Published in J Am Chem Soc on June 15, 2011
Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines. Nucleic Acids Res (2012) 0.95
Minor groove to major groove, an unusual DNA sequence-dependent change in bend directionality by a distamycin dimer. Biochemistry (2011) 0.94
Small-molecule binding to the DNA minor groove is mediated by a conserved water cluster. J Am Chem Soc (2013) 0.89
Correlation of local effects of DNA sequence and position of β-alanine inserts with polyamide-DNA complex binding affinities and kinetics. Biochemistry (2012) 0.88
Structure-based DNA-targeting strategies with small molecule ligands for drug discovery. Med Res Rev (2013) 0.84
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Anticancer, antioxidant activities, and DNA affinity of novel monocationic bithiophenes and analogues. Drug Des Devel Ther (2014) 0.77
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A modular design for minor groove binding and recognition of mixed base pair sequences of DNA. Chem Commun (Camb) (2017) 0.75
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Heat capacity effects in protein folding and ligand binding: a re-evaluation of the role of water in biomolecular thermodynamics. Biophys Chem (2004) 1.38
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Thiophene-based diamidine forms a "super" at binding minor groove agent. J Am Chem Soc (2004) 1.18
Out-of-shape DNA minor groove binders: induced fit interactions of heterocyclic dications with the DNA minor groove. Biochemistry (2005) 1.12
Quantitative analysis of small molecule-nucleic acid interactions with a biosensor surface and surface plasmon resonance detection. Methods Mol Biol (2010) 1.11
A role for water molecules in DNA-ligand minor groove recognition. Acc Chem Res (2009) 1.10
Dicationic near-linear biphenyl benzimidazole derivatives as DNA-targeted antiprotozoal agents. Bioorg Med Chem (2005) 1.10
Circular dichroism to determine binding mode and affinity of ligand-DNA interactions. Nat Protoc (2007) 1.09
Extending the language of DNA molecular recognition by polyamides: unexpected influence of imidazole and pyrrole arrangement on binding affinity and specificity. J Am Chem Soc (2005) 1.06
Strong binding in the DNA minor groove by an aromatic diamidine with a shape that does not match the curvature of the groove. J Am Chem Soc (2002) 1.06
Direct inhibition of the DNA-binding activity of POU transcription factors Pit-1 and Brn-3 by selective binding of a phenyl-furan-benzimidazole dication. Nucleic Acids Res (2008) 1.04
Design of DNA minor groove binding diamidines that recognize GC base pair sequences: a dimeric-hinge interaction motif. J Am Chem Soc (2007) 1.02
Dicationic biphenyl benzimidazole derivatives as antiprotozoal agents. Bioorg Med Chem (2004) 1.01
Novel dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents. J Med Chem (2004) 1.01
Crystal structure of the DNA decamer d(CGCAATTGCG) complexed with the minor groove binding drug netropsin. Biochemistry (1997) 1.01
Large, sequence-dependent effects on DNA conformation by minor groove binding compounds. Nucleic Acids Res (2009) 1.00
DNA minor groove induced dimerization of heterocyclic cations: compound structure, binding affinity, and specificity for a TTAA site. J Mol Biol (2010) 0.96
Induced topological changes in DNA complexes: influence of DNA sequences and small molecule structures. Nucleic Acids Res (2011) 0.95
Synthesis, DNA binding, fluorescence measurements and antiparasitic activity of DAPI related diamidines. Bioorg Med Chem (2009) 0.92
Heterocyclic diamidine interactions at AT base pairs in the DNA minor groove: effects of heterocycle differences, DNA AT sequence and length. J Phys Chem B (2008) 0.91
Thermodynamic characterization of the multivalent binding of chartreusin to DNA. Nucleic Acids Res (2002) 0.89
Molecular dynamics of water-mediated interactions of a linear benzimidazole-biphenyl diamidine with the DNA minor groove. J Am Chem Soc (2009) 0.85
Polyamide curvature and DNA sequence selective recognition: use of 4-aminobenzamide to adjust curvature. Med Chem (2009) 0.78
Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell (2007) 8.99
Crystal structure of parallel quadruplexes from human telomeric DNA. Nature (2002) 8.90
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci (2006) 8.24
Quadruplex DNA: sequence, topology and structure. Nucleic Acids Res (2006) 6.42
Epigenetic regulation in psychiatric disorders. Nat Rev Neurosci (2007) 6.00
Highly prevalent putative quadruplex sequence motifs in human DNA. Nucleic Acids Res (2005) 5.34
Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron (2007) 4.96
Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? Nat Rev Drug Discov (2011) 3.54
Putative DNA quadruplex formation within the human c-kit oncogene. J Am Chem Soc (2005) 3.28
Loop-length-dependent folding of G-quadruplexes. J Am Chem Soc (2004) 3.16
Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron (2008) 3.01
Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins. Neuron (2009) 2.97
IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates. Nat Neurosci (2006) 2.71
A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene. Biochemistry (2006) 2.62
A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc Natl Acad Sci U S A (2010) 2.57
Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure. J Neurosci (2008) 2.34
Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures. J Neurosci (2004) 2.30
Crystal structure of the potassium form of an Oxytricha nova G-quadruplex. J Mol Biol (2002) 2.29
Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter. J Am Chem Soc (2007) 2.26
Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward. J Neurosci (2009) 2.25
Imipramine treatment and resiliency exhibit similar chromatin regulation in the mouse nucleus accumbens in depression models. J Neurosci (2009) 2.18
An essential role for DeltaFosB in the nucleus accumbens in morphine action. Nat Neurosci (2006) 2.17
The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the Ikappa B kinase complex. J Biol Chem (2002) 2.13
CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits. Nat Neurosci (2009) 2.11
Antiparasitic compounds that target DNA. Biochimie (2008) 2.00
Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test. Lancet (2005) 1.94
Telomestatin and diseleno sapphyrin bind selectively to two different forms of the human telomeric G-quadruplex structure. J Am Chem Soc (2005) 1.87
The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Res (2005) 1.84
qDTY₁.₁, a major QTL for rice grain yield under reproductive-stage drought stress with a consistent effect in multiple elite genetic backgrounds. BMC Genet (2011) 1.76
G-quadruplex nucleic acids as therapeutic targets. Curr Opin Chem Biol (2009) 1.74
New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289. Antimicrob Agents Chemother (2009) 1.73
Dications that target the DNA minor groove: compound design and preparation, DNA interactions, cellular distribution and biological activity. Curr Med Chem Anticancer Agents (2005) 1.66
Epigenetics in the nervous system. J Neurosci (2008) 1.65
Role of 68Ga-DOTATOC PET/CT in initial evaluation of patients with suspected bronchopulmonary carcinoid. Eur J Nucl Med Mol Imaging (2014) 1.63
The influence of DeltaFosB in the nucleus accumbens on natural reward-related behavior. J Neurosci (2008) 1.58
Biosensor-surface plasmon resonance: quantitative analysis of small molecule-nucleic acid interactions. Methods (2007) 1.58
Accumulation and intracellular distribution of antitrypanosomal diamidine compounds DB75 and DB820 in African trypanosomes. Antimicrob Agents Chemother (2006) 1.57
Endoscope-assisted intubation: an approach to airway management. Anesth Analg (2007) 1.49
Structure of a G-quadruplex-ligand complex. J Mol Biol (2003) 1.49
Synthesis and antiprotozoal activity of aza-analogues of furamidine. J Med Chem (2003) 1.49
Meta-analysis of grain yield QTL identified during agricultural drought in grasses showed consensus. BMC Genomics (2011) 1.48
Novel arylimidamides for treatment of visceral leishmaniasis. Antimicrob Agents Chemother (2010) 1.45
Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells. PLoS One (2012) 1.45
Interleukin 1 activates STAT3/nuclear factor-kappaB cross-talk via a unique TRAF6- and p65-dependent mechanism. J Biol Chem (2003) 1.45
DNA sequence dependent monomer-dimer binding modulation of asymmetric benzimidazole derivatives. J Am Chem Soc (2004) 1.44
Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes. Antimicrob Agents Chemother (2007) 1.44
Diamidines for human African trypanosomiasis. Curr Opin Investig Drugs (2010) 1.42
Constitutive NF-kappaB activation, normal Fas-induced apoptosis, and increased incidence of lymphoma in human herpes virus 8 K13 transgenic mice. Proc Natl Acad Sci U S A (2005) 1.41
Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure. J Am Chem Soc (2005) 1.40
A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics. J Am Chem Soc (2009) 1.40
A National Analysis of Long-term Survival Following Thoracoscopic Versus Open Lobectomy for Stage I Non-small-cell Lung Cancer. Ann Surg (2017) 1.39
Pharmacokinetics and clinical utility of sodium bromide (NaBr) as an estimator of extracellular fluid volume in horses. J Vet Intern Med (2003) 1.38
Structural basis for binding of porphyrin to human telomeres. Biochemistry (2007) 1.37
Synthesis of some new 2-substituted-phenyl-1H-benzimidazole-5-carbonitriles and their potent activity against Candida species. Bioorg Med Chem (2002) 1.37
Concurrent benign schwannoma of oesophagus and posterior mediastinum. Interact Cardiovasc Thorac Surg (2009) 1.36
Induction of inducible cAMP early repressor expression in nucleus accumbens by stress or amphetamine increases behavioral responses to emotional stimuli. J Neurosci (2006) 1.35
Epigenetic mechanisms and gene networks in the nervous system. J Neurosci (2005) 1.33
Fine mapping of QTLs for rice grain yield under drought reveals sub-QTLs conferring a response to variable drought severities. Theor Appl Genet (2012) 1.33
A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. Mol Pharmacol (2002) 1.33
Structure-specific recognition of quadruplex DNA by organic cations: influence of shape, substituents and charge. Biophys Chem (2006) 1.32
Genetic, physiological, and gene expression analyses reveal that multiple QTL enhance yield of rice mega-variety IR64 under drought. PLoS One (2013) 1.32
Proteasome-dependent and -independent mechanisms for FosB destabilization: identification of FosB degron domains and implications for DeltaFosB stability. Eur J Neurosci (2007) 1.31
CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime]. Drug Metab Dispos (2006) 1.30
Structure of the first parallel DNA quadruplex-drug complex. J Am Chem Soc (2003) 1.26
Structural basis of DNA quadruplex recognition by an acridine drug. J Am Chem Soc (2008) 1.25
Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter. Nucleic Acids Res (2007) 1.24
A novel linear programming approach to fluence map optimization for intensity modulated radiation therapy treatment planning. Phys Med Biol (2003) 1.22
Comparative analysis of root transcriptome profiles of two pairs of drought-tolerant and susceptible rice near-isogenic lines under different drought stress. BMC Plant Biol (2011) 1.21
Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas' disease treatment. Antimicrob Agents Chemother (2010) 1.20
Early stress evokes age-dependent biphasic changes in hippocampal neurogenesis, BDNF expression, and cognition. Biol Psychiatry (2012) 1.19
Thiophene-based diamidine forms a "super" at binding minor groove agent. J Am Chem Soc (2004) 1.18
Role of nuclear factor kappaB in ovarian hormone-mediated stress hypersensitivity in female mice. Biol Psychiatry (2009) 1.17
Synthesis, DNA affinity, and antiprotozoal activity of linear dications: Terphenyl diamidines and analogues. J Med Chem (2006) 1.17
A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex. Nucleic Acids Res (2010) 1.16
Large spontaneous coronary artery dissections-a study of three cases, literature review, and possible therapeutic strategies. Angiology (2004) 1.16
Molecular dynamics and principal components analysis of human telomeric quadruplex multimers. Biophys J (2008) 1.16
Stabilization of G-quadruplex DNA and inhibition of telomerase activity by square-planar nickel(II) complexes. J Am Chem Soc (2006) 1.15
Selective recognition of G-qQuadruplex telomeric DNA by a bis(quinacridine) macrocycle. J Am Chem Soc (2003) 1.15
Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule. J Med Chem (2009) 1.15
Tinospora cordifolia (Willd.) Hook. f. and Thoms. (Guduchi) - validation of the Ayurvedic pharmacology through experimental and clinical studies. Int J Ayurveda Res (2010) 1.14
Liver abscess in children. Indian J Pediatr (2006) 1.14
Metabolic control analysis is helpful for informed genetic manipulation of oilseed rape (Brassica napus) to increase seed oil content. J Exp Bot (2008) 1.13
qDTY12.1: a locus with a consistent effect on grain yield under drought in rice. BMC Genet (2013) 1.12