) 0.77
Synthesis, antitumor activity, and mechanism of action of benzo[b]chromeno[6,5-g][1,8]naphthyridin-7-one analogs of acronycine. J Med Chem (2014) 0.77
Structure-activity relationships and mechanism of action of antitumor benzo[b]pyrano[3,2-h]acridin-7-one acronycine analogues. J Med Chem (2003) 0.76
Topoisomerase I-mediated DNA relaxation as a tool to study intercalation of small molecules into supercoiled DNA. Methods Mol Biol (2010) 0.76
Influence of the stereoisomeric position of the reactive acetate groups of the benzo[b]acronycine derivative S23906-1 on its DNA alkylation, helix-opening, cytotoxic, and antitumor activities. Mol Pharmacol (2009) 0.76
Design, synthesis, and DNA-binding of N-alkyl(anilino)quinazoline derivatives. J Med Chem (2010) 0.75
Synthesis, cytotoxic activity, and DNA binding properties of antitumor cis-1,2-dihydroxy-1,2-dihydrobenzo[b]acronycine cinnamoyl esters. Bioorg Med Chem (2009) 0.75
Rational design of bisubstrate-type analogs as inhibitors of DNA methyltransferases in cancer cells. J Med Chem (2017) 0.75
Synthesis, cytotoxic activity, and mechanism of action of furo[2,3-c]acridin-6-one and benzo[b]furo[3,2-h]acridin-6-one analogues of psorospermin and acronycine. J Med Chem (2008) 0.75
Design, synthesis, and cytotoxic activity of Michael acceptors and enol esters in the benzo[b]acronycine series. Chem Pharm Bull (Tokyo) (2005) 0.75
Synthesis and biological evaluation of dialkylaminoalkylamino benzo[c][1,7] and [1,8]phenanthrolines as antiproliferative agents. Eur J Med Chem (2010) 0.75