Published in J Biol Chem on August 24, 2010
mTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic Interventions. Mol Biol Int (2014) 0.92
Loss of PINK1 attenuates HIF-1α induction by preventing 4E-BP1-dependent switch in protein translation under hypoxia. J Neurosci (2014) 0.87
High expression of phosphorylated 4E-binding protein 1 is an adverse prognostic factor in esophageal squamous cell carcinoma. Virchows Arch (2010) 0.87
Association of maternal mRNA and phosphorylated EIF4EBP1 variants with the spindle in mouse oocytes: localized translational control supporting female meiosis in mammals. Genetics (2013) 0.86
Prognostic significance of phosphorylated 4E-binding protein 1 in non-small cell lung cancer. Int J Clin Exp Pathol (2015) 0.84
Rapamycin-insensitive mTORC1 activity controls eIF4E:4E-BP1 binding. F1000Res (2012) 0.84
6-Mercaptopurine attenuates tumor necrosis factor-α production in microglia through Nur77-mediated transrepression and PI3K/Akt/mTOR signaling-mediated translational regulation. J Neuroinflammation (2016) 0.79
The translational repressor eIF4E-binding protein 2 (4E-BP2) correlates with selective delayed neuronal death after ischemia. J Cereb Blood Flow Metab (2013) 0.79
Dissociation of eIF4E-binding protein 2 (4E-BP2) from eIF4E independent of Thr37/Thr46 phosphorylation in the ischemic stress response. PLoS One (2015) 0.76
Immunohistochemical Assessment of Phosphorylated mTORC1-Pathway Proteins in Human Brain Tumors. PLoS One (2015) 0.75
AKT/PKB signaling: navigating downstream. Cell (2007) 31.26
Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell (2009) 14.51
Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol (2009) 13.89
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev (1999) 8.14
Ischemic cell death in brain neurons. Physiol Rev (1999) 8.01
Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev (2001) 5.37
Identification of a tumour suppressor network opposing nuclear Akt function. Nature (2006) 3.68
Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein. Proc Natl Acad Sci U S A (1999) 3.49
Signalling to translation: how signal transduction pathways control the protein synthetic machinery. Biochem J (2007) 3.28
TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. Cancer Res (2009) 2.96
4E-binding protein 1: a key molecular "funnel factor" in human cancer with clinical implications. Cancer Res (2007) 2.67
Brain ischemia and reperfusion: molecular mechanisms of neuronal injury. J Neurol Sci (2000) 2.56
Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins. J Mol Biol (2002) 2.53
Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins. Mol Cell Biol (2005) 2.47
Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression. Mol Cell Biol (2000) 2.35
Oxidants, antioxidants and the ischemic brain. J Exp Biol (2004) 2.05
Translational control: the cancer connection. Int J Biochem Cell Biol (1999) 1.95
Molecular mechanisms for the control of translation by insulin. Biochem J (1997) 1.89
Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies. J Biol Chem (2000) 1.83
4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle. Am J Physiol Endocrinol Metab (2000) 1.75
mTOR signaling: implications for cancer and anticancer therapy. Br J Cancer (2006) 1.72
mTOR-mediated regulation of translation factors by amino acids. Biochem Biophys Res Commun (2004) 1.69
Delayed neuronal death. Neuropathology (2000) 1.49
Mechanisms of ROS modulated cell survival during carcinogenesis. Cancer Lett (2008) 1.44
eIF4E: new family members, new binding partners, new roles. J Biol Chem (2009) 1.42
Genomics of the periinfarction cortex after focal cerebral ischemia. J Cereb Blood Flow Metab (2003) 1.32
Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1. J Biol Chem (2003) 1.29
Dissociation of the eukaryotic initiation factor-4E/4E-BP1 complex involves phosphorylation of 4E-BP1 by an mTOR-associated kinase. FEBS Lett (1999) 1.24
The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation. Mol Cell Biol (2003) 1.22
Possible mechanisms involved in the down-regulation of translation during transient global ischaemia in the rat brain. Biochem J (2001) 1.11
mTORC1 signaling can regulate growth factor activation of p44/42 mitogen-activated protein kinases through protein phosphatase 2A. J Biol Chem (2007) 0.99
Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated dissociation from eIF4E. J Biol Chem (2003) 0.97
Pattern-specific sustained activation of tyrosine hydroxylase by intermittent hypoxia: role of reactive oxygen species-dependent downregulation of protein phosphatase 2A and upregulation of protein kinases. Antioxid Redox Signal (2009) 0.96
Phosphorylation of the alpha subunit of initiation factor 2 correlates with the inhibition of translation following transient cerebral ischaemia in the rat. Biochem J (1994) 0.95
Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2. Genomics (1996) 0.95
Ischaemia induces changes in the association of the binding protein 4E-BP1 and eukaryotic initiation factor (eIF) 4G to eIF4E in differentiated PC12 cells. Biochem J (2000) 0.95
Chronic alcohol consumption alters mammalian target of rapamycin (mTOR), reduces ribosomal p70s6 kinase and p4E-BP1 levels in mouse cerebral cortex. Exp Neurol (2007) 0.91
Two different signal transduction pathways are implicated in the regulation of initiation factor 2B activity in insulin-like growth factor-1-stimulated neuronal cells. J Biol Chem (2000) 0.90
Antibodies reactive to heat shock protein 90 induce oligodendrocyte precursor cell death in culture. Implications for demyelination in multiple sclerosis. FASEB J (2003) 0.88
Regulation of cap-dependent translation by insulin-like growth factor-1 in neuronal cells. Biochem Biophys Res Commun (2002) 0.87
Regulatory proteins of eukaryotic initiation factor 2-alpha subunit (eIF2 alpha) phosphatase, under ischemic reperfusion and tolerance. J Neurochem (2007) 0.86
Signal transduction molecules in gliomas of all grades. J Neurooncol (2008) 0.85
Dissociation of Akt/PKB and ribosomal S6 kinase signaling markers in a transgenic mouse model of Alzheimer's disease. Neurobiol Dis (2007) 0.85
Proteomic characterization of protein phosphatase 1 complexes in ischemia-reperfusion and ischemic tolerance. Proteomics (2007) 0.84
Reactive oxygen species sensitivity of angiotensin II-dependent translation initiation in vascular smooth muscle cells. J Biol Chem (2003) 0.84
Delayed postconditionig initiates additive mechanism necessary for survival of selectively vulnerable neurons after transient ischemia in rat brain. Cell Mol Neurobiol (2006) 1.17
The MyD116 African swine fever virus homologue interacts with the catalytic subunit of protein phosphatase 1 and activates its phosphatase activity. J Virol (2007) 0.98
Evidence for a role of second pathophysiological stress in prevention of delayed neuronal death in the hippocampal CA1 region. Neurochem Res (2005) 0.92
Ischaemic preconditioning in the rat brain: effect on the activity of several initiation factors, Akt and extracellular signal-regulated protein kinase phosphorylation, and GRP78 and GADD34 expression. J Neurochem (2004) 0.90
Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1. Exp Cell Res (2004) 0.90
Antibodies reactive to heat shock protein 90 induce oligodendrocyte precursor cell death in culture. Implications for demyelination in multiple sclerosis. FASEB J (2003) 0.88
Regulation of cap-dependent translation by insulin-like growth factor-1 in neuronal cells. Biochem Biophys Res Commun (2002) 0.87
Eukaryotic initiation factors (eIF) 2alpha and 4E expression, localization, and phosphorylation in brain tumors. J Histochem Cytochem (2009) 0.87
Regulatory proteins of eukaryotic initiation factor 2-alpha subunit (eIF2 alpha) phosphatase, under ischemic reperfusion and tolerance. J Neurochem (2007) 0.86
Calpain inhibition stimulates caspase-dependent apoptosis induced by taxol in NIH3T3 cells. Exp Cell Res (2006) 0.86
Initiation factor 2B activity is regulated by protein phosphatase 1, which is activated by the mitogen-activated protein kinase-dependent pathway in insulin-like growth factor 1-stimulated neuronal cells. J Biol Chem (2003) 0.85
Translation regulation after taxol treatment in NIH3T3 cells involves the elongation factor (eEF)2. Exp Cell Res (2007) 0.85
Low concentrations of glutamate induce apoptosis in cultured neurons: implications for amyotrophic lateral sclerosis. J Neurol Sci (2003) 0.85
A DNA aptamer population specifically detects Leishmania infantum H2A antigen. Lab Invest (2007) 0.84
Proteomic characterization of protein phosphatase 1 complexes in ischemia-reperfusion and ischemic tolerance. Proteomics (2007) 0.84
The proteome of human brain after ischemic stroke. J Neuropathol Exp Neurol (2010) 0.82
Suppression of human Mnk1 by small interfering RNA increases the eukaryotic initiation factor 4F activity in HEK293T cells. FEBS Lett (2004) 0.81
Characterization of the activity of human MAP kinase-interacting kinase Mnk1b. Biochim Biophys Acta (2007) 0.81
Anti-heat shock protein 90beta antibodies decrease pre-oligodendrocyte population in perinatal and adult cell cultures. Implications for remyelination in multiple sclerosis. J Neurochem (2005) 0.80
Selection of aptamers against KMP-11 using colloidal gold during the SELEX process. Biochem Biophys Res Commun (2003) 0.80
Citicoline (CDP-choline) increases Sirtuin1 expression concomitant to neuroprotection in experimental stroke. J Neurochem (2013) 0.80
Role of protein synthesis in the ischemic tolerance acquisition induced by transient forebrain ischemia in the rat. Neurochem Res (2003) 0.80
The translational repressor eIF4E-binding protein 2 (4E-BP2) correlates with selective delayed neuronal death after ischemia. J Cereb Blood Flow Metab (2013) 0.79
eIF4F complex disruption causes protein synthesis inhibition during hypoxia in nerve growth factor (NGF)-differentiated PC12 cells. Biochim Biophys Acta (2011) 0.78
Protective effect of L-trans-pyrrolidine-2,4-dicarboxilic acid preload against cell death induced by oxygen/glucose deprivation in differentiated PC12 cells. J Neurosci Res (2005) 0.78
Neuronal apoptosis induced by cerebrospinal fluid from multiple sclerosis patients correlates with hypointense lesions on T1 magnetic resonance imaging. J Neurol Sci (2002) 0.78
Analysis of the protein expression changes during taxol-induced apoptosis under translation inhibition conditions. Mol Cell Biochem (2010) 0.77
Assessment of protein expression levels after transient global cerebral ischemia using an antibody microarray analysis. Neurochem Res (2010) 0.77
Cerebral postischemic reperfusion-induced demethylation of the protein phosphatase 2A catalytic subunit. J Neurosci Res (2002) 0.76
Α-aryl-N-alkyl nitrones, as potential agents for stroke treatment: synthesis, theoretical calculations, antioxidant, anti-inflammatory, neuroprotective, and brain-blood barrier permeability properties. J Med Chem (2011) 0.75