Published in World J Gastroenterol on August 28, 2010
Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis. Cancer Res (2012) 1.71
Is tail vein injection a relevant breast cancer lung metastasis model? J Thorac Dis (2013) 1.11
Export of sphingosine-1-phosphate and cancer progression. J Lipid Res (2014) 1.09
Prognostic and survival analysis of 837 Chinese colorectal cancer patients. World J Gastroenterol (2013) 1.09
Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network. FASEB J (2012) 1.09
Recombinant human endostatin endostar suppresses angiogenesis and lymphangiogenesis of malignant pleural effusion in mice. PLoS One (2012) 1.00
Sphingosine-1-phosphate in chronic intestinal inflammation and cancer. Adv Biol Regul (2013) 1.00
Emerging Role of Sphingosine-1-phosphate in Inflammation, Cancer, and Lymphangiogenesis. Biomolecules (2013) 0.93
Bevacizumab and breast cancer: what does the future hold? Future Oncol (2012) 0.92
The role of sphingosine-1-phosphate in breast cancer tumor-induced lymphangiogenesis. Lymphat Res Biol (2012) 0.92
The role of lymphangiogenesis and angiogenesis in tumor metastasis. Cell Oncol (Dordr) (2016) 0.89
Sphingosine-1-phosphate transporters as targets for cancer therapy. Biomed Res Int (2014) 0.89
Advances in the management of peritoneal mesothelioma. World J Gastroenterol (2014) 0.87
Insulin-like growth factor-1 induces lymphangiogenesis and facilitates lymphatic metastasis in colorectal cancer. World J Gastroenterol (2013) 0.87
Natural history of hepatic metastases from colorectal cancer--pathobiological pathways with clinical significance. World J Gastroenterol (2014) 0.86
Twofer anti-vascular therapy targeting sphingosine-1-phosphate for breast cancer. Gland Surg (2012) 0.82
Photoacoustic imaging: a potential tool to detect early indicators of metastasis. Expert Rev Med Devices (2013) 0.80
High levels of sphingolipids in human breast cancer. J Surg Res (2016) 0.77
Breast cancer sphingosine-1-phosphate is associated with phospho-sphingosine kinase 1 and lymphatic metastasis. J Surg Res (2016) 0.77
Impact of the prolymphangiogenic crosstalk in the tumor microenvironment on lymphatic cancer metastasis. Biomed Res Int (2014) 0.77
The Amazing Power of Cancer Cells to Recapitulate Extraembryonic Functions: The Cuckoo's Tricks. J Oncol (2011) 0.76
Sphingosine-1-phosphate in the lymphatic fluid determined by novel methods. Heliyon (2016) 0.76
Is T790M mutation the key in development of resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs)? J Thorac Dis (2011) 0.75
Angiopoietin pathway gene expression associated with poor breast cancer survival. Breast Cancer Res Treat (2017) 0.75
Computational Identification of Novel Stage-Specific Biomarkers in Colorectal Cancer Progression. PLoS One (2016) 0.75
S1P Provokes Tumor Lymphangiogenesis via Macrophage-Derived Mediators Such as IL-1β or Lipocalin-2. Mediators Inflamm (2017) 0.75
Cancer statistics, 2009. CA Cancer J Clin (2009) 83.57
Tumor angiogenesis: therapeutic implications. N Engl J Med (1971) 35.36
Prox1 function is required for the development of the murine lymphatic system. Cell (1999) 7.57
Isolation of a tumor factor responsible for angiogenesis. J Exp Med (1971) 7.12
Lymphangiogenesis: Molecular mechanisms and future promise. Cell (2010) 5.84
Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis. Am J Pathol (2002) 4.66
PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis. Cancer Cell (2004) 4.12
VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis. J Exp Med (2005) 3.98
"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacol Rev (2008) 3.80
Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages. J Clin Invest (2005) 3.77
Vascular endothelial growth factor C induces angiogenesis in vivo. Proc Natl Acad Sci U S A (1998) 3.72
Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids). Fed Proc (1976) 3.19
Molecular mechanisms of lymphangiogenesis in health and disease. Cancer Cell (2002) 3.11
The rediscovery of the lymphatic system: old and new insights into the development and biological function of the lymphatic vasculature. Genes Dev (2002) 2.99
Molecular characterization of lymphatic endothelial cells. Proc Natl Acad Sci U S A (2002) 2.68
VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites. Blood (2006) 2.66
The staging of colorectal cancer: 2004 and beyond. CA Cancer J Clin (2004) 2.65
Molecular biology and pathology of lymphangiogenesis. Annu Rev Pathol (2008) 2.49
Tumour markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines for clinical use. Eur J Cancer (2007) 2.36
Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. J Exp Med (2009) 2.34
Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing. Am J Pathol (2000) 2.24
Risk of bleeding with vascular endothelial growth factor receptor tyrosine-kinase inhibitors sunitinib and sorafenib: a systematic review and meta-analysis of clinical trials. Lancet Oncol (2009) 2.23
Adjuvant treatment of colorectal cancer. CA Cancer J Clin (2007) 2.22
Intratumoral lymphangiogenesis and lymph node metastasis in head and neck cancer. Cancer Res (2002) 2.13
Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes. Mod Pathol (2005) 2.12
Prognostic implications of lymphangiogenesis in muscle-invasive transitional cell carcinoma of the bladder. Eur Urol (2007) 2.09
Dose-dependent response of FGF-2 for lymphangiogenesis. Proc Natl Acad Sci U S A (2004) 1.98
A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J (1996) 1.95
Lymph node evaluation and long-term survival in Stage II and Stage III colon cancer: a national study. Ann Surg Oncol (2008) 1.94
Lymphatic vessels in vascularized human corneas: immunohistochemical investigation using LYVE-1 and podoplanin. Invest Ophthalmol Vis Sci (2002) 1.82
Predictive value of vascular endothelial growth factor (VEGF) in metastasis and prognosis of human colorectal cancer. Br J Cancer (1998) 1.82
VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors. Int J Cancer (2002) 1.80
Functions of the multifaceted family of sphingosine kinases and some close relatives. J Biol Chem (2006) 1.76
Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation. Blood (2005) 1.75
Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2. J Biol Chem (2010) 1.74
Independent prognostic impact of lymphatic vessel density and presence of low-grade lymphangiogenesis in cutaneous melanoma. Clin Cancer Res (2003) 1.74
Lymphatic density and metastatic spread in human malignant melanoma. Br J Cancer (2004) 1.63
Control of angiogenesis by heparin and other sulfated polysaccharides. Adv Exp Med Biol (1992) 1.60
Pathways targeting tumor lymphangiogenesis. Clin Cancer Res (2006) 1.56
Absence of lymphangiogenesis and intratumoural lymph vessels in human metastatic breast cancer. J Pathol (2003) 1.56
Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action. Blood (2006) 1.52
Metastasis of cancer: a conceptual history from antiquity to the 1990s. Cancer Metastasis Rev (2000) 1.47
Inflammatory manifestations of experimental lymphatic insufficiency. PLoS Med (2006) 1.41
Lymphatic microvessel density and lymphovascular invasion assessed by anti-podoplanin immunostaining in human breast cancer. Anticancer Res (2001) 1.40
Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D, and their receptor VEGFR-3, during different stages of cervical carcinogenesis. J Pathol (2003) 1.39
The lymphatics revisited: new perspectives from the hyaluronan receptor LYVE-1. Trends Cardiovasc Med (2003) 1.39
Mechanisms of lymphatic metastasis in human colorectal adenocarcinoma. J Pathol (2009) 1.39
Prognostic molecular markers for planning adjuvant chemotherapy trials in Dukes' B colorectal cancer patients: how much evidence is enough? Ann Oncol (2003) 1.36
Characterization of lymphangiogenesis in a model of adult skin regeneration. Am J Physiol Heart Circ Physiol (2006) 1.35
High LYVE-1-positive lymphatic vessel numbers are associated with poor outcome in breast cancer. Clin Cancer Res (2004) 1.35
Generation and characterization of telomerase-transfected human lymphatic endothelial cells with an extended life span. Am J Pathol (2004) 1.35
Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways. Blood (2008) 1.30
Conditioned medium from mouse sarcoma 180 cells contains vascular endothelial growth factor. Growth Factors (1990) 1.28
Lymphangiogenesis correlates with lymph node metastasis, prognosis, and angiogenic phenotype in human non-small cell lung cancer. Clin Cancer Res (2005) 1.24
Monoclonal antibodies targeting vascular endothelial growth factor: current status and future challenges in cancer therapy. BioDrugs (2009) 1.22
Lymphatic endothelial tumors induced by intraperitoneal injection of incomplete Freund's adjuvant. Exp Cell Res (1999) 1.21
Evidence for lymphangiogenesis and its prognostic implications in head and neck squamous cell carcinoma. J Pathol (2005) 1.21
Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro. FASEB J (2010) 1.16
Colorectal cancer. Mayo Clin Proc (2007) 1.12
Lymphangiogenesis and angiogenesis in bladder cancer: prognostic implications and regulation by vascular endothelial growth factors-A, -C, and -D. Clin Cancer Res (2006) 1.12
Lymphatic microvessel density as prognostic marker in colorectal cancer. Mod Pathol (2006) 1.12
Clinical and biological significance of angiogenesis and lymphangiogenesis in colorectal cancer. Dig Liver Dis (2008) 1.11
Combination chemoprevention for colon cancer targeting polyamine synthesis and inflammation. Clin Cancer Res (2009) 1.11
Tumor lymphatics. Semin Cancer Biol (2009) 1.10
Tumor angiogenesis and novel antiangiogenic strategies. Int J Cancer (2010) 1.08
Lymphatic vessel density, microvessel density and lymphangiogenic growth factor expression in colorectal cancer. Colorectal Dis (2007) 1.06
Lymphangiogenesis: in vitro and in vivo models. FASEB J (2009) 1.05
Inhibition of lymphangiogenesis-related properties of murine lymphatic endothelial cells and lymph node metastasis of lung cancer by the matrix metalloproteinase inhibitor MMI270. Cancer Sci (2004) 1.04
Current progress in targeted therapy for colorectal cancer. Cancer Control (2010) 1.01
Animal models for the molecular and mechanistic study of lymphatic biology and disease. Ann N Y Acad Sci (2008) 1.00
Coexpression of VEGF-C and Cox-2 in human colorectal cancer and its association with lymph node metastasis. Dis Colon Rectum (2006) 1.00
VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab. World J Gastroenterol (2008) 0.98
Therapeutic targets of multiple angiogenic factors for the treatment of cancer and metastasis. Adv Cancer Res (2007) 0.97
Direct role of PDGF-BB in lymphangiogenesis and lymphatic metastasis. Cell Cycle (2005) 0.96
Celecoxib inhibits tumor growth and angiogenesis in an orthotopic implantation tumor model of human colon cancer. Exp Oncol (2008) 0.95
Depth of invasion determines the postresectional prognosis for patients with T1 extrahepatic cholangiocarcinoma. Cancer (2010) 0.95
From anti-angiogenesis to anti-lymphangiogenesis: emerging trends in cancer therapy. Lymphat Res Biol (2008) 0.94
Quantitative analysis of lymphangiogenic markers in human colorectal cancer. Int J Oncol (2003) 0.91
Genesis and pathogenesis of lymphatic vessels. Cell Tissue Res (2003) 0.91
Vector-based RNA interference against vascular endothelial growth factor-C inhibits tumor lymphangiogenesis and growth of colorectal cancer in vivo in mice. Chin Med J (Engl) (2008) 0.91
Development of a new method for isolation and long-term culture of organ-specific blood vascular and lymphatic endothelial cells of the mouse. FEBS J (2008) 0.91
Lymphangiogenesis in colorectal cancer--prognostic and therapeutic aspects. Int J Cancer (2007) 0.91
Lymphangiogenic and angiogenic microvessel density in human primary sporadic colorectal carcinoma. World J Gastroenterol (2008) 0.90
Vascular endothelial growth factor C promotes human gastric carcinoma lymph node metastasis in mice. J Exp Clin Cancer Res (2001) 0.90
Expression of vascular endothelial growth factor-C and angiogenesis in esophageal squamous cell carcinoma. World J Gastroenterol (2006) 0.89
Expression of Tiam1 and VEGF-C correlates with lymphangiogenesis in human colorectal carcinoma. Cancer Biol Ther (2009) 0.88
Tumor angiogenesis. J Investig Dermatol Symp Proc (2000) 0.88
Genetic changes of p53, K-ras, and microsatellite instability in gallbladder carcinoma in high-incidence areas of Japan and Hungary. World J Gastroenterol (2008) 0.87
Expression of vascular endothelial growth factor-C and the relationship between lymphangiogenesis and lymphatic metastasis in colorectal cancer. World J Gastroenterol (2004) 0.86
Molecular profile and proliferative responses of rat lymphatic endothelial cells in culture. Lymphat Res Biol (2006) 0.86
Perimuscular connective tissue contains more and larger lymphatic vessels than the shallower layers in human gallbladders. World J Gastroenterol (2007) 0.86
Circulating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance? World J Gastroenterol (2008) 0.85
Clinical significance of plasma level of vascular endothelial growth factor-C in patients with colorectal cancer. Jpn J Clin Oncol (2008) 0.85
Vascular endothelial growth factor C promotes lymph node metastasis in a rectal cancer orthotopic model. Surg Today (2005) 0.85
Who discovered the lymphatic system. Lymphology (1997) 0.84
Host prostaglandin EP3 receptor signaling relevant to tumor-associated lymphangiogenesis. Biomed Pharmacother (2009) 0.84
Establishment and characterization of conditionally immortalized endothelial cell lines from the thoracic duct and inferior vena cava of tsA58/EGFP double-transgenic rats. Cell Tissue Res (2006) 0.83
Development and characterization of endothelial cells from rat microlymphatics. Lymphat Res Biol (2003) 0.82
Inhibiting tumor growth of colorectal cancer by blocking the expression of vascular endothelial growth factor receptor 3 using interference vector-based RNA interference. Int J Mol Med (2010) 0.82
Targeted therapy in rectal cancer. Oncology (Williston Park) (2007) 0.82
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. Cancer Cell (2012) 3.24
Targeting SphK1 as a new strategy against cancer. Curr Drug Targets (2008) 1.91
Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression. Hepatology (2015) 1.81
High expression of ATP-binding cassette transporter ABCC11 in breast tumors is associated with aggressive subtypes and low disease-free survival. Breast Cancer Res Treat (2013) 1.78
Export and functions of sphingosine-1-phosphate. Biochim Biophys Acta (2009) 1.76
Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2. J Biol Chem (2010) 1.74
Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis. Cancer Res (2012) 1.71
Identification of regions of the sigma-1 receptor ligand binding site using a novel photoprobe. Mol Pharmacol (2007) 1.37
Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion. Cancer Res (2008) 1.34
Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes. Hepatology (2011) 1.33
Methods of esophagogastric anastomoses following esophagectomy for cancer: A systematic review. J Surg Oncol (2010) 1.26
Preoperative diagnosis of malignant transformation arising from mature cystic teratoma of the ovary. Gynecol Oncol (2003) 1.18
Resection of the primary tumor improves survival in metastatic breast cancer by reducing overall tumor burden. Surgery (2013) 1.16
Voltage-gated sodium channel modulation by sigma-receptors in cardiac myocytes and heterologous systems. Am J Physiol Cell Physiol (2009) 1.13
Is tail vein injection a relevant breast cancer lung metastasis model? J Thorac Dis (2013) 1.11
Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network. FASEB J (2012) 1.09
Inverted Meckel's diverticulum as a cause of occult lower gastrointestinal hemorrhage. World J Gastroenterol (2012) 1.09
Juxtaposition of the steroid binding domain-like I and II regions constitutes a ligand binding site in the sigma-1 receptor. J Biol Chem (2008) 1.07
A hybrid technique: video-assisted thoracoscopic surgery (VATS) pulmonary resections for community-based surgeons. Surg Endosc (2009) 1.07
An improved syngeneic orthotopic murine model of human breast cancer progression. Breast Cancer Res Treat (2014) 1.03
Successful treatment of primary pulmonary melanoma. J Thorac Dis (2011) 1.02
Chylothorax after blunt trauma. J Thorac Dis (2012) 1.01
Outcomes of a hybrid technique for video-assisted thoracoscopic surgery (VATS) pulmonary resection in a community setting. J Thorac Dis (2010) 1.01
Anti-hyperlipidemic and antioxidant potential of different fractions of Terminalia arjuna Roxb. bark against PX- 407 induced hyperlipidemia. Indian J Exp Biol (2011) 0.98
The evolution of the role of surgery in the management of breast cancer lung metastasis. J Thorac Dis (2012) 0.96
Lysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1-dependent upregulation of sphingosine kinase 1 transcription. FEBS Lett (2010) 0.94
Photoaffinity labeling of the sigma-1 receptor with N-[3-(4-nitrophenyl)propyl]-N-dodecylamine: evidence of receptor dimers. Biochemistry (2013) 0.93
Emerging Role of Sphingosine-1-phosphate in Inflammation, Cancer, and Lymphangiogenesis. Biomolecules (2013) 0.93
The role of sphingosine-1-phosphate in breast cancer tumor-induced lymphangiogenesis. Lymphat Res Biol (2012) 0.92
Bevacizumab and breast cancer: what does the future hold? Future Oncol (2012) 0.92
Minimally invasive colostomy revision for palliation of large stomal prolapse and an adherent sliding peristomal hernia. Am Surg (2013) 0.91
Animal models for exploring the pharmacokinetics of breast cancer therapies. Expert Opin Drug Metab Toxicol (2014) 0.87
Does removal of the primary tumor in metastatic breast cancer improve survival? J Womens Health (Larchmt) (2013) 0.86
Management of massive soft tissue defects: The use of INTEGRA® artificial skin after necrotizing soft tissue infection of the chest. J Thorac Dis (2012) 0.86
Targeting sphingosine-1-phosphate in hematologic malignancies. Anticancer Agents Med Chem (2011) 0.85
The ligand binding region of the sigma-1 receptor: studies utilizing photoaffinity probes, sphingosine and N-alkylamines. Curr Pharm Des (2012) 0.84
Sentinel Lymph Node Biopsy for Breast Cancer: Our Technique and Future Directions in Lymph Node Staging. J Nucl Med Radiat Ther (2012) 0.83
Thymic neoplasm: a rare disease with a complex clinical presentation. J Thorac Dis (2013) 0.83
Are video-assisted thoracoscopic surgery (VATS) and robotic video-assisted thoracic surgery (RVATS) for pulmonary resection ready for prime time? J Thorac Dis (2012) 0.82
Chemokines, chemokine receptors and the gastrointestinal system. World J Gastroenterol (2013) 0.82
Investigation of in vivo antioxidant property of Abelmoschus esculentus (L) moench. fruit seed and peel powders in streptozotocin-induced diabetic rats. J Ayurveda Integr Med (2012) 0.82
Cell-type specific expression of the vasopressin gene analyzed by AAV mediated gene delivery of promoter deletion constructs into the rat SON in vivo. PLoS One (2012) 0.82
Facial aesthetic preferences among Asian women: are all oriental Asians the same? Aesthetic Plast Surg (2006) 0.81
Characterization of interactions of 4-nitrophenylpropyl-N-alkylamine with ς receptors. Biochemistry (2011) 0.81
Analysis of transcription factor mRNAs in identified oxytocin and vasopressin magnocellular neurons isolated by laser capture microdissection. PLoS One (2013) 0.81
Intralesional therapy for metastatic melanoma. Expert Opin Pharmacother (2014) 0.80
Effect of adenovirus-mediated overexpression of follistatin and extracellular domain of activin receptor type II on gonadotropin secretion in vitro and in vivo. Endocrinology (2002) 0.79
Chemosaturation with percutaneous hepatic perfusion for unresectable metastatic melanoma or sarcoma to the liver: a single institution experience. J Surg Oncol (2013) 0.78
Computed tomography is useful for preoperative workup of gastric rupture caused by blunt trauma. Surg Today (2009) 0.78
Developments in Intralesional Therapy for Metastatic Melanoma. Cancer Control (2016) 0.77
Earwax type and osmidrosis: prognostic factor for breast cancer? Response to letter to the editor. Breast Cancer Res Treat (2013) 0.75
Pneumothorax, an underappreciated complication with an airway exchange catheter. J Thorac Dis (2012) 0.75
Image of the month--quiz case. Heterotopic gastric mucosa. Arch Surg (2008) 0.75