Published in Mol Cell Biol on August 01, 1991
A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J (1998) 7.39
Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem J (2004) 3.01
Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase. EMBO J (1996) 2.38
Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase. Proc Natl Acad Sci U S A (1994) 2.00
Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation. Proc Natl Acad Sci U S A (1993) 1.95
Expression cloning of oncogenes by retroviral transfer of cDNA libraries. Mol Cell Biol (1995) 1.89
Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105. Mol Cell Biol (2004) 1.86
Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation. Mol Cell Biol (2000) 1.80
The COOH-terminal domain of wild-type Cot regulates its stability and kinase specific activity. Mol Cell Biol (2003) 1.45
Molecular cloning and characterization of a conserved nuclear serine(threonine) protein kinase. Proc Natl Acad Sci U S A (1995) 1.42
Mutational activation of the MAP3K8 protooncogene in lung cancer. Genes Chromosomes Cancer (2004) 1.42
Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription. Mol Cell Biol (2002) 1.39
A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation. J Clin Invest (2004) 1.24
Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase. Cell Res (2010) 1.20
Uncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivo. Mol Ther (2014) 1.13
The oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2. J Virol (2002) 1.03
Cot, a novel kinase of histone H3, induces cellular transformation through up-regulation of c-fos transcriptional activity. FASEB J (2007) 0.90
Cot kinase promotes Ca2+ oscillation/calcineurin-independent osteoclastogenesis by stabilizing NFATc1 protein. Mol Cell Biol (2012) 0.85
TPL2/COT/MAP3K8 (TPL2) activation promotes androgen depletion-independent (ADI) prostate cancer growth. PLoS One (2011) 0.85
Expression of MAP3 kinase COT1 is up-regulated by 1,25-dihydroxyvitamin D3 in parallel with activated c-jun during differentiation of human myeloid leukemia cells. J Steroid Biochem Mol Biol (2010) 0.82
RelB-induced expression of Cot, an MAP3K family member, rescues RANKL-induced osteoclastogenesis in alymphoplasia mice by promoting NF-κB2 processing by IKKα. J Biol Chem (2014) 0.81
Pharmacological inhibition of TPL2/MAP3K8 blocks human cytotoxic T lymphocyte effector functions. PLoS One (2014) 0.81
Altered prostanoid signaling contributes to increased skin tumorigenesis in Tpl2 knockout mice. PLoS One (2013) 0.80
Oncoprotein Cot1 represses kinase suppressors of Ras1/2 and 1,25-dihydroxyvitamin D3-induced differentiation of human acute myeloid leukemia cells. J Cell Physiol (2011) 0.78
Tpl2 knockout keratinocytes have increased biomarkers for invasion and metastasis. Carcinogenesis (2013) 0.77
TEC and MAPK Kinase Signalling Pathways in T helper (TH) cell Development, TH2 Differentiation and Allergic Asthma. J Clin Cell Immunol (2012) 0.77
MAP3K8/TPL-2/COT is a potential predictive marker for MEK inhibitor treatment in high-grade serous ovarian carcinomas. Nat Commun (2015) 0.76
Syrian hamster embryo cell lines useful for detecting transforming genes in mouse tumours: detection of transforming genes in X-ray-related mouse tumours. Br J Cancer (1993) 0.75
Involvement of MAP3K8 and miR-17-5p in poor virologic response to interferon-based combination therapy for chronic hepatitis C. PLoS One (2014) 0.75
Mycobacteria induce TPL-2 mediated IL-10 in IL-4-generated alternatively activated macrophages. PLoS One (2017) 0.75
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology (1973) 127.36
Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res (1984) 86.56
Rapid and sensitive protein similarity searches. Science (1985) 76.83
An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res (1987) 36.83
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science (1988) 35.59
Recognition of protein coding regions in DNA sequences. Nucleic Acids Res (1982) 28.91
Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell (1979) 21.15
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature (1984) 17.70
The sequence 5'-AAUAAA-3'forms parts of the recognition site for polyadenylation of late SV40 mRNAs. Cell (1981) 12.26
A thousand and one protein kinases. Cell (1987) 7.61
The codon preference plot: graphic analysis of protein coding sequences and prediction of gene expression. Nucleic Acids Res (1984) 6.98
Isolation of a transforming sequence from a human bladder carcinoma cell line. Cell (1982) 6.93
A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature (1986) 5.88
Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature (1984) 5.85
A new selective phage cloning vector, lambda 2001, with sites for XbaI, BamHI, HindIII, EcoRI, SstI and XhoI. Gene (1984) 5.29
Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells. Nature (1982) 4.30
The complete primary structure of protein kinase C--the major phorbol ester receptor. Science (1986) 4.02
Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene. Cell (1986) 3.59
Human DNA sequence homologous to the transforming gene (mos) of Moloney murine sarcoma virus. Proc Natl Acad Sci U S A (1982) 3.14
Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains. Cell (1986) 2.65
Guanosine cyclic 3',5'-phosphate dependent protein kinase, a chimeric protein homologous with two separate protein families. Biochemistry (1984) 2.62
Oncogenes in human tumor cell lines: molecular cloning of a transforming gene from human bladder carcinoma cells. Proc Natl Acad Sci U S A (1982) 2.55
The complete coding sequence of the human raf oncogene and the corresponding structure of the c-raf-1 gene. Nucleic Acids Res (1986) 2.50
Alphaherpesviruses possess a gene homologous to the protein kinase gene family of eukaryotes and retroviruses. Nucleic Acids Res (1986) 2.18
A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene. Proc Natl Acad Sci U S A (1984) 2.07
New cosmid vectors developed for eukaryotic DNA cloning. Gene (1984) 1.97
STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases. Mol Cell Biol (1991) 1.97
Molecular cloning of an activated human oncogene, homologous to v-raf, from primary stomach cancer. Proc Natl Acad Sci U S A (1985) 1.83
Isolation of a new human oncogene from a diffuse B-cell lymphoma. Nature (1985) 1.68
Human cellular src gene: nucleotide sequence and derived amino acid sequence of the region coding for the carboxy-terminal two-thirds of pp60c-src. Mol Cell Biol (1985) 1.46
New acceptor cell for transfected genomic DNA: oncogene transfer into a mouse mammary epithelial cell line. Mol Cell Biol (1985) 1.26
Distinctive transforming genes in x-ray-transformed mammalian cells. Proc Natl Acad Sci U S A (1987) 1.07
Molecular cloning of integrated Gardner-Rasheed feline sarcoma virus: genetic structure of its cell-derived sequence differs from that of other tyrosine kinase-coding onc genes. J Virol (1983) 1.05
Hamster cell line suitable for transfection assay of transforming genes. Proc Natl Acad Sci U S A (1990) 0.97
Transformation of human cells by DNAs ineffective in transformation of NIH 3T3 cells. Proc Natl Acad Sci U S A (1985) 0.93
Differential requirements of gag and gamma-actin domains for transforming potential of Gardner-Rasheed feline sarcoma virus. J Virol (1989) 0.88
Alteration of N-ras gene mutation after relapse in acute lymphoblastic leukemia. Blood (1990) 0.80
A novel repeated element with Z-DNA-forming potential is widely found in evolutionarily diverse eukaryotic genomes. Proc Natl Acad Sci U S A (1982) 8.15
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature (1997) 5.55
Molecular structure and evolutionary origin of human cardiac muscle actin gene. Proc Natl Acad Sci U S A (1982) 4.97
Molecular structure of the human cytoplasmic beta-actin gene: interspecies homology of sequences in the introns. Proc Natl Acad Sci U S A (1985) 4.80
Potential Z-DNA forming sequences are highly dispersed in the human genome. Nature (1982) 4.41
Characterization of genomic poly(dT-dG).poly(dC-dA) sequences: structure, organization, and conformation. Mol Cell Biol (1984) 3.42
Identification of a putative target for Rho as the serine-threonine kinase protein kinase N. Science (1996) 3.09
Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho. Science (1996) 2.99
Coexpression of a mutant beta-actin and the two normal beta- and gamma-cytoplasmic actins in a stably transformed human cell line. Cell (1980) 2.58
Neoplastic transformation of human diploid fibroblast cells by chemical carcinogens. Proc Natl Acad Sci U S A (1978) 2.24
Structure of a human smooth muscle actin gene (aortic type) with a unique intron site. Mol Cell Biol (1984) 2.11
Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus. J Biol Chem (1999) 2.10
Expression of a variant form of actin and additional polypeptide changes following chemical-induced in vitro neoplastic transformation of human fibroblasts. J Biol Chem (1980) 1.94
Variations in expression of mutant beta actin accompanying incremental increases in human fibroblast tumorigenicity. Cell (1982) 1.86
Histamine-induced vasoconstriction involves phosphorylation of a specific inhibitor protein for myosin phosphatase by protein kinase C alpha and delta isoforms. J Biol Chem (2001) 1.77
cDNA cloning of a calcineurin B homolog in Saccharomyces cerevisiae. Biochem Biophys Res Commun (1991) 1.68
Endoscopic treatment for laterally spreading tumors in the colon. Endoscopy (2001) 1.68
Salt-sensitive hypertension in endothelin-B receptor-deficient rats. J Clin Invest (2000) 1.65
GNE mutations causing distal myopathy with rimmed vacuoles with inflammation. Neurology (2003) 1.63
N (epsilon)-(carboxymethyl)lysine protein adduct is a major immunological epitope in proteins modified with advanced glycation end products of the Maillard reaction. Biochemistry (1996) 1.63
Phosphorylation of the retinoblastoma protein by cdk2. Proc Natl Acad Sci U S A (1992) 1.61
A quantitative system for assay of malignant transformation by chemical carcinogens using a clone derived from BALB-3T3. Int J Cancer (1973) 1.58
A phase II study of eribulin in Japanese patients with heavily pretreated metastatic breast cancer. Ann Oncol (2011) 1.54
Alpha-amylase from the hyperthermophilic archaebacterium Pyrococcus furiosus. Cloning and sequencing of the gene and expression in Escherichia coli. J Biol Chem (1993) 1.47
Intermolecular and interdomain interactions of a dynamin-related GTP-binding protein, Dnm1p/Vps1p-like protein. J Biol Chem (1999) 1.46
Comparison of spontaneous mutation rates of normal and chemically transformed human skin fibroblasts. Cancer Res (1983) 1.45
Two surgically cured cases of subependymoma with emphasis on magnetic resonance imaging. Surg Neurol (1990) 1.45
Delayed (18)F-fluoro-2-deoxy-D-glucose positron emission tomography scan for differentiation between malignant and benign lesions in the pancreas. Cancer (2000) 1.43
Mutated beta-actin gene: coexpression with an unmutated allele in a chemically transformed human fibroblast cell line. Proc Natl Acad Sci U S A (1981) 1.36
The SH3 domain of Crk binds specifically to a conserved proline-rich motif in Eps15 and Eps15R. J Biol Chem (1995) 1.36
Proteolytic activation of PKN by caspase-3 or related protease during apoptosis. Proc Natl Acad Sci U S A (1998) 1.31
Exocytosis in chromaffin cells. Possible involvement of the heterotrimeric GTP-binding protein G(o). J Biol Chem (1993) 1.31
Properties of hamster embryonic cells transformed by 4-nitroquinoline-1-oxide in vitro and their correlations with the malignant properties of the cells. Biken J (1968) 1.26
Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton. Proc Natl Acad Sci U S A (2000) 1.24
Isolation of two novel genes, down-regulated in gastric cancer. Jpn J Cancer Res (2000) 1.24
Structure, chromosome location, and expression of the human smooth muscle (enteric type) gamma-actin gene: evolution of six human actin genes. Mol Cell Biol (1991) 1.22
The diagnosis of pancreatic cancer by endoscopic ultrasonography. Gastrointest Endosc (1988) 1.21
Identification of the human beta-actin enhancer and its binding factor. Mol Cell Biol (1988) 1.21
Studies on the regulation of glutathione level in rat liver. J Biochem (1974) 1.20
Air ion effects on the oxygen consumption of barley seedlings. Nature (1965) 1.19
Staging of pancreatic carcinoma by endoscopic ultrasonography. Endoscopy (1993) 1.18
The interaction of phosphofructokinase with erythrocyte membranes. J Biol Chem (1979) 1.18
Association of immature hypophosphorylated protein kinase cepsilon with an anchoring protein CG-NAP. J Biol Chem (2000) 1.18
Gustatory neural responses in three different strains of mice. Brain Res (1984) 1.18
Hydroxyl radical mediates N epsilon-(carboxymethyl)lysine formation from Amadori product. Biochem Biophys Res Commun (1997) 1.17
Qualitative discrimination of gustatory stimuli in three different strains of mice. Brain Res (1984) 1.17
Studies on the formation of germ cells in a compound ascidian Botryllus primigenus Oka. J Morphol (1976) 1.17
A minor outer capsid protein, P9, of Rice dwarf virus. Arch Virol (2003) 1.16
The synthesis and turnover of rat liver peroxisomes. 3. The size distribution of peroxisomes and the incorporation of new catalase. J Cell Biol (1970) 1.15
Enhancement of calcium sensitivity of lipocortin I in phospholipid binding induced by limited proteolysis and phosphorylation at the amino terminus as analyzed by phospholipid affinity column chromatography. J Biol Chem (1989) 1.15
Macrophage scavenger receptor mediates the endocytic uptake and degradation of advanced glycation end products of the Maillard reaction. Eur J Biochem (1995) 1.15
Serum thrombopoietin level is mainly regulated by megakaryocyte mass rather than platelet mass in human subjects. Br J Haematol (1998) 1.14
Changes in gene expression accompanying chemically-induced malignant transformation of human fibroblasts. Carcinogenesis (1982) 1.14
Distinct cellular expression of calcineurin A alpha and A beta in rat brain. J Neurochem (1992) 1.12
Rat liver glutathione: possible role as a reservoir of cysteine. J Nutr (1977) 1.12
Cell transformation by chemical agents--a review and analysis of the literature. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat Res (1983) 1.11
Requirement for cell replication in the fixation and expression of the transformed state in mouse cells treated with 4-nitroquinoline-1-oxide. Int J Cancer (1974) 1.10
Characterization of the interaction between RhoA and the amino-terminal region of PKN. FEBS Lett (1996) 1.09
A novel physiological role of liver glutathione as a reservoir of L-cysteine. J Biochem (1977) 1.08
A novel point mutation at codon 146 of the K-ras gene in a human colorectal cancer identified by the polymerase chain reaction. Virus Genes (1991) 1.07
Cell variants showing differential susceptibility to ultraviolet light--induced transformation. Science (1980) 1.07
Shape memory alloy catheter system for peroral pancreatoscopy using an ultrathin-caliber endoscope. Endoscopy (1994) 1.07
Expression of membrane cofactor protein (MCP, CD46) in human liver diseases. Br J Cancer (1999) 1.07
L-type Ca(2+) channel-mediated Zn(2+) toxicity and modulation by ZnT-1 in PC12 cells. Brain Res (2000) 1.06
Hematopoietic stem cell transplantation for natural killer-cell lineage neoplasms. Bone Marrow Transplant (2006) 1.05
Transformation of bile acids by Clostridium perfringens. Appl Environ Microbiol (1981) 1.04
Evidence for a second isoform of the catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A). Biochem Biophys Res Commun (1989) 1.04
Crystal structure analysis of omega-amino acid:pyruvate aminotransferase with a newly developed Weissenberg camera and an imaging plate using synchrotron radiation. J Biochem (1989) 1.04
The multiple roles of macrophage scavenger receptors (MSR) in vivo: resistance to atherosclerosis and susceptibility to infection in MSR knockout mice. J Atheroscler Thromb (1997) 1.04
Identification of proacrosin binding protein sp32 precursor as a human cancer/testis antigen. Proc Natl Acad Sci U S A (2001) 1.04
PKN binds and phosphorylates human papillomavirus E6 oncoprotein. J Biol Chem (2000) 1.04
Sequential changes of extracellular matrix and proliferation of Ito cells with enhanced expression of desmin and actin in focal hepatic injury. Am J Pathol (1986) 1.04
The role of cell division in the malignant transformation of mouse cells treated with 3-methylcholanthrene. Cancer Res (1975) 1.02
Methyl p-hydroxybenzoate causes pain sensation through activation of TRPA1 channels. Br J Pharmacol (2007) 1.02
A mutation in actin associated with neoplastic transformation. Fed Proc (1984) 1.01
DNA bending and binding factors of the human beta-actin promoter. Nucleic Acids Res (1989) 1.01
Apoptosis and proliferation of human hepatocellular carcinoma. Liver (1996) 1.01
Detection of alcohol-tolerant hiochi bacteria by PCR. Appl Environ Microbiol (1994) 1.01
Advantage of gene gun-mediated over intramuscular inoculation of plasmid DNA vaccine in reproducible induction of specific immune responses. Vaccine (2000) 1.01
Ca2+/calmodulin-activated protein phosphatase (PP2B) of Saccharomyces cerevisiae. PP2B activity is not essential for growth. FEBS Lett (1992) 1.00
Interaction of the small G protein RhoA with the C terminus of human phospholipase D1. J Biol Chem (1999) 1.00
Reduced insulinotropic effects of glucagonlike peptide I-(7-36)-amide and gastric inhibitory polypeptide in isolated perfused diabetic rat pancreas. Diabetes (1990) 0.99
Distribution of dopamine-beta-hydroxylase in subcellular fractions of adrenal medulla. Life Sci (1967) 0.99
Amplification and specific detection of transforming gene region of human papillomavirus 16, 18 and 33 in cervical carcinoma by means of the polymerase chain reaction. Jpn J Cancer Res (1990) 0.99
Cellular distribution of transcripts for tissue inhibitor of metalloproteinases 1 and 2 in human hepatocellular carcinomas. Hepatology (1996) 0.99
Prediction of epidemic cholera due to Vibrio cholerae O1 in children younger than 10 years using climate data in Bangladesh. Epidemiol Infect (2007) 0.98
Cystadenocarcinoma (papillary cystadenocarcinoma) of the submandibular gland. J Laryngol Otol (2006) 0.98
Strong transcriptional promoter in the 5' upstream region of the human beta-actin gene. Gene (1988) 0.98
PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family. J Biochem (2001) 0.98
Mutational analysis of the regulatory mechanism of PKN: the regulatory region of PKN contains an arachidonic acid-sensitive autoinhibitory domain. J Biochem (1999) 0.98
Changes in human serum dopamine- -hydroxylase activity with age. Nature (1972) 0.98
Hamster cell line suitable for transfection assay of transforming genes. Proc Natl Acad Sci U S A (1990) 0.97
Phosphorylation of tau is regulated by PKN. J Biol Chem (2000) 0.97
Determinant factor for clearance of ceramic fibres from rat lungs. Br J Ind Med (1992) 0.97
The relationship of glycosylation and isoelectric point with tumor accumulation of avidin. J Nucl Med (1999) 0.96
The role of the unique motifs in the amino-terminal region of PKN on its enzymatic activity. Biochem Biophys Res Commun (1996) 0.96
Protooncogene expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus as an indicator of the disease activity. Clin Immunol Immunopathol (1987) 0.95
Comparative effects of GTPgammaS and insulin on the activation of Rho, phosphatidylinositol 3-kinase, and protein kinase N in rat adipocytes. Relationship to glucose transport. J Biol Chem (1998) 0.95
Butyltin residues in livers of humans and wild terrestrial mammals and in plastic products. Environ Pollut (1999) 0.95