Published in Nature on September 03, 2008
Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Nat Rev Genet (2010) 15.70
Conservation and divergence of methylation patterning in plants and animals. Proc Natl Acad Sci U S A (2010) 7.30
Epigenetic inheritance during the cell cycle. Nat Rev Mol Cell Biol (2009) 4.43
Rethinking how DNA methylation patterns are maintained. Nat Rev Genet (2009) 4.03
Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation. Nucleic Acids Res (2012) 2.55
Mammalian cytosine methylation at a glance. J Cell Sci (2009) 2.43
Regulation and function of DNA methylation in plants and animals. Cell Res (2011) 2.41
Selective anchoring of DNA methyltransferases 3A and 3B to nucleosomes containing methylated DNA. Mol Cell Biol (2009) 2.34
A common mode of recognition for methylated CpG. Trends Biochem Sci (2013) 2.28
Regulation of imprinted gene expression in Arabidopsis endosperm. Proc Natl Acad Sci U S A (2011) 2.01
Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells. EMBO Rep (2009) 1.89
Recognition of 5-hydroxymethylcytosine by the Uhrf1 SRA domain. PLoS One (2011) 1.88
Interpreting the language of histone and DNA modifications. Biochim Biophys Acta (2014) 1.80
Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Nat Struct Mol Biol (2012) 1.77
DNA methylation and its basic function. Neuropsychopharmacology (2012) 1.76
Coordinated chromatin control: structural and functional linkage of DNA and histone methylation. Biochemistry (2010) 1.74
Emerging roles for chromatin as a signal integration and storage platform. Nat Rev Mol Cell Biol (2013) 1.65
UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9. Nat Commun (2013) 1.61
Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1). Proc Natl Acad Sci U S A (2011) 1.52
SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation. Nature (2014) 1.51
UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma. Cancer Cell (2014) 1.50
UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications. Epigenetics (2009) 1.45
Molecular coupling of DNA methylation and histone methylation. Epigenomics (2010) 1.43
A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo. Genes Dev (2011) 1.43
An atomic model of Zfp57 recognition of CpG methylation within a specific DNA sequence. Genes Dev (2012) 1.38
Disruption of Dnmt1/PCNA/UHRF1 interactions promotes tumorigenesis from human and mice glial cells. PLoS One (2010) 1.37
The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain. Nat Commun (2011) 1.37
Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication. Nature (2013) 1.35
ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection. Biochem Soc Trans (2013) 1.30
Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation. Genes Dev (2013) 1.30
Keeping it in the family: diverse histone recognition by conserved structural folds. Crit Rev Biochem Mol Biol (2010) 1.29
DNA methylation pathways and their crosstalk with histone methylation. Nat Rev Mol Cell Biol (2015) 1.29
Understanding the relationship between DNA methylation and histone lysine methylation. Biochim Biophys Acta (2014) 1.23
Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1. Proc Natl Acad Sci U S A (2012) 1.22
The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1. J Biol Chem (2011) 1.22
Trans-generational epigenetic regulation of C. elegans primordial germ cells. Epigenetics Chromatin (2010) 1.22
Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein Kaiso. Proc Natl Acad Sci U S A (2012) 1.18
UHRF1 is a novel diagnostic marker of lung cancer. Br J Cancer (2010) 1.18
UHRF1 is a novel molecular marker for diagnosis and the prognosis of bladder cancer. Br J Cancer (2009) 1.18
Dynamic instability of genomic methylation patterns in pluripotent stem cells. Epigenetics Chromatin (2010) 1.15
Cytosine methylation alters DNA mechanical properties. Nucleic Acids Res (2011) 1.12
UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis. Biochem J (2011) 1.11
S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance. Cell Res (2011) 1.09
The UHRF1 protein stimulates the activity and specificity of the maintenance DNA methyltransferase DNMT1 by an allosteric mechanism. J Biol Chem (2013) 1.08
Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties. J Exp Clin Cancer Res (2011) 1.07
Computational identification of novel biochemical systems involved in oxidation, glycosylation and other complex modifications of bases in DNA. Nucleic Acids Res (2013) 1.06
Mechanism of DNA methylation-directed histone methylation by KRYPTONITE. Mol Cell (2014) 1.05
Cooperative DNA and histone binding by Uhrf2 links the two major repressive epigenetic pathways. J Cell Biochem (2011) 1.05
Histone demethylases and cancer. Adv Cancer Res (2009) 1.05
The DNA methyltransferase Dnmt1 directly interacts with the SET and RING finger-associated (SRA) domain of the multifunctional protein Uhrf1 to facilitate accession of the catalytic center to hemi-methylated DNA. J Biol Chem (2013) 1.05
The recognition domain of the methyl-specific endonuclease McrBC flips out 5-methylcytosine. Nucleic Acids Res (2012) 1.03
Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9. Nature (2015) 1.03
A SILAC-based screen for Methyl-CpG binding proteins identifies RBP-J as a DNA methylation and sequence-specific binding protein. PLoS One (2011) 1.03
Molecular and enzymatic profiles of mammalian DNA methyltransferases: structures and targets for drugs. Curr Med Chem (2010) 0.99
Dnmt1/Transcription factor interactions: an alternative mechanism of DNA methylation inheritance. Genes Cancer (2010) 0.99
Structure and cleavage activity of the tetrameric MspJI DNA modification-dependent restriction endonuclease. Nucleic Acids Res (2012) 0.98
UHRF1 phosphorylation by cyclin A2/cyclin-dependent kinase 2 is required for zebrafish embryogenesis. Mol Biol Cell (2011) 0.97
DNA methylation, its mediators and genome integrity. Int J Biol Sci (2015) 0.96
The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein. Oncogene (2012) 0.96
The lytic phase of epstein-barr virus requires a viral genome with 5-methylcytosine residues in CpG sites. J Virol (2011) 0.95
The Roles of the Methyl-CpG Binding Proteins in Cancer. Genes Cancer (2011) 0.94
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The PHD finger of human UHRF1 reveals a new subgroup of unmethylated histone H3 tail readers. PLoS One (2011) 0.92
An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1. Cell Rep (2015) 0.91
Dissection of cell cycle-dependent dynamics of Dnmt1 by FRAP and diffusion-coupled modeling. Nucleic Acids Res (2013) 0.90
Unlocking epigenetic codes in neurogenesis. Genes Dev (2014) 0.89
DNA damage regulates UHRF1 stability via the SCF(β-TrCP) E3 ligase. Mol Cell Biol (2013) 0.89
A discontinuous DNA glycosylase domain in a family of enzymes that excise 5-methylcytosine. Nucleic Acids Res (2010) 0.88
Crystal structure of the 5hmC specific endonuclease PvuRts1I. Nucleic Acids Res (2014) 0.88
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Differential binding of Escherichia coli McrA protein to DNA sequences that contain the dinucleotide m5CpG. Nucleic Acids Res (2009) 0.87
Structure of 5-hydroxymethylcytosine-specific restriction enzyme, AbaSI, in complex with DNA. Nucleic Acids Res (2014) 0.86
On how mammalian transcription factors recognize methylated DNA. Epigenetics (2013) 0.86
Structure and mutagenesis of the DNA modification-dependent restriction endonuclease AspBHI. Sci Rep (2014) 0.86
Depletion of Uhrf1 inhibits chromosomal DNA replication in Xenopus egg extracts. Nucleic Acids Res (2013) 0.86
Structural biology-based insights into combinatorial readout and crosstalk among epigenetic marks. Biochim Biophys Acta (2014) 0.85
Epigenetics, development, and cancer: zebrafish make their mark.. Birth Defects Res C Embryo Today (2011) 0.85
Frequent SOCS3 and 3OST2 promoter methylation and their epigenetic regulation in endometrial carcinoma. Am J Cancer Res (2014) 0.84
The nuclear protein UHRF2 is a direct target of the transcription factor E2F1 in the induction of apoptosis. J Biol Chem (2013) 0.84
DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos. Development (2015) 0.84
TET proteins and 5-methylcytosine oxidation in the immune system. Cold Spring Harb Symp Quant Biol (2014) 0.84
Methylation Profiling of Multiple Tumor Suppressor Genes in Hepatocellular Carcinoma and the Epigenetic Mechanism of 3OST2 Regulation. J Cancer (2015) 0.83
A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice. Nat Commun (2016) 0.82
DNA-Destabilizing Agents as an Alternative Approach for Targeting DNA: Mechanisms of Action and Cellular Consequences. J Nucleic Acids (2010) 0.81
Negative regulation of the acetyltransferase TIP60-p53 interplay by UHRF1 (ubiquitin-like with PHD and RING finger domains 1). J Biol Chem (2013) 0.81
Age dependent changes in the LPS induced transcriptome of bovine dermal fibroblasts occurs without major changes in the methylome. BMC Genomics (2015) 0.81
Structural basis for the substrate selectivity of PvuRts1I, a 5-hydroxymethylcytosine DNA restriction endonuclease. Acta Crystallogr D Biol Crystallogr (2014) 0.81
H3K9 methyltransferase G9a negatively regulates UHRF1 transcription during leukemia cell differentiation. Nucleic Acids Res (2015) 0.80
Prostate cancer epigenetics and its clinical implications. Asian J Androl (2016) 0.80
UHRF1 Links the Histone code and DNA Methylation to ensure Faithful Epigenetic Memory Inheritance. Genet Epigenet (2010) 0.80
Modification-dependent restriction endonuclease, MspJI, flips 5-methylcytosine out of the DNA helix. Nucleic Acids Res (2014) 0.80
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Cellular response to DNA interstrand crosslinks: the Fanconi anemia pathway. Cell Mol Life Sci (2016) 0.79
Uhrf1 controls the self-renewal versus differentiation of hematopoietic stem cells by epigenetically regulating the cell-division modes. Proc Natl Acad Sci U S A (2016) 0.79
DNA Base Flipping: A General Mechanism for Writing, Reading, and Erasing DNA Modifications. Adv Exp Med Biol (2016) 0.78
Conserved linker regions and their regulation determine multiple chromatin-binding modes of UHRF1. Nucleus (2015) 0.78
Topoisomerase II regulates the maintenance of DNA methylation. J Biol Chem (2014) 0.78
Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition. Nat Commun (2016) 0.78
Reading between the Lines: "ADD"-ing Histone and DNA Methylation Marks toward a New Epigenetic "Sum". ACS Chem Biol (2015) 0.78
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